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Recent student publications

2017

Howe JR 6th, Li ES, Streeter SE, Rahme GJ, Chipumuro E, Russo GB, Litzky JF, Hills LB,
Rodgers KR, Skelton PD, Luikart BW. MiR-338-3p regulates neuronal maturation and
suppresses glioblastoma proliferation. PLoS One. 2017 May
11;12(5):e0177661.doi:10.1371/journal.pone.0177661. eCollection 2017.

Dumitru, A.M.G., Rusin, S.F., Clark, A.E.M., Kettenbach, A.N.; Compton, D.A. Cyclin
A/Cdk1 modulates Plk1 activity in prometaphase to regulate k-MT attachment stability. In
submission, Developmental Cell (2017).
Submitted/To be submitted soon

Hua C, Gacerez A, Sentman CL, Ackerman ME. Development of human scFvs targeting a novel
epitope of tumor antigen B7H6 with anti-tumor cell activity as Chimeric Antigen Receptors
(CARs) in T cells.

Hua C, Gacerez A, Sentman CL, Ackerman ME, Choi Y* and Bailey-Kellogg C*.
Computationally-driven identification of Antibody Epitopes. (*indicates equal contribution).

Hua C, Ackerman ME. Gain in Function through engineering HIV broadly neutralizing
antibodies.

Qian DC, Molfese DL, Jin JL, Titus AJ, He Y, Li Y, Vaissié M, Viswanath H, Baldwin PR,
Salas R, Amos CI. "Genome-wide imaging association study implicates functional activity and
glial homeostasis of the caudate in smoking addiction". BMC Genomics [revision under review]

Ji X, Bossé Y, Landi MT, Gui J, Xiao X, Qian DC, Joubert P, Lamontagne M, Li Y, Gorlov IP,
De Biasi M, Han Y, Gorlova OY, Hung RJ, Wu X, McKay JD, Zong X, Carreras-Torres R,
Christiani DC, Caporaso NE, et al. "Identification of susceptibility pathways for the role of
chromosome 15q25.1 in modifying lung cancer risk". Nat Commun [revision under review]

Schwartz AG, Lusk C, Wenzlaff AS, de Andrade M, Mandal D, Gaba C, Yang P, You M,
Kupert EY, Anderson MW, Han Y, Byun J, Li Y, Qian DC, Stilp A, Laurie C, Hung RJ,
Brennan P, Bickeböller H, Caporaso NE, Landi MT, et al. "Genome-Wide Association Study of
Familial Lung Cancer". Nat Genet [under review]

Feng Y, Wang Y, Liu H, Liu Z, Mills C, Owzar K, Han Y, Qian DC, Hung RJ, Brhane Y,
McLaughlin JR, Brennan P, Bickeböller H, Rosenberger A, Houlston RS, Caporaso NE, Landi
MT, Brüske I, Risch A, Ye Y, et al. "Novel Genetic Variants in the P38MAPK Pathway Gene
ZAK and Susceptibility to Lung Cancer". Mol Carcinog [under review]

Deng J, Lines JL, Lee YC, Qian DC, Pechenick DA, Manivanh R, Sarde A, LeMercier I,
Lowrey CH, Varn FS, Cheng C, Leib DA, Noelle RJ, Mabaera R. "Hypoxia-induced VISTA
promotes the suppressive function of myeloid-derived suppressor cells in the tumor
microenvironment". Cancer Res [under review]

McKay JD, Hung RJ, Han Y, Zong X, Carreras-Torres R, Christiani DC, Caporaso NE,
Johansson M, Xiao X, Li Y, Byun J, Dunning A, Pooley KA, Qian DC, Ji X, Liu G, Timofeeva
MN, Bojesen SE, Wu X, Le Marchand L, et al. (2017) "Large scale genetic analysis identifies
novel loci and histological variability in susceptibility to lung cancer". Nat Genet [accepted]

Qian DC, Xiao X, Byun J, Suriawinata AA, Her SC, Amos CI, Barth RJ Jr (2017)
"PI3K/Akt/mTOR signaling and plasma membrane proteins are implicated in
responsiveness to adjuvant dendritic cell vaccination for metastatic colorectal cancer".
Clin Cancer Res 23, 399–406.

Merkel P, Xie G, Monach P, Ji X, Ciavatta D, Byun J, Pinder B, Zhao A, Zhang J, Tadesse J,
Qian DC, Nair R, Tsoi A, Ripke S, Pagnoux C, Carette S, Chung S, Cuthbertson
D, Davis J Jr, Dellaripa P, et al. (2017) "Identification of functional and expression
polymorphisms associated with risk for anti-neutrophil cytoplasmic autoantibody-associated
vasculitis". Arthritis Rheumatol 69, 1054–1066.

Qian DC, Busam JA, Xiao X, O'Mara TA, Eeles RA, Schumacher FR, Phelan CM,
Amos CI (2017) "seXY: A tool for sex inference from genotype arrays". Bioinformatics 33, 561–563.

Bender AC, Austin AA, Grodstein F, Bynum J. Executive function, episodic
memory and Medicare expenditures. Alzheimer’s & Dementia. 2017. In press.

Jiang, Y., Patel, C.D., Manivanh, R., North, B., Backes, I., Posner, D.,
Gilli, F., Pachner, A.R., Nguyen, L.N.,and Leib, D.A. (2017). Maternal antiviral
immunoglobulin accumulates in neural tissue of neonates to prevent HSV neurological

Lischinsky, J. E., Sokolowski, K., Li, P., Esumi, S., Kamal, Y., Goodrich, M.,
Corbin, J. G. (2017). Embryonic transcription factor expression in mice predicts medial
amygdala neuronal identity and sex-specific responses to innate behavioral
cues. eLife, 6. http://doi.org/10.7554/eLife.21012

Shee K, Ghali FM, Hyams ES. Practice Makes Perfect: Correlations Between Prior
Experience in High-level Athletics and Robotic Surgical Performance Do Not Persist After
Task Repetition. J Surg Educ. 2017 Jan 10.

