Leslie P. Henderson, Ph.D.
Title(s):
Professor of Physiology and Neurobiology
Professor of Biochemistry
Senior Associate Dean for Faculty Affairs
Department(s):
Physiology and Neurobiology
Biochemistry
Education:
Stanford University, PhD 1982
Programs:
Molecular and Cellular Biology Graduate Programs
Neuroscience Center at Dartmouth
Program in Experimental and Molecular Medicine
Websites:
http:
http:
http:
http:
http:
Contact Information:
Geisel School of Medicine
HB 7701
Hanover NH 03755
Office: Rope Ferry 211
Phone: 650-1751 or 1312
Email: leslie.henderson@dartmouth.edu
Assistant: Faith Goodness
Asst. Phone: 650-1453
Asst. Email: faith.goodness@dartmouth.edu
Professional Interests:
The long-term goals of my laboratory are to understand the cellular basis for behavioral changes associated with anabolic androgenic steroid (AAS) use. The AAS are synthetic derivatives of testosterone originally developed for clinical purposes, but now predominantly taken at supraphysiological levels as drugs of abuse. To date, more than 100 different AAS compounds that vary in metabolic fate and physiological effects have been designed and synthesized. Steroid abuse is typified by the concurrent use of multiple AAS, and divergence in the effects of AAS use in different individuals will reflect the age, sex, genetic makeup and hormonal state of these subjects, as well as the diversity in the chemical make-up and signaling capabilities of the steroids. Because of the interactions of these variables, the behavioral manifestations of steroid abuse are diverse; however changes in sexual/reproductive behaviors, aggression and anxiety are the most commonly reported behavioral alterations in both human and non-human subjects. My laboratory studies both acute and long-tern effects on neural signaling, with particular emphasis on neurotransmission mediated by GABAA receptors, modulation of neurotransmission by corticotrophin releasing factor (CRF), the role of androgen and estrogen receptor signaling pathways in imparting AAS actions, and the behavioral outcomes of these neural perturbations.
I am a member of the Molecular, Cellular and Systems Physiology Graduate Program, the Molecular and Cellular Biology Graduate Program, the Program in Experimental and Molecular Medicine Program and have had 4 students who have received both their MD and PhD degrees.
Rotations and Thesis Projects:
(Past 5 years):
* Interactions of anabolic steroids and stress hormones in the forebrain
* Anabolic androgenic steroid regulation of anxiety and stress
* Anabolic steroid and alcohol interactions
* Anabolic androgenic steroid regulation of GnRH neuron function
* Effects of chronic anabolic androgenic steroid exposure on GABAergic neurotransmission and neuronal activity in the mammalian forebrain
* Allosteric modulation of GABAA Receptors by anabolic-androgenic steroids
* Effects of endocrine disruptors on the developing nervous system of the frog,Xenopus laevis.
Grant Information:
R01-DA/NS14137-19; NIH (NIDA); Principal investigator; Steroid regulation of ion channels
Project Period: 01/08/1990-06/30/12 (with no cost extension through 2013; this grant was R01-NS28668 for 1990-1995)
1P20RR030360-01; NIH (NCRR); Mentoring faculty member; New Hampshire idea network of biological research excellence (NH INBRE)
Project Period: 09/01/2010-06/30/2015
Courses Taught:
2009-present PEMM Core Course 102
2008-present PEMM 271: Advanced Biology of Integrated Systems
2007-present Physiology 115: Advanced Endocrine
2006-present PEMM Core Course 101
2006 Advanced Undergraduate Neurobiology (Biol Sci 74): Co-instructor with RA Maue
2005 Animal Physiology (Bio 35): Guest lecturer
2004-present Pathophysiology of Brain Disease
2003-2006 Molecular Cellular Biology Core Course (Biochem 103)
2001-2003 Graduate Toxicology (PharmTox 123)
1999-2002 Cell Physiology 125 (Biochemistry 144)
1998 Gastrointestinal Physiology
1998-present Presidential Scholar's Program for Undergraduates
1996-present Medical Neuroscience 115
1996-1998 Invited Faculty Cold Spring Harbor Course on Integrative Approaches to Ion Channel Biology
1996-2004 Pharmacology 129 (Receptors)
1992 Women in Science Program (WISP) for Undergraduates
1991-present Established Graduate Neurosciences I and II (Physiology,
Biochemistry, Pharmacology and Psychology 150, 151) at Dartmouth with co-founders R.A. Maue, P.D. Gardner, and J.S. Taube
1990-1992 Neuroscience Journal Club: Initiated this course with R.A. Maue
19901992 Initiated and organized The Molecular and Cellular Neurosciences Seminar Series with R.A. Maue and P.D. Gardner
1990-1995 Medical Physiology 112
1990-1993 Physiology of Excitable Cells
1990-2005 Engineering 148 (I performed one demonstration each year for this course)
1989-present Howard Hughes Scholarship Program for Undergraduates
Selected Publications: |
|
Penatti CA, Porter DM, Henderson LP. Chronic exposure to anabolic androgenic steroids alters neuronal function in the mammalian forebrain via androgen receptor- and estrogen receptor-mediated mechanisms. J Neurosci. 29(40):12484-96 (view details on MedLine) Penatti CA, Costine BA, Porter DM, Henderson LP Effects of chronic exposure to an anabolic androgenic steroid cocktail on alpha5-receptor-mediated GABAergic transmission and neural signaling in the forebrain of female mice. Neuroscience 161(2):526-37 (view details on MedLine) Penatti CAA, Henderson LP LP Androgen Actions on Receptors and Channels: Regulation of Electrical Excitability and Synaptic Transmission. Hormones, Brain and Behavior (Elsevier). Pfaff DW, Arnold A, Etgen A, Fahrbach S, Rubin R (second edition); pp 1245-1274; 2009. Penatti CA, Davis MC, Porter DM, Henderson LP. Altered GABAA receptor-mediated synaptic transmission disrupts the firing of gonadotropin-releasing hormone neurons in male mice under conditions that mimic steroid abuse. J Neurosci. 2010 May 12;30(19):6497-506. (view details on MedLine) Costine BA, Oberlander JG, Davis MC, Penatti CA, Porter DM, Leaton RN, Henderson LP. Chronic anabolic androgenic steroid exposure alters corticotropin releasing factor expression and anxiety-like behaviors in the female mouse. Psychoneuroendocrinology. 2010 Nov;35(10):1473-85. (view details on MedLine) Penatti CA, Oberlander JG, Davis MC, Porter DM, Henderson LP. Chronic exposure to anabolic androgenic steroids alters activity and synaptic function in neuroendocrine control regions of the female mouse. Neuropharmacology. 2011 Sep;61(4):653-64. (view details on MedLine) Oberlander JG, Henderson LP. Corticotropin-releasing factor modulation of forebrain GABAergic transmission has a pivotal role in the expression of anabolic steroid-induced anxiety in the female mouse. Neuropsychopharmacology. 2012 May;37(6):1483-99. (view details on MedLine) Oberlander JG, Henderson LP. The Sturm und Drang of anabolic steroid use: angst, anxiety, and aggression. Trends Neurosci. 2012 Jun;35(6):382-92. (view details on MedLine) |
|