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Research Projects

Research supported by NH-INBRE
All of the NH-INBRE Goals are strongly supported by the Developmental Research Projects Program (DRPP), which funds competitive cutting-edge biomedical research proposed and led by faculty at Partner institutions that enables intense engagement by both students and faculty at Partners.

NH-INBRE funding establishes research programs that successfully compete for other funding sources as the research develops.

Research projects are of three types:
(1) Research Projects
require a 50% effort commitment from the faculty principal investigator.
(2) Pilot Projects
require a 25% effort commitment from the faculty principal investigator.
(3) Collaborative Projects
are Research or Pilot Projects that include a collaborating faculty member from Dartmouth or UNH.

Alternative Funding Mechanisms:
(1) Seed Grant: to provide 1-year of funding (potentially renewable) to test new research idea(s) – entirely original areas of investigation for the investigator or a substantially new extension of previous work. No salary support.
(2) Targeted Incentive Grant: to expedite submission of-

  • Manuscripts (especially data driven; reviews will be considered; however not letters to the editor, etc
  • New/ Revised Grant Applications to national funding sources (NIH, NSF, and/or foundations)

 

Current Research Projects

SEED GRANT
Michelle Beck, Rivier University
Exposure and physiological effects of element contamination associated with urbanization.

SEED GRANT
Michael Brian, University of New Hampshire
The effects of body composition on blood pressure and arterial stiffening in young adults.

COLLABORATIVE PILOT PROJECT
Geoffrey Cook, New England College
Bioprospecting for novel antimicrobial peptides in corals and other marine organisms.
Scientific Advisors: Feixia Chu (Collaborator), University of New Hampshire; Ambrose Cheung, Geisel School of Medicine at Dartmouth
Professional Mentor: Jim Newcomb, New England College

SEED GRANT
Jeremiah Johnson, University of New Hampshire at Manchester
Using Artificial Intelligence to Understand the Neurological Basis of Autism Spectrum Disorder.

SEED GRANT
Nicole Jaskiewicz, Plymouth State University
The role of Hexosamine Biosynthesis Pathway in the Heat Stress Response of Granulosa Cells 

PILOT PROJECT
Kristen Johnson, University of New Hampshire at Manchester
Understanding the mechanisms of FOXN2 regulation of EMT in pancreatic cancer.
Scientific Advisors: Steve Leach, Geisel School of Medicine at Dartmouth; Kenneth Olive, Columbia University Medical Center
Professional Mentor: Kyle MacLea, University of New Hampshire at Manchester

SEED GRANT
Tatiana Jones, Rivier University
Extracellular RNA as a potential inducer of Interleukin 6 (IL6) production by activated macrophages.

PILOT PROJECT
James Jukosky, Colby-Sawyer College
Exploring eastern newt antimicrobial peptides and immune system role in regeneration.
Scientific Advisors: Steve Fiering, Geisel School of Medicine at Dartmouth; William Green, Geisel School of Medicine at Dartmouth
Professional Mentor: Benjamin Steele, Colby-Sawyer College

TARGETED INCENTIVE GRANT
James Newcomb, New England College
Nudibranch opsins: identification, localization, and potential roles in extraocular photoreception and circadian rhythms. 

PILOT PROJECT
Jennifer Pace, Saint Anselm College
Synthesis and Evaluation of Flufenamic Acid Analogues for Hippo Pathway Inhibition.
Scientific Advisor: Paul Baures, Keene State College
Professional Mentor: Derk Wierda, Saint Anselm College

PILOT PROJECT
Britney Privett, Saint Anselm College
Biophysical characterization of metal binding to ZNF750, a ZNF implicated in tumorigenesis.
Scientific Advisor: Dale Mierke, Geisel School of Medicine at Dartmouth
Professional Mentor: Derk Wierda, Saint Anselm College

PILOT PROJECT
Priyanka Roy Chowdhury, Keene State College
Determinants of susceptibility to transgenerational Arsenic exposure.
Scientific Advisors: Brian Jackson, Geisel School of Medicine at Dartmouth; Kate Buckman, Geisel School of Medicine at Dartmouth
Professional Mentor: Jason Pellettieri, Keene State College

SEED GRANT
William Schmidt, Rivier University
Effect of Tropomyosin Lysine Acetylation on Binding to Filamentous Actin.

SEED GRANT
Won Hyuk Suh, University of New Hampshire at Manchester
Self-Assembling Peptide Amphiphile Hydrogels for 3D Printing Nerve Tissue Organoids.

