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Steven N. Fiering, Ph.D.

Title(s):
Professor of Microbiology and Immunology
Professor of Genetics
Professor of Genetics

Department(s):
Microbiology and Immunology
Genetics

Education:
Stanford, Ph.D., 1990
University of Michigan, BS, 1975

Dr. Fiering received his Bachelor of Science from the University of Michigan in 1975, and his Doctorate from Stanford in 1990. After postdoctoral work as an NIH research fellow and research associate at the Fred Hutchinson Cancer Research Center, Dr. Fiering joined the faculty of the Department of Microbiology at Dartmouth Medical School in 1997.

Programs:
Immunology Program
Molecular and Cellular Biology Graduate Programs
Norris Cotton Cancer Center

Websites:
http://dms.dartmouth.edu/microbio/
http://dms.dartmouth.edu/immuno/
http://www.dartmouth.edu/~mcb/
http://dms.dartmouth.edu/COBRE/

Contact Information:

Dartmouth Medical School
Rubin Bldg. HB 7936
1 Medical Center Drive
Lebanon NH 03756

Phone: 603-653-9966
Fax: 603-653-9952
Email: Steven.N.Fiering@Dartmouth.EDU


Professional Interests:

My lab is primarily focused on developing novel immune-based strategies for treating cancer. The basic idea is to inject various immunostimulatory reagents, including live attenuated microorganisms into a primary tumor. This treatment can stimulate an immune response against the tumor and develop systemic anti-tumor immunity that protects against metastatic disease.

We are also interested in mouse models of cancer and are developing novel mouse models. The influence of tobacco smoke exposure on the innate immune system is another area of research in the lab.

Courses Taught:

Human Genetics graduate course


Selected Publications:

 

Myeloid Acyl-CoA:cholesterol acyltransferase 1 deficiency reduces lesion macrophage content and suppresses atherosclerosis progression.
Huang LH, Melton EM, Li H, Sohn P, Rogers MA, Mulligan-Kehoe MJ, Fiering SN, Hickey WF, Chang CC, Chang TY
J Biol Chem. 2016 Jan 21; pii: jbc.M116.713818. Epub 2016 Jan 21.
PMID: 26801614

In vivo Cigarette Smoke Exposure Decreases CCL20, SLPI, and BD-1 Secretion by Human Primary Nasal Epithelial Cells.
Jukosky J, Gosselin BJ, Foley L, Dechen T, Fiering S, Crane-Godreau MA
Front Psychiatry. 2015;6:185. doi: 10.3389/fpsyt.2015.00185. Epub 2016 Jan 13.
PMID: 26793127

Virus-based nanoparticles as platform technologies for modern vaccines.
Lee KL, Twyman RM, Fiering S, Steinmetz NF
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2016 Jan 19; doi: 10.1002/wnan.1383. Epub 2016 Jan 19.
PMID: 26782096

Toward Localized <i>In Vivo</i> Biomarker Concentration Measurements.
Zhang X, Reeves D, Shi Y, Gimi B, Nemani KV, Perreard IM, Toraya-Brown S, Fiering S, Weaver JB
IEEE Trans Magn. 2015 Feb;51(2):1-4.
PMID: 26203196

Registered report: Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis.
Fiering S, Ang LH, Lacoste J, Smith TD, Griner E, Reproducibility Project: Cancer Biology
Elife. 2015 Jul 16;4:e04796. doi: 10.7554/eLife.04796. Epub 2015 Jul 16.
PMID: 26179155

Structure-based redesign of lysostaphin yields potent antistaphylococcal enzymes that evade immune cell surveillance.
Blazanovic K, Zhao H, Choi Y, Li W, Salvat RS, Osipovitch DC, Fields J, Moise L, Berwin BL, Fiering SN, Bailey-Kellogg C, Griswold KE
Mol Ther Methods Clin Dev. 2015;2:15021. doi: 10.1038/mtm.2015.21. Epub 2015 Jun 17.
PMID: 26151066

Depletion of T cell epitopes in lysostaphin mitigates anti-drug antibody response and enhances antibacterial efficacy in vivo.
Zhao H, Verma D, Li W, Choi Y, Ndong C, Fiering SN, Bailey-Kellogg C, Griswold KE
Chem Biol. 2015 May 21;22(5):629-39. doi: 10.1016/j.chembiol.2015.04.017.
PMID: 26000749

Antibody-mediated targeting of iron oxide nanoparticles to the folate receptor alpha increases tumor cell association in vitro and in vivo.
Ndong C, Toraya-Brown S, Kekalo K, Baker I, Gerngross TU, Fiering SN, Griswold KE
Int J Nanomedicine. 2015;10:2595-617. doi: 10.2147/IJN.S79367. Epub 2015 Apr 1.
PMID: 25878495

Variable transcriptional regulation of the human aldosterone synthase gene causes salt-dependent high blood pressure in transgenic mice.
Mopidevi B, Kaw MK, Puri N, Ponnala M, Jain S, Rana A, Keetha NR, Khuder SA, Fiering SN, Kumar A
Circ Cardiovasc Genet. 2015 Feb;8(1):30-9. doi: 10.1161/CIRCGENETICS.114.000694. Epub 2014 Dec 12.
PMID: 25504670

Local tumour hyperthermia as immunotherapy for metastatic cancer.
Toraya-Brown S, Fiering S
Int J Hyperthermia. 2014 Dec;30(8):531-9. doi: 10.3109/02656736.2014.968640.
PMID: 25430985