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Constance E. Brinckerhoff, Ph.D.

Professor of Medicine
Professor of Biochemistry


Smith College, BA
SUNY - Buffalo, PHD
SUNY - Buffalo, MA

Molecular and Cellular Biology Graduate Programs

NIH Biosketch:

Contact Information:

Dartmouth Medical School
HB 7936
Lebanon NH 03756

Phone: 603-653-9957
Fax: 603-653-9952
Email: brinckerhoff@dartmouth.edu

Professional Interests:

Research focuses on the molecular and cellular mechanisms by which the Matrix Metalloproteinases (MMPs), enzymes that degrade the extracellular matrix at neutral pH, facilitate the invasive and metastatic behavior of tumor cells. In most normal cells, constitutive expression of MMPs is low, but increases in response to cytokines and growth factors. In some tumors (e.g., breast cancer and melanoma), however, MMP expression is constutively high, and the high expression enhances their invasiveness. This lab is using a novel invasion assay to monitor the invasion of tumor cells through the extracellular matrix and to document the efficacy of novel agents that suppress MMPs to also suppress invasion and metastasis.

Grant Information:

AR-26599-28. Regulation of Collagenase Gene Expression
CA-77267-07. Invasive Behavior of Tumor cells Producing Collagenase-1

Selected Publications:


The BRAF<sup>V600E</sup> inhibitor, PLX4032, increases type I collagen synthesis in melanoma cells.
Jenkins MH, Croteau W, Mullins DW, Brinckerhoff CE
Matrix Biol. 2015 May 16; pii: S0945-053X(15)00106-7. doi: 10.1016/j.matbio.2015.05.007. Epub 2015 May 16.
PMID: 25989506

CXCR3 signaling in BRAFWT melanoma increases IL-8 expression and tumorigenicity.
Jenkins MH, Brinckerhoff CE, Mullins DW
PLoS One. 2015;10(3):e0121140. doi: 10.1371/journal.pone.0121140. Epub 2015 Mar 23.
PMID: 25798946

BRAF inhibition alleviates immune suppression in murine autochthonous melanoma.
Steinberg SM, Zhang P, Malik BT, Boni A, Shabaneh TB, Byrne KT, Mullins DW, Brinckerhoff CE, Ernstoff MS, Bosenberg MW, Turk MJ
Cancer Immunol Res. 2014 Nov;2(11):1044-50. doi: 10.1158/2326-6066.CIR-14-0074. Epub 2014 Sep 2.
PMID: 25183499

Multiple murine BRaf(V600E) melanoma cell lines with sensitivity to PLX4032.
Jenkins MH, Steinberg SM, Alexander MP, Fisher JL, Ernstoff MS, Turk MJ, Mullins DW, Brinckerhoff CE
Pigment Cell Melanoma Res. 2014 May;27(3):495-501. doi: 10.1111/pcmr.12220. Epub 2014 Mar 6.
PMID: 24460976

Differential mechanisms of tumor progression in clones from a single heterogeneous human melanoma.
Croteau W, Jenkins MH, Ye S, Mullins DW, Brinckerhoff CE
J Cell Physiol. 2013 Apr;228(4):773-80. doi: 10.1002/jcp.24225.
PMID: 23001823

Distal interleukin-1β (IL-1β) response element of human matrix metalloproteinase-13 (MMP-13) binds activator protein 1 (AP-1) transcription factors and regulates gene expression.
Schmucker AC, Wright JB, Cole MD, Brinckerhoff CE
J Biol Chem. 2012 Jan 6;287(2):1189-97. doi: 10.1074/jbc.M111.264077. Epub 2011 Nov 18.
PMID: 22102411

Matrix metalloproteinase and G protein coupled receptors: co-conspirators in the pathogenesis of autoimmune disease and cancer.
Eck SM, Blackburn JS, Schmucker AC, Burrage PS, Brinckerhoff CE
J Autoimmun. 2009 Nov-Dec;33(3-4):214-21. doi: 10.1016/j.jaut.2009.09.011. Epub 2009 Oct 1.
PMID: 19800199

CXCR4 and matrix metalloproteinase-1 are elevated in breast carcinoma-associated fibroblasts and in normal mammary fibroblasts exposed to factors secreted by breast cancer cells.
Eck SM, Cote AL, Winkelman WD, Brinckerhoff CE
Mol Cancer Res. 2009 Jul;7(7):1033-44. doi: 10.1158/1541-7786.MCR-09-0015. Epub 2009 Jul 7.
PMID: 19584257

Site controlled transgenic mice validating increased expression from human matrix metalloproteinase (MMP-1) promoter due to a naturally occurring SNP.
Coon CI, Fiering S, Gaudet J, Wyatt CA, Brinckerhoff CE
Matrix Biol. 2009 Sep;28(7):425-31. doi: 10.1016/j.matbio.2009.06.003. Epub 2009 Jul 3.
PMID: 19577645

PTEN suppression of YY1 induces HIF-2 activity in von-Hippel-Lindau-null renal-cell carcinoma.
Petrella BL, Brinckerhoff CE
Cancer Biol Ther. 2009 Jul;8(14):1389-401. Epub 2009 Jul 30.
PMID: 19483472