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Matthew C. Havrda, PhD

Title(s):
Assistant Professor of Molecular and Systems Biology

Department(s):
Molecular and Systems Biology

Education:
University of Maine: Graduate School of Biomedical Sciences and Engineering, Ph.D.

Programs:
Norris Cotton Cancer Center
Program in Experimental and Molecular Medicine

Contact Information:


Professional Interests:

Neurodegenerative Diseases
Glial Cell Biology
Neuroimmunology
Brain Cancer

Rotations and Thesis Projects:

Parkinson's disease
Neuroinflammation
Translational Neurobiology

Grant Information:

Target Validation Award: The Michael J. Fox Foundation for Parkinson's Disease Research
Dartmouth SYNERGY Scholars Award
The Hitchcock Foundation
NIN/NINDS 1F32NS059126-01A1
NIH-NIEHS 1R01ES024745: Mechanisms of rotenone-induced neuroinflammation and Parkinsonism in aging mice

Courses Taught:

Course Co-Director, Neurobiology of Disease (PEMM 211)

Biography:

Dr. Havrda is a neurobiologist interested in characterizing the molecular basis of brain disorders, especially Parkinson’s disease and its various pathologic manifestations. He received his Ph.D. in 2006 from the Graduate School of Biomedical Science and Engineering of the University of Maine at the Maine Medical Center Research Institute. Dr. Havrda is an Assistant Professor at the Geisel School of Medicine at Dartmouth affiliated with the Parkinson’s Center at Dartmouth working at the Dartmouth-Hitchcock Medical Center in Lebanon, New Hampshire. Throughout his career he has published numerous research reports and book chapters while receiving academic awards including the Ian Sinclair Scholarship, the Apollon Valakis Scholarship and the Doris G. Alexander Memorial Scholarship. More recently Dr. Havrda has received prestigious young investigator awards including the Ruth L. Kirschstein National Research Service Award, the Dartmouth SYNERGY Scholar Award for Clinical and Translational Research, and a Target Validation Award from the Michael J. Fox Foundation. Dr. Havrda’s research program is focused on characterizing the molecular basis of neuroinflammation during the progression of Parkinson’s disease both in cellular and animal models as well as in biofluids and post-mortem tissues obtained from Parkinson’s patients. Such studies are expected to provide new platforms from which to discover, monitor and evaluate diagnostic indicators and therapeutic targets.


Selected Publications:

 

Editor's Highlight: Nlrp3 Is Required for Inflammatory Changes and Nigral Cell Loss Resulting From Chronic Intragastric Rotenone Exposure in Mice.
Martinez EM, Young AL, Patankar YR, Berwin BL, Wang L, von Herrmann KM, Weier JM, Havrda MC
Toxicol Sci. 2017 Sep 1;159(1):64-75. doi: 10.1093/toxsci/kfx117.
PMID: 28903492

ID2 promotes survival of glioblastoma cells during metabolic stress by regulating mitochondrial function.
Zhang Z, Rahme GJ, Chatterjee PD, Havrda MC, Israel MA
Cell Death Dis. 2017 Feb 16;8(2):e2615. doi: 10.1038/cddis.2017.14. Epub 2017 Feb 16.
PMID: 28206987

Insulin-Mediated Signaling Facilitates Resistance to PDGFR Inhibition in Proneural hPDGFB-Driven Gliomas.
Almiron Bonnin DA, Ran C, Havrda MC, Liu H, Hitoshi Y, Zhang Z, Cheng C, Ung M, Israel MA
Mol Cancer Ther. 2017 Apr;16(4):705-716. doi: 10.1158/1535-7163.MCT-16-0616. Epub 2017 Jan 30.
PMID: 28138037

Phosphorylation Regulates Id2 Degradation and Mediates the Proliferation of Neural Precursor Cells.
Sullivan JM, Havrda MC, Kettenbach AN, Paolella BR, Zhang Z, Gerber SA, Israel MA
Stem Cells. 2016 May;34(5):1321-31. doi: 10.1002/stem.2291. Epub 2016 Feb 1.
PMID: 26756672

Inhibitor of differentiation 4 (ID4): From development to cancer.
Patel D, Morton DJ, Carey J, Havrda MC, Chaudhary J
Biochim Biophys Acta. 2015 Jan;1855(1):92-103. doi: 10.1016/j.bbcan.2014.12.002. Epub 2014 Dec 12.
PMID: 25512197

Id2 mediates oligodendrocyte precursor cell maturation arrest and is tumorigenic in a PDGF-rich microenvironment.
Havrda MC, Paolella BR, Ran C, Jering KS, Wray CM, Sullivan JM, Nailor A, Hitoshi Y, Israel MA
Cancer Res. 2014 Mar 15;74(6):1822-32. doi: 10.1158/0008-5472.CAN-13-1839. Epub 2014 Jan 14.
PMID: 24425046

Id4 deficiency attenuates prostate development and promotes PIN-like lesions by regulating androgen receptor activity and expression of NKX3.1 and PTEN.
Sharma P, Knowell AE, Chinaranagari S, Komaragiri S, Nagappan P, Patel D, Havrda MC, Chaudhary J
Mol Cancer. 2013 Jun 21;12:67. doi: 10.1186/1476-4598-12-67. Epub 2013 Jun 21.
PMID: 23786676

Behavioral abnormalities and Parkinson's-like histological changes resulting from Id2 inactivation in mice.
Havrda MC, Paolella BR, Ward NM, Holroyd KB
Dis Model Mech. 2013 May;6(3):819-27. doi: 10.1242/dmm.010041. Epub 2012 Dec 20.
PMID: 23264561

p53 directly represses Id2 to inhibit the proliferation of neural progenitor cells.
Paolella BR, Havrda MC, Mantani A, Wray CM, Zhang Z, Israel MA
Stem Cells. 2011 Jul;29(7):1090-101. doi: 10.1002/stem.660.
PMID: 21608079

Id2 is required for specification of dopaminergic neurons during adult olfactory neurogenesis.
Havrda MC, Harris BT, Mantani A, Ward NM, Paolella BR, Cuzon VC, Yeh HH, Israel MA
J Neurosci. 2008 Dec 24;28(52):14074-86. doi: 10.1523/JNEUROSCI.3188-08.2008.
PMID: 19109490