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Paul M. Guyre, PhD

Emeritus Professor of Microbiology and Immunology

Microbiology and Immunology

Montclair State College, BA 1972
U. New Hampshire, PHD 1979
U. New Hampshire, MS 1976

Immunology Program
Molecular and Cellular Biology Graduate Programs
Norris Cotton Cancer Center
Program in Experimental and Molecular Medicine

NIH Biosketch:


Contact Information:

Geisel School of Medicine at Dartmouth
HB 7556
Lebanon NH 03756

Phone: 603 650-7924

Professional Interests:

Dr. Guyre's principal research interests to date have been: (i) Cancer immunotherapy; (ii) understanding the regulation and function of IgG Fc receptors on phagocytes, and (iii) how hormones and cytokines regulate the functional activity of white blood cells including monocytes, macrophages, dendritic cells, and neutrophils. The Guyre lab team is currently focused on finding biomarkers for the neuroimmune related disease, myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and the tick-induced mammalian meat allergy Alpha Gal Syndrome. Vastly underdiagnosed, IgE anti-alpha gal (a sugar found on all mammals except humans) can induce life threatening anaphylaxis to not only meals of beef and pork, but to medications contained in gelatin capsules.

Courses Taught:

DMSI Physiology
DMSI Immunology
Advanced Endocrinology
Advanced Biomedical Sciences


After Dr. Guyre received his Ph.D from the University of New Hampshire in 1978, he trained as a postodoctoral research associate with Allan Munck in the DMS Department of Physiology. He joined the Physiology faculty in 1980, and has been a Professor of Physiology and of Microbiology/Immunology since 1991.

Selected Publications:


The Stress Hormone Cortisol Enhances Interferon-υ-Mediated Proinflammatory Responses of Human Immune Cells.
Yeager MP, Guyre CA, Sites BD, Collins JE, Pioli PA, Guyre PM
Anesth Analg. 2018 Aug;127(2):556-563. doi: 10.1213/ANE.0000000000003481.
PMID: 30028389

Glucocorticoids enhance the in vivo migratory response of human monocytes.
Yeager MP, Pioli PA, Collins J, Barr F, Metzler S, Sites BD, Guyre PM
Brain Behav Immun. 2016 May;54:86-94. doi: 10.1016/j.bbi.2016.01.004. Epub 2016 Jan 11.
PMID: 26790757

A subset of human uterine endometrial macrophages is alternatively activated.
Jensen AL, Collins J, Shipman EP, Wira CR, Guyre PM, Pioli PA
Am J Reprod Immunol. 2012 Nov;68(5):374-86. doi: 10.1111/j.1600-0897.2012.01181.x. Epub 2012 Aug 6.
PMID: 22882270

Cortisol exerts bi-phasic regulation of inflammation in humans.
Yeager MP, Pioli PA, Guyre PM
Dose Response. 2011;9(3):332-47. doi: 10.2203/dose-response.10-013.Yeager. Epub 2010 Aug 12.
PMID: 22013396

Hydrocortisone at stress-associated concentrations helps maintain human heart rate variability during subsequent endotoxin challenge.
Rassias AJ, Guyre PM, Yeager MP
J Crit Care. 2011 Dec;26(6):636.e1-5. doi: 10.1016/j.jcrc.2011.01.009. Epub 2011 Apr 21.
PMID: 21514093

Human uterine epithelial cell secretions regulate dendritic cell differentiation and responses to TLR ligands.
Ochiel DO, Ghosh M, Fahey JV, Guyre PM, Wira CR
J Leukoc Biol. 2010 Sep;88(3):435-44. doi: 10.1189/jlb.1009700. Epub 2010 Apr 12.
PMID: 20385795

Estradiol suppresses NF-kappa B activation through coordinated regulation of let-7a and miR-125b in primary human macrophages.
Murphy AJ, Guyre PM, Pioli PA
J Immunol. 2010 May 1;184(9):5029-37. doi: 10.4049/jimmunol.0903463. Epub 2010 Mar 29.
PMID: 20351193

Pretreatment with stress cortisol enhances the human systemic inflammatory response to bacterial endotoxin.
Yeager MP, Rassias AJ, Pioli PA, Beach ML, Wardwell K, Collins JE, Lee HK, Guyre PM
Crit Care Med. 2009 Oct;37(10):2727-32.
PMID: 19885996

Estradiol regulates expression of estrogen receptor ERalpha46 in human macrophages.
Murphy AJ, Guyre PM, Wira CR, Pioli PA
PLoS One. 2009;4(5):e5539. doi: 10.1371/journal.pone.0005539. Epub 2009 May 18.
PMID: 19440537

Functional expression of pattern recognition receptors in tissues of the human female reproductive tract.
Hart KM, Murphy AJ, Barrett KT, Wira CR, Guyre PM, Pioli PA
J Reprod Immunol. 2009 Jun;80(1-2):33-40. doi: 10.1016/j.jri.2008.12.004. Epub 2009 Apr 29.
PMID: 19406482

View more publications on PubMed