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Matthew S Hayden, MD, PhD

Contact Information

Professional Interests

Immune Signaling in Inflammation, Autoimmunity, and Cancer
Dysregulation of the immune response is a hallmark of disease. Unchecked innate and adaptive immunity can lead to chronic inflammation or autoimmunity, while compromised immune responses facilitate infection and tumorigenesis. The NF-kappaB signaling pathway is an essential mediator of communication amongst cells of the immune system and between the immune system and non-immune host cells. Dysregulation of NF-kappaB in autoimmunity and cancer is well described, yet effective clinical targeting of the pathway has not been achieved. In the Hayden lab, we are interested in elucidating the mechanisms leading to NF-kappaB dysregulation and are working to identify more selective approaches to manipulating NF-kappaB signaling in order to develop novel immunomodulatory therapies.

Rotations and Thesis Projects

Detection and Targeting of Oncoviruses. Use new CRISPR enzymes and NGS to target and detect viruses like HBV, HTLV-1, and MCPyV that cause human cancers.

Specificity in the NF-kappaB Pathway – Use next generation sequencing and genome editing to identify novel, selective inhibitors of the NF-kappaB in cancer.

Enhanced Tumor Targeting - Test a novel, combination therapeutic to enhance the delivery of drugs and other cargoes in melanoma.

Chronic Inflammatory Responses In Psoriasis. Use novel next generation sequencing approaches to investigate the sustained inflammatory responses driving psoriasis.

Characterization of a Tumor Suppressor. Use genome engineering and targeted resequencing to characterize the function of a novel tumor suppressor in non-melanoma skin cancer.

Grant Information

Work in the Hayden lab is currently has funding from the Department of Dermatology; BioMT Pilot Project - NIH/NIGMS P20GM113132; NIH/NIGMS SBIR R43GM133289; and The Hitchcock Foundation.

Biography

Dr. Hayden received his B.A. in 1994 in biology from Oberlin College, Oberlin OH. In 1998 he joined the Gladstone Institute of Virology and Immunology as a research assistant exploring HIV drug resistance and viral fitness. In 2000 he entered the MSTP at Yale Medical School, performing doctoral research in the department of Immunobiology. From 2010-2011 Dr. Hayden did post-doctoral research at Columbia University, before becoming an Assistant Professor in the Departments of Dermatology and Microbiology & Immunology at Columbia University Medical Center, where, in 2013 he was named the George Henry Fox Assistant Professor of Dermatology and Columbia University Medical Center. Dr. Hayden joined the Dermatology at Dartmouth-Hitchcock Medical Center and Geisel School of Medicine in 2017.