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Patricia A. Pioli, PhD

Title(s)
Associate Professor of Microbiology and Immunology

Additional Titles/Positions/Affiliations
NCCC Member

Department(s)
Microbiology and Immunology

Education
Dartmouth Medical School, Ph.D. 2001
George Washington University, B.S. 1993

Programs
Immunology Program
Molecular and Cellular Biology Graduate Programs
Program in Experimental and Molecular Medicine

Websites
https://geiselmed.dartmouth.edu/pioli/

Contact Information

Dartmouth Medical School
HB 7556
Lebanon NH 03756

Office: 644E Borwell Building
Phone: 603-650-2584
Fax: 603-650-6130
Email: pioli@dartmouth.edu


Professional Interests

autoimmunity, cancer immunotherapy, molecular immunology, endocrinology

Rotations and Thesis Projects

1. Determine how aberrant regulation of miRNAs affects activation of macrophages in autoimmune systemic sclerosis (scleroderma)

2. Identify the role that macrophages play in the immune/fibrotic axis in scleroderma

3. Determine how modulation of the tumor immune landscape (microenvironment) can be used to combat cancer

Biography

Dr. Pioli received a B.S. in biology from George Washington University in 1993 and a Ph.D. in biochemistry from Dartmouth Medical School in 2001. She performed post-doctoral research with Dr. Paul Guyre at Dartmouth from 2001-2004, studying the mechanisms by which cortisol influences macrophage activation and immune function. She was appointed Research Assistant Professor of Physiology from 2004-2010. In July 2010, Dr. Pioli joined the faculty of Dartmouth Medical School as Assistant Professor in the Department of Obstetrics and Gynecology and Microbiology and Immunology.


Selected Publications

 

T Cells and CDDO-Me Attenuate Immunosuppressive Activation of Human Melanoma-Conditioned Macrophages.
Torres GM, Yang H, Park C, Spezza PA, Khatwani N, Bhandari R, Liby KT, Pioli PA
Front Immunol. 2022;13:768753. doi: 10.3389/fimmu.2022.768753. Epub 2022 Feb 21.
PMID: 35265066

Self-Assembled Human Skin Equivalents Model Macrophage Activation of Cutaneous Fibrogenesis in Systemic Sclerosis.
Huang M, Smith A, Watson M, Bhandari R, Baugh LM, Ivanovska I, Watkins T, Lang I, Trojanowska M, Black LD 3rd, Pioli PA, Garlick J, Whitfield ML
Arthritis Rheumatol. 2022 Jul;74(7):1245-1256. doi: 10.1002/art.42097. Epub 2022 May 30.
PMID: 35212485

CDDO-Me Alters the Tumor Microenvironment in Estrogen Receptor Negative Breast Cancer.
Ball MS, Bhandari R, Torres GM, Martyanov V, ElTanbouly MA, Archambault K, Whitfield ML, Liby KT, Pioli PA
Sci Rep. 2020 Apr 16;10(1):6560. doi: 10.1038/s41598-020-63482-x. Epub 2020 Apr 16.
PMID: 32300202

Profibrotic Activation of Human Macrophages in Systemic Sclerosis.
Bhandari R, Ball MS, Martyanov V, Popovich D, Schaafsma E, Han S, ElTanbouly M, Orzechowski NM, Carns M, Arroyo E, Aren K, Hinchcliff M, Whitfield ML, Pioli PA
Arthritis Rheumatol. 2020 Jul;72(7):1160-1169. doi: 10.1002/art.41243. Epub 2020 May 31.
PMID: 32134204

Systemic Sclerosis Dermal Fibroblasts Induce Cutaneous Fibrosis Through Lysyl Oxidase-like 4: New Evidence From Three-Dimensional Skin-like Tissues.
Huang M, Cai G, Baugh LM, Liu Z, Smith A, Watson M, Popovich D, Zhang T, Stawski LS, Trojanowska M, Georgakoudi I, Black LD III, Pioli PA, Whitfield ML, Garlick J
Arthritis Rheumatol. 2020 May;72(5):791-801. doi: 10.1002/art.41163. Epub 2020 Apr 4.
PMID: 31705627

Macrophages in Systemic Sclerosis: Novel Insights and Therapeutic Implications.
Toledo DM, Pioli PA
Curr Rheumatol Rep. 2019 May 23;21(7):31. doi: 10.1007/s11926-019-0831-z. Epub 2019 May 23.
PMID: 31123840

Microbiome dysbiosis is associated with disease duration and increased inflammatory gene expression in systemic sclerosis skin.
Johnson ME, Franks JM, Cai G, Mehta BK, Wood TA, Archambault K, Pioli PA, Simms RW, Orzechowski N, Arron S, Whitfield ML
Arthritis Res Ther. 2019 Feb 6;21(1):49. doi: 10.1186/s13075-019-1816-z. Epub 2019 Feb 6.
PMID: 30728065

The Stress Hormone Cortisol Enhances Interferon-υ-Mediated Proinflammatory Responses of Human Immune Cells.
Yeager MP, Guyre CA, Sites BD, Collins JE, Pioli PA, Guyre PM
Anesth Analg. 2018 Aug;127(2):556-563. doi: 10.1213/ANE.0000000000003481.
PMID: 30028389

Mycophenolate Mofetil Treatment of Systemic Sclerosis Reduces Myeloid Cell Numbers and Attenuates the Inflammatory Gene Signature in Skin.
Hinchcliff M, Toledo DM, Taroni JN, Wood TA, Franks JM, Ball MS, Hoffmann A, Amin SM, Tan AU, Tom K, Nesbeth Y, Lee J, Ma M, Aren K, Carns MA, Pioli PA, Whitfield ML
J Invest Dermatol. 2018 Jun;138(6):1301-1310. doi: 10.1016/j.jid.2018.01.006. Epub 2018 Jan 31.
PMID: 29391252

A novel multi-network approach reveals tissue-specific cellular modulators of fibrosis in systemic sclerosis.
Taroni JN, Greene CS, Martyanov V, Wood TA, Christmann RB, Farber HW, Lafyatis RA, Denton CP, Hinchcliff ME, Pioli PA, Mahoney JM, Whitfield ML
Genome Med. 2017 Mar 23;9(1):27. doi: 10.1186/s13073-017-0417-1. Epub 2017 Mar 23.
PMID: 28330499

View more publications on PubMed