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Steven N. Fiering, Ph.D.

Professor of Microbiology and Immunology
Professor of Genetics
Professor of Genetics

Microbiology and Immunology

Stanford, Ph.D., 1990
University of Michigan, BS, 1975

Dr. Fiering received his Bachelor of Science from the University of Michigan in 1975, and his Doctorate from Stanford in 1990. After postdoctoral work as an NIH research fellow and research associate at the Fred Hutchinson Cancer Research Center, Dr. Fiering joined the faculty of the Department of Microbiology at Dartmouth Medical School in 1997.

Immunology Program
Molecular and Cellular Biology Graduate Programs
Norris Cotton Cancer Center


Contact Information:

Dartmouth Medical School
Rubin Bldg. HB 7936
1 Medical Center Drive
Lebanon NH 03756

Phone: 603-653-9966
Fax: 603-653-9952
Email: Steven.N.Fiering@Dartmouth.EDU

Professional Interests:

My lab is primarily focused on developing novel immune-based strategies for treating cancer. The basic idea is to inject various immunostimulatory reagents, including live attenuated microorganisms into a primary tumor. This treatment can stimulate an immune response against the tumor and develop systemic anti-tumor immunity that protects against metastatic disease.

We are also interested in mouse models of cancer and are developing novel mouse models. The influence of tobacco smoke exposure on the innate immune system is another area of research in the lab.

Courses Taught:

Human Genetics graduate course

Selected Publications:


Mopidevi B, Kaw MK, Puri N, Ponnala M, Jain S, Rana A, Keetha NR, Khuder SA, Fiering SN, Kumar A
Variable transcriptional regulation of the human aldosterone synthase gene causes salt-dependent high blood pressure in transgenic mice.
Circ Cardiovasc Genet 2015 Feb; 8(1):30-9
PMID: 25504670

Toraya-Brown S, Fiering S
Local tumour hyperthermia as immunotherapy for metastatic cancer.
Int J Hyperthermia 2014 Dec; 30(8):531-9
PMID: 25430985

Martinez ME, Charalambous M, Saferali A, Fiering S, Naumova AK, St Germain D, Ferguson-Smith AC, Hernandez A
Genomic imprinting variations in the mouse type 3 deiodinase gene between tissues and brain regions.
Mol Endocrinol 2014 Nov; 28(11):1875-86
PMID: 25232934

Lizotte PH, Baird JR, Stevens CA, Lauer P, Green WR, Brockstedt DG, Fiering SN
Attenuated Listeria monocytogenes reprograms M2-polarized tumor-associated macrophages in ovarian cancer leading to iNOS-mediated tumor cell lysis.
Oncoimmunology 2014; 3:e28926
PMID: 25083323

Sheen MR, Lizotte PH, Toraya-Brown S, Fiering S
Stimulating antitumor immunity with nanoparticles.
Wiley Interdiscip Rev Nanomed Nanobiotechnol 2014 Sep-Oct; 6(5):496-505
PMID: 25069691

Cadiz-Rivera B, Fromm G, de Vries C, Fields J, McGrath KE, Fiering S, Bulger M
The chromatin "landscape" of a murine adult β-globin gene is unaffected by deletion of either the gene promoter or a downstream enhancer.
PLoS One 2014; 9(5):e92947
PMID: 24817273

Rutkowski MR, Allegrezza MJ, Svoronos N, Tesone AJ, Stephen TL, Perales-Puchalt A, Nguyen J, Zhang PJ, Fiering SN, Tchou J, Conejo-Garcia JR
Initiation of metastatic breast carcinoma by targeting of the ductal epithelium with adenovirus-cre: a novel transgenic mouse model of breast cancer.
J Vis Exp 2014 Mar 26; (85)
PMID: 24748051

Toraya-Brown S, Sheen MR, Zhang P, Chen L, Baird JR, Demidenko E, Turk MJ, Hoopes PJ, Conejo-Garcia JR, Fiering S
Local hyperthermia treatment of tumors induces CD8(+) T cell-mediated resistance against distal and secondary tumors.
Nanomedicine 2014 Aug; 10(6):1273-85
PMID: 24566274

Busch AM, Galimberti F, Nehls KE, Roengvoraphoj M, Sekula D, Li B, Guo Y, Direnzo J, Fiering SN, Spinella MJ, Robbins DJ, Memoli VA, Freemantle SJ, Dmitrovsky E
All-trans-retinoic acid antagonizes the Hedgehog pathway by inducing patched.
Cancer Biol Ther 2014 Apr; 15(4):463-72
PMID: 24496080

Weaver JB, Zhang X, Kuehlert E, Toraya-Brown S, Reeves DB, Perreard IM, Fiering S
Quantification of magnetic nanoparticles with low frequency magnetic fields: compensating for relaxation effects.
Nanotechnology 2013 Aug 16; 24(32):325502
PMID: 23867287