PILOT PROJECT
Joseph Troisi, Saint Anselm College
Sex Differences in the Discriminative Stimulus Effects of Nicotine: An evaluation of acquisition, extinction, and recovery.
Scientific Advisor: Chuck Cole, Geisel School of Medicine at Dartmouth

PILOT PROJECT
Chery Whipple, Colby-Sawyer College
The impact of the emergent contaminants, PFOA and PFHxA, on development, growth, and viability in the nematode Caenorhabditis elegans.
Scientific Advisors: Erik Griffin, Geisel School of Medicine at Dartmouth; Nora Traviss, Keene State College
Professional Mentor: Benjamin Steele, Colby-Sawyer College

SEED GRANT
Matthew Young, New England College
Exploring the Molecular Dynamics of Hydrogel Capture of Human Anti-bacterial Peptides

 

Past Research Projects

Years 2020 - 2021

SEED GRANT
Sarah Gunnery, New England College
The Effects of Facial Masking on Health Related Quality of Life in Care Partners of People with Parkinson’s Disease.

SEED GRANT
Matthew Hurley, Saint Anselm College
Developing and Evaluating Surfactant Vesicles for Targeted Drug Delivery Applications.

PILOT PROJECT
Meenalosini Vimal Cruz, Keene State College
Development of Artificial Intelligence-based Remote Health Monitoring System (AIRHMS).
Scientific Advisors: Saeed Hassanpour, Geisel School of Medicine at Dartmouth
Professional Mentor: Jason Pellettieri, Keene State College

 

Years 2018 - 2020

PILOT PROJECT
Michael Brian, Plymouth State University
Effects of varying intensity exercise on glycemic control & blood pressure regulation in sedentary young adults at-risk for Metabolic Syndrome.
Scientific Advisors: Sushela Chaidarun, Geisel School of Medicine at Dartmouth; Mark Craeger, Geisel School of Medicine at Dartmouth
Professional Mentor: Christopher Chabot, Plymouth State University

PILOT PROJECT
Heather Doherty, Plymouth State University
Detection of CTGF SNPs and correlation to clinical variables in the Framingham Heart Study Omni Cohort 1.
Scientific Advisors: Brock Christensen, Geisel School of Medicine at Dartmouth; John Batsis, Dartmouth Hitchcock Medical Center
Professional Mentor: Christopher Chabot, Plymouth State University

COLLABORATIVE PILOT PROJECT
Harlan Fichtenholtz, Keene State College
Neural Mechanisms of Emotional Vigilance in Posttraumatic Stress Disorder (PTSD).
Scientific Advisors: Matthew Friedman, Dartmouth Hitchcock Medical Center; Kevin Fleming, White River Junction VA Medical Center
Professional Mentor: Jason Pellettieri, Keene State College

PILOT PROJECT
Leila Jabbour, Franklin Pierce University
Expression Pattern of △FosB in Human Post Mortem Tissue from Opioid Overdose.
Scientific Advisor: Kyle Smith, Geisel School of Medicine at Dartmouth
Professional Mentor: Catherine Koning, Franklin Pierce University

PILOT PROJECT
Kyle MacLea, University of New Hampshire at Manchester
Factors Affecting the Propagation of [PSI+] Prions in Saccharomyces cerevisiae.
Scientific Advisors: Surachai Supattapone, Geisel School of Medicine at Geisel; Charles Barlowe, Geisel School of Medicine at Dartmouth
Professional Mentor: Steven Pugh, University of New Hampshire at Manchester

PILOT PROJECT
Daniel Seichepine, University of New Hampshire at Manchester
Effects of Parkinson’s disease subtype on executive function and personality attributes.
Scientific Advisor: Stephen Lee, Dartmouth Hitchcock Medical Center
Professional Mentor: Steven Pugh, University of New Hampshire at Manchester

 

Years 2015 - 2020

COLLABORATIVE PILOT PROJECT
Paul Baures
, Keene State College
Advancement of a novel fatty acid synthase inhibitor
Collaborator and Mentor: William Kinlaw, Geisel School of Medicine at Dartmouth

PILOT PROJECT
Deborah McCarter
, Saint Anselm College
Enhancing follow-up mechanisms for women at risk for postpartum depression
Mentor: Mark Hegel, Dartmouth Hitchcock Medical Center

 

Years 2015 - 2018

COLLABORATIVE PILOT PROJECT
Lori Bergeron
, New England College
C-di-GMP mediated biofilm formation in Pseudomonas fluorescens
Collaborator and Mentor: George O’Toole, Geisel School of Medicine at Dartmouth

PILOT PROJECT
Daniel Broek, Saint Anselm College
Cell survival through a dicentric chromosome phase
Mentor: Duane Compton, Geisel School of Medicine at Dartmouth

COLLABORATIVE PILOT PROJECT
Chris Chabot, Plymouth State University
Molecular and cellular mechanisms of circadian and circatidal rhythms                                                                 
Collaborator and Mentor: Winsor Watson, University of New Hampshire

COLLABORATIVE PROJECT
James Newcomb
, New England College
Neural mechanisms of circadian rhythms and interactions between clocks
Collaborator and Mentor: Winsor Watson, University of New Hampshire

