Researchers led by Dartmouth’s and Dartmouth-Hitchcock’s Norris Cotton Cancer Center are studying a valuable target in regulating the immune response in cancer and autoimmunity. VISTA is a tempering molecule that hinders T cells in the immune system from activating against self-antigens such as cancer cells. Their new publication describes how VISTA controls T-cell responses.
Researchers at Dartmouth’s and Dartmouth-Hitchcock’s Norris Cotton Cancer Center have discovered that a receptor found in almost all cells plays a big role in the body’s metabolism. By blocking the receptor with use of a drug, mice on a high-fat diet did not become any fatter than mice on a low-fat control diet, and obese mice dropped in weight with use of the same drug. No ill side effects were observed in either study.
A new study by scientists at Dartmouth’s Norris Cotton Cancer Center and the Dartmouth Institute for Health Policy and Clinical Practice conducted focus groups with women in three different states to learn what they did and did not know about breast density, in general and their own. The study found that women had varying knowledge. What they all had in common was a strong desire to learn more.
Scientists at Dartmouth’s Norris Cotton Cancer Center make a direct connection between dietary fat and cancer cell biology by showing that fat particles from the blood are taken into breast cancer cells through a novel mechanism.
Mary Jo Turk, PhD, has been named the O. Ross McIntyre, MD, Professor at the Geisel School of Medicine at Dartmouth. Turk, a professor of microbiology and immunology and co-director of the Immunology and Cancer Immunotherapy Program at Dartmouth’s Norris Cotton Cancer Center, joined the faculty of Dartmouth’s medical school 15 years ago and conducts pioneering research on the complex interactions between the immune system and cancer.
Scott A. Gerber, PhD, professor of molecular and systems biology and of biochemistry and cell biology at the Geisel School of Medicine at Dartmouth, and program director of the Cancer Biology and Therapeutics Research Program at Dartmouth’s Norris Cotton Cancer Center, has been named the Kenneth E. and Carol L. Weg Distinguished Professor.
Preliminary evidence from a new national Dartmouth study suggests that external food cue responsiveness is measurable by parental report in preschool-age children. Responsiveness was greater among children with, versus without, usual TV advertisement exposure. These results may provide a better understanding of how an obesogenic food environment shapes the development of children’s eating behaviors at a young age.
Effective cervical cancer screening initiative by Dartmouth researchers in Honduras identifies different human papillomavirus types than those in the U.S.
Dartmouth researchers have found a machine learning method that can predict the likelihood that a high-risk type of breast lesion is cancerous, potentially saving some women from unnecessary surgeries and overtreatment.
Steven D. Leach, MD, director of the Dartmouth-Hitchcock Norris Cotton Cancer Center and the Preston T. and Virginia R. Kelsey Distinguished Chair in Cancer at the Geisel School of Medicine at Dartmouth, has been named a Fellow of the American Association for the Advancement of Science.
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