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Steven N. Fiering, Ph.D.

Professor of Microbiology and Immunology
Professor of Genetics
Professor of Genetics

Microbiology and Immunology

Stanford, Ph.D., 1990
University of Michigan, BS, 1975

Dr. Fiering received his Bachelor of Science from the University of Michigan in 1975, and his Doctorate from Stanford in 1990. After postdoctoral work as an NIH research fellow and research associate at the Fred Hutchinson Cancer Research Center, Dr. Fiering joined the faculty of the Department of Microbiology at Dartmouth Medical School in 1997.

Immunology Program
Molecular and Cellular Biology Graduate Programs
Norris Cotton Cancer Center


Contact Information:

Dartmouth Medical School
Rubin Bldg. HB 7936
1 Medical Center Drive
Lebanon NH 03756

Phone: 603-653-9966
Fax: 603-653-9952
Email: Steven.N.Fiering@Dartmouth.EDU

Professional Interests:

My lab is primarily focused on developing novel immune-based strategies for treating cancer. The basic idea is to inject various immunostimulatory reagents, including live attenuated microorganisms into a primary tumor. This treatment can stimulate an immune response against the tumor and develop systemic anti-tumor immunity that protects against metastatic disease.

We are also interested in mouse models of cancer and are developing novel mouse models. The influence of tobacco smoke exposure on the innate immune system is another area of research in the lab.

Courses Taught:

Human Genetics graduate course

Selected Publications:


Zhang X, Reeves D, Shi Y, Gimi B, Nemani KV, Perreard IM, Toraya-Brown S, Fiering S, Weaver JB
Toward Localized In Vivo Biomarker Concentration Measurements.
IEEE Trans Magn 2015 Feb; 51(2):1-4
PMID: 26203196

Fiering S, Ang LH, Lacoste J, Smith TD, Griner E
Registered report: Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis.
Elife 2015 Jul 16; 4
PMID: 26179155

Blazanovic K, Zhao H, Choi Y, Li W, Salvat RS, Osipovitch DC, Fields J, Moise L, Berwin BL, Fiering SN, Bailey-Kellogg C, Griswold KE
Structure-based redesign of lysostaphin yields potent antistaphylococcal enzymes that evade immune cell surveillance.
Mol Ther Methods Clin Dev 2015; 2:15021
PMID: 26151066

Zhao H, Verma D, Li W, Choi Y, Ndong C, Fiering SN, Bailey-Kellogg C, Griswold KE
Depletion of T cell epitopes in lysostaphin mitigates anti-drug antibody response and enhances antibacterial efficacy in vivo.
Chem Biol 2015 May 21; 22(5):629-39
PMID: 26000749

Ndong C, Toraya-Brown S, Kekalo K, Baker I, Gerngross TU, Fiering SN, Griswold KE
Antibody-mediated targeting of iron oxide nanoparticles to the folate receptor alpha increases tumor cell association in vitro and in vivo.
Int J Nanomedicine 2015; 10:2595-617
PMID: 25878495

Mopidevi B, Kaw MK, Puri N, Ponnala M, Jain S, Rana A, Keetha NR, Khuder SA, Fiering SN, Kumar A
Variable transcriptional regulation of the human aldosterone synthase gene causes salt-dependent high blood pressure in transgenic mice.
Circ Cardiovasc Genet 2015 Feb; 8(1):30-9
PMID: 25504670

Toraya-Brown S, Fiering S
Local tumour hyperthermia as immunotherapy for metastatic cancer.
Int J Hyperthermia 2014 Dec; 30(8):531-9
PMID: 25430985

Martinez ME, Charalambous M, Saferali A, Fiering S, Naumova AK, St Germain D, Ferguson-Smith AC, Hernandez A
Genomic imprinting variations in the mouse type 3 deiodinase gene between tissues and brain regions.
Mol Endocrinol 2014 Nov; 28(11):1875-86
PMID: 25232934

Lizotte PH, Baird JR, Stevens CA, Lauer P, Green WR, Brockstedt DG, Fiering SN
Attenuated Listeria monocytogenes reprograms M2-polarized tumor-associated macrophages in ovarian cancer leading to iNOS-mediated tumor cell lysis.
Oncoimmunology 2014; 3:e28926
PMID: 25083323

Sheen MR, Lizotte PH, Toraya-Brown S, Fiering S
Stimulating antitumor immunity with nanoparticles.
Wiley Interdiscip Rev Nanomed Nanobiotechnol 2014 Sep-Oct; 6(5):496-505
PMID: 25069691