Welcome to our laboratory

Welcome to the Cramer Laboratory in the Department of Microbiology and Immunology at the Geisel School of Medicine at Dartmouth in Hanover, New Hampshire. Our laboratory is focused on elucidating the pathogenesis mechanisms of the human fungal pathogen Aspergillus fumigatus. A. fumigatus is a filamentous fungus (mold) and causes invasive pulmonary aspergillosis (IPA) in immunocompromised patients and hypersensitivity type diseases such as Allergic Bronchopulmonary Aspergillosis (ABPA) in immunocompetent individuals. Current treatment options for aspergillosis in all its manifestations are limited in part due to the genetic similarity between humans and fungi. A better understanding of how A. fumigatus is able to colonize, infect, and cause disease is expected to lead to better diagnostics and improved therapies.

Aspergillus fumigatus in vitro hypoxia culture

Aspergillus fumigatus infection in the lung

Aspergillus fumigatus hyphae in hypoxia

Resistance test to antifungal drugs

The Cramer laboratory is committed to a culture of anti-racism and social justice and is dedicated to playing an active role in upholding the human dignity of every person’s life. We stand in solidarity with all people of color throughout our society who face systemic racism everyday of their lives and welcome all interested scientists into our group without reservation. Our laboratory is a welcoming space for all members to thrive scientifically and advance in the pursuit of knowledge without persecution or power imbalances. We can, and must, do better as scientists to create a culture of love, hope, charity, justice, and life throughout our communities. Our laboratory is committed to this social justice mission to eliminate the plague of social injustice that continues to threaten all of our communities.