Hampsch RA, Shee K, Bates D, Lewis LD, Desire L, Leblond B, Stefan K, Miller
TW. Therapeutic sensitivity to Rac GTPase inhibition requires consequential suppression of
mTORC1, AKT, and MEK signaling in breast cancer." Oncotarget 8.13 (2017):
21806. Co-
First Authorship

Geller LT, Barzily-Rokni M, Danino T, Jonas O, Shental N, Najman D, Cooper ZA,
Shee K, Thaiss CA, Reuben A, Livny J, Avraham R, Frederick DT, Ligorio M,
Chatman K, Johnson S, Mosher CM, Smith DA, Michaud M, Trauger SA, Flaherty KT,

Mandinova A, Garrett WS, Thayer SP, Ferrone CR, Huttenhower C, Bhatia SN, Gevers D,
Wargo JA, Golub TR, Straussman R. Intra-tumor bacteria elicit drug resistance in
pancreatic ductal adenocarcinoma. Science (Manuscript under review in Science).

Chamberlin MD, Shee K, Varn FS, Bean JR, Marotti JD, Wells WA, Trask HW,
Hailton JS, West RJ, Bhatt A, Kaufman PA, Schwartz GN, Gemery JM, McNulty NJ,
Tsapakos MJ, Barth RJ, Arrick BA, Gui J, Cheng C, Miller TW. Plasma DNA as “liquid
biopsy” only partially complements tumor biopsy for identification of mutations in
metastatic breast cancer (Manuscript under review in PLOS One). Co-First Authorship

Rees CA, Burklund A, Stefanuto P-H, Schwartzman JD, Hill JE. Volatile
metabolic fingerprinting of bacterial and fungal pathogen groups. (Submitted).

Rees CA, Stefanuto P-H, Beattie SR, Cramer RA, Hill JE. Sniffing out the hypoxia
volatile metabolic signature of Aspergillus fumigatus. J Breath Res. (In revision).

Mellors TR, Rees CA, Wieland-Alter WF, von Reyn CF, Hill JE. The volatile
molecule signature of four mycobacteria species. J Breath Res. 2017. (Accepted).

Rees CA, Nordick KV, Franchina FA, Lewis AE, Hirsch EB, Hill JE. Volatile
metabolic diversity of Klebsiella pneumoniae in nutrient-replete conditions.
Metabolomics. 2017; 13:18.

Jones SE, Ho L, Rees CA, Hill JE, Nodwell JR, Elliot MA. Streptomyces
exploration is triggered by fungal interactions and volatile signals. eLife. 2017; 6:e21738.

James R Howe, Emily S Li, Sarah E Streeter; Gilbert J Rahme; Edmond Chipumuro; Grace
B Russo; Julia F Litzky; L Benjamin Hills; Kyla R Rodgers; Patrick D Skelton;
Bryan W Luikart; MiR-338-3p Regulates Neuronal Differentiation and Suppresses
Glioblastoma Proliferation. PLoS ONE 2017; (in press)

Julia F Litzky, Maya A Deyssenroth, Todd M Everson, David A Armstrong, Luca
Lambertini, Jia Chen, & Carmen J Marsit; Placental Imprinting Variation Associated with
Assisted Reproductive Technologies and Subfertility. Epigenetics (in press)

Delatour LC, Yeh HH. FASD and Brain Development: Perspectives on Where We are and
Where We Need to Go. OBM Neurobiology 2017;1(1):002;
doi:10.21926/obm.neurobiol.1701002.
Insulin-mediated signaling facilitates resistance to PDGFR inhibition in proneural
hPDGFB-driven gliomas. Damian A Almiron Bonnin, Cong Ran, Matthew C Havrda, Huan
Liu, Yasuyuki Hitoshi, Zhonghua Zhang, Chao Cheng, Matthew Ung and Mark A
Israel. Mol Cancer Ther January 30 2017 DOI: 10.1158/1535-7163.MCT-16-0616
(Publication chosen for cover of Molecular Cancer Therapeutics April issue)

Secretion-mediated STAT3 activation promotes Self-renewal of Glioma Stem-like Cells
during hypoxia. Damian A Almiron Bonnin et al. (under review in Oncogene)

Intratumoral heterogeneity determines 5-aminolevunic acid induced fluorescence in GBM.
Damian A Almiron Bonnin et al. (In preparation for submission/planning to
submit by the end of June)

2016

Hua CK, Ackerman ME. Engineering broadly neutralizing antibodies for HIV Br>prevention and therapy. Advanced Drug Delivery Reviews, 2016. 103:157-73.

Qian DC, Han Y, Byun J, Shin HR, Hung RJ, McLaughlin JR, Landi MT,
Seminara D, Amos CI (2016) "A novel pathway-based approach improves lung cancer risk
prediction using germline genetic variations". Cancer Epidemiol Biomarkers
Prev
25, 1208–1215.

Kashyap MK, Kumar D, Jones H, et al. Ulocuplumab (BMS-936564 / MDX1338):
a fully human anti-CXCR4 antibody induces cell death in chronic lymphocytic leukemia
mediated through a reactive oxygen species-dependent pathway. Oncotarget.
2016;7(3):2809-2822. doi:10.18632/oncotarget.6465.

Bender AC, Luikart BW, Lenck-Santini PP. Cognitive deficits associated with
Nav1.1 Alterations: Involvement of neuronal firing dynamics and oscillations. PLoS One.
2016 Mar;1(3):e0151538

Insulin-mediated signaling facilitates resistance to PDGFR inhibition in proneural hPDGFB-
driven gliomas. Damian A Almiron Bonnin et al. DOI: 10.1158/1535-
7163.MCT-16-0616

David A Armstrong, Benjamin B Green, Bailey A Blair, Dylan J Guerin, Julia F Litzky,
Niraj R Chavan, Kevin J Pearson, Carmen J Marsit; Maternal smoking during
pregnancy is associated with mitochondrial DNA methylation. Environ Epigenet
2016; 2 (3): dvw020. doi: 10.1093/eep/dvw020

Yang W, Hosford SR, Dillon LM, Shee K, Liu SC, Bean JR, Salphati L, Pang J,
Zhang X, Nannini MA, Demidenko E, Bates D, Lewis LD, Marotti JD, Eastman AR, Miller
TW. Strategically Timing Inhibition of Phosphatidylinositol 3-Kinase to Maximize
Therapeutic Index in Estrogen Receptor Alpha-Positive, PIK3CA-Mutant Breast Cancer.
Clin Cancer Res. 2016;22(9):2250-60.

Shee K, Lucas A, Flashman LA, Nho K, Tsongalis GJ, McDonald BC, Saykin AJ,
McAllister TW, Rhodes CH. Alpha-synuclein (SNCA) polymorphisms exert protective
effects on memory after mild traumatic brain injury. Neurosci Lett. 2016 Jul 28.

