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Constance E. Brinckerhoff, Ph.D.

Title(s):
Professor of Medicine
Professor of Biochemistry

Department(s):
Medicine
Biochemistry

Education:
Smith College, BA
SUNY - Buffalo, PHD
SUNY - Buffalo, MA

Programs:
Molecular and Cellular Biology Graduate Programs

NIH Biosketch:
Brinckerhoff_C_BIO_2009-01-30.pdf

Contact Information:

Dartmouth Medical School
HB 7936
Lebanon NH 03756

Phone: 603-653-9957
Fax: 603-653-9952
Email: brinckerhoff@dartmouth.edu


Professional Interests:

Research focuses on the molecular and cellular mechanisms by which the Matrix Metalloproteinases (MMPs), enzymes that degrade the extracellular matrix at neutral pH, facilitate the invasive and metastatic behavior of tumor cells. In most normal cells, constitutive expression of MMPs is low, but increases in response to cytokines and growth factors. In some tumors (e.g., breast cancer and melanoma), however, MMP expression is constutively high, and the high expression enhances their invasiveness. This lab is using a novel invasion assay to monitor the invasion of tumor cells through the extracellular matrix and to document the efficacy of novel agents that suppress MMPs to also suppress invasion and metastasis.

Grant Information:

AR-26599-28. Regulation of Collagenase Gene Expression
CA-77267-07. Invasive Behavior of Tumor cells Producing Collagenase-1


Selected Publications:

 

Steinberg SM, Zhang P, Malik B, Boni A, Shabaneh T, Byrne K, Mullins DW, Brinckerhoff CE, Ernstoff M, Bosenberg MW, Turk MJ
BRAF-inhibition alleviates immune suppression in murine autochthonous melanoma.
Cancer Immunol Res 2014 Sep 2;
PMID: 25183499

Jenkins MH, Steinberg SM, Alexander MP, Fisher JL, Ernstoff MS, Turk MJ, Mullins DW, Brinckerhoff CE
Multiple murine BRaf(V600E) melanoma cell lines with sensitivity to PLX4032.
Pigment Cell Melanoma Res 2014 May; 27(3):495-501
PMID: 24460976

Croteau W, Jenkins MH, Ye S, Mullins DW, Brinckerhoff CE
Differential mechanisms of tumor progression in clones from a single heterogeneous human melanoma.
J Cell Physiol 2013 Apr; 228(4):773-80
PMID: 23001823

Schmucker AC, Wright JB, Cole MD, Brinckerhoff CE
Distal interleukin-1β (IL-1β) response element of human matrix metalloproteinase-13 (MMP-13) binds activator protein 1 (AP-1) transcription factors and regulates gene expression.
J Biol Chem 2012 Jan 6; 287(2):1189-97
PMID: 22102411

Eck SM, Blackburn JS, Schmucker AC, Burrage PS, Brinckerhoff CE
Matrix metalloproteinase and G protein coupled receptors: co-conspirators in the pathogenesis of autoimmune disease and cancer.
J Autoimmun 2009 Nov-Dec; 33(3-4):214-21
PMID: 19800199

Eck SM, Cote AL, Winkelman WD, Brinckerhoff CE
CXCR4 and matrix metalloproteinase-1 are elevated in breast carcinoma-associated fibroblasts and in normal mammary fibroblasts exposed to factors secreted by breast cancer cells.
Mol Cancer Res 2009 Jul; 7(7):1033-44
PMID: 19584257

Coon CI, Fiering S, Gaudet J, Wyatt CA, Brinckerhoff CE
Site controlled transgenic mice validating increased expression from human matrix metalloproteinase (MMP-1) promoter due to a naturally occurring SNP.
Matrix Biol 2009 Sep; 28(7):425-31
PMID: 19577645

Petrella BL, Brinckerhoff CE
PTEN suppression of YY1 induces HIF-2 activity in von-Hippel-Lindau-null renal-cell carcinoma.
Cancer Biol Ther 2009 Jul; 8(14):1389-401
PMID: 19483472

Burrage PS, Schmucker AC, Ren Y, Sporn MB, Brinckerhoff CE
Retinoid X receptor and peroxisome proliferator-activated receptor-gamma agonists cooperate to inhibit matrix metalloproteinase gene expression.
Arthritis Res Ther 2008; 10(6):R139
PMID: 19046432

Blackburn JS, Brinckerhoff CE
Matrix metalloproteinase-1 and thrombin differentially activate gene expression in endothelial cells via PAR-1 and promote angiogenesis.
Am J Pathol 2008 Dec; 173(6):1736-46
PMID: 18988801