Is the Interstitium Really a New Organ? – The Scientist

Read article - Cites comments by Radu Stan, associate professor of biochemistry and cell biology, and of pathology and laboratory medicine, about the recent news that a team of researchers used a new in vivo microscopy technique to present evidence that the human interstitium—the space between cells—is more like a matrix of collagen bundles interspersed with fluid than the densely-packed stacks of connective tissue it appears to be in fixed slides. Stan, who wasn't involved in the study, notes that the concept of a fluid-filled matrix is not "earth-shattering," and that sectioning and imaging unfixed tissue as the authors did, which could tear and create artifacts, presents limitations.