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Paul M. Guyre, Ph.D.

Title(s):
Professor of Physiology
Professor of Microbiology and Immunology

Department(s):
Physiology

Education:
Montclair State College, BA 1972
U. New Hampshire, PHD 1979
U. New Hampshire, MS 1976

Programs:
Immunology Program
Molecular and Cellular Biology Graduate Programs
Norris Cotton Cancer Center
Program in Experimental and Molecular Medicine

NIH Biosketch:
Guyre_P_BIO_2009-02-09.pdf

Websites:
http://dms.dartmouth.edu/COBRE/
http://dms.dartmouth.edu/immuno/
http://dms.dartmouth.edu/microbio/

Contact Information:

Dartmouth Medical School
HB 7700
Hanover NH 03755

Office: Borwell 740W
Phone: 603 650-7924
Fax: 603 650-6130
Email: paul.guyre@dartmouth.edu


Professional Interests:

Dr. Guyre's principal research interest is understanding how hormones and cytokines regulate the functional activity of white blood cells including monocytes, macrophages, dendritic cells, and neutrophils. The goal of Dr. Guyre's current research is to elucidate the physiologic interactions between steroid hormones that often regulate immune responses and molecules that activate the immune system such as cytokines and interferons. For example, bacterial infections stimulate the production of cytokines that activate leukocytes, but also feed back via the brain and pituitary to stimulate the release of cortisol from the adrenal gland. Cortisol (as well as related steroids that are used therapeutically as anti-inflammatory agents) then interacts with cytokines to either enhance or inhibit leukocyte activation as needed. Together with collaborators Drs. Pioli, Yeager and Wira,, Dr. Guyre's research team is identifying the mechanisms by which leukocyte receptors and signaling pathways are regulated by hormones and cytokines to enhance the killing of pathogens and/or suppress inflammation in sepsis, autoimmunity and cardiovascular disease.

Rotations and Thesis Projects:

Not accepting new students in 2012-2013

Grant Information:

NIH 1R21AI090578-01A1 Physiological vs. pharmacological effects of glucocorticoids on human monocytes

Courses Taught:

DMSI Physiology
DMSI Immunology
Advanced Endocrinology
Advanced Biomedical Sciences

Biography:

After Dr. Guyre received his Ph.D from the University of New Hampshire in 1978, he trained as a postodoctoral research associate with Allan Munck in the DMS Department of Physiology. He joined the Physiology faculty in 1980, and has been a Professor of Physiology and of Microbiology/Immunology since 1991.


Selected Publications:

 

  • Pioli PA, Jensen AL, Weaver LK, Amiel E, Shen Z, Shen L, Wira CR, Guyre PM. Estradiol attenuates lipopolysaccharide-induced CXC chemokine ligand 8 production. J Immunol. 2007 Nov 1;179(9):6284-90. (view details on MedLine)

  • Huarte E, Cubillos-Ruiz JR, Nesbeth YC, Scarlett UK, Martinez DG, Engle XA, Rigby WF, Pioli PA, Guyre PM, Conejo-Garcia JR. PILAR is a novel modulator of human T-cell expansion. Blood 2008 Aug 15; 112(4):1259-68. (view details on MedLine)

  • Yeager MP, Pioli PA, Wardwell K, Beach ML, Martel P, Lee HK, Rassias AJ, Guyre PM. In vivo exposure to high or low cortisol has biphasic effects on inflammatory response pathways of human monocytes. Anesth Analg 2008 Nov; 107(5):1726-34. (view details on MedLine)

  • Hart KM, Murphy AJ, Barrett KT, Wira CR, Guyre PM, Pioli PA. Functional expression of pattern recognition receptors in tissues of the human female reproductive tract. J Reprod Immunol 2009 Jun; 80(1-2):33-40. (view details on MedLine)

  • Murphy AJ, Guyre PM, Wira CR, Pioli PA. Estradiol regulates expression of estrogen receptor ERalpha46 in human macrophages. PLoS One 2009; 4(5):e5539. (view details on MedLine)

  • Yeager MP, Rassias AJ, Pioli PA, Beach ML, Wardwell K, Collins JE, Lee HK, Guyre PM. Pretreatment with stress cortisol enhances the human systemic inflammatory response to bacterial endotoxin. Crit Care Med 2009 Oct; 37(10):2727-32 (view details on MedLine)

  • Murphy AJ, Guyre PM, Pioli PA. Estradiol suppresses NF-kappa B activation through coordinated regulation of let-7a and miR-125b in primary human macrophages. J Immunol 2010 May 1; 184(9):5029-37. (view details on MedLine)

  • Ochiel DO, Ghosh M, Fahey JV, Guyre PM, Wira CR. Human uterine epithelial cell secretions regulate dendritic cell differentiation and responses to TLR ligands. J Leukoc Biol 2010 Sep; 88(3):435-44. (view details on MedLine)

  • Rassias AJ, Guyre PM, Yeager MP. Hydrocortisone at stress-associated concentrations helps maintain human heart rate variability during subsequent endotoxin challenge. J Crit Care. 2011 Dec;26(6):636.e1-5. (view details on MedLine)

  • Yeager MP, Pioli PA, Guyre PM. Cortisol exerts bi-phasic regulation of inflammation in humans. Dose Response. 2011;9(3):332-47 (view details on MedLine)