PI3Kδ inhibition alters CD8 T cell differentiation and reprograms the tumor microenvironment following adoptive immunotherapy.
Turnquist A, Javaid A, Wilkins OM, Kolling Iv F, Pioli PA, Paulos CM, Robert Frost H, Usherwood EJ
J Immunol. 2026 May 14;215(5) pii: vkag108. doi: 10.1093/jimmun/vkag108.
PMID: 42215073
Retroelement Hypomethylation Links Hypoxia Signaling, Immune Phenotypes, and Survival in Clear Cell Renal Cell Carcinoma.
Nnam CF, Mboya EA, Li Y, Zhang M, Kolling F, Perrard L, Palys TJ, Pflugradt E, Pioli PA, Ernstoff M, Seigne JD, Pettus JR, Ren B, Song L, Christensen BC, Salas LA
bioRxiv. 2026 May 8; pii: 2026.05.01.722263. doi: 10.64898/2026.05.01.722263. Epub 2026 May 8.
PMID: 42146529
WNT5A induces profibrotic activation of human macrophages via pSTAT3.
Morris EA, Wang CY, Park C, Parvizi R, Whitfield ML, Garlick JA, Pioli PA
Rheumatology (Oxford). 2026 Apr 6;65(4) pii: keag104. doi: 10.1093/rheumatology/keag104.
PMID: 41739705
RUNX1 is expressed in a subpopulation of dermal fibroblasts and is associated with disease severity of systemic sclerosis.
Parvizi R, Gong Z, Jarnagin HC, Toledo DM, Abel TR, Popovich D, Morrisson MJ, Wood TA, Shenk S, Sarkar MK, Plazyo O, Dey P, Coon A, Erba JM, Tsoi LC, Tsou PS, Hinchcliff ME, Khanna D, Garlick JA, Gudjonsson JE, Pioli PA, Whitfield ML
Ann Rheum Dis. 2026 Mar;85(3):507-518. doi: 10.1016/j.ard.2025.10.033. Epub 2025 Dec 11.
PMID: 41381303
Multimodal analyses of early, untreated systemic sclerosis skin identify a proinflammatory vascular niche of macrophage-fibroblast signaling.
Jarnagin HC, Parvizi R, Gong Z, Gedert R, Xing X, Tsoi LAC, Bogle R, Morrisson MJ, Perreard L, Pioli PA, Kolling F 4th, Gudjonsson JE, Khanna D, Whitfield ML
JCI Insight. 2026 Feb 9;11(3) doi: 10.1172/jci.insight.198954. Epub 2025 Dec 18.
PMID: 41411065
A streamlined and comprehensive protocol for the generation and multi-omic analysis of human monocyte-derived macrophages.
Palmer OG, Perreard L, Kolling Iv FW, Pioli PA, Goods BA
BMC Biotechnol. 2025 Dec 29;25(1):141. doi: 10.1186/s12896-025-01071-4. Epub 2025 Dec 29.
PMID: 41466393
Anti-CD206 CAR T Cell Treatment Restores Fibrosis-Induced Loss of Dermal White Adipose Tissue.
Park C, Mohamed AO, Jarnagin HC, Bhandari R, Gunn J, Murad-Mabaera J, Kosarek NN, Kolling FW, Wilkins OM, Huang YH, Whitfield ML, Pioli PA
bioRxiv. 2025 Oct 16; pii: 2025.10.16.682860. doi: 10.1101/2025.10.16.682860. Epub 2025 Oct 16.
PMID: 41279642
T Cells Enhance Tissue Complexity and Function to Study Fibrosis in 3D Skin-Like Tissue Models.
Singh I, Morrisson M, Shenk S, Jarnagin H, Hauer J, Lobo A, Brown L, Houck T, Altman-Sagan L, Pioli PA, Whitfield ML, Garlick JA
Tissue Eng Part C Methods. 2025 Jul;31(7):248-260. doi: 10.1177/19373341251360742.
PMID: 40690724
Geographic Clustering of Systemic Sclerosis in Areas of Environmental Pollution.
Kosarek NN, Romano ME, Moen EL, Simms RW, Erickson A, Khanna D, Pioli PA, Whitfield ML
Arthritis Care Res (Hoboken). 2025 Jul;77(7):855-866. doi: 10.1002/acr.25504. Epub 2025 Feb 28.
PMID: 39895067
A streamlined and comprehensive protocol for the generation and multi-omic analysis of human monocyte-derived macrophages.
Palmer OG, Perreard L, Kolling FW, Pioli PA, Goods BA
bioRxiv. 2025 May 30; pii: 2025.05.30.655544. doi: 10.1101/2025.05.30.655544. Epub 2025 May 30.
PMID: 40501670