David J. Gladstone, ScD
Title(s)
Adjunct Professor of Medicine
Additional Titles/Positions/Affiliations
Professor of Engineering, Thayer School of Engineering at Dartmouth
Department(s)
Medicine
Education
Harvard Medical School, Post Doctoral Fellowship 1991
Massachusetts Institute of Technology Sc.D. 1989
University of Denver, B.S.Ch. 1983
Programs
Norris Cotton Cancer Center
Contact Information
Dartmouth Medical School
HB 7999
Hanover NH 03755
Office: 1 Medical Center Drive
Phone: 603-640-6442
Fax: 603-650-6616
Email: david.j.gladstone@dartmouth.edu
Assistant: Pamela Easton
Asst. Phone: 603-650-6614
Asst. Email: Pamela.L.Easton@hitchcock.org
Professional Interests
Highly conformal radiation therapy to spare normal tissues from damage secondary to treatment. Image guided radiation therapy, biological gating of therapeutic X-ray beams, image guided brachytherapy. Cherenkov emission during radiotherapy. Ultra-high dose rate radiation therapy to elicit the FLASH normal tissue sparing effect.
Grant Information
Drug-eluding Brachytherapy Implants Co-I 5% NIH/NCI R42CA224646-02
Norris Cotton Cancer Center Core Co-Director 2% NIH/NCI $3,290,263 Grant Radiation Shared Resource
5