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Paul M. Guyre, PhD

Title(s):
Active Emeritus Professor of Microbiology and Immunology

Department(s):
Microbiology and Immunology

Education:
Montclair State College, BA 1972
U. New Hampshire, PHD 1979
U. New Hampshire, MS 1976

Programs:
Immunology Program
Molecular and Cellular Biology Graduate Programs
Norris Cotton Cancer Center
Program in Experimental and Molecular Medicine

NIH Biosketch:
Guyre_P_BIO_2009-02-09.pdf

Websites:
http://dms.dartmouth.edu/COBRE/
http://dms.dartmouth.edu/immuno/
http://dms.dartmouth.edu/microbio/

Contact Information:

Geisel School of Medicine at Dartmouth
HB 7556
Lebanon NH 03756

Phone: 603 650-7924
Email: paul.guyre@dartmouth.edu


Professional Interests:

Dr. Guyre's principal research interest is understanding how hormones and cytokines regulate the functional activity of white blood cells including monocytes, macrophages, dendritic cells, and neutrophils. The goal of Dr. Guyre's current research is to elucidate the physiologic interactions between steroid hormones that often regulate immune responses and molecules that activate the immune system such as cytokines and interferons. For example, bacterial infections stimulate the production of cytokines that activate leukocytes, but also feed back via the brain and pituitary to stimulate the release of cortisol from the adrenal gland. Cortisol (as well as related steroids that are used therapeutically as anti-inflammatory agents) then interacts with cytokines to either enhance or inhibit leukocyte activation as needed. Together with collaborators Drs. Pioli, Yeager and Wira,, Dr. Guyre's research team is identifying the mechanisms by which leukocyte receptors and signaling pathways are regulated by hormones and cytokines to enhance the killing of pathogens and/or suppress inflammation in sepsis, autoimmunity and cardiovascular disease.

Courses Taught:

DMSI Physiology
DMSI Immunology
Advanced Endocrinology
Advanced Biomedical Sciences

Biography:

After Dr. Guyre received his Ph.D from the University of New Hampshire in 1978, he trained as a postodoctoral research associate with Allan Munck in the DMS Department of Physiology. He joined the Physiology faculty in 1980, and has been a Professor of Physiology and of Microbiology/Immunology since 1991.


Selected Publications:

 

The Stress Hormone Cortisol Enhances Interferon-υ-Mediated Proinflammatory Responses of Human Immune Cells.
Yeager MP, Guyre CA, Sites BD, Collins JE, Pioli PA, Guyre PM
Anesth Analg. 2018 Aug;127(2):556-563. doi: 10.1213/ANE.0000000000003481.
PMID: 30028389

Glucocorticoids enhance the in vivo migratory response of human monocytes.
Yeager MP, Pioli PA, Collins J, Barr F, Metzler S, Sites BD, Guyre PM
Brain Behav Immun. 2016 May;54:86-94. doi: 10.1016/j.bbi.2016.01.004. Epub 2016 Jan 11.
PMID: 26790757

A subset of human uterine endometrial macrophages is alternatively activated.
Jensen AL, Collins J, Shipman EP, Wira CR, Guyre PM, Pioli PA
Am J Reprod Immunol. 2012 Nov;68(5):374-86. doi: 10.1111/j.1600-0897.2012.01181.x. Epub 2012 Aug 6.
PMID: 22882270

Cortisol exerts bi-phasic regulation of inflammation in humans.
Yeager MP, Pioli PA, Guyre PM
Dose Response. 2011;9(3):332-47. doi: 10.2203/dose-response.10-013.Yeager. Epub 2010 Aug 12.
PMID: 22013396

Hydrocortisone at stress-associated concentrations helps maintain human heart rate variability during subsequent endotoxin challenge.
Rassias AJ, Guyre PM, Yeager MP
J Crit Care. 2011 Dec;26(6):636.e1-5. doi: 10.1016/j.jcrc.2011.01.009. Epub 2011 Apr 21.
PMID: 21514093

Human uterine epithelial cell secretions regulate dendritic cell differentiation and responses to TLR ligands.
Ochiel DO, Ghosh M, Fahey JV, Guyre PM, Wira CR
J Leukoc Biol. 2010 Sep;88(3):435-44. doi: 10.1189/jlb.1009700. Epub 2010 Apr 12.
PMID: 20385795

Estradiol suppresses NF-kappa B activation through coordinated regulation of let-7a and miR-125b in primary human macrophages.
Murphy AJ, Guyre PM, Pioli PA
J Immunol. 2010 May 1;184(9):5029-37. doi: 10.4049/jimmunol.0903463. Epub 2010 Mar 29.
PMID: 20351193

Pretreatment with stress cortisol enhances the human systemic inflammatory response to bacterial endotoxin.
Yeager MP, Rassias AJ, Pioli PA, Beach ML, Wardwell K, Collins JE, Lee HK, Guyre PM
Crit Care Med. 2009 Oct;37(10):2727-32.
PMID: 19885996

Estradiol regulates expression of estrogen receptor ERalpha46 in human macrophages.
Murphy AJ, Guyre PM, Wira CR, Pioli PA
PLoS One. 2009;4(5):e5539. doi: 10.1371/journal.pone.0005539. Epub 2009 May 18.
PMID: 19440537

Functional expression of pattern recognition receptors in tissues of the human female reproductive tract.
Hart KM, Murphy AJ, Barrett KT, Wira CR, Guyre PM, Pioli PA
J Reprod Immunol. 2009 Jun;80(1-2):33-40. doi: 10.1016/j.jri.2008.12.004. Epub 2009 Apr 29.
PMID: 19406482