Richard I. Enelow, M.D.
Title(s):
Professor of Medicine
Professor of Microbiology and Immunology
Vice-Chair for Research Affairs, Dept. of Medicine
Department(s):
Medicine
Microbiology and Immunology
Education:
BA Amherst College, 1978
MD Boston University, 1983.
Post-doctoral fellowship, Viral Immunology, University of Virginia, 1992-97
Programs:
Immunology Program
Program in Experimental and Molecular Medicine
SYNERGY
Other
Websites:
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Contact Information:
1 Medical Center Drive
Lebanon NH 03756
Office: DHMC
Phone: (603) 650-5533
Fax: (603) 650-0580
Email: richard.i.enelow@dartmouth.edu
Assistant: Brittany Bergeron
Asst. Phone: (603) 650-5533
Asst. Email: brittany.j.bergeron@hitchcock.org
Professional Interests:
Immunopathogenesis of respiratory virus infection;
Influenza pathogenesis;
Inflammatory and immune-mediated lung disease
Grant Information:
R01AI069360 (PI: Enelow)
NIH/NIAID
"TNF Processing in Pulmonary Immunopathology"
U19 AI83024 (PI: Enelow)
NIH/NIAID
"Innate Regulation of CD8+ T Cell Effector Activities"
Courses Taught:
Advanced Topics in Immunology
PEMM Immunology Module
Biography:
My area of research broadly concerns the mechanisms that underlie the immune-mediated damage to the lungs which occurs in the context of respiratory virus infection. My clinical interests include immune-mediated lung disease, particularly the idiopathic interstitial pneumonias, and I have spent my entire career exploring the potential relationship between antiviral T cell responses to respiratory infection to chronic inflammatory lung disease. I became interested in host responses to pulmonary infection as a research fellow in Infectious Disease at the University of Virginia, while pursuing clinical training in Pulmonary Disease. I then spent the next 5 years as a post-doctoral fellow in the laboratory of Dr. Thomas J. Braciale, M.D., Ph.D., (Microbiology/Pathology), Director of the newly-established Beirne B. Carter Center for Immunology Research at the University of Virginia, in order to receive rigorous training in viral immunopathogenesis. Aside from outstanding training and mentoring in addressing questions in basic cellular and molecular immunology, I became fascile with the techniques necessary to work with and manipulate negative-strand RNA viruses, such as influenza and RSV, and these respiratory infections have been the focus of most of my work after moving to Yale, and then to Dartmouth. I have extensive experience in mouse and human basic immunology, and my laboratory is currently home to 2 junior faculty members, 3 postdoctoral fellows, 1 graduate student, and 2 research assistants, so I have ample capacity to take on a variety of collaborative projects in addition to our primary areas of exploration. In addition I have 20 years of experience participating in multi-investigator clinical trials, in interstitial lung disease (particularly idiopathic pulmonary fibrosis), my clinical area of interest, and several publications which have come from these endeavors. For information on the Clinical Research Program in Interstitial Lung Disease see http://www.dartmouth.edu/~renelowlab/the-dartmouth-interstitial.html
Selected Publications: |
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Pociask DA, Scheller EV, Mandalapu S, McHugh KJ, Enelow RI, Fattman CL, Kolls JK, Alcorn JF Hufford MM, Richardson G, Zhou H, Manicassamy B, Garcia-Sastre A, Enelow RI, Braciale TJ Gifford AH, Matsuoka M, Ghoda LY, Homer RJ, Enelow RI Kozul-Horvath CD, Zandbergen F, Jackson BP, Enelow RI, Hamilton JW Kudva A, Scheller EV, Robinson KM, Crowe CR, Choi SM, Slight SR, Khader SA, Dubin PJ, Enelow RI, Kolls JK, Alcorn JF Srikiatkhachorn A, Chintapalli J, Liu J, Jamaluddin M, Harrod KS, Whitsett JA, Enelow RI, Ramana CV Ramana CV, Cheng GS, Kumar A, Kwon HJ, Enelow RI Crowe CR, Chen K, Pociask DA, Alcorn JF, Krivich C, Enelow RI, Ross TM, Witztum JL, Kolls JK Kozul CD, Ely KH, Enelow RI, Hamilton JW King TE Jr, Albera C, Bradford WZ, Costabel U, Hormel P, Lancaster L, Noble PW, Sahn SA, Szwarcberg J, Thomeer M, Valeyre D, du Bois RM |
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