Program in Immunology

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• Identification of Zbtb20 as novel regulator of T cell immunometabolism

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• VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance

  VISTA: a Very Important Silencer of non-specific T cell Activity To ensure the specificity of the immune response, the majority of naive T cells must be kept silent. VISTA is an inhibitory receptor uniquely expressed on naive T cells. ElTanbouly et al show that VISTA functions in two interrelated ways to keep T cells silent. First, VISTA actively shapes the heterogeneity of the naïve T cell compartment to one that is more uniformly quiescent and quiet. Second, VISTA induces the death of naïve T cells inappropriately activated by self-antigen avoiding the development of autoimmunity.  

  VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance about VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance

• Mothers with history of herpes can protect their offspring…

  Maternal antibodies providing neural protection to the infants "hasn't been noted before and is very important for pathogens that infect newborns because there is often some kind of neurologic consequence that may impact their entire lives," added lead study author Yike Jiang, an M.D./Ph.D. student at the medical school.

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• FDA Approves First Gene Therapy For Leukemia (NPR)

  The treatment involves removing immune system cells known as T cells from each patient and genetically modifying the cells in the laboratory to attack and kill leukemia cells. The genetically modified cells are then infused back into patients. It's also known as CAR-T cell therapy.

  FDA News -CAR-T cell therapy about FDA Approves First Gene Therapy For Leukemia (NPR)