Koo K, Shee K, Yap RL. Readability analysis of online health information about
overactive bladder. Neurourology and Urodynamics. 2016 Oct 29.

Shee K, Kono AT, D'Anna SP, Seltzer MA, Lu X, Miller TW, Chamberlin MD.
Maximizing the Benefit-Cost Ratio of Anthracyclines in Metastatic Breast Cancer: Case
Report of a Patient with a Complete Response to High-Dose Doxorubicin. Case Reports
in Oncology.
2016 Dec 8;9(3):840-6.

Koo K, Shee K, Yap RL. News Media Analysis of the United States Preventive
Services Task Force and American Urological Association Prostate Cancer Screening
Guidelines. Urology Practice. 2016 Dec 10.

Rees CA, Franchina FA, Nordick KV, Kim PJ, Hill JE. Expanding the
Klebsiella pneumoniae volatile metabolome using advanced analytical
instrumentation for the detection of novel metabolites. J Appl Microbiol. 2016;
122(3):785-795.

Rees C, Warner CJ, Powell RJ, Erkmen CP. Novel use of thoracic endovascular
aortic repair in mediastinitis-induced aortic erosion: a case series. Chirurgia. 2016; 29
(6): 203-206.

Bean HD*, Rees CA*, Hill JE. Comparative analysis of the volatile metabolomes
of P. aeruginosa clinical isolates. J Breath Res. 2016; 10(2): 047102.

Rees CA, Shen A, Hill JE. Characterization of the Clostridium difficile
volatile metabolome using comprehensive two-dimensional gas chromatography time-of-
flight mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2016;
1039: 8-16.

Rees CA, Smolinska A, Hill JE. The volatile metabolome of Klebsiella
pneumoniae
in human blood. J Breath Res. 2016; 10(2): 027101.
Noble GP, Dolph PJ, Supattapone S. Interallelic transcriptionalenhancement as an
in vivo measure of transvection in Drosophila melanogaster. G3, 6:3139-48.

2015

Choi Y*, Hua C*, Sentman CL, Ackerman ME, Bailey-Kellogg C. Antibody
humanization by structure-based computational protein design. MAbs, 2015. 7(6):1045-57.
(*indicates equal contribution)

Halloran JW, Zhu D, Qian DC, Byun J, Gorlova OY, Amos CI, Gorlov IP (2015)
"Prediction of the gene expression in normal lung tissue by the gene expression in blood".
BMC Med Genomics 8, 77:1‒6.

Qian DC, Byun J, Han Y, Greene CS, Field JK, Hung RJ, Brhane Y, McLaughlin
JR, Fehringer G, Landi MT, Rosenberger A, Bickeböller H, Malhotra J, Risch A, Heinrich
J, Hunter DJ, Henderson BE, Haiman CA, Schumacher FR, Eeles RA, Easton DF, Seminara
D, Amos CI (2015) "Identification of shared and unique susceptibility pathways among
cancers of the lung, breast, and prostate from genome-wide association studies and tissue-
specific protein interactions". Hum Mol Genet 24, 7406‒7420.

Cordell HJ, Han Y, Mells GF, Li Y, Hirschfield GM, Greene CS, Xie G, Juran BD, Zhu D,
Qian DC, Floyd JA, Morley KI, Prati D, Lleo A, Cusi D, Canadian-US PBC
Consortium, Italian PBC Genetics Study Group, UK-PBC Consortium, Gershwin ME,
Anderson CA, et al. (2015) "International genome-wide meta-analysis identifies new
primary biliary cirrhosis risk loci and targetable pathogenic pathways". Nat Commun 6, 8019:1‒11.

Onyango EO, Kelly AR, Qian DC, Gribble GW (2015) "Novel Synthesis of 1-
bromo-8-methylnaphthalene and 1-bromo-5-methylnaphthalene". J Org Chem 80, 5970‒5972.

Erdos, B., I. Backes, M.L. McCowan, L.F. Hayward, and D.A. Scheuer. 2015.
“Brain-Derived Neurotrophic Factor Modulates Angiotensin Signaling in the Hypothalamus
to Increase Blood Pressure in Rats.” American Journal of Physiology - Heart and
Circulatory Physiology
308 (6): H612–22. doi:10.1152/ajpheart.00776.2014.

Bean JR, Hosford SR, Symonds LK, Owens P, Dillon LM, Yang W, Shee K,
Schwartz GN, Marotti JD, Muller KE, Rosenkranz KM, Barth RJ, Chen VS, Agarwal VR,
Miller TW. The PI3K/mTOR dual inhibitor P7170 demonstrates potent activity against
endocrine-sensitive and endocrine-resistant ER+ breast cancer. Breast Cancer Res Treat.
2015;149(1):69-79.

Dillon LM, Bean JR, Yang W, Shee K, Symonds LK, Balko JM, McDonald WH,
Liu S, Gonzalez-Angulo AM, Mills GB, Arteaga CL, Miller TW. P-REX1 creates a positive
feedback loop to activate growth factor receptor, PI3K/AKT and MEK/ERK signaling in
breast cancer. Oncogene. 2015;34(30):3968-76.

Gogna R, Shee K, Moreno E. Cell Competition During Growth and Regeneration.
Annu Rev Genet. 2015;49:697-718.

Noble GP, Wang DW, Walsh DJ, Barone JR Miller MB, Nishina KA, Li S,
Supattapone S. A structural and functional comparison between infectious and non-
infectious autocatalytic recombinant PrP conformers. PLoS Path. 11:e1005017.

Noble GP, Walsh DJ, Miller MB, Jackson WJ, Supattapone S. Requirments for
mutant and wild-type prion protein misfolding in vitro. Biochemistry, 54:1180-7.

Noble GP, Supattapone S. Dissociation of recombinant prion autocatalysis from
infectivity. Prion, 9:405-11. (Invited Review Article)

Wang X, Hills LB, Huang YH. Lipid and Protein Co-Regulation of PI3K Effectors
Akt and Itk in Lymphocytes. Frontiers in Immunology – 2015 (Vol. 6, Issue 117,
Online Publication)

2014

COOK J.B., DUMITRU, A.M., O’BUCKLEY T.K., MORROW A.L. Ethanol
administration produces divergent changes in GABAergic neuroactive steroid
immunohistochemistry in the rat brain. Alcoholism Clinical and Experimental Research
(2014) 38: 90-99. PMCID: PMC4196317

Kashyap MK, Kumar D, Villa R, Clair J, Benner C, Sasik R, Jones H, et al.
Targeting the spliceosome in chronic lymphocytic leukemia with the macrolides FD-895
and pladienolide-B. Haematologica. 2015;100(7):945-954.
doi:10.3324/haematol.2014.122069.

