Publications (10 Most Recent)

BTK drives neutrophil activation for sterilizing antifungal immunity.
Desai JV, Zarakas MA, Wishart AL, Roschewski M, Aufiero MA, Donko Á, Wigerblad G, Shlezinger N, Plate M, James MR, Lim JK, Uzel G, Bergerson JR, Fuss I, Cramer RA, Franco LM, Clark ES, Khan WN, Yamanaka D, Chamilos G, El-Benna J, Kaplan MJ, Staudt LM, Leto TL, Holland SM, Wilson WH, Hohl TM, Lionakis MS
J Clin Invest. 2024 May 2;134(12) doi: 10.1172/JCI176142. Epub 2024 May 2.
PMID: 38696257

Intestinal Bacteroides modulates inflammation, systemic cytokines, and microbial ecology via propionate in a mouse model of cystic fibrosis.
Price CE, Valls RA, Ramsey AR, Loeven NA, Jones JT, Barrack KE, Schwartzman JD, Royce DB, Cramer RA, Madan JC, Ross BD, Bliska J, O'Toole GA
mBio. 2024 Feb 14;15(2):e0314423. doi: 10.1128/mbio.03144-23. Epub 2024 Jan 5.
PMID: 38179971

The cystic fibrosis treatment Trikafta affects the growth, viability, and cell wall of Aspergillus fumigatus biofilms.
Jones JT, Morelli KA, Vesely EM, Puerner CTS, Pavuluri CK, Ross BS, van Rhijn N, Bromley MJ, Cramer RA
mBio. 2023 Oct 31;14(5):e0151623. doi: 10.1128/mbio.01516-23. Epub 2023 Oct 13.
PMID: 37830825

Aspergillus fumigatus cytochrome c impacts conidial survival during sterilizing immunity.
James MR, Aufiero MA, Vesely EM, Dhingra S, Liu K-W, Hohl TM, Cramer RA
mSphere. 2023 Dec 20;8(6):e0030523. doi: 10.1128/msphere.00305-23. Epub 2023 Oct 12.
PMID: 37823656

Recent Advances in Understanding the Human Fungal Pathogen Hypoxia Response in Disease Progression.
Puerner C, Vellanki S, Strauch JL, Cramer RA
Annu Rev Microbiol. 2023 Sep 15;77:403-425. doi: 10.1146/annurev-micro-032521-021745.
PMID: 37713457

Aspergillus fumigatus cytochrome c impacts conidial survival during sterilizing immunity.
James MR, Aufiero MA, Vesely EM, Dhingra S, Liu KW, Hohl TM, Cramer RA
bioRxiv. 2023 Jun 7; pii: 2023.06.07.544103. doi: 10.1101/2023.06.07.544103. Epub 2023 Jun 7.
PMID: 37333187

Luciferase-Based High-Throughput Screen with Aspergillus fumigatus to Identify Antifungal Small Molecules.
Opperman TJ, Dhingra S, Gutierrez-Perez C, Kwasny SM, Cramer RA
Methods Mol Biol. 2023;2658:17-34. doi: 10.1007/978-1-0716-3155-3_2.
PMID: 37024692

The pan-genome of Aspergillus fumigatus provides a high-resolution view of its population structure revealing high levels of lineage-specific diversity driven by recombination.
Lofgren LA, Ross BS, Cramer RA, Stajich JE
PLoS Biol. 2022 Nov;20(11):e3001890. doi: 10.1371/journal.pbio.3001890. Epub 2022 Nov 17.
PMID: 36395320

Postinfluenza Environment Reduces Aspergillus fumigatus Conidium Clearance and Facilitates Invasive Aspergillosis In Vivo.
Liu KW, Grau MS, Jones JT, Wang X, Vesely EM, James MR, Gutierrez-Perez C, Cramer RA, Obar JJ
mBio. 2022 Dec 20;13(6):e0285422. doi: 10.1128/mbio.02854-22. Epub 2022 Nov 15.
PMID: 36377895

A Fungal Sterylglucosidase at the Intersection of Virulence, Host Immunity, and Therapeutic Development.
Cramer RA
mBio. 2022 Dec 20;13(6):e0242522. doi: 10.1128/mbio.02425-22. Epub 2022 Oct 18.
PMID: 36255237