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Steven N. Fiering, PhD

Title(s):
Professor of Microbiology and Immunology
Professor of Genetics
Professor of Genetics

Department(s):
Microbiology and Immunology
Genetics

Education:
Stanford, Ph.D., 1990
University of Michigan, BS, 1975

Dr. Fiering received his Bachelor of Science from the University of Michigan in 1975, and his Doctorate from Stanford in 1990. After postdoctoral work as an NIH research fellow and research associate at the Fred Hutchinson Cancer Research Center, Dr. Fiering joined the faculty of the Department of Microbiology at Dartmouth Medical School in 1997.

Programs:
Immunology Program
Molecular and Cellular Biology Graduate Programs
Norris Cotton Cancer Center

Websites:
http://dms.dartmouth.edu/microbio/
http://dms.dartmouth.edu/immuno/
http://www.dartmouth.edu/~mcb/
http://dms.dartmouth.edu/COBRE/

Contact Information:

Dartmouth Medical School
Rubin Bldg. HB 7936
1 Medical Center Drive
Lebanon NH 03756

Phone: 603-653-9966
Fax: 603-653-9952
Email: Steven.N.Fiering@Dartmouth.EDU


Professional Interests:

My lab is primarily focused on developing novel immune-based strategies for treating cancer. The basic idea is to inject various immunostimulatory reagents, including live attenuated microorganisms into a primary tumor. This treatment can stimulate an immune response against the tumor and develop systemic anti-tumor immunity that protects against metastatic disease.

We are also interested in mouse models of cancer and are developing novel mouse models. The influence of tobacco smoke exposure on the innate immune system is another area of research in the lab.

Courses Taught:

Human Genetics graduate course


Selected Publications:

 

Myristoylated p110α Causes Embryonic Death Due to Developmental and Vascular Defects.
Sheen MR, Warner SL, Fields JL, Conejo-Garcia JR, Fiering S
Open Life Sci. 2015 Oct;10(1):461-478. Epub 2015 Oct 19.
PMID: 27482546

Meditative Movement as a Treatment for Pulmonary Dysfunction in Flight Attendants Exposed to Second-Hand Cigarette Smoke: Study Protocol for a Randomized Trial.
Payne P, Zava D, Fiering S, Crane-Godreau M
Front Psychiatry. 2016;7:38. doi: 10.3389/fpsyt.2016.00038. Epub 2016 Mar 22.
PMID: 27047398

IL15 Agonists Overcome the Immunosuppressive Effects of MEK Inhibitors.
Allegrezza MJ, Rutkowski MR, Stephen TL, Svoronos N, Tesone AJ, Perales-Puchalt A, Nguyen JM, Sarmin F, Sheen MR, Jeng EK, Tchou J, Wong HC, Fiering SN, Conejo-Garcia JR
Cancer Res. 2016 May 1;76(9):2561-72. doi: 10.1158/0008-5472.CAN-15-2808. Epub 2016 Mar 15.
PMID: 26980764

PDGF Engages an E2F-USP1 Signaling Pathway to Support ID2-Mediated Survival of Proneural Glioma Cells.
Rahme GJ, Zhang Z, Young AL, Cheng C, Bivona EJ, Fiering SN, Hitoshi Y, Israel MA
Cancer Res. 2016 May 15;76(10):2964-76. doi: 10.1158/0008-5472.CAN-15-2157. Epub 2016 Mar 7.
PMID: 26951930

Myeloid Acyl-CoA:Cholesterol Acyltransferase 1 Deficiency Reduces Lesion Macrophage Content and Suppresses Atherosclerosis Progression.
Huang LH, Melton EM, Li H, Sohn P, Rogers MA, Mulligan-Kehoe MJ, Fiering SN, Hickey WF, Chang CC, Chang TY
J Biol Chem. 2016 Mar 18;291(12):6232-44. doi: 10.1074/jbc.M116.713818. Epub 2016 Jan 21.
PMID: 26801614

In vivo Cigarette Smoke Exposure Decreases CCL20, SLPI, and BD-1 Secretion by Human Primary Nasal Epithelial Cells.
Jukosky J, Gosselin BJ, Foley L, Dechen T, Fiering S, Crane-Godreau MA
Front Psychiatry. 2015;6:185. doi: 10.3389/fpsyt.2015.00185. Epub 2016 Jan 13.
PMID: 26793127

Virus-based nanoparticles as platform technologies for modern vaccines.
Lee KL, Twyman RM, Fiering S, Steinmetz NF
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2016 Jul;8(4):554-78. doi: 10.1002/wnan.1383. Epub 2016 Jan 19.
PMID: 26782096

Toward Localized <i>In Vivo</i> Biomarker Concentration Measurements.
Zhang X, Reeves D, Shi Y, Gimi B, Nemani KV, Perreard IM, Toraya-Brown S, Fiering S, Weaver JB
IEEE Trans Magn. 2015 Feb;51(2):1-4.
PMID: 26203196

Registered report: Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis.
Fiering S, Ang LH, Lacoste J, Smith TD, Griner E, Reproducibility Project: Cancer Biology
Elife. 2015 Jul 16;4:e04796. doi: 10.7554/eLife.04796. Epub 2015 Jul 16.
PMID: 26179155

Structure-based redesign of lysostaphin yields potent antistaphylococcal enzymes that evade immune cell surveillance.
Blazanovic K, Zhao H, Choi Y, Li W, Salvat RS, Osipovitch DC, Fields J, Moise L, Berwin BL, Fiering SN, Bailey-Kellogg C, Griswold KE
Mol Ther Methods Clin Dev. 2015;2:15021. doi: 10.1038/mtm.2015.21. Epub 2015 Jun 17.
PMID: 26151066