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Robert A. Maue, Ph.D.

Title(s):
Professor of Physiology
Professor of Biochemistry
Adjunct Professor of Psychological Brain Sciences
Adjunct Professor of Biological Sciences

Department(s):
Physiology
Biochemistry

Education:
U. California - San Diego, PHD 1985

Programs:
Academy of Master Faculty Educators
Molecular and Cellular Biology Graduate Programs
Neuroscience Center at Dartmouth
Program in Experimental and Molecular Medicine

Websites:
http://dms.dartmouth.edu/ncd/

Contact Information:

Geisel School of Medicine
HB 7701
Hanover NH 03755

Office: Remsen 210
Phone: 603-650-1726/650-1119
Fax: 603-650-1128
Email: robert.maue@dartmouth.edu


Professional Interests:

We are interested in understanding the mechanisms important for the development and differentiation of neurons in the brain. In particular, we are interested in the means by which a family of growth factors known as neurotrophins (NGF, BDNF, NT-3) exert their influence the growth and electrical activity of neurons, including their regulation of process outgrowth and ion channel expression. Our recent efforts have focused on a class of neurons in the brain known as cerebellar Purkinje cells, and our interest in events associated with their development has recently focused on the pathology and abnormal development of these neurons in neurological disorders such as Niemann Pick Type C (NPC) disease. NPC disease is a fatal genetic disorder associated with abnormal cellular cholesterol accumulation, and a hallmark of this disorder is the preferential loss of Purkinje cells. Given the recent appreciation of the importance of cholesterol in the brain, particularly during neurodegenerative diseases such as NPC disease, Alzheimer's disease, and Huntington’s disease, understanding the effects of NPC disease and cholesterol abnormalities on Purkinje cells has widespread implications.

In our experiments we have taken advantage of transgenic mice expressing mutant ion channel genes, knockout mice lacking neurotrophin receptors, and novel mouse models of NPC disease that we've developed to analyze neurons in primary culture, in brain slices, and in vivo. This has included immunocytochemical and morphometric analyses, Western blotting and biochemical assays, single-cell, real time PCR analyses of gene expression, patch clamp recording of ion channels and electrical activity, virus-mediated expression of fluorescent proteins in vivo and in cultured neurons, and behavioral analyses of cerebellar function.

Grant Information:

National Institutes of Health, National Niemann Pick Disease Foundation, Ara Parseghian Medical Research Foundation, Hereditary Disease Foundation, Epilepsy Foundation, Wellcome Trust

Courses Taught:

-Instructor Medical Neuroscience (Medical student course) 1990-present

-Instructor PEMM Core Course (Grad course PEMM Program) 2006-2013

-Director/Lecturer Adv Biomed Sci (Grad course PEMM Program) 2008-2010

-Instructor Molec Cell Biol (Grad core course - MCB Program) 1999-2003

-Instructor Receptor Pharm (Grad course -– Pharmacology Program) 1996-2006

-Director/Instructor Stystems Neuroscience course (PBS 65 upper div undergrad course) 2010-present

-Director/Instruct Cellular/ Molec Neuro course (PBS 46 upper div undergrad course) 2007-present

-Director/Instruct Physiol (Bio 14 upper division undergrad course) 2008- present

-Director/Instruct Physiology (Bio 35 upper division undergrad course) 2006

-Director/Instruct Adv Neurobiology (Bio 74 upper div undergrad course) 2006

-Instructor Biochemistry (Bio 78 upper division undergrad course) 1998-2005

-Instructor Intro Cell Biology (Bio 15 upper division undergrad course) 2003

Biography:

Born in Anoka, Minnesota, a small town (now suburb) just north of Minneapolis/St Paul. After attending Anoka Senior High School, went to small, all male, liberal arts college/monastery in northern Minnesota called St. John’s University where he majored in Biology. Attended graduate school at University of California at San Diego in Physiology /Pharmacology. Not only obtained a PhD in Physiology and Pharmacology, but also served as a member of two research expeditions to Antarctica while there. Did Postdoctoral fellowships at Brandies University in Waltham and Tufts-New England Medical Center in Boston before becoming an Assistant Professor at Dartmouth in 1989. Is married (to Dr. Leslie Henderson) and has two sons who have graduated from college.


Selected Publications:

 

  • Paul CA, Boegle AK, Maue RA. Before the loss: neuronal dysfunction in Niemann-Pick Type C disease. Biochim Biophys Acta. 2004 Oct 11;1685(1-3):63-76. Review. (view details on MedLine)

  • Paul CA, Reid PC, Boegle AK, Karten B, Zhang M, Jiang ZG, Franz D, Lin L, Chang TY, Vance JE, Blanchette-Mackie J, Maue RA. Adenovirus expressing an NPC1-GFP fusion gene corrects neuronal and nonneuronal defects associated with Niemann pick type C disease. J Neurosci Res. 2005 Sep 1;81(5):706-19. (view details on MedLine)

  • Fry M, Boegle AK, Maue RA. Differentiated pattern of sodium channel expression in dissociated Purkinje neurons maintained in long-term culture. J Neurochem. 2007 May;101(3):737-48. (view details on MedLine)

  • Maue RA. Understanding ion channel biology using epitope tags: progress, pitfalls, and promise. J Cell Physiol. 2007 Dec;213(3):618-25. Review. (view details on MedLine)

  • Claudepierre T, Paques M, Simonutti M, Buard I, Sahel J, Maue RA, Picaud S, Pfrieger FW. Lack of Niemann-Pick type C1 induces age-related degeneration in the mouse retina. Mol Cell Neurosci. 2010 Jan;43(1):164-76. (view details on MedLine)

  • Maue RA, Burgess RW, Wang B, Wooley CM, Seburn KL, Vanier MT, Rogers MA, Chang CC, Chang TY, Harris BT, Graber DJ, Penatti CA, Porter DM, Szwergold BS, Henderson LP, Totenhagen JW, Trouard TP, Borbon IA, Erickson RP. A novel mouse model of Niemann-Pick type C disease carrying a D1005G-Npc1 mutation comparable to commonly observed human mutations. Hum Mol Genet. 2012 Feb 15;21(4):730-50. (view details on MedLine)

  • Fry, M, Boegle, AK, Maue, RA Differentiated pattern of sodium channel expression in dissociated Purkinje neurons maintained in long-term culture. J Neurochem 2007 May 101(3): 737-748 (view details on MedLine)

  • Paul, CA, Reid PC, Boegle, AK, Karten B, Zhang M, Jiang ZG, Franz D, Lin L, Chang TY, Vance JE, Blanchette-Mackie J, Maue RA Aenovirus expressing an NPC1-GFP fusion gene corrects neuronal and nonneuronal defects associated with Niemann Pick type C disease. J Neurosci Res 2005 Sep 81(5):706-719 (view details on MedLine)

  • Henderson LP, Lin L, Prasad A, Paul CA, Chang TY, Maue RA Embryonic striatal neurons from Niemann Pick type C mice exhibit defects in cholesterol metabolism and neurotrophin responsiveness. J Biol Chem 2000 Jun 30 275(26):20179-87 (view details on MedLine)

  • Murali A, Maue RA, Dolph PJ Reversible symptoms and clearance of mutant prion protein in an inducible model of genetic prion disease in Drosophila Melanogaster. J Neurobiol Dis 2014 (in press)