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Patricia A. Pioli, PhD

Title(s):
Assistant Professor of Microbiology and Immunology

Additional Titles/Positions/Affiliations:
NCCC Member

Department(s):
Microbiology and Immunology

Education:
Dartmouth Medical School, Ph.D. 2001
George Washington University, B.S. 1993

Programs:
Immunology Program
Molecular and Cellular Biology Graduate Programs
Program in Experimental and Molecular Medicine

Websites:
https://geiselmed.dartmouth.edu/pioli/

Contact Information:

Dartmouth Medical School
HB 7556
Lebanon NH 03756

Office: 644E Borwell Building
Phone: 603-650-2584
Fax: 603-650-6130
Email: pioli@dartmouth.edu


Professional Interests:

autoimmunity, cancer immunotherapy, molecular immunology, endocrinology

Rotations and Thesis Projects:

1. Determine how aberrant regulation of miRNAs affects activation of macrophages in autoimmune systemic sclerosis (scleroderma)

2. Identify the role that macrophages play in the immune/fibrotic axis in scleroderma

3. Determine how modulation of the tumor immune landscape (microenvironment) can be used to combat cancer

Biography:

Dr. Pioli received a B.S. in biology from George Washington University in 1993 and a Ph.D. in biochemistry from Dartmouth Medical School in 2001. She performed post-doctoral research with Dr. Paul Guyre at Dartmouth from 2001-2004, studying the mechanisms by which cortisol influences macrophage activation and immune function. She was appointed Research Assistant Professor of Physiology from 2004-2010. In July 2010, Dr. Pioli joined the faculty of Dartmouth Medical School as Assistant Professor in the Department of Obstetrics and Gynecology and Microbiology and Immunology.


Selected Publications:

 

Systemic Sclerosis Dermal Fibroblasts Induce Cutaneous Fibrosis Through LOXL4: New Evidence from 3D Skin-like Tissues.
Huang M, Cai G, Baugh LM, Liu Z, Smith A, Watson M, Popovich D, Zhang T, Stawski LS, Trojanowska M, Georgakoudi I, Black LD 3rd, Pioli PA, Whitfield ML, Garlick J
Arthritis Rheumatol. 2019 Nov 9; doi: 10.1002/art.41163. Epub 2019 Nov 9.
PMID: 31705627

Macrophages in Systemic Sclerosis: Novel Insights and Therapeutic Implications.
Toledo DM, Pioli PA
Curr Rheumatol Rep. 2019 May 23;21(7):31. doi: 10.1007/s11926-019-0831-z. Epub 2019 May 23.
PMID: 31123840

Microbiome dysbiosis is associated with disease duration and increased inflammatory gene expression in systemic sclerosis skin.
Johnson ME, Franks JM, Cai G, Mehta BK, Wood TA, Archambault K, Pioli PA, Simms RW, Orzechowski N, Arron S, Whitfield ML
Arthritis Res Ther. 2019 Feb 6;21(1):49. doi: 10.1186/s13075-019-1816-z. Epub 2019 Feb 6.
PMID: 30728065

The Stress Hormone Cortisol Enhances Interferon-υ-Mediated Proinflammatory Responses of Human Immune Cells.
Yeager MP, Guyre CA, Sites BD, Collins JE, Pioli PA, Guyre PM
Anesth Analg. 2018 Aug;127(2):556-563. doi: 10.1213/ANE.0000000000003481.
PMID: 30028389

Mycophenolate Mofetil Treatment of Systemic Sclerosis Reduces Myeloid Cell Numbers and Attenuates the Inflammatory Gene Signature in Skin.
Hinchcliff M, Toledo DM, Taroni JN, Wood TA, Franks JM, Ball MS, Hoffmann A, Amin SM, Tan AU, Tom K, Nesbeth Y, Lee J, Ma M, Aren K, Carns MA, Pioli PA, Whitfield ML
J Invest Dermatol. 2018 Jun;138(6):1301-1310. doi: 10.1016/j.jid.2018.01.006. Epub 2018 Jan 31.
PMID: 29391252

A novel multi-network approach reveals tissue-specific cellular modulators of fibrosis in systemic sclerosis.
Taroni JN, Greene CS, Martyanov V, Wood TA, Christmann RB, Farber HW, Lafyatis RA, Denton CP, Hinchcliff ME, Pioli PA, Mahoney JM, Whitfield ML
Genome Med. 2017 Mar 23;9(1):27. doi: 10.1186/s13073-017-0417-1. Epub 2017 Mar 23.
PMID: 28330499

Bromodomain inhibitors, JQ1 and I-BET 762, as potential therapies for pancreatic cancer.
Leal AS, Williams CR, Royce DB, Pioli PA, Sporn MB, Liby KT
Cancer Lett. 2017 May 28;394:76-87. doi: 10.1016/j.canlet.2017.02.021. Epub 2017 Feb 27.
PMID: 28254412

The triterpenoid CDDO-imidazolide reduces immune cell infiltration and cytokine secretion in the KrasG12D;Pdx1-Cre (KC) mouse model of pancreatic cancer.
Leal AS, Sporn MB, Pioli PA, Liby KT
Carcinogenesis. 2016 Dec;37(12):1170-1179. Epub 2016 Sep 22.
PMID: 27659181

CDDO-Me Redirects Activation of Breast Tumor Associated Macrophages.
Ball MS, Shipman EP, Kim H, Liby KT, Pioli PA
PLoS One. 2016;11(2):e0149600. doi: 10.1371/journal.pone.0149600. Epub 2016 Feb 26.
PMID: 26918785

Glucocorticoids enhance the in vivo migratory response of human monocytes.
Yeager MP, Pioli PA, Collins J, Barr F, Metzler S, Sites BD, Guyre PM
Brain Behav Immun. 2016 May;54:86-94. doi: 10.1016/j.bbi.2016.01.004. Epub 2016 Jan 11.
PMID: 26790757

View more publications on PubMed