Recent student publications


Howe JR 6th, Li ES, Streeter SE, Rahme GJ, Chipumuro E, Russo GB, Litzky JF, Hills LB,

Rodgers KR, Skelton PD, Luikart BW. MiR-338-3p regulates neuronal maturation and

suppresses glioblastoma proliferation. PLoS One. 2017 May

11;12(5):e0177661.doi:10.1371/journal.pone.0177661. eCollection 2017.

Dumitru, A.M.G., Rusin, S.F., Clark, A.E.M., Kettenbach, A.N.; Compton, D.A. Cyclin

A/Cdk1 modulates Plk1 activity in prometaphase to regulate k-MT attachment stability. In

submission, Developmental Cell (2017).

Submitted/To be submitted soon

Hua C, Gacerez A, Sentman CL, Ackerman ME. Development of human scFvs targeting a novel

epitope of tumor antigen B7H6 with anti-tumor cell activity as Chimeric Antigen Receptors

(CARs) in T cells.

Hua C, Gacerez A, Sentman CL, Ackerman ME, Choi Y* and Bailey-Kellogg C*.

Computationally-driven identification of Antibody Epitopes. (*indicates equal contribution).

Hua C, Ackerman ME. Gain in Function through engineering HIV broadly neutralizing


Qian DC, Molfese DL, Jin JL, Titus AJ, He Y, Li Y, Vaissié M, Viswanath H, Baldwin PR,

Salas R, Amos CI. "Genome-wide imaging association study implicates functional activity and

glial homeostasis of the caudate in smoking addiction". BMC Genomics [revision under review]

Ji X, Bossé Y, Landi MT, Gui J, Xiao X, Qian DC, Joubert P, Lamontagne M, Li Y, Gorlov IP,

De Biasi M, Han Y, Gorlova OY, Hung RJ, Wu X, McKay JD, Zong X, Carreras-Torres R,

Christiani DC, Caporaso NE, et al. "Identification of susceptibility pathways for the role of

chromosome 15q25.1 in modifying lung cancer risk". Nat Commun [revision under review]

Schwartz AG, Lusk C, Wenzlaff AS, de Andrade M, Mandal D, Gaba C, Yang P, You M,

Kupert EY, Anderson MW, Han Y, Byun J, Li Y, Qian DC, Stilp A, Laurie C, Hung RJ,

Brennan P, Bickeböller H, Caporaso NE, Landi MT, et al. "Genome-Wide Association Study of

Familial Lung Cancer". Nat Genet [under review]

Feng Y, Wang Y, Liu H, Liu Z, Mills C, Owzar K, Han Y, Qian DC, Hung RJ, Brhane Y,

McLaughlin JR, Brennan P, Bickeböller H, Rosenberger A, Houlston RS, Caporaso NE, Landi

MT, Brüske I, Risch A, Ye Y, et al. "Novel Genetic Variants in the P38MAPK Pathway Gene

ZAK and Susceptibility to Lung Cancer". Mol Carcinog [under review]

Deng J, Lines JL, Lee YC, Qian DC, Pechenick DA, Manivanh R, Sarde A, LeMercier I,

Lowrey CH, Varn FS, Cheng C, Leib DA, Noelle RJ, Mabaera R. "Hypoxia-induced VISTA

promotes the suppressive function of myeloid-derived suppressor cells in the tumor

microenvironment". Cancer Res [under review]

McKay JD, Hung RJ, Han Y, Zong X, Carreras-Torres R, Christiani DC, Caporaso NE,

Johansson M, Xiao X, Li Y, Byun J, Dunning A, Pooley KA, Qian DC, Ji X, Liu G, Timofeeva

MN, Bojesen SE, Wu X, Le Marchand L, et al. (2017) "Large scale genetic analysis identifies

novel loci and histological variability in susceptibility to lung cancer". Nat Genet [accepted]

Qian DC, Xiao X, Byun J, Suriawinata AA, Her SC, Amos CI, Barth RJ Jr (2017)
"PI3K/Akt/mTOR signaling and plasma membrane proteins are implicated in
responsiveness to adjuvant dendritic cell vaccination for metastatic colorectal cancer".
Clin Cancer Res 23, 399–406.

