patricia.a.pioli@dartmouth.edu
Office number: 603-650-2584
Lab number: 603-650-8479
Borwell 644E
Pioli Laboratory
Featured
Research
Our research is focused on identifying the molecular mechanisms that regulate macrophage activation in autoimmunity and cancer, and how macrophage activation can be redirected for therapeutic benefit. We study the role that macrophages play in the induction and progression of the autoimmune disease systemic sclerosis (SSc) and cancer using both primary human cells and mouse models of SSc and breast cancer.
Publications
PI3Kδ inhibition alters CD8 T cell differentiation and reprograms the tumor microenvironment following adoptive immunotherapy.
Turnquist A, Javaid A, Wilkins OM, Kolling Iv F, Pioli PA, Paulos CM, Robert Frost H, Usherwood EJ
J Immunol. 2026 May 14;215(5) pii: vkag108. doi: 10.1093/jimmun/vkag108.
PMID: 42215073