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Steven N. Fiering, Ph.D.

Title(s):
Professor of Microbiology and Immunology
Professor of Genetics
Professor of Genetics

Department(s):
Microbiology and Immunology
Genetics

Education:
Stanford, Ph.D., 1990
University of Michigan, BS, 1975

Dr. Fiering received his Bachelor of Science from the University of Michigan in 1975, and his Doctorate from Stanford in 1990. After postdoctoral work as an NIH research fellow and research associate at the Fred Hutchinson Cancer Research Center, Dr. Fiering joined the faculty of the Department of Microbiology at Dartmouth Medical School in 1997.

Programs:
Immunology Program
Molecular and Cellular Biology Graduate Programs
Norris Cotton Cancer Center

NIH Biosketch:
Fiering_S_BIO_2013-04-24.doc

Websites:
http://dms.dartmouth.edu/microbio/
http://dms.dartmouth.edu/immuno/
http://www.dartmouth.edu/~mcb/
http://dms.dartmouth.edu/COBRE/

Contact Information:

Dartmouth Medical School
Rubin Bldg. HB 7936
1 Medical Center Drive
Lebanon NH 03756

Phone: 603-653-9966
Fax: 603-653-9952
Email: Steven.N.Fiering@Dartmouth.EDU


Professional Interests:

My lab is primarily focused on developing novel immune-based strategies for treating cancer. The basic idea is to inject various immunostimulatory reagents, including live attenuated microorganisms into a primary tumor. This treatment can stimulate an immune response against the tumor and develop systemic anti-tumor immunity that protects against metastatic disease.

We are also interested in mouse models of cancer and are developing novel mouse models. The influence of tobacco smoke exposure on the innate immune system is another area of research in the lab.

Courses Taught:

Human Genetics graduate course


Selected Publications:

 

Sheen MR, Lizotte PH, Toraya-Brown S, Fiering S
Stimulating antitumor immunity with nanoparticles.
Wiley Interdiscip Rev Nanomed Nanobiotechnol 2014 Sep; 6(5):496-505
PMID: 25069691

Cadiz-Rivera B, Fromm G, de Vries C, Fields J, McGrath KE, Fiering S, Bulger M
The chromatin "landscape" of a murine adult β-globin gene is unaffected by deletion of either the gene promoter or a downstream enhancer.
PLoS One 2014; 9(5):e92947
PMID: 24817273

Rutkowski MR, Allegrezza MJ, Svoronos N, Tesone AJ, Stephen TL, Perales-Puchalt A, Nguyen J, Zhang PJ, Fiering SN, Tchou J, Conejo-Garcia JR
Initiation of metastatic breast carcinoma by targeting of the ductal epithelium with adenovirus-cre: a novel transgenic mouse model of breast cancer.
J Vis Exp 2014 Mar 26; (85)
PMID: 24748051

Toraya-Brown S, Sheen MR, Zhang P, Chen L, Baird JR, Demidenko E, Turk MJ, Hoopes PJ, Conejo-Garcia JR, Fiering S
Local hyperthermia treatment of tumors induces CD8+ T cell-mediated resistance against distal and secondary tumors.
Nanomedicine 2014 Feb 22;
PMID: 24566274

Busch AM, Galimberti F, Nehls KE, Roengvoraphoj M, Sekula D, Li B, Guo Y, Direnzo J, Fiering SN, Spinella MJ, Robbins DJ, Memoli VA, Freemantle SJ, Dmitrovsky E
All-trans-retinoic acid antagonizes the Hedgehog pathway by inducing patched.
Cancer Biol Ther 2014 Apr; 15(4):463-72
PMID: 24496080

Weaver JB, Zhang X, Kuehlert E, Toraya-Brown S, Reeves DB, Perreard IM, Fiering S
Quantification of magnetic nanoparticles with low frequency magnetic fields: compensating for relaxation effects.
Nanotechnology 2013 Aug 16; 24(32):325502
PMID: 23867287

Crane-Godreau MA, Black CC, Giustini AJ, Dechen T, Ryu J, Jukosky JA, Lee HK, Bessette K, Ratcliffe NR, Hoopes PJ, Fiering S, Kelly JA, Leiter JC
Modeling the influence of vitamin D deficiency on cigarette smoke-induced emphysema.
Front Physiol 2013; 4:132
PMID: 23781205

Baird JR, Fox BA, Sanders KL, Lizotte PH, Cubillos-Ruiz JR, Scarlett UK, Rutkowski MR, Conejo-Garcia JR, Fiering S, Bzik DJ
Avirulent Toxoplasma gondii generates therapeutic antitumor immunity by reversing immunosuppression in the ovarian cancer microenvironment.
Cancer Res 2013 Jul 1; 73(13):3842-51
PMID: 23704211

Stan RV, Tse D, Deharvengt SJ, Smits NC, Xu Y, Luciano MR, McGarry CL, Buitendijk M, Nemani KV, Elgueta R, Kobayashi T, Shipman SL, Moodie KL, Daghlian CP, Ernst PA, Lee HK, Suriawinata AA, Schned AR, Longnecker DS, Fiering SN, Noelle RJ, Gimi B, Shworak NW, Carriere C
The diaphragms of fenestrated endothelia: gatekeepers of vascular permeability and blood composition.
Dev Cell 2012 Dec 11; 23(6):1203-18
PMID: 23237953

Baird JR, Byrne KT, Lizotte PH, Toraya-Brown S, Scarlett UK, Alexander MP, Sheen MR, Fox BA, Bzik DJ, Bosenberg M, Mullins DW, Turk MJ, Fiering S
Immune-mediated regression of established B16F10 melanoma by intratumoral injection of attenuated Toxoplasma gondii protects against rechallenge.
J Immunol 2013 Jan 1; 190(1):469-78
PMID: 23225891