COVID-19 Information

Publications

CDDO-Me Alters the Tumor Microenvironment in Estrogen Receptor Negative Breast Cancer.
Ball MS, Bhandari R, Torres GM, Martyanov V, ElTanbouly MA, Archambault K, Whitfield ML, Liby KT, Pioli PA
Sci Rep. 2020 Apr 16;10(1):6560. doi: 10.1038/s41598-020-63482-x. Epub 2020 Apr 16.
PMID: 32300202

Profibrotic Activation of Human Macrophages in Systemic Sclerosis.
Bhandari R, Ball MS, Martyanov V, Popovich D, Schaafsma E, Han S, ElTanbouly M, Orzechowski NM, Carns M, Arroyo E, Aren K, Hinchcliff M, Whitfield ML, Pioli PA
Arthritis Rheumatol. 2020 Jul;72(7):1160-1169. doi: 10.1002/art.41243. Epub 2020 May 31.
PMID: 32134204

Systemic Sclerosis Dermal Fibroblasts Induce Cutaneous Fibrosis Through Lysyl Oxidase-like 4: New Evidence From Three-Dimensional Skin-like Tissues.
Huang M, Cai G, Baugh LM, Liu Z, Smith A, Watson M, Popovich D, Zhang T, Stawski LS, Trojanowska M, Georgakoudi I, Black LD III, Pioli PA, Whitfield ML, Garlick J
Arthritis Rheumatol. 2020 May;72(5):791-801. doi: 10.1002/art.41163. Epub 2020 Apr 4.
PMID: 31705627

Macrophages in Systemic Sclerosis: Novel Insights and Therapeutic Implications.
Toledo DM, Pioli PA
Curr Rheumatol Rep. 2019 May 23;21(7):31. doi: 10.1007/s11926-019-0831-z. Epub 2019 May 23.
PMID: 31123840

Microbiome dysbiosis is associated with disease duration and increased inflammatory gene expression in systemic sclerosis skin.
Johnson ME, Franks JM, Cai G, Mehta BK, Wood TA, Archambault K, Pioli PA, Simms RW, Orzechowski N, Arron S, Whitfield ML
Arthritis Res Ther. 2019 Feb 6;21(1):49. doi: 10.1186/s13075-019-1816-z. Epub 2019 Feb 6.
PMID: 30728065

The Stress Hormone Cortisol Enhances Interferon-υ-Mediated Proinflammatory Responses of Human Immune Cells.
Yeager MP, Guyre CA, Sites BD, Collins JE, Pioli PA, Guyre PM
Anesth Analg. 2018 Aug;127(2):556-563. doi: 10.1213/ANE.0000000000003481.
PMID: 30028389

Mycophenolate Mofetil Treatment of Systemic Sclerosis Reduces Myeloid Cell Numbers and Attenuates the Inflammatory Gene Signature in Skin.
Hinchcliff M, Toledo DM, Taroni JN, Wood TA, Franks JM, Ball MS, Hoffmann A, Amin SM, Tan AU, Tom K, Nesbeth Y, Lee J, Ma M, Aren K, Carns MA, Pioli PA, Whitfield ML
J Invest Dermatol. 2018 Jun;138(6):1301-1310. doi: 10.1016/j.jid.2018.01.006. Epub 2018 Jan 31.
PMID: 29391252

A novel multi-network approach reveals tissue-specific cellular modulators of fibrosis in systemic sclerosis.
Taroni JN, Greene CS, Martyanov V, Wood TA, Christmann RB, Farber HW, Lafyatis RA, Denton CP, Hinchcliff ME, Pioli PA, Mahoney JM, Whitfield ML
Genome Med. 2017 Mar 23;9(1):27. doi: 10.1186/s13073-017-0417-1. Epub 2017 Mar 23.
PMID: 28330499

Bromodomain inhibitors, JQ1 and I-BET 762, as potential therapies for pancreatic cancer.
Leal AS, Williams CR, Royce DB, Pioli PA, Sporn MB, Liby KT
Cancer Lett. 2017 May 28;394:76-87. doi: 10.1016/j.canlet.2017.02.021. Epub 2017 Feb 27.
PMID: 28254412

The triterpenoid CDDO-imidazolide reduces immune cell infiltration and cytokine secretion in the KrasG12D;Pdx1-Cre (KC) mouse model of pancreatic cancer.
Leal AS, Sporn MB, Pioli PA, Liby KT
Carcinogenesis. 2016 Dec;37(12):1170-1179. Epub 2016 Sep 22.
PMID: 27659181