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Richard J. Barth, MD

Title(s):
Professor of Surgery

Department(s):
Surgery

Education:
A.B. - Biochemical Sciences, Princeton, 1981.
M.D. - Harvard, 1985

Programs:
Norris Cotton Cancer Center

Curriculum Vitae:
Barth_R_CV_2009-02-12.pdf

NIH Biosketch:
Barth_R_BIO_2009-02-12.pdf

Websites:
http://dms.dartmouth.edu/immuno/

Contact Information:

DHMC
1 Medical Center Drive
Lebanon NH 03756

Email: Richard.J.Barth.Jr@Hitchcock.ORG


Professional Interests:

This lab has been interested in understanding the immune response to tumors in vivo by characterizing the cytokines expressed by lymphocytes infiltrating tumors and the tumors themselves. We have recently demonstrated that CD40/CD154 interactions are crucial in the generation of anti-tumor immunity by tumor vaccines in mice. We are now actively investigating the mechanisms underlying this phenomenon, and are trying to exploit this in the generation of more effective vaccines.


Selected Publications:

 

Personal history of proliferative breast disease with atypia and risk of multifocal breast cancer.
Nutter EL, Weiss JE, Marotti JD, Barth RJ Jr, Eliassen MS, Goodrich ME, Petersen CL, Onega T
Cancer. 2017 Dec 20; doi: 10.1002/cncr.31202. Epub 2017 Dec 20.
PMID: 29266172

Guideline for Discharge Opioid Prescriptions after Inpatient General Surgical Procedures.
Hill MV, Stucke RS, Billmeier SE, Kelly JL, Barth RJ Jr
J Am Coll Surg. 2017 Nov 8; pii: S1072-7515(17)32055-0. doi: 10.1016/j.jamcollsurg.2017.10.012. Epub 2017 Nov 8.
PMID: 29198638

A Patient-Specific 3D-Printed Form Accurately Transfers Supine MRI-Derived Tumor Localization Information to Guide Breast-Conserving Surgery.
Barth RJ Jr, Krishnaswamy V, Paulsen KD, Rooney TB, Wells WA, Rizzo E, Angeles CV, Marotti JD, Zuurbier RA, Black CC
Ann Surg Oncol. 2017 Oct;24(10):2950-2956. doi: 10.1245/s10434-017-5979-z. Epub 2017 Aug 1.
PMID: 28766199

Completion Dissection or Observation for Sentinel-Node Metastasis in Melanoma.
Faries MB, Thompson JF, Cochran AJ, Andtbacka RH, Mozzillo N, Zager JS, Jahkola T, Bowles TL, Testori A, Beitsch PD, Hoekstra HJ, Moncrieff M, Ingvar C, Wouters MWJM, Sabel MS, Levine EA, Agnese D, Henderson M, Dummer R, Rossi CR, Neves RI, Trocha SD, Wright F, Byrd DR, Matter M, Hsueh E, MacKenzie-Ross A, Johnson DB, Terheyden P, Berger AC, Huston TL, Wayne JD, Smithers BM, Neuman HB, Schneebaum S, Gershenwald JE, Ariyan CE, Desai DC, Jacobs L, McMasters KM, Gesierich A, Hersey P, Bines SD, Kane JM, Barth RJ, McKinnon G, Farma JM, Schultz E, Vidal-Sicart S, Hoefer RA, Lewis JM, Scheri R, Kelley MC, Nieweg OE, Noyes RD, Hoon DSB, Wang HJ, Elashoff DA, Elashoff RM
N Engl J Med. 2017 Jun 8;376(23):2211-2222. doi: 10.1056/NEJMoa1613210.
PMID: 28591523

Relationship of breast MRI to recurrence rates in patients undergoing breast-conservation treatment.
Hill MV, Beeman JL, Jhala K, Holubar SD, Rosenkranz KM, Barth RJ Jr
Breast Cancer Res Treat. 2017 Jun;163(3):615-622. doi: 10.1007/s10549-017-4205-9. Epub 2017 Mar 18.
PMID: 28315967

An Educational Intervention Decreases Opioid Prescribing After General Surgical Operations.
Hill MV, Stucke RS, McMahon ML, Beeman JL, Barth RJ Jr
Ann Surg. 2017 Mar 6; doi: 10.1097/SLA.0000000000002198. Epub 2017 Mar 6.
PMID: 28267689

Wide Variation and Excessive Dosage of Opioid Prescriptions for Common General Surgical Procedures.
Hill MV, McMahon ML, Stucke RS, Barth RJ Jr
Ann Surg. 2017 Apr;265(4):709-714. doi: 10.1097/SLA.0000000000001993.
PMID: 27631771

PI3K/Akt/mTOR Signaling and Plasma Membrane Proteins Are Implicated in Responsiveness to Adjuvant Dendritic Cell Vaccination for Metastatic Colorectal Cancer.
Qian DC, Xiao X, Byun J, Suriawinata AA, Her SC, Amos CI, Barth RJ Jr
Clin Cancer Res. 2017 Jan 15;23(2):399-406. doi: 10.1158/1078-0432.CCR-16-0623. Epub 2016 Jul 19.
PMID: 27435399

Cost-effectiveness and clinical efficacy of biliary stents in patients undergoing neoadjuvant therapy for pancreatic adenocarcinoma in a randomized controlled trial.
Gardner TB, Spangler CC, Byanova KL, Ripple GH, Rockacy MJ, Levenick JM, Smith KD, Colacchio TA, Barth RJ, Zaki BI, Tsapakos MJ, Gordon SR
Gastrointest Endosc. 2016 Sep;84(3):460-6. doi: 10.1016/j.gie.2016.02.047. Epub 2016 Mar 10.
PMID: 26972022

Genomic characterization of patient-derived xenograft models established from fine needle aspirate biopsies of a primary pancreatic ductal adenocarcinoma and from patient-matched metastatic sites.
Allaway RJ, Fischer DA, de Abreu FB, Gardner TB, Gordon SR, Barth RJ, Colacchio TA, Wood M, Kacsoh BZ, Bouley SJ, Cui J, Hamilton J, Choi JA, Lange JT, Peterson JD, Padmanabhan V, Tomlinson CR, Tsongalis GJ, Suriawinata AA, Greene CS, Sanchez Y, Smith KD
Oncotarget. 2016 Mar 29;7(13):17087-102. doi: 10.18632/oncotarget.7718.
PMID: 26934555