Welcome to our laboratory
Welcome to the Cramer Laboratory in the Department of Microbiology and Immunology at the Geisel School of Medicine at Dartmouth in Hanover, New Hampshire. Our laboratory is focused on elucidating the pathogenesis mechanisms of the human fungal pathogen Aspergillus fumigatus. A. fumigatus is a filamentous fungus (mold) and causes invasive pulmonary aspergillosis (IPA) in immunocompromised patients and hypersensitivity type diseases such as Allergic Bronchopulmonary Aspergillosis (ABPA) in immunocompetent individuals. Current treatment options for aspergillosis in all its manifestations are limited in part due to the genetic similarity between humans and fungi. A better understanding of how A. fumigatus is able to colonize, infect, and cause disease is expected to lead to better diagnostics and improved therapies.
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Aspergillus fumigatus in vitro hypoxia culture |
Aspergillus fumigatus infection in the lung |
Aspergillus fumigatus hyphae in hypoxia |
Resistance test to antifungal drugs |
Dartmouth and the Cramer Lab is committed to academic excellence and encourages the open exchange of ideas within a culture of mutual respect. People with different backgrounds, life experiences, and perspectives make the Dartmouth and Cramer Lab community diverse, which enhances academic excellence.