Patricia A. Pioli, PhD
Title(s)
Associate Professor of Microbiology and Immunology
Additional Titles/Positions/Affiliations
NCCC Member
Department(s)
Microbiology and Immunology
Education
Dartmouth Medical School, Ph.D. 2001
George Washington University, B.S. 1993
Programs
Immunology Program
Molecular and Cellular Biology Graduate Programs
Program in Experimental and Molecular Medicine
Contact Information
Dartmouth Medical School
HB 7556
Lebanon NH 03756
Office: 644E Borwell Building
Phone: 603-650-2584
Fax: 603-650-6130
Email: pioli@dartmouth.edu
Professional Interests
autoimmunity, cancer immunotherapy, molecular immunology, endocrinology
Rotations and Thesis Projects
1. Determine how aberrant regulation of miRNAs affects activation of macrophages in autoimmune systemic sclerosis (scleroderma)
2. Identify the role that macrophages play in the immune/fibrotic axis in scleroderma
3. Determine how modulation of the tumor immune landscape (microenvironment) can be used to combat cancer
Biography
Dr. Pioli received a B.S. in biology from George Washington University in 1993 and a Ph.D. in biochemistry from Dartmouth Medical School in 2001. She performed post-doctoral research with Dr. Paul Guyre at Dartmouth from 2001-2004, studying the mechanisms by which cortisol influences macrophage activation and immune function. She was appointed Research Assistant Professor of Physiology from 2004-2010. In July 2010, Dr. Pioli joined the faculty of Dartmouth Medical School as Assistant Professor in the Department of Obstetrics and Gynecology and Microbiology and Immunology.
A streamlined and comprehensive protocol for the generation and multi-omic analysis of human monocyte-derived macrophages. Multimodal Analyses of Early, Untreated SSc Skin Identify a Proinflammatory Vascular Niche of Macrophage-Fibroblast Signaling. RUNX1 is expressed in a subpopulation of dermal fibroblasts and is associated with disease severity of systemic sclerosis. Anti-CD206 CAR T Cell Treatment Restores Fibrosis-Induced Loss of Dermal White Adipose Tissue. T Cells Enhance Tissue Complexity and Function to Study Fibrosis in 3D Skin-Like Tissue Models. A streamlined and comprehensive protocol for the generation and multi-omic analysis of human monocyte-derived macrophages. Geographic Clustering of Systemic Sclerosis in Areas of Environmental Pollution. Mycophenolate mofetil directly modulates myeloid viability and pro-fibrotic activation of human macrophages. Single-cell epigenomic dysregulation of Systemic Sclerosis fibroblasts via CREB1/EGR1 axis in self-assembled human skin equivalents. CDDO-Methyl Ester Inhibits BRAF Inhibitor Resistance and Remodels the Myeloid Compartment in BRAF-mutant Melanoma. |
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