Klein RD, Chidawanyika T, Tims HS, Meulia T, Bouchard RA, Pett VB.
Chaperone function of two small heat shock proteins from maize. Plant Sci. 2014
May;221-222:48-58. doi: 10.1016/j.plantsci.2014.01.012

Zurawel AA, Walsh DJ, Fortier AM, Chidawanyika T, Sengupta S, Zilm, K,
Supattapone S. Prion nucleation site unmasked by transient interaction with phospholipid cofactor. Biochemistry. 2014 Jan 14;53(1):68-76. doi: 10.1021/bi4014825

2013

Michael B. Miller, Daphne W. Wang, Fei Wang, Geoffrey P. Noble, Jiyan Ma, Virgil L. Woods, Jr., Sheng Li, and Surachai Supattapone. "Cofactor Molecules Induce Structural Transformation During Infectious Prion Formation" Structure. 2013. In press.

Audu CO, Cochran JC, Pellegrini M, Mierke DF. "Recombinant production of TEV cleaved human parathyroid hormone" J Pept Sci. 2013 Aug;19(8):504-10. doi: 10.1002/psc.2528. Epub 2013 Jun 23.

Cook, J. B., Dumitru, A. M. G., O'Buckley, T. K. and Morrow, A. L. (2013), Ethanol Administration Produces Divergent Changes in GABAergic Neuroactive Steroid Immunohistochemistry in the Rat Brain. Alcoholism: Clinical and Experimental Research. doi: 10.1111/acer.12223

Hahn, CK and Lowrey, CH. Eukaryotic Initiation Factor 2 αλπηα Phosphorylation Mediates Fetal Hemoglobin Induction through a Post-Transcriptional Mechanism. Blood, 122 (4): 477-485 (2013)

Bekelis K (co-first author), Bakhoum SF (co-first author), Desai A, Mackenzie TA, Roberts DW, "Outcome prediction in intracranial tumor surgery: the National Surgical Quality Improvement Program 2005-2010" J Neurooncol. 2013 Feb 24. [Epub ahead of print], PMID: 23436132

Bekelis K (co-first author), Bakhoum SF (co-first author), Desai A, Mackenzie TA, Goodney P, Labropoulos N. "A Risk Factor-based Predictive Model of Outcomes in Carotid Endarterectomy: The National Surgical Quality Improvement Program 2005-2010" Stroke. 2013 Feb 14. [Epub ahead of print] PMID: 23412374

Ran C, Liu H, Hitoshi Y, Israel M. "Proliferation-independent control of tumor glycolysis by PDGFR-mediated AKT activation" Cancer Res. 2013 Jan 15. [Epub ahead of print] PMID: 23322009

Sexton K, Davis S, McClatchy B, Valdes PA, Kanick SC, Paulsen KD, Roberts DW, Pogue BW. Pulsed light imaging for fluorescence guided surgery under normal room lighting. (Opt Lett. 2013 Sep 1;38(17):3249-52).PMID: Pending EDIT FOR ERAS

Valdes PA, Jacobs VL, Wilson BC, Leblond F, Roberts DW, Paulsen KD. System and methods for wide-field quantitative fluorescence imaging during neurosurgery. (Opt Lett. 2013 Aug 1;38(15):2786-8). PMID: 23903142

Valdes PA, Bekelis K, Harris BT, Wilson BC, Leblond F, Kim A, Erkmen K, Paulsen KD, Roberts DW. 5-aminolevulinic acid-induced protoporphyrin IX fluorescence guided surgery in meningiomas: qualitative and quantitative measurements in vivo. (Neurosurgery 2013 Jul 24 [Epub ahead of print]). PMID: 23887194

A. Petryk, A. J. Giustini, R. E. Gottesman, P. A. Kaufman, P. J. Hoopes. "Magnetic nanoparticle hyperthermia enhancement of cisplatinum chemotherapy cancer treatment." International Journal of Hyperthermia (2013). Accepted

J. Pearce, A. J. Giustini, R. S. Stigliano, P. Jack Hoopes. "Magnetic Heating of Nanoparticles: The Importance of Particle Clustering to Achieve Therapeutic Temperatures" Journal of Nanotechnology in Engineering and Medicine (2013). 4(1), 110071-1100714. PMID: 23919112

M. A. Crane-Godreau, C. C. Black, A. J. Giustini, T. Dechen, J. Ryu, J. A. Jukosky, H.-K. Lee, K. Bessette, N. R. Ratcliffe, P. J. Hoopes, S. Fiering, J. A. Kelly, J. C. Leiter. "Modeling the influence of vitamin D deficiency on cigarette smoke-induced emphysema." Frontiers in Physiology (2013). 4, 132.

Rasapalli S, Fan Y, Yu M, Rees C, Harris JT, Golen JA, Jasinski JP, Rheingold AL, Kwasny SM, Opperman TJ. "Detour of prenostodione synthesis towards pyrazolones for antibacterial activity." Bioorganic & Medicinal Chemistry Letters, Volume 23, Issue 11, 1 June 2013, Pages 3235-3238

2012

Supattapone S and MB Miller, "Cofactor Involvement in Prion Propagation". In W-Q Zou and P Gambetti [Ed.] Prions and Diseases: Physiology and Pathophysiology [vol. 1]. Springer, 2012.

Turnbaugh JA, U Unterberger, P Saá, T Massignan, B Fluharty, I Solomon, MB Miller, S Supattapone, E Biasini, and DA Harris, "The N-Terminal, Polybasic Region of PrPC Dictates the Efficiency of Prion Propagation by Binding to PrPSc" Journal of Neuroscience, 2012; 32(26):8817-8830.

Audu CO, O'Hara B, Pellegrini M, Wang L, Atwood WJ, Mierke DF. "Reining in Polyoma Virus Associated Nephropathy: Design and Characterization of a Template Mimicking BK Viral Coat Protein Cellular Binding" Biochemistry 2012; 51 (41), 8092-8099.

