James C. Leiter, MD
Professor of Molecular and Systems Biology
Professor of Medicine
Molecular and Systems Biology
Dartmouth College, AB 1975
Dartmouth Medical School, MD 1979
Neuroscience Center at Dartmouth
Program in Experimental and Molecular Medicine
Geisel School of Medicine
Hanover NH 03755
Dr. Leiter is interested in the neurophysiology of respiratory control, central chemosensitivity and Sudden Infant Death Syndrome. He is interested in the role of astrocytes in all of these topics. Additional interests include the neurobiology of deep brain stimulation in Parkinson's Disease and psychiatric disorders.
Rotations and Thesis Projects:
There are current opportunities to work studying interactions among central chemosensitivity and the laryngeal chemoreflex as it pertains to SIDS. They are examining the role of serotonin and adenosine in the modulation of these reflex responses. We are using lentiviral vectors to alter astrocytic functions and thereby alter cardiorespiratory reflex control of autonomic function.
In respect to deep brain stimulation, we are studying the role of DBS in movement disorders and substance abuse. A strong background in engineering and mathematics is helpful in these studies.
Dr. Leiter is accepting rotation students in the fall, winter and spring terms and might be available as a thesis mentor for 2016-17 (pending funding).
NIH NICHD. RO1 HD042707-01. The upper airway and the Sudden Infant Death Syndrome. (co-investigator with Donald Bartlett, Jr.).
NIH NICHD. Program Project Grant: The ventral medulla and the sudden infant death syndrome. Project II: The medullary serotonergic system and respiratory control in the unanesthetized piglet. (co-investigator with H. Kinney.).
NIH R21. Real-time Monitoring of Neurotransmitters in a Hypoxic Environment. Dr. S. Andreescu, PI; Leiter, co-PI.
Njagi J, Chernov MM, Leiter JC, Andreescu S. Amperometric detection of dopamine in vivo with an enzyme based carbon fiber microbiosensor. Anal Chem. 2010 Feb 1;82(3):989-96. (view details on MedLine)
Chernov MM, Erlichman JS, Leiter JC. Ionic mechanisms of central CO(2) chemosensitivity. Respir Physiol Neurobiol. 2010 Oct 31;173(3):298-304. (view details on MedLine)
Erlichman JS, Leiter JC, Gourine AV. ATP, glia and central respiratory control. Respir Physiol Neurobiol. 2010 Oct 31;173(3):305-11. (view details on MedLine)
Tawfik VL, Chang SY, Hitti FL, Roberts DW, Leiter JC, Jovanovic S, Lee KH. Deep brain stimulation results in local glutamate and adenosine release: investigation into the role of astrocytes. Neurosurgery. 2010 Aug;67(2):367-75. (view details on MedLine)
Henderson MB, Green AI, Bradford PS, Chau DT, Roberts DW, Leiter JC. Deep brain stimulation of the nucleus accumbens reduces alcohol intake in alcohol-preferring rats. Neurosurg Focus. 2010 Aug;29(2):E12. (view details on MedLine)
Leiter JC, Manning HL. The Hering-Breuer reflex, feedback control, and mechanical ventilation: the promise of neurally adjusted ventilatory assist. Crit Care Med. 2010 Sep;38(9):1915-6. (view details on MedLine)
Gifford AH, Leiter JC, Manning HL. Respiratory function in an obese patient with sleep-disordered breathing. Chest. 2010 Sep;138(3):704-15. (view details on MedLine)
Xia L, Bartlett D Jr, Leiter JC. TRPV1 channels in the nucleus of the solitary tract mediate thermal prolongation of the LCR in decerebrate piglets. Respir Physiol Neurobiol. 2011 Apr 30;176(1-2):21-31. (view details on MedLine)
Lee KH, Hitti FL, Chang SY, Lee DC, Roberts DW, McIntyre CC, Leiter JC. High frequency stimulation abolishes thalamic network oscillations: an electrophysiological and computational analysis. J Neural Eng. 2011 Aug;8(4):046001 (view details on MedLine)
Estevez AY, Pritchard S, Harper K, Aston JW, Lynch A, Lucky JJ, Ludington JS, Chatani P, Mosenthal WP, Leiter JC, Andreescu S, Erlichman JS. Neuroprotective mechanisms of cerium oxide nanoparticles in a mouse hippocampal brain slice model of ischemia. Free Radic Biol Med. 2011 Sep 15;51(6):1155-63. (view details on MedLine)