Paul M. Guyre, PhD
Title(s):
Emeritus Professor of Microbiology and Immunology
Department(s):
Microbiology and Immunology
Education:
Montclair State College, BA 1972
U. New Hampshire, PHD 1979
U. New Hampshire, MS 1976
Programs:
Immunology Program
Molecular and Cellular Biology Graduate Programs
Norris Cotton Cancer Center
Program in Experimental and Molecular Medicine
NIH Biosketch:
Guyre_P_BIO_2009-02-09.pdf
Websites:
http:
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Contact Information:
Geisel School of Medicine at Dartmouth
HB 7556
Lebanon NH 03756
Phone: 603 650-7924
Email: paul.guyre@dartmouth.edu
Professional Interests:
Dr. Guyre's principal research interests to date have been: (i) Cancer immunotherapy; (ii) understanding the regulation and function of IgG Fc receptors on phagocytes, and (iii) how hormones and cytokines regulate the functional activity of white blood cells including monocytes, macrophages, dendritic cells, and neutrophils. The Guyre lab team is currently focused on finding biomarkers for the neuroimmune related disease, myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and the tick-induced mammalian meat allergy Alpha Gal Syndrome. Vastly underdiagnosed, IgE anti-alpha gal (a sugar found on all mammals except humans) can induce life threatening anaphylaxis to not only meals of beef and pork, but to medications contained in gelatin capsules.
Courses Taught:
DMSI Physiology
DMSI Immunology
Advanced Endocrinology
Advanced Biomedical Sciences
Biography:
After Dr. Guyre received his Ph.D from the University of New Hampshire in 1978, he trained as a postodoctoral research associate with Allan Munck in the DMS Department of Physiology. He joined the Physiology faculty in 1980, and has been a Professor of Physiology and of Microbiology/Immunology since 1991.
Selected Publications: |
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The Stress Hormone Cortisol Enhances Interferon-υ-Mediated Proinflammatory Responses of Human Immune Cells. Glucocorticoids enhance the in vivo migratory response of human monocytes. A subset of human uterine endometrial macrophages is alternatively activated. Cortisol exerts bi-phasic regulation of inflammation in humans. Hydrocortisone at stress-associated concentrations helps maintain human heart rate variability during subsequent endotoxin challenge. Human uterine epithelial cell secretions regulate dendritic cell differentiation and responses to TLR ligands. Estradiol suppresses NF-kappa B activation through coordinated regulation of let-7a and miR-125b in primary human macrophages. Pretreatment with stress cortisol enhances the human systemic inflammatory response to bacterial endotoxin. Estradiol regulates expression of estrogen receptor ERalpha46 in human macrophages. Functional expression of pattern recognition receptors in tissues of the human female reproductive tract. |
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