Valdés PA, Moses ZM, Kim A, Paulsen KD, Wilson BC, Roberts DW, Harris BT. Relationship between ex vivo gadolinium concentrations and 5-aminolevulinic acid-induced protoporphyrin IX levels in gliomas: a quantitative study on a relationship between protoporphyrin IX levels and blood-brain barrier breakdown. (J Neuropathol Exp Neurol. 2012 Aug 8 [Epub ahead of print]).

Roberts DW, Valdés PA, Harris BT, Hartov A, Fan X, Songbai J, Pogue BW, Lebnlond F, Tosteson TD, Wilson BC, Paulsen KD. Glioblastoma Multiforme Treatment with Clinical Trials for Surgical Resection (Aminolevulinic Acid). (Neurosurg Clin N Am, 2012 Jul;23(3):371-7).

Valdés PA, Leblond F, Kim A, Paulsen KD, Wilson BC, Roberts DW. A spectrally-constrained dual-band normalization technique for protoporphyrin IX quantification in fluorescence guided surgery. (Opt Lett. 2012 Jun 1;37(11):1817-9).

Jacobs VL, Liu Y, De Leo JA. Propentofylline targets TROY, a novel microglial signaling pathway. PLoS One. 2012;7(5):e37955. Epub 2012 May 23. PMID: 22649568

Konecky SD, Owen CM, Rice T, Valdés PA, Kolste K, Wilson BC, Leblond F, Roberts DW, Paulsen KD, Tromberg BJ. Spatial frequency domain tomography of protoporphyrin IX fluorescence in preclinical glioma models. (J Biomed Opt. 2012 May;17(5):0506008).

Landry RP, Jacobs VL, Romero-Sandoval EA, DeLeo JA. Propentofylline, a CNS glial modulator does not decrease pain in post-herpetic neuralgia patients: in vitro evidence for differential responses in human and rodent microglia and macrophages. Exp Neurol. 2012 Apr;234(2):340-50. Epub 2011 Nov 15. Review. PMID: 22119425

Bakhoum SF, Compton DA. Chromosomal instability and cancer: a complex relationship with therapeutic potential. J Clin Invest. 2012 Apr 2;122(4):1138-43. doi: 10.1172/JCI59954. Epub 2012 Apr 2.

Bakhoum SF, Compton DA. Kinetochores and disease: keeping microtubule dynamics in check! Curr Opin Cell Biol. 2012 Feb;24(1):64-70. Epub 2011 Dec 21.

Walsh DJ, Noble GP, Piro JR, Supattapone S. Non-reducing alkaline solubilization and rapid on-column refolding of recombinant prion protein. Prep Biochem Biotechnol. 2012 Jan; 42(1):77-86. PubMed PMID: 22239709.

Bakhoum SF, Compton DA. Chromosomal instability and cancer: a complex relationship with therapeutic potential. The Journal of Clinical Investigation. Accepted, in press.

Valdés PA, Leblond F, Jacobs VL, Paulsen KD, Roberts DW. In vivo fluorescence detection in surgery: A review of principles, methods, and applications. (Current Medical Imaging Reviews, In Press, 2012).

Valdes PA, Leblond F, Jacobs VL, Wilson BC, Paulsen KD, Roberts DW. Quantitative, spectrally-resolved intraoperative fluorescence imaging. (Sci Rep. 2012;2:798. doi: 10.1038/srep00798. Epub 2012 Nov 12). PMID: 23152935

A. J. Giustini, I. Perreard, A. M. Rauwerdink, J. B. Weaver , P. J. Hoopes. "Noninvasive assessment of magnetic nanoparticle-cancer cell interactions." Integrative Biology (2012), 4, 1283–1288.

A. J. Giustini, A. A. Petryk, P. J. Hoopes. "Ionizing radiation increases systemic nanoparticle tumor accumulation" Nanomedicine: Nanotechnology, Biology, and Medicine (2012), 8(6), 818–821.

Bender AC, Natola H, Ndong C, Holmes GL, Scott RC, Lenck-Santini PP. Focal Scn1a knockdown induces cognitive impairment without seizures. Neurobiol Dis. 2013 Jun;54:297-307. doi: 10.1016/j.nbd.2012.12.021. Epub 2013 Jan 11. PubMed PMID: 23318929; PubMed Central PMCID: PMC3628954.

2011

Bakhoum SF, Danilova OV, Kaur P, Levy NB, Compton DA. Chromosomal instability substantiates poor prognosis in patients with diffuse large B-cell lymphoma. Clin Cancer Res. 2011 Dec 15;17(24):7704-11.

Belden CJ, Valdés PA, Ran C, Pastel DA, Harris BT, Fadul CE, Israel MA, Paulsen KD, Roberts DW. Genetics of glioblastoma: A window into its imaging and histopathologic variability. (Radiographics, 2011 Oct 31: 1717-1740). Invited Review. PMID: 21997991

Leblond F, Ovanesyan Z, Davis SC, Valdés PA, Kim A, Wilson BC, Hartov A, Pogue BW, Paulsen KD, Roberts DW. Analytic expression of fluorescence ratio detection correlates with depth in multi-spectral sub surface imaging. (Phys Med Biol, 2011 Oct 5; 56(21): 6823-6837). Review. PMID: 21971201

Valdés PA, Kim A, Leblond F, Conde OM, Harris BT, Paulsen KD, Wilson BC, Roberts DW. Combined fluorescence and reflectance spectroscopy for in vivo quantification of cancer biomarkers in low- and high-grade glioma surgery. J Biomed Opt. 2011 Nov;16(11):116007.

Jacobs VL, Landry RP, Liu Y, Romero-Sandoval EA, De Leo JA. Propentofylline decreases tumor growth in a rodent model of glioblastoma multiforme by a direct mechanism on microglia. Neuro Oncol. 2011 Nov 15. [Epub ahead of print]

Bender AC, Morse RP, Scott RC, Holmes GL, Lenck-Santini PP. SCN1A mutations in Dravet syndrome: Impact of interneuron dysfunction on neural networks and cognitive outcome. Epilepsy Behav. Accepted 2011 Nov 27.

Holmes GL, Bender AC, Wu EX, Scott RC, Lenck-Santini PP, Morse RP. Maturation of EEG oscillations in children with sodium channel mutations. Brain Dev. 2011 Sep 20.

Kleen JK, Wu EX, Holmes GL, Scott RC, Lenck-Santini PP. Enhanced oscillatory activity in the hippocampal-prefrontal network is related to short-term memory function after early-life seizures. J Neurosci. 2011 Oct 26;31(43):15397-406.

