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Core Instrumentation Labs

Bioinformatics

Provides a wide range of services including applied bioinformatics and data mining, computer programming and software engineering, database development and programming, and high-performance computing and systems administration. More information.

Biostatistics

Expertise includes clinical trial design, longitudinal data, statistical methods for genomics and managing data, measurement error methods, nonlinear dose response modeling, quality of life data, decision sciences, cost effectiveness analysis, and diagnostic test assessment; maintains an extensive statistical software library providing access to all major statistical analysis platforms. More information.

Clinical Pharmacology

Supports investigators in the design, analysis, and interpretation of clinical pharmacology objectives in preclinical and clinical studies, including chemoprevention and epidemiological studies; equipment includes bioanalytical hardware and computer hardware and state-of-the-art commercial software programs. More information.

DartMouse - Speed Congenics

Facilitates the development of congenic mice in support of pre-clinical projects; provides expert advice on mouse speed congenic development, mouse genetic background analysis, and mouse genetic mapping. More information.

Genomics

Provides technologies that enable profiling of gene expression, miRNA, GpC Island, and CGH on a whole-genome scale, and provides high-quality genomics and microarray data. More information.

GeoSpatial Resource

Provides expert consultation and collaboration for research projects in behavior, epidemiology, and health services research; also strives to educate members of the community in different aspects of geospatial analysis by providing courses through The Dartmouth Institute and at Dartmouth College. More information.

Immune Monitoring and Flow Cytometry

Provides various services such as isolation and cryopreservation of PBMCs and plasma or serum for clinical trials, as well as carrying out a spectrum of immunoassays and developing customized immunoassays; also provides dedicated equipment such as cell sorters, flow cytometers, an ELISPOT reader, a Bio-Plex array reader, an autoMACS and a Robosep. More information.

Irradiation & Small-Animal Imaging

Delivers ionizing irradiation to cells, rodents, and large animals, including spontaneous animal tumors, as well as providing an experimental irradiation service to investigators; also offers research imaging modalities. More information.

Molecular Biology

Provides sample cycling and cleaning for sequencing, DNA sequencing and DNA fragment analysis, and data review, troubleshooting, and analysis resources. More information.

Office of Clinical Research

Provides the necessary components for conducting high-quality clinical cancer research, including clinical trials initiated by Dartmouth investigators as well as industrially sponsored studies and cooperative group studies. More information.

Pathology Translational Research

Partners researchers with appropriate pathologists; coordinates the procurement, preservation, and distribution of human tissues and cells for funded and developmental basic and clinical research; performs histologic, immunohistologic, and molecular diagnostic procedures including DNA sequencing SNP genotyping and quantitative gene expression analysis; and provides a GMP cell processing laboratory for the isolation/purification, manipulation, expansion and/or storage of cells derived from a patient's/subject's peripheral blood intended for autologous reinfusion. More information.

Transgenics & Genetic Constructs

Provides the full range of services required to design, generate, and maintain transgenic mouse lines, such as planning and designing transgenic experiments, production of genetic constructs for use in transgenic animal production through "recombineering" in either yeast or E. coli, manipulating the mouse embryo, cryopreservation, and genotyping and mouse husbandry services. More information.