PILOT PROJECT
Amy Piispanen
, Franklin Pierce University
Regulation of the Cek1 MAP kinase cascade and morphogenesis in Candida albicans
Mentor: Paula Sundstrom, Geisel School of Medicine at Dartmouth

COLLABORATIVE PILOT PROJECT
Anthony Scioli
, Keene State College
An efficacy and feasibility study of a hope-centered intervention for adolescents
Collaborator and Mentor: Anna Adachi-Mejia, Geisel School of Medicine at Dartmouth

PILOT PROJECT
Thomas Shell
, Saint Anselm College
Targeted treatment of cancer and neurological disorders
Mentor: Marc Spaller, Geisel School of Medicine at Dartmouth

RESEARCH PROJECT
Mike Son, Plymouth State University
The effects of clinically relevant SNPs on virulence capabilities of V. cholerae
Mentor: Deborah Hogan, Geisel School of Medicine at Dartmouth

PILOT PROJECT
Lawrence Welkowitz
, Keene State College
Behavioral and cortical effects of computerized language training for autism.
Mentor: Laura Flashman, Geisel School of Medicine at Dartmouth

 

Years 2013 - 2015

PILOT PROJECT
James Jukosky,
Colby-Sawyer College
Developing novel antimicrobials derived from burying beetles                                                                                 
 Mentor: Steven Fiering, Geisel School of Medicine at Dartmouth

PILOT PROJECT
Jason Pellettieri,
Keene State College
Light-Induced Pigment Cell Apoptosis                                 
Mentor: David Mullins, Geisel School of Medicine at Dartmouth

PILOT PROJECT
Mike Son, Plymouth State University,
Characterization of increased virulence mechanisms in clinical V. cholerae                  
Mentor: Deborah Hogan, Geisel School of Medicine at Dartmouth

 

Years 2010 - 2015

COLLABORATIVE PILOT PROJECT
Susan Arruda
, Franklin Pierce University
Characterizing a novel G protein-coupled receptor in Drosophila vision
Collaborator and Mentor: Patrick Dolph, Geisel School of Medicine at Dartmouth

COLLABORATIVE PILOT PROJECT
Lori Bergeron
, New England College
Metal dependent gene expression in A. naeslundii
Collaborator and Mentor: George O’Toole, Geisel School of Medicine at Dartmouth

RESEARCH PROJECT
Daniel Broek, Saint Anselm College
A yeast-based screen for identification of mammalian genes that regulate ploidy
Mentor: Duane Compton, Geisel School of Medicine at Dartmouth

RESEARCH PROJECT
Chris Chabot, Plymouth State University
Molecular and cellular mechanisms of circadian and circatidal rhythms                                                                 
Mentor: Winsor Watson, University of New Hampshire

PILOT PROJECT
Marjorie King, Plymouth State University
Reliability of center of foot pressure in the older adult population                                                             
Mentor: Jon Lurie, Geisel School of Medicine at Dartmouth

COLLABORATIVE PILOT PROJECT
James Newcomb
, New England College
Molecular & neural mechanisms of circadian rhythms in a gastropod model organism
Collaborator and Mentor: Winsor Watson, University of New Hampshire

COLLABORATIVE PROJECT
Susan Whittemore, Keene State College
Identification of signaling pathways affected by early exposure to prevalent PAHs
Collaborator and Mentor: Leslie Henderson, Geisel School of Medicine at Dartmouth

 

Years 2010 - 2013

COLLABORATIVE PROJECT
Nicholas Baer, Colby Sawyer
The role of ecological, chemical and landscape factors in determining methyl mercury bioaccumulation in stream food webs
Collaborator: Celia Chen, Geisel School of Medicine at Dartmouth

PILOT PROJECT
Katie Rose Boissonneault, Plymouth State University
Genetic Transformation of the Toxic Diatom Pseudo-nitzschia multiseries

PILOT PROJECT
Heather Frasier Chabot,
New England College
Health and its association with physiologic distress and bystander intervention in domestic violence  

PILOT PROJECT
Loren Launen, Keene State College
A molecular characterization of the structure and function of aromatic hydrocarbon degrading microbes present in the tidal wetlands of the Great Bay estuary   

PILOT PROJECT
Bill Thomas, Colby-Sawyer College
An analysis of a-catenin functions in transfected DLC1 carcinoma cells       

PILOT PROJECT
Joseph Troisi, Saint Anselm College
Pavlovian and operant interactions of discriminant stimulus effects of nicotine and ETOH in rats: Analyses of conditioned reinforcement, extinction, and response recovery.

COLLABORATIVE PROJECT
Adam Wenzel, Saint Anselm College
The influence of body mass index on changes in macular pigment, serum carotenoids and c-reactive protein.
Collaborator: Joanne Curran Celentano, University of New Hampshire