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Anne G Hoen

Title(s):
Assistant Professor of Epidemiology
Assistant Professor of Biomedical Data Science
Assistant Professor of Microbiology and Immunology

Department(s):
Epidemiology
Biomedical Data Science
Microbiology and Immunology

Programs:
Program in Experimental and Molecular Medicine
Quantitative Biomedical Sciences

Websites:
http://discovery.dartmouth.edu/hoenlab/

Contact Information:

Dartmouth-Hitchcock Medical Center
One Medical Center Drive
HB 7927
Lebanon NH 03756

Office: Rubin 888
Phone: 603-653-6087
Email: Anne.G.Hoen@Dartmouth.edu


Professional Interests:

Dr. Hoen's research focus is on the development of the microbiome in infants and children, and the associations between environmental and dietary exposures, the microbiome, and risk for infectious and other diseases. She has a broad interest in the predictors of disease risk and microbial colonization dynamics in human populations and the environment as reflected in microbial genetic sequence variation and health informatics streams over space and time. Interdisciplinary approaches used in her research include spatial and time-series statistics, population genetics and novel disease surveillance methodologies along with tools from the fields of microbial ecology, molecular epidemiology and landscape epidemiology.

Rotations and Thesis Projects:

Development of network-based methods to capture the evolving interactions between the microorganisms that form the intestinal microbiome in infants and young children
Environmental drivers of infant intestinal microbiome development
Associations between patterns of infant intestinal microbiome establishment and health outcomes in children
Role of the intestinal and airway microbiomes in the clinical progression of cystic fibrosis

Grant Information:

K01LM011985: Bioinformatics strategies for early life microbiomics

Courses Taught:

QBS 136 Applied Epidemiologic Methods

Biography:

Dr. Hoen completed her PhD in epidemiology and public health at Yale University and received post-doctoral training at Children's Hospital Boston, Harvard Medical School and McGill University. She has broad training in biostatistics, epidemiology and public health with research experience in the evaluation of interventions, understanding infectious disease emergence and spread, and evaluating associations between the microbiome and human health. Her research uses advanced spatial and time series analysis as well as informatics and complex systems approaches. Past studies include modeling the timing and spread of influenza to estimate the effects of interventions targeting children, modeling the evolutionary ecology of the Lyme disease agent, Borrelia burgdorferi and characterizing the initial development of the human micrbiome in early life and its associations with common exposures and infectious outcomes.


Selected Publications:

 

Vaccine-induced mucosal immunity to poliovirus: analysis of cohorts from an open-label, randomised controlled trial in Latin American infants.
Wright PF, Connor RI, Wieland-Alter WF, Hoen AG, Boesch AW, Ackerman ME, Oberste MS, Gast C, Brickley EB, Asturias EJ, Ruttimann R, Bandyopadhyay AS
Lancet Infect Dis. 2016 Dec;16(12):1377-1384. doi: 10.1016/S1473-3099(16)30169-4. Epub 2016 Sep 13.
PMID: 27638357

Correlates of Immunity to Influenza as Determined by Challenge of Children with Live, Attenuated Influenza Vaccine.
Wright PF, Hoen AG, Ilyushina NA, Brown EP, Ackerman ME, Wieland-Alter W, Connor RI, Jegaskanda S, Rosenberg-Hasson Y, Haynes BC, Luke CJ, Subbarao K, Treanor JJ
Open Forum Infect Dis. 2016 Apr;3(2):ofw108. doi: 10.1093/ofid/ofw108. Epub 2016 May 23.
PMID: 27419180

Prospective Study of Human Polyomaviruses and Risk of Cutaneous Squamous Cell Carcinoma in the United States.
Gossai A, Waterboer T, Nelson HH, Doherty JA, Michel A, Willhauck-Fleckenstein M, Farzan SF, Christensen BC, Hoen AG, Perry AE, Pawlita M, Karagas MR
Cancer Epidemiol Biomarkers Prev. 2016 May;25(5):736-44. doi: 10.1158/1055-9965.EPI-15-1111. Epub 2016 Feb 11.
PMID: 26908434

Human polyomaviruses and incidence of cutaneous squamous cell carcinoma in the New Hampshire skin cancer study.
Gossai A, Waterboer T, Hoen AG, Farzan SF, Nelson HH, Michel A, Willhauck-Fleckenstein M, Christensen BC, Perry AE, Pawlita M, Karagas MR
Cancer Med. 2016 Jun;5(6):1239-50. doi: 10.1002/cam4.674. Epub 2016 Feb 21.
PMID: 26899857

Association of Cesarean Delivery and Formula Supplementation With the Intestinal Microbiome of 6-Week-Old Infants.
Madan JC, Hoen AG, Lundgren SN, Farzan SF, Cottingham KL, Morrison HG, Sogin ML, Li H, Moore JH, Karagas MR
JAMA Pediatr. 2016 Mar;170(3):212-9. doi: 10.1001/jamapediatrics.2015.3732.
PMID: 26752321

Seroepidemiology of Human Polyomaviruses in a US Population.
Gossai A, Waterboer T, Nelson HH, Michel A, Willhauck-Fleckenstein M, Farzan SF, Hoen AG, Christensen BC, Kelsey KT, Marsit CJ, Pawlita M, Karagas MR
Am J Epidemiol. 2016 Jan 1;183(1):61-9. doi: 10.1093/aje/kwv155. Epub 2015 Dec 13.
PMID: 26667254

Epidemic Wave Dynamics Attributable to Urban Community Structure: A Theoretical Characterization of Disease Transmission in a Large Network.
Hoen AG, Hladish TJ, Eggo RM, Lenczner M, Brownstein JS, Meyers LA
J Med Internet Res. 2015 Jul 8;17(7):e169. doi: 10.2196/jmir.3720. Epub 2015 Jul 8.
PMID: 26156032

Whole genome capture of vector-borne pathogens from mixed DNA samples: a case study of Borrelia burgdorferi.
Carpi G, Walter KS, Bent SJ, Hoen AG, Diuk-Wasser M, Caccone A
BMC Genomics. 2015 Jun 6;16:434. doi: 10.1186/s12864-015-1634-x. Epub 2015 Jun 6.
PMID: 26048573

Associations between Gut Microbial Colonization in Early Life and Respiratory Outcomes in Cystic Fibrosis.
Hoen AG, Li J, Moulton LA, O'Toole GA, Housman ML, Koestler DC, Guill MF, Moore JH, Hibberd PL, Morrison HG, Sogin ML, Karagas MR, Madan JC
J Pediatr. 2015 Jul;167(1):138-47.e1-3. doi: 10.1016/j.jpeds.2015.02.049. Epub 2015 Mar 26.
PMID: 25818499

Fetal exposures and perinatal influences on the stool microbiota of premature infants.
Chernikova DA, Koestler DC, Hoen AG, Housman ML, Hibberd PL, Moore JH, Morrison HG, Sogin ML, Zain-Ul-Abideen M, Madan JC
J Matern Fetal Neonatal Med. 2016;29(1):99-105. doi: 10.3109/14767058.2014.987748. Epub 2015 Sep 4.
PMID: 25394613