Mary Jo Turk, PhD
Professor of Microbiology and Immunology
O. Ross McIntyre, M.D. Endowed Professor
Co-Director, Immunology and Cancer Immunotherapy Program
Norris-Cotton Cancer Center
Microbiology and Immunology
Dr. Turk received her B.S. from John Carroll University, and her Ph.D. from Purdue University. She conducted postdoctoral work at the Memorial Sloan-Kettering Cancer Center. Dr. Turk joined the faculty of Dartmouth in 2004.
Molecular and Cellular Biology Graduate Programs
Norris Cotton Cancer Center
One Medical Center Drive
Rubin Building 732, HB 7937
Lebanon NH 03756
Office: Rubin 732
Asst. Phone: 603-653-9952
Tumor Immunology and T cell memory
Our laboratory's research focuses on generating durable memory T cell responses to cancer. What is known about generating immunological memory has historically derived from studies of infectious pathogens. Because tumors are an altered form of self-tissue, memory T cell responses to tumors have been characteristically difficult to generate, and mechanisms for their maintenance have not been well understood.
Our laboratory has established that autoimmune disease is a critical determinant for the maintenance of T cell memory to tumor antigens. We have also shown that the most functional tumor-specific memory T cells reside in peripheral tissues. Our research has established that tissue-resident memory T cells are a critical component of long-lived immunity to cancer.
Anti-CTLA-4 Activates Intratumoral NK Cells and Combined with IL15/IL15Rα Complexes Enhances Tumor Control.
Tissue Resident CD8 Memory T Cell Responses in Cancer and Autoimmunity.
A Leukocyte Infiltration Score Defined by a Gene Signature Predicts Melanoma Patient Prognosis.
Oncogenic BRAFV600E Governs Regulatory T-cell Recruitment during Melanoma Tumorigenesis.
VISTA expression on tumor-infiltrating inflammatory cells in primary cutaneous melanoma correlates with poor disease-specific survival.
Age effects of distinct immune checkpoint blockade treatments in a mouse melanoma model.
Resident memory T cells in the skin mediate durable immunity to melanoma.
Myeloid Cells That Impair Immunotherapy Are Restored in Melanomas with Acquired Resistance to BRAF Inhibitors.
Tumor-Intrinsic PD-L1 Signals Regulate Cell Growth, Pathogenesis, and Autophagy in Ovarian Cancer and Melanoma.
The mitogen-activated protein kinase pathway plays a critical role in regulating immunological properties of BRAF mutant cutaneous melanoma cells.