Publications (10 Most Recent)
A ceramide synthase is important for filamentous fungal biofilm morphology and antifungal drug susceptibility.
Puerner CTS, Wilkins OM, Cramer RA
mBio. 2026 May 14;:e0348725. doi: 10.1128/mbio.03487-25. Epub 2026 May 14.
PMID: 42132439
Myeloid Cell States in Influenza-Associated Pulmonary Aspergillosis Are Shaped by Iron Overload and Metabolic Reprogramming.
Grau MS, Jackson BP, Ringelberg C, Kolling FW, Deepe GS, Cramer RA, Obar JJ
bioRxiv. 2026 Apr 25; pii: 2026.04.22.720189. doi: 10.64898/2026.04.22.720189. Epub 2026 Apr 25.
PMID: 42079193
An epigenetic mechanism of azole tolerance facilitates acquired antifungal resistance in Aspergillus fumigatus.
Vellanki S, DeMichaelis N, Liao C, Stajich JE, Cramer RA
bioRxiv. 2026 Mar 16; pii: 2026.03.16.712083. doi: 10.64898/2026.03.16.712083. Epub 2026 Mar 16.
PMID: 41889904
An Antifungal with a Novel Mechanism of Action Discovered via Resistance Gene-Guided Genome Mining.
Perlatti B, Vellanki S, Zhang Y, Chiang YM, Hu Y, Yuan M, Dunbar K, Fine A, Grau MF, Li S, O'Donnell T, Shenoy R, Li H, Shi H, Xu X, Chen Z, Arvedson T, Tang Y, Cramer RA, Cee V, Harvey CJB
ACS Cent Sci. 2026 Feb 25;12(2):197-207. doi: 10.1021/acscentsci.5c02019. Epub 2026 Jan 31.
PMID: 41768770
Insights into Aspergillus fumigatus morphogenesis and pathogenesis through the putative lipid transporter ArvA.
Gutierrez-Perez C, Jones JT, Puerner CTS, Vellanki S, Kordana NE, James MR, Vesely EM, Johnson A, Cramer RA
bioRxiv. 2025 Dec 4; pii: 2025.12.04.692327. doi: 10.64898/2025.12.04.692327. Epub 2025 Dec 4.
PMID: 41573828
Home sputum collection for Aspergillus fumigatus detection in adults with cystic fibrosis.
Hong G, Walsh J, Koshy A, Hsu JY, O'Dea AL, Vesely EM, Memon W, Dezube RH, Goss CH, Goss LB, Greene A, Gross JE, Wilson A, Nichols DP, Zhang SX, Cramer RA
ERJ Open Res. 2025 Nov;11(6) pii: 00272-2025. doi: 10.1183/23120541.00272-2025. Epub 2025 Dec 1.
PMID: 41333983
A ceramide synthase is important for filamentous fungal biofilm morphology and antifungal drug resistance.
Puerner CTS, Wilkins OM, Cramer RA
bioRxiv. 2025 Nov 17; pii: 2025.11.16.688756. doi: 10.1101/2025.11.16.688756. Epub 2025 Nov 17.
PMID: 41332551
Transcriptional and metabolic modeling analyses of developing Aspergillus fumigatus biofilms reveal metabolic shifts required for biofilm maturation.
Puerner C, Morelli KA, Kerkaert JD, Jones JT, Quinn KG, DeMichaelis N, Vellanki S, Liao C, Cramer RA
mSphere. 2025 Dec 23;10(12):e0075225. doi: 10.1128/msphere.00752-25. Epub 2025 Nov 28.
PMID: 41314177
Transcriptional analysis of developing Aspergillus fumigatus biofilms reveals metabolic shifts required for biofilm maintenance.
Puerner C, Morelli KA, Kerkaert JD, Jones JT, Quinn KG, Vellanki S, Cramer RA
bioRxiv. 2025 Jun 2; pii: 2025.06.02.657448. doi: 10.1101/2025.06.02.657448. Epub 2025 Jun 2.
PMID: 40501668
Propranolol is efficacious against Aspergillus and Fusarium corneal isolates in vitro and in a murine model of Aspergillus keratitis.
Zegans ME, Kamath MM, Jones JT, Bao R, Ross BS, Gutierrez-Perez C, Adams EM, Lightfoot JD, Poimenidou G, Pavuluri C, Prajna V, Cramer RA, Fuller KK
Antimicrob Agents Chemother. 2025 Jun 4;69(6):e0166424. doi: 10.1128/aac.01664-24. Epub 2025 May 15.
PMID: 40372030