Core Instrumentation Labs

Bioinformatics (BISR)

The Bioinformatics Resource provides a wide range of different services including applied bioinformatics and data mining, computer programming and software engineering, database development and programming, and high-performance computing and systems administration.

Biostatistics (BSR)

The Biostatistics Resource provides scientific interpretation for all statistical analyses. All initial consultations are free. More extensive efforts may require additional funding depending on how much time is required. The GeoSpatial Section provides expert consultation and collaboration for research projects in behavior, epidemiology, health services and other disciplines.

Clinical Pharmacology (CP)

The Clinical Pharmacology Resource supports investigators in the design, analysis, and interpretation of clinical pharmacology objectives in preclinical and clinical studies, including chemoprevention and epidemiological studies. In addition to the biorepository function of our resource we also have bioanalytical hardware, computer hardware, and state-of-the-art commercial software programs for application to individual and population-based pharmacokinetic and pharmacodynamic modeling, and modeling drug in vitro and in vivo combination drug effects.

Genomics and Molecular Biology (GMB)

The Microarray and Next-Gen Sequencing Section provides technologies that enable profiling of gene expression, miRNA, CpG Island, and CGH on a whole-genome scale, and provides high-quality genomics and microarray data. The Molecular Biology Section provides DNA fragment analysis, qPCR, Sanger sequencing and NanoString Technology.

Immune Monitoring and Flow Cytometry (IMFC)

The Immune Monitoring and Flow Cytometry Resource provides various services such as isolation and cryopreservation of PBMCs and plasma or serum for clinical trials, as well as carrying out a spectrum of immunoassays and developing customized immunoassays. It also provides dedicated equipment such as sell sorters, flow cytometers, ELISPOT reader, Bio-Plex array reader, autoMACS and RoboSep.

Irradiation, Pre-clinical Imaging, and Microscopy (IPIM)

The Irradiation Resource assists investigators in radiation treatment planning and delivery of ionizing irradiation to cells, rodents, large animals and spontaneous animal tumors. Pre-clinical Imaging provides technologies for non-invasive, whole-animal imgaing of rodents used in preclinical research studies. The Microscopy Section provides access to point scanning confocal microscopy, conventional bright field and flourescence light microscopy, and image analysis resources. The facility provides individual and group training for operation of the light microscopes.

Office of Clinical Research

The Office of Clinical Research assists with the planning, conduct, and compliance of clinical trials involving cancer treatment medications and devices. Studies include investigator-initiated, cooperative group, working group and industry-supported clinical trials. Services include regulatory work, clinical research coordination and research nursing.

Pathology Shared Resources (PSR)

The Pathology Shared Resources facilitates project planning, clinical validation and implementation of novel translational technology and research in the fields of molecular diagnostics, molecular therapeutics, pharmacogenomics, quantitative morphologic image analysis and immunohistochemistry (IHC) in a CLIA-certified, CAP-accredited laboratory ensuring optimal clinical quality assurance.

Trace Element Analysis (TEA)

The Trace Element Analysis Resource specializes in low-level trace metal analysis and speciation in environmental and biological samples. We use inductively coupled plasma mass spectrometry (ICP-MS) for metals analysis and several "hyphenated" techniques that couple instruments together for speciation analyses of water, soil and biological tissue samples.

Transgenics and Genetic Constructs (TGC)

The Transgenics and Genetic Constructs Resource supports the generation and utilization of genetically modified mice by members of the Dartmouth research community. We offer a wide variety of services that assist researchers in construct design and creation of novel transgenic mice. We also offer mice with a human immune system that allows our investigators a better way to study viruses and other human infections. The Speed Congenics Service facilitates the development of congenic mice in support of pre-clinical projects. We provide expert advice on mouse speed congenic development, mouse genetic background analysis and mouse genetic mapping.