Merkel P, Xie G, Monach P, Ji X, Ciavatta D, Byun J, Pinder B, Zhao A, Zhang J, Tadesse J,
Qian DC, Nair R, Tsoi A, Ripke S, Pagnoux C, Carette S, Chung S, Cuthbertson
D, Davis J Jr, Dellaripa P, et al. (2017) "Identification of functional and expression
polymorphisms associated with risk for anti-neutrophil cytoplasmic autoantibody-associated
vasculitis". Arthritis Rheumatol 69, 1054–1066.

Qian DC, Busam JA, Xiao X, O'Mara TA, Eeles RA, Schumacher FR, Phelan CM,
Amos CI (2017) "seXY: A tool for sex inference from genotype arrays". Bioinformatics 33, 561–563.

Bender AC, Austin AA, Grodstein F, Bynum J. Executive function, episodic
memory and Medicare expenditures. Alzheimer’s & Dementia. 2017. In press.

Jiang, Y., Patel, C.D., Manivanh, R., North, B., Backes, I., Posner, D.,
Gilli, F., Pachner, A.R., Nguyen, L.N.,and Leib, D.A. (2017). Maternal antiviral
immunoglobulin accumulates in neural tissue of neonates to prevent HSV neurological

Lischinsky, J. E., Sokolowski, K., Li, P., Esumi, S., Kamal, Y., Goodrich, M.,
Corbin, J. G. (2017). Embryonic transcription factor expression in mice predicts medial
amygdala neuronal identity and sex-specific responses to innate behavioral
cues. eLife, 6.

Shee K, Ghali FM, Hyams ES. Practice Makes Perfect: Correlations Between Prior
Experience in High-level Athletics and Robotic Surgical Performance Do Not Persist After
Task Repetition. J Surg Educ. 2017 Jan 10.

Hampsch RA, Shee K, Bates D, Lewis LD, Desire L, Leblond B, Stefan K, Miller
TW. Therapeutic sensitivity to Rac GTPase inhibition requires consequential suppression of
mTORC1, AKT, and MEK signaling in breast cancer." Oncotarget 8.13 (2017):
21806. Co-
First Authorship

Geller LT, Barzily-Rokni M, Danino T, Jonas O, Shental N, Najman D, Cooper ZA,
Shee K, Thaiss CA, Reuben A, Livny J, Avraham R, Frederick DT, Ligorio M,
Chatman K, Johnson S, Mosher CM, Smith DA, Michaud M, Trauger SA, Flaherty KT,

Mandinova A, Garrett WS, Thayer SP, Ferrone CR, Huttenhower C, Bhatia SN, Gevers D,
Wargo JA, Golub TR, Straussman R. Intra-tumor bacteria elicit drug resistance in
pancreatic ductal adenocarcinoma. Science (Manuscript under review in Science).

Chamberlin MD, Shee K, Varn FS, Bean JR, Marotti JD, Wells WA, Trask HW,
Hailton JS, West RJ, Bhatt A, Kaufman PA, Schwartz GN, Gemery JM, McNulty NJ,
Tsapakos MJ, Barth RJ, Arrick BA, Gui J, Cheng C, Miller TW. Plasma DNA as “liquid
biopsy” only partially complements tumor biopsy for identification of mutations in
metastatic breast cancer (Manuscript under review in PLOS One). Co-First Authorship

Rees CA, Burklund A, Stefanuto P-H, Schwartzman JD, Hill JE. Volatile
metabolic fingerprinting of bacterial and fungal pathogen groups. (Submitted).

Rees CA, Stefanuto P-H, Beattie SR, Cramer RA, Hill JE. Sniffing out the hypoxia
volatile metabolic signature of Aspergillus fumigatus. J Breath Res. (In revision).

Mellors TR, Rees CA, Wieland-Alter WF, von Reyn CF, Hill JE. The volatile
molecule signature of four mycobacteria species. J Breath Res. 2017. (Accepted).