Kleen JK, Sesqué A, Wu EX, Miller FA, Hernan AE, Holmes GL, Scott RC. Early-life seizures produce lasting alterations in the structure and function of the prefrontal cortex. Epilepsy Behav. 2011 Oct;22(2):214-9.

Wood M, Rawe M, Johansson G, Pang S, Soderquist RS, Patel AV, Nelson S, Seibel W, Ratner N, Sanchez Y. Discovery of a Small Molecule Targeting IRA2 Deletion in Budding Yeast and Neurofibromin Loss in Malignant Peripheral Nerve Sheath Tumor Cells Mol. Cancer Ther. 2011 Sep;10(9):1740-50. Epub 2011 Jun 22

Jacobs VL, Valdés PA, Hickey WF, De Leo JA. Current review of in vivo GBM rodent models: emphasis on the CNS-1 tumor model. ASN Neuro, 2011 Aug 3;3(3).

Pablo A. Valdés, Anthony Kim, Marco Brantsch, Carolyn Niu, Ziev B. Moses, Tor D. Tosteson, Brian C. Wilson, Keith D. Paulsen, David W. Roberts, and Brent T. Harris. δ-aminolevulinic acid-induced protoporphyrin IX concentration correlates with histopathologic markers of malignancy in human gliomas: the need for quantitative fluorescence-guided resection to identify regions of increasing malignancy. Neuro Oncol (2011) 13(8): 846-856 doi:10.1093/neuonc/nor086.

Isaev D, Zhao Q, Kleen JK, Lenck-Santini PP, Adstamongkonkul D, Isaeva E, Holmes GL. Neuroaminidase reduces interictal spikes in a rat temporal lobe epilepsy model. Epilepsia. 2011 Mar;52(3):e12-5. doi:10.1111/j.1528-1167.2011.02988.x. Epub 2011 Mar 2. PubMed PMID: 21366554.

Megli CJ, Yuen AS, Kolappan S, Richardson MR, Dharmasena MN, Krebs SJ, Taylor RK, Craig L. Crystal structure of the Vibrio cholerae colonization factor TcpF and identification of a functional immunogenic site. J Mol Biol. 2011 Mar 24. [Epub ahead of print] PubMed PMID: 21440558.

Miller MB, Supattapone S. Superparamagnetic nanoparticle capture of prions for amplification. J Virol. 2011 Mar;85(6):2813-7. Epub 2011 Jan 12. PubMed PMID: 21228242.

Bekelis K, Valdes PA, Erkmen K, Leblond F, Kim A, Wilson BC, Harris BT, Paulsen KD, Roberts DW. Quantitative and qualitative ALA-induced PpIX fluorescence in skull base meningiomas. (Neurosurgical Focus, 2011 May; 30(5): E8) PMID: 21529179

Valdés PA, Leblond F, Kim A, Harris BT, Wilson BC, Fan X, Tosteson TD, Hartov A, Ji S, Paulsen KD, Roberts DW. Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as a surgical biomarker to guide resection procedures. (Journal of Neurosurgery, 2011 Mar 25. [Epub ahead of print]) PMID: 21529179

Whitson W, Valdés PA, Harris BT, Paulsen KD, Roberts DW. Confocal microscopy for the histologic fluorescence pattern of a recurrent atypical meningioma. (Neurosurgery, 2011 Mar 8. [Epub ahead of print]) PMID: 2138989

Roberts DW, Valdés PA, Harris BT, Fontaine KM, Hartov A, Fan X, Ji S, Lollis SS, Pogue BW, Leblond F, Tosteson T, Wilson BC, Paulsen KD. Co-registered Fluorescence-Enhanced Tumor Resection of Malignant Glioma: Relationships between ALA-Induced PpIX Fluorescence, MRI Enhancement and Neuropathological Parameters. (J Neurosurg, 2011 Mar; 114(3): 595-603. [Epub ahead of print, Apr 9]) PMID: 2038053

A. J. Giustini, R. Ivkov, P. J. Hoopes. "Magnetic nanoparticle biodistribution following intratumoral administration." Nanotechnology (2011) vol. 22 (34) pp. 345101

2010

Manning AL, Bakhoum SF, Maffini S, Correia-Melo C, Maiato H, Compton DA. CLASP1, astrin and Kif2b form a molecular switch that regulates kinetochore-microtubule dynamics to promote mitotic progression and fidelity. EMBO J. 2010 Oct 20;29(20):3531-43. Epub 2010 Sep 17. PubMed PMID: 20852589; PubMed Central PMCID: PMC2964175.

Thompson SL, Bakhoum SF, Compton DA. Mechanisms of chromosomal instability. Curr Biol. 2010 Mar 23;20(6):R285-95. Review. PubMed PMID: 20334839.

Guo Y, Dolinko AV, Chinyengetere F, Stanton B, Bomberger JM, Demidenko E, Zhou DC, Gallagher R, Ma T, Galimberti F, Liu X, Sekula D, Freemantle S, Dmitrovsky E. Blockade of the ubiquitin protease UBP43 destabilizes transcription factor PML/RARα and inhibits the growth of acute promyelocytic leukemia. Cancer Res. 2010 Dec 1;70(23):9875-85. Epub 2010 Oct 8. PubMed PMID: 20935222; PubMed Central PMCID: PMC2999664.

Elfenbein A, Simons M. Auxiliary and autonomous proteoglycan signaling networks. Methods Enzymol. 2010;480:3-31. Review. PubMed PMID: 20816202.

Rauwerdink AM, Giustini AJ, Weaver JB. Simultaneous quantification of multiple magnetic nanoparticles. Nanotechnology. 2010 Nov 12;21(45):455101. Epub 2010 Oct 14. PubMed PMID: 20947953.

Horvath RJ, Landry RP, Romero-Sandoval EA, DeLeo JA. Morphine tolerance attenuates the resolution of postoperative pain and enhances spinal microglial p38 and extracellular receptor kinase phosphorylation. Neuroscience. 2010 Aug 25;169(2):843-54. Epub 2010 May 22. PubMed PMID: 20493931; PubMed Central PMCID: PMC2904400.

Côté AL, Zhang P, O'Sullivan JA, Jacobs VL, Clemis CR, Sakaguchi S, Guevara-Patino JA, Turk MJ. Stimulation of the glucocorticoid-induced TNF receptor family-related receptor on CD8 T cells induces protective and high-avidity T cell responses to tumor-specific antigens. J Immunol. 2011 Jan 1;186(1):275-83. Epub 2010 Nov 24. PubMed PMID: 21106849; PubMed Central PMCID: PMC3050990.

Kleen JK, Holmes GL. Taming TLR4 may ease seizures. Nat Med. 2010 Apr;16(4):369-70. PubMed PMID: 20376038.

Kleen JK, Scott RC, Holmes GL, Lenck-Santini PP. Hippocampal interictal spikes disrupt cognition in rats. Ann Neurol. 2010 Feb;67(2):250-7. PubMed PMID: 20225290; PubMed Central PMCID: PMC2926932.

Martinez RM, Megli CJ, Taylor RK. Growth and laboratory maintenance of Vibrio cholerae. Curr Protoc Microbiol. 2010 May;Chapter 6:Unit 6A.1. PubMed PMID: 20440684.

Chang TY, Chang CC, Bryleva E, Rogers MA, Murphy SR. Neuronal cholesterol esterification by ACAT1 in Alzheimer's disease. IUBMB Life. 2010 Apr;62(4):261-7. Review. PubMed PMID: 20101629.

Murad JM, Place CS, Ran C, Hekmatyar SK, Watson NP, Kauppinen RA, Israel MA. Inhibitor of DNA binding 4 (ID4) regulation of adipocyte differentiation and adipose tissue formation in mice. J Biol Chem. 2010 Jul 30;285(31):24164-73. Epub 2010 May 11. PubMed PMID: 20460371; PubMed Central PMCID: PMC2911309.

Corpora T, Roudaia L, Oo ZM, Chen W, Manuylova E, Cai X, Chen MJ, Cierpicki T, Speck NA, Bushweller JH. Structure of the AML1-ETO NHR3-PKA(RIIα) complex and its contribution to AML1-ETO activity. J Mol Biol. 2010 Sep 24;402(3):560-77. Epub 2010 Aug 11. PubMed PMID: 20708017; PubMed Central PMCID: PMC2945414.

Shindiapina P, Barlowe C. Requirements for transitional endoplasmic reticulum site structure and function in Saccharomyces cerevisiae. Mol Biol Cell. 2010 May 1;21(9):1530-45. Epub 2010 Mar 3. PubMed PMID: 20200224; PubMed Central PMCID: PMC2861612.

Pogue BW, Gibbs-Strauss S, Valdés PA, Samkoe K, Roberts, DW, Paulsen KD. Review of Neurosurgical Fluorescence Imaging Methodologies. (IEEE Journal of Selected Topics in Quantum Electronics, 2010 Jun; 16(3): 493-505). Invited Review PMID: 20671936

Valdés PA, Samkoe K, O'Hara JA, Roberts DW, Paulsen KD, Pogue BW. Deferoxamine iron chelation increases delta-aminolevulinic acid induced protoporphyrin IX in xenograft glioma model. Photochem Photobiol. 2010 Mar-Apr;86(2):471-5. Epub 2009 Dec 7. PubMed PMID: 20003159; PubMed Central PMCID: PMC2875336.

Lollis SS, Valdés PA, Li Z, Ball PA, Roberts DW. Cause-specific mortality among neurosurgeons. (J Neurosurg, 2010 Sep; 113(3): 474-478. [Epub ahead of print, Feb 19]) PMID: 20170305

Wood MD, Sanchez Y. Deregulated Ras signaling compromises DNA damage checkpoint recovery in S. cerevisiae. Cell Cycle. 2010 Aug 15;9(16):3353-63. Epub 2010 Aug 17. PubMed PMID: 20716966.

A. J. Giustini, et al. "Magnetic Nanoparticle Hyperthermia in Cancer Treatment." Nano LIFE (2010). Vol 1 (1-2) 17-32.

Rosas HD, Lee SY, Bender AC, Zaleta AK, Vangel M, Yu P, Fischl B, Pappu V,Onorato C, Cha JH, Salat DH, Hersch SM. Altered white matter microstructure in the corpus callosum in Huntington's disease: implications for cortical "disconnection". Neuroimage. 2010 Feb 15;49(4):2995-3004. doi: 10.1016/j.neuroimage.2009.10.015. Epub 2009 Oct 19. PubMed PMID: 19850138; PubMed Central PMCID: PMC3725957.

2009

Kollu S, Bakhoum SF, Compton DA. Interplay of microtubule dynamics and sliding during bipolar spindle formation in mammalian cells. Curr Biol. 2009 Dec 29;19(24):2108-13. PubMed PMID: 19931454; PubMed Central PMCID: PMC2805786.

Bakhoum SF, Genovese G, Compton DA. Deviant kinetochore microtubule dynamics underlie chromosomal instability. Curr Biol. 2009 Dec 1;19(22):1937-42. Epub 2009 Oct 29. PubMed PMID: 19879145; PubMed Central PMCID: PMC2787757.

Bakhoum SF, Compton DA. Cancer: CINful centrosomes. Curr Biol. 2009 Aug 11;19(15):R642-5. Review. PubMed PMID: 19674544.

Bakhoum SF, Thompson SL, Manning AL, Compton DA. Genome stability is ensured by temporal control of kinetochore-microtubule dynamics. Nat Cell Biol. 2009 Jan;11(1):27-35. Epub 2008 Dec 7. PubMed PMID: 19060894; PubMed Central PMCID: PMC2614462.

Elfenbein A, Rhodes JM, Meller J, Schwartz MA, Matsuda M, Simons M. Suppression of RhoG activity is mediated by a syndecan 4-synectin-RhoGDI1 complex and is reversed by PKCalpha in a Rac1 activation pathway. J Cell Biol. 2009 Jul 13;186(1):75-83. Epub 2009 Jul 6. PubMed PMID: 19581409; PubMed Central PMCID: PMC2712988.

Romero-Sandoval EA, Horvath R, Landry RP, DeLeo JA. Cannabinoid receptor type 2 activation induces a microglial anti-inflammatory phenotype and reduces migration via MKP induction and ERK dephosphorylation. Mol Pain. 2009 May 28;5:25. PubMed PMID: 19476641; PubMed Central PMCID: PMC2704199.

Horvath RJ, DeLeo JA. Morphine enhances microglial migration through modulation of P2X4 receptor signaling. J Neurosci. 2009 Jan 28;29(4):998-1005. PubMed PMID: 19176808; PubMed Central PMCID: PMC2727471.