Rees CA, Nordick KV, Franchina FA, Lewis AE, Hirsch EB, Hill JE. Volatile
metabolic diversity of Klebsiella pneumoniae in nutrient-replete conditions.
Metabolomics. 2017; 13:18.

Jones SE, Ho L, Rees CA, Hill JE, Nodwell JR, Elliot MA. Streptomyces
exploration is triggered by fungal interactions and volatile signals. eLife. 2017; 6:e21738.

James R Howe, Emily S Li, Sarah E Streeter; Gilbert J Rahme; Edmond Chipumuro; Grace
B Russo; Julia F Litzky; L Benjamin Hills; Kyla R Rodgers; Patrick D Skelton;
Bryan W Luikart; MiR-338-3p Regulates Neuronal Differentiation and Suppresses
Glioblastoma Proliferation. PLoS ONE 2017; (in press)

Julia F Litzky, Maya A Deyssenroth, Todd M Everson, David A Armstrong, Luca
Lambertini, Jia Chen, & Carmen J Marsit; Placental Imprinting Variation Associated with
Assisted Reproductive Technologies and Subfertility. Epigenetics (in press)

Delatour LC, Yeh HH. FASD and Brain Development: Perspectives on Where We are and
Where We Need to Go. OBM Neurobiology 2017;1(1):002;

Insulin-mediated signaling facilitates resistance to PDGFR inhibition in proneural
hPDGFB-driven gliomas. Damian A Almiron Bonnin, Cong Ran, Matthew C Havrda, Huan
Liu, Yasuyuki Hitoshi, Zhonghua Zhang, Chao Cheng, Matthew Ung and Mark A
Israel. Mol Cancer Ther January 30 2017 DOI: 10.1158/1535-7163.MCT-16-0616
(Publication chosen for cover of Molecular Cancer Therapeutics April issue)

Secretion-mediated STAT3 activation promotes Self-renewal of Glioma Stem-like Cells
during hypoxia. Damian A Almiron Bonnin et al. (under review in Oncogene)

Intratumoral heterogeneity determines 5-aminolevunic acid induced fluorescence in GBM.
Damian A Almiron Bonnin et al. (In preparation for submission/planning to
submit by the end of June)


Hua CK, Ackerman ME. Engineering broadly neutralizing antibodies for HIV Br>prevention and therapy. Advanced Drug Delivery Reviews, 2016. 103:157-73.

Qian DC, Han Y, Byun J, Shin HR, Hung RJ, McLaughlin JR, Landi MT,
Seminara D, Amos CI (2016) "A novel pathway-based approach improves lung cancer risk
prediction using germline genetic variations". Cancer Epidemiol Biomarkers
25, 1208–1215.

Kashyap MK, Kumar D, Jones H, et al. Ulocuplumab (BMS-936564 / MDX1338):
a fully human anti-CXCR4 antibody induces cell death in chronic lymphocytic leukemia
mediated through a reactive oxygen species-dependent pathway. Oncotarget.
2016;7(3):2809-2822. doi:10.18632/oncotarget.6465.

Bender AC, Luikart BW, Lenck-Santini PP. Cognitive deficits associated with
Nav1.1 Alterations: Involvement of neuronal firing dynamics and oscillations. PLoS One.
2016 Mar;1(3):e0151538

Insulin-mediated signaling facilitates resistance to PDGFR inhibition in proneural hPDGFB-
driven gliomas. Damian A Almiron Bonnin et al. DOI: 10.1158/1535-

David A Armstrong, Benjamin B Green, Bailey A Blair, Dylan J Guerin, Julia F Litzky,
Niraj R Chavan, Kevin J Pearson, Carmen J Marsit; Maternal smoking during
pregnancy is associated with mitochondrial DNA methylation. Environ Epigenet
2016; 2 (3): dvw020. doi: 10.1093/eep/dvw020

Yang W, Hosford SR, Dillon LM, Shee K, Liu SC, Bean JR, Salphati L, Pang J,
Zhang X, Nannini MA, Demidenko E, Bates D, Lewis LD, Marotti JD, Eastman AR, Miller
TW. Strategically Timing Inhibition of Phosphatidylinositol 3-Kinase to Maximize

Therapeutic Index in Estrogen Receptor Alpha-Positive, PIK3CA-Mutant Breast Cancer.
Clin Cancer Res. 2016;22(9):2250-60.