Geoghegan JC, Miller MB, Kwak AH, Harris BT, Supattapone S. Trans-dominant inhibition of prion propagation in vitro is not mediated by an accessory cofactor. PLoS Pathog. 2009 Jul;5(7):e1000535. Epub 2009 Jul 31. PubMed PMID: 19649330; PubMed Central PMCID: PMC2713408.

Roudaia L, Cheney MD, Manuylova E, Chen W, Morrow M, Park S, Lee CT, Kaur P, Williams O, Bushweller JH, Speck NA. CBFbeta is critical for AML1-ETO and TEL-AML1 activity. Blood. 2009 Mar 26;113(13):3070-9. Epub 2009 Jan 29. PubMed PMID: 19179469; PubMed Central PMCID: PMC2662647.

Valdés PA, Fan X, Ji S, Harris BT, Paulsen KD, Roberts DW. Estimation of brain deformation for volumetric image updating in protoporphyrin IX fluorescence-guided resection. Stereotact Funct Neurosurg. 2010;88(1):1-10. Epub 2009 Nov 12. PubMed PMID: 19907205; PubMed Central PMCID: PMC2813794.

Leblond F, Davis SC, Valdés PA, Pogue BW. Pre-clinical Whole-Body Fluorescence Imaging: Review of Instruments, Methods, and Applications. (J Photochem Photobiol B, 2009 Nov 26. [Epub ahead of print]) Review PMID: 20031443

Yasaitis L, Fisher E, Mackenzie TA, Wasson J. Healthcare intensity is associated with lower ratings of healthcare quality by younger adults. J Ambul Care Manage. 2009 Jul-Sep;32(3):226-31. PubMed PMID: 19542812.

Yasaitis L, Fisher ES, Skinner JS, Chandra A. Hospital quality and intensity of spending: is there an association? Health Aff (Millwood). 2009 Jul-Aug;28(4):w566-72. Epub 2009 May 21. PubMed PMID: 19460774; PubMed Central PMCID: PMC2768577.

2008

Chinyengetere F, Jamieson ER. Impact of the oxidized guanine lesion spiroiminodihydantoin on the conformation and thermodynamic stability of a 15-mer DNA duplex. Biochemistry. 2008 Feb 26;47(8):2584-91. PubMed PMID: 18281959.

Murakami M, Elfenbein A, Simons M. Non-canonical fibroblast growth factor signalling in angiogenesis. Cardiovasc Res. 2008 May 1;78(2):223-31. Epub 2007 Dec 4. Review. PubMed PMID: 18056763.

Horvath RJ, Nutile-McMenemy N, Alkaitis MS, Deleo JA. Differential migration, LPS-induced cytokine, chemokine, and NO expression in immortalized BV-2 and HAPI cell lines and primary microglial cultures. J Neurochem. 2008 Oct;107(2):557-69. Epub 2008 Sep 18. PubMed PMID: 18717813; PubMed Central PMCID: PMC2581646.

Romero-Sandoval EA, Horvath RJ, DeLeo JA. Neuroimmune interactions and pain: focus on glial-modulating targets. Curr Opin Investig Drugs. 2008 Jul;9(7):726-34. Review. PubMed PMID: 18600578; PubMed Central PMCID: PMC2696046.

Kleen JK, Holmes GL. Brain inflammation initiates seizures. Nat Med. 2008 Dec;14(12):1309-10. PubMed PMID: 19057551.

Urano Y, Watanabe H, Murphy SR, Shibuya Y, Geng Y, Peden AA, Chang CC, Chang TY. Transport of LDL-derived cholesterol from the NPC1 compartment to the ER involves the trans-Golgi network and the SNARE protein complex. Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16513-8. Epub 2008 Oct 22. Erratum in: Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19561. PubMed PMID: 18946045; PubMed Central PMCID: PMC2575451.

Roudaia L, Speck NA. A MENage a Trois in leukemia. Cancer Cell. 2008 Jul 8;14(1):3-5. PubMed PMID: 18598937.

2007

Manning AL, Ganem NJ, Bakhoum SF, Wagenbach M, Wordeman L, Compton DA. The kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distinct roles during mitosis in human cells. Mol Biol Cell. 2007 Aug;18(8):2970-9. Epub 2007 May 30. PubMed PMID: 17538014; PubMed Central PMCID: PMC1949365.

Tirziu D, Chorianopoulos E, Moodie KL, Palac RT, Zhuang ZW, Tjwa M, Roncal C, Eriksson U, Fu Q, Elfenbein A, Hall AE, Carmeliet P, Moons L, Simons M. Myocardial hypertrophy in the absence of external stimuli is induced by angiogenesis in mice. J Clin Invest. 2007 Nov;117(11):3188-97. PubMed PMID: 17975666; PubMed Central PMCID: PMC2045601.

Gorczynski MJ, Grembecka J, Zhou Y, Kong Y, Roudaia L, Douvas MG, Newman M, Bielnicka I, Baber G, Corpora T, Shi J, Sridharan M, Lilien R, Donald BR, Speck NA, Brown ML, Bushweller JH. Allosteric inhibition of the protein-protein interaction between the leukemia-associated proteins Runx1 and CBFbeta. Chem Biol. 2007 Oct;14(10):1186-97. PubMed PMID: 17961830.

Liu Y, Chen W, Gaudet J, Cheney MD, Roudaia L, Cierpicki T, Klet RC, Hartman K, Laue TM, Speck NA, Bushweller JH. Structural basis for recognition of SMRT/N-CoR by the MYND domain and its contribution to AML1/ETO's activity. Cancer Cell. 2007 Jun;11(6):483-97. PubMed PMID: 17560331; PubMed Central PMCID: PMC1978186.

Matheny CJ, Speck ME, Cushing PR, Zhou Y, Corpora T, Regan M, Newman M, Roudaia L, Speck CL, Gu TL, Griffey SM, Bushweller JH, Speck NA. Disease mutations in RUNX1 and RUNX2 create nonfunctional, dominant-negative, or hypomorphic alleles. EMBO J. 2007 Feb 21;26(4):1163-75. Epub 2007 Feb 8. PubMed PMID: 17290219; PubMed Central PMCID: PMC1852839.

Geoghegan JC, Valdés PA, Orem NR, Deleault NR, Williamson RA, Harris BT, Supattapone S. Selective incorporation of polyanionic molecules into hamster prions. (J Biol Chem, 2007 Dec 14; 282(50): 36341-53) PMID: 17949287