Shee K, Lucas A, Flashman LA, Nho K, Tsongalis GJ, McDonald BC, Saykin AJ,
McAllister TW, Rhodes CH. Alpha-synuclein (SNCA) polymorphisms exert protective
effects on memory after mild traumatic brain injury. Neurosci Lett. 2016 Jul 28.

Koo K, Shee K, Yap RL. Readability analysis of online health information about
overactive bladder. Neurourology and Urodynamics. 2016 Oct 29.

Shee K, Kono AT, D'Anna SP, Seltzer MA, Lu X, Miller TW, Chamberlin MD.
Maximizing the Benefit-Cost Ratio of Anthracyclines in Metastatic Breast Cancer: Case
Report of a Patient with a Complete Response to High-Dose Doxorubicin. Case Reports
in Oncology.
2016 Dec 8;9(3):840-6.

Koo K, Shee K, Yap RL. News Media Analysis of the United States Preventive
Services Task Force and American Urological Association Prostate Cancer Screening
Guidelines. Urology Practice. 2016 Dec 10.

Rees CA, Franchina FA, Nordick KV, Kim PJ, Hill JE. Expanding the
Klebsiella pneumoniae volatile metabolome using advanced analytical
instrumentation for the detection of novel metabolites. J Appl Microbiol. 2016;

Rees C, Warner CJ, Powell RJ, Erkmen CP. Novel use of thoracic endovascular
aortic repair in mediastinitis-induced aortic erosion: a case series. Chirurgia. 2016; 29
(6): 203-206.

Bean HD*, Rees CA*, Hill JE. Comparative analysis of the volatile metabolomes
of P. aeruginosa clinical isolates. J Breath Res. 2016; 10(2): 047102.

Rees CA, Shen A, Hill JE. Characterization of the Clostridium difficile
volatile metabolome using comprehensive two-dimensional gas chromatography time-of-
flight mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2016;
1039: 8-16.

Rees CA, Smolinska A, Hill JE. The volatile metabolome of Klebsiella
in human blood. J Breath Res. 2016; 10(2): 027101.

Noble GP, Dolph PJ, Supattapone S. Interallelic transcriptionalenhancement as an
in vivo measure of transvection in Drosophila melanogaster. G3, 6:3139-48.


Choi Y*, Hua C*, Sentman CL, Ackerman ME, Bailey-Kellogg C. Antibody
humanization by structure-based computational protein design. MAbs, 2015. 7(6):1045-57.
(*indicates equal contribution)

Halloran JW, Zhu D, Qian DC, Byun J, Gorlova OY, Amos CI, Gorlov IP (2015)
"Prediction of the gene expression in normal lung tissue by the gene expression in blood".
BMC Med Genomics 8, 77:1‒6.

Qian DC, Byun J, Han Y, Greene CS, Field JK, Hung RJ, Brhane Y, McLaughlin
JR, Fehringer G, Landi MT, Rosenberger A, Bickeböller H, Malhotra J, Risch A, Heinrich
J, Hunter DJ, Henderson BE, Haiman CA, Schumacher FR, Eeles RA, Easton DF, Seminara
D, Amos CI (2015) "Identification of shared and unique susceptibility pathways among
cancers of the lung, breast, and prostate from genome-wide association studies and tissue-
specific protein interactions". Hum Mol Genet 24, 7406‒7420.

Cordell HJ, Han Y, Mells GF, Li Y, Hirschfield GM, Greene CS, Xie G, Juran BD, Zhu D,
Qian DC, Floyd JA, Morley KI, Prati D, Lleo A, Cusi D, Canadian-US PBC
Consortium, Italian PBC Genetics Study Group, UK-PBC Consortium, Gershwin ME,
Anderson CA, et al. (2015) "International genome-wide meta-analysis identifies new
primary biliary cirrhosis risk loci and targetable pathogenic pathways". Nat Commun 6, 8019:1‒11.

Onyango EO, Kelly AR, Qian DC, Gribble GW (2015) "Novel Synthesis of 1-
bromo-8-methylnaphthalene and 1-bromo-5-methylnaphthalene". J Org Chem 80, 5970‒5972.

Erdos, B., I. Backes, M.L. McCowan, L.F. Hayward, and D.A. Scheuer. 2015.
“Brain-Derived Neurotrophic Factor Modulates Angiotensin Signaling in the Hypothalamus
to Increase Blood Pressure in Rats.” American Journal of Physiology - Heart and
Circulatory Physiology
308 (6): H612–22. doi:10.1152/ajpheart.00776.2014.

Bean JR, Hosford SR, Symonds LK, Owens P, Dillon LM, Yang W, Shee K,
Schwartz GN, Marotti JD, Muller KE, Rosenkranz KM, Barth RJ, Chen VS, Agarwal VR,
Miller TW. The PI3K/mTOR dual inhibitor P7170 demonstrates potent activity against
endocrine-sensitive and endocrine-resistant ER+ breast cancer. Breast Cancer Res Treat.

Dillon LM, Bean JR, Yang W, Shee K, Symonds LK, Balko JM, McDonald WH,
Liu S, Gonzalez-Angulo AM, Mills GB, Arteaga CL, Miller TW. P-REX1 creates a positive
feedback loop to activate growth factor receptor, PI3K/AKT and MEK/ERK signaling in
breast cancer. Oncogene. 2015;34(30):3968-76.

Gogna R, Shee K, Moreno E. Cell Competition During Growth and Regeneration.
Annu Rev Genet. 2015;49:697-718.

Noble GP, Wang DW, Walsh DJ, Barone JR Miller MB, Nishina KA, Li S,
Supattapone S. A structural and functional comparison between infectious and non-
infectious autocatalytic recombinant PrP conformers. PLoS Path. 11:e1005017.

Noble GP, Walsh DJ, Miller MB, Jackson WJ, Supattapone S. Requirments for
mutant and wild-type prion protein misfolding in vitro. Biochemistry, 54:1180-7.

Noble GP, Supattapone S. Dissociation of recombinant prion autocatalysis from
infectivity. Prion, 9:405-11. (Invited Review Article)

Wang X, Hills LB, Huang YH. Lipid and Protein Co-Regulation of PI3K Effectors
Akt and Itk in Lymphocytes. Frontiers in Immunology – 2015 (Vol. 6, Issue 117,
Online Publication)


administration produces divergent changes in GABAergic neuroactive steroid
immunohistochemistry in the rat brain. Alcoholism Clinical and Experimental Research
(2014) 38: 90-99. PMCID: PMC4196317

Kashyap MK, Kumar D, Villa R, Clair J, Benner C, Sasik R, Jones H, et al.
Targeting the spliceosome in chronic lymphocytic leukemia with the macrolides FD-895
and pladienolide-B. Haematologica. 2015;100(7):945-954.

Klein RD, Chidawanyika T, Tims HS, Meulia T, Bouchard RA, Pett VB.
Chaperone function of two small heat shock proteins from maize. Plant Sci. 2014
May;221-222:48-58. doi: 10.1016/j.plantsci.2014.01.012

Zurawel AA, Walsh DJ, Fortier AM, Chidawanyika T, Sengupta S, Zilm, K,
Supattapone S. Prion nucleation site unmasked by transient interaction with phospholipid cofactor. Biochemistry. 2014 Jan 14;53(1):68-76. doi: 10.1021/bi4014825


Michael B. Miller, Daphne W. Wang, Fei Wang, Geoffrey P. Noble, Jiyan Ma, Virgil L. Woods, Jr., Sheng Li, and Surachai Supattapone. "Cofactor Molecules Induce Structural Transformation During Infectious Prion Formation" Structure. 2013. In press.

Audu CO, Cochran JC, Pellegrini M, Mierke DF. "Recombinant production of TEV cleaved human parathyroid hormone" J Pept Sci. 2013 Aug;19(8):504-10. doi: 10.1002/psc.2528. Epub
2013 Jun 23.

Cook, J. B., Dumitru, A. M. G., O'Buckley, T. K. and Morrow, A. L. (2013), Ethanol Administration Produces Divergent Changes in GABAergic Neuroactive Steroid Immunohistochemistry in the Rat Brain. Alcoholism: Clinical and Experimental Research. doi: 10.1111/acer.12223

Hahn, CK and Lowrey, CH. Eukaryotic Initiation Factor 2 αλπηα Phosphorylation Mediates Fetal Hemoglobin Induction through a Post-Transcriptional Mechanism. Blood, 122 (4): 477-485 (2013)

Bekelis K (co-first author), Bakhoum SF (co-first author), Desai A, Mackenzie TA, Roberts DW, "Outcome prediction in intracranial tumor surgery: the National Surgical Quality Improvement Program 2005-2010" J Neurooncol. 2013 Feb 24. [Epub ahead of print], PMID: 23436132

Bekelis K (co-first author), Bakhoum SF (co-first author), Desai A, Mackenzie TA, Goodney P, Labropoulos N. "A Risk Factor-based Predictive Model of Outcomes in Carotid Endarterectomy: The National Surgical Quality Improvement Program 2005-2010" Stroke. 2013 Feb 14. [Epub ahead of print] PMID: 23412374

Ran C, Liu H, Hitoshi Y, Israel M. "Proliferation-independent control of tumor glycolysis by PDGFR-mediated AKT activation" Cancer Res. 2013 Jan 15. [Epub ahead of print] PMID: 23322009

Sexton K, Davis S, McClatchy B, Valdes PA, Kanick SC, Paulsen KD, Roberts DW, Pogue BW. Pulsed light imaging for fluorescence guided surgery under normal room lighting. (Opt Lett. 2013 Sep 1;38(17):3249-52).PMID: Pending EDIT FOR ERAS

Valdes PA, Jacobs VL, Wilson BC, Leblond F, Roberts DW, Paulsen KD. System and methods for wide-field quantitative fluorescence imaging during neurosurgery. (Opt Lett. 2013 Aug 1;38(15):2786-8). PMID: 23903142

Valdes PA, Bekelis K, Harris BT, Wilson BC, Leblond F, Kim A, Erkmen K, Paulsen KD, Roberts DW. 5-aminolevulinic acid-induced protoporphyrin IX fluorescence guided surgery in meningiomas: qualitative and quantitative measurements in vivo. (Neurosurgery 2013 Jul 24 [Epub ahead of print]). PMID: 23887194

A. Petryk, A. J. Giustini, R. E. Gottesman, P. A. Kaufman, P. J. Hoopes. "Magnetic nanoparticle hyperthermia enhancement of cisplatinum chemotherapy cancer treatment." International Journal of Hyperthermia (2013). Accepted

J. Pearce, A. J. Giustini, R. S. Stigliano, P. Jack Hoopes. "Magnetic Heating of Nanoparticles: The Importance of Particle Clustering to Achieve Therapeutic Temperatures" Journal of Nanotechnology in Engineering and Medicine (2013). 4(1), 110071-1100714. PMID: 23919112

M. A. Crane-Godreau, C. C. Black, A. J. Giustini, T. Dechen, J. Ryu, J. A. Jukosky, H.-K. Lee, K. Bessette, N. R. Ratcliffe, P. J. Hoopes, S. Fiering, J. A. Kelly, J. C. Leiter. "Modeling the influence of vitamin D deficiency on cigarette smoke-induced emphysema." Frontiers in Physiology (2013). 4, 132.

Rasapalli S, Fan Y, Yu M, Rees C, Harris JT, Golen JA, Jasinski JP, Rheingold AL, Kwasny SM, Opperman TJ. "Detour of prenostodione synthesis towards pyrazolones for antibacterial activity." Bioorganic & Medicinal Chemistry Letters, Volume 23, Issue 11, 1 June 2013, Pages 3235-3238


Supattapone S and MB Miller, "Cofactor Involvement in Prion Propagation". In W-Q Zou and P Gambetti [Ed.] Prions and Diseases: Physiology and Pathophysiology [vol. 1]. Springer, 2012.

Turnbaugh JA, U Unterberger, P Saá, T Massignan, B Fluharty, I Solomon, MB Miller, S Supattapone, E Biasini, and DA Harris, "The N-Terminal, Polybasic Region of PrPC Dictates the Efficiency of Prion Propagation by Binding to PrPSc" Journal of Neuroscience, 2012; 32(26):8817-8830.

Audu CO, O'Hara B, Pellegrini M, Wang L, Atwood WJ, Mierke DF. "Reining in Polyoma Virus Associated Nephropathy: Design and Characterization of a Template Mimicking BK Viral Coat Protein Cellular Binding" Biochemistry 2012; 51 (41), 8092-8099.

Valdés PA, Moses ZM, Kim A, Paulsen KD, Wilson BC, Roberts DW, Harris BT. Relationship between ex vivo gadolinium concentrations and 5-aminolevulinic acid-induced protoporphyrin IX levels in gliomas: a quantitative study on a relationship between protoporphyrin IX levels and blood-brain barrier breakdown. (J Neuropathol Exp Neurol. 2012 Aug 8 [Epub ahead of print]).

Roberts DW, Valdés PA, Harris BT, Hartov A, Fan X, Songbai J, Pogue BW, Lebnlond F, Tosteson TD, Wilson BC, Paulsen KD. Glioblastoma Multiforme Treatment with Clinical Trials for Surgical Resection (Aminolevulinic Acid). (Neurosurg Clin N Am, 2012 Jul;23(3):371-7).

Valdés PA, Leblond F, Kim A, Paulsen KD, Wilson BC, Roberts DW. A spectrally-constrained dual-band normalization technique for protoporphyrin IX quantification in fluorescence guided surgery. (Opt Lett. 2012 Jun 1;37(11):1817-9).

Jacobs VL, Liu Y, De Leo JA. Propentofylline targets TROY, a novel microglial signaling pathway. PLoS One. 2012;7(5):e37955. Epub 2012 May 23. PMID: 22649568

Konecky SD, Owen CM, Rice T, Valdés PA, Kolste K, Wilson BC, Leblond F, Roberts DW, Paulsen KD, Tromberg BJ. Spatial frequency domain tomography of protoporphyrin IX fluorescence in preclinical glioma models. (J Biomed Opt. 2012 May;17(5):0506008).

Landry RP, Jacobs VL, Romero-Sandoval EA, DeLeo JA. Propentofylline, a CNS glial modulator does not decrease pain in post-herpetic neuralgia patients: in vitro evidence for differential responses in human and rodent microglia and macrophages. Exp Neurol. 2012 Apr;234(2):340-50. Epub 2011 Nov 15. Review. PMID: 22119425

Bakhoum SF, Compton DA. Chromosomal instability and cancer: a complex relationship with therapeutic potential. J Clin Invest. 2012 Apr 2;122(4):1138-43. doi: 10.1172/JCI59954. Epub 2012 Apr 2.

Bakhoum SF, Compton DA. Kinetochores and disease: keeping microtubule dynamics in check! Curr Opin Cell Biol. 2012 Feb;24(1):64-70. Epub 2011 Dec 21.

Walsh DJ, Noble GP, Piro JR, Supattapone S. Non-reducing alkaline solubilization and rapid on-column refolding of recombinant prion protein. Prep Biochem Biotechnol. 2012 Jan; 42(1):77-86. PubMed PMID: 22239709.

Bakhoum SF, Compton DA. Chromosomal instability and cancer: a complex relationship with therapeutic potential. The Journal of Clinical Investigation. Accepted, in press.

Valdés PA, Leblond F, Jacobs VL, Paulsen KD, Roberts DW. In vivo fluorescence detection in surgery: A review of principles, methods, and applications. (Current Medical Imaging Reviews, In Press, 2012).

Valdes PA, Leblond F, Jacobs VL, Wilson BC, Paulsen KD, Roberts DW. Quantitative, spectrally-resolved intraoperative fluorescence imaging. (Sci Rep. 2012;2:798. doi: 10.1038/srep00798. Epub 2012 Nov 12). PMID: 23152935

A. J. Giustini, I. Perreard, A. M. Rauwerdink, J. B. Weaver , P. J. Hoopes. "Noninvasive assessment of magnetic nanoparticle-cancer cell interactions." Integrative Biology (2012), 4, 1283–1288.

A. J. Giustini, A. A. Petryk, P. J. Hoopes. "Ionizing radiation increases systemic nanoparticle tumor accumulation" Nanomedicine: Nanotechnology, Biology, and Medicine (2012), 8(6), 818–821.

Bender AC, Natola H, Ndong C, Holmes GL, Scott RC, Lenck-Santini PP. Focal
Scn1a knockdown induces cognitive impairment without seizures. Neurobiol Dis.
2013 Jun;54:297-307. doi: 10.1016/j.nbd.2012.12.021. Epub 2013 Jan 11. PubMed
PMID: 23318929; PubMed Central PMCID: PMC3628954.


Bakhoum SF, Danilova OV, Kaur P, Levy NB, Compton DA. Chromosomal instability substantiates poor prognosis in patients with diffuse large B-cell lymphoma. Clin Cancer Res. 2011 Dec 15;17(24):7704-11.

Belden CJ, Valdés PA, Ran C, Pastel DA, Harris BT, Fadul CE, Israel MA, Paulsen KD, Roberts DW. Genetics of glioblastoma: A window into its imaging and histopathologic variability. (Radiographics, 2011 Oct 31: 1717-1740). Invited Review. PMID: 21997991

Leblond F, Ovanesyan Z, Davis SC, Valdés PA, Kim A, Wilson BC, Hartov A, Pogue BW, Paulsen KD, Roberts DW. Analytic expression of fluorescence ratio detection correlates with depth in multi-spectral sub surface imaging. (Phys Med Biol, 2011 Oct 5; 56(21): 6823-6837). Review. PMID: 21971201

Valdés PA, Kim A, Leblond F, Conde OM, Harris BT, Paulsen KD, Wilson BC, Roberts DW. Combined fluorescence and reflectance spectroscopy for in vivo quantification of cancer biomarkers in low- and high-grade glioma surgery. J Biomed Opt. 2011 Nov;16(11):116007.

Jacobs VL, Landry RP, Liu Y, Romero-Sandoval EA, De Leo JA. Propentofylline decreases tumor growth in a rodent model of glioblastoma multiforme by a direct mechanism on microglia. Neuro Oncol. 2011 Nov 15. [Epub ahead of print]

Bender AC, Morse RP, Scott RC, Holmes GL, Lenck-Santini PP. SCN1A mutations in Dravet syndrome: Impact of interneuron dysfunction on neural networks and cognitive outcome. Epilepsy Behav. Accepted 2011 Nov 27.

Holmes GL, Bender AC, Wu EX, Scott RC, Lenck-Santini PP, Morse RP. Maturation of EEG oscillations in children with sodium channel mutations. Brain Dev. 2011 Sep 20.

Kleen JK, Wu EX, Holmes GL, Scott RC, Lenck-Santini PP. Enhanced oscillatory activity in the hippocampal-prefrontal network is related to short-term memory function after early-life seizures. J Neurosci. 2011 Oct 26;31(43):15397-406.

Kleen JK, Sesqué A, Wu EX, Miller FA, Hernan AE, Holmes GL, Scott RC. Early-life seizures produce lasting alterations in the structure and function of the prefrontal cortex. Epilepsy Behav. 2011 Oct;22(2):214-9.

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Kleen JK, Holmes GL. Brain inflammation initiates seizures. Nat Med. 2008 Dec;14(12):1309-10. PubMed PMID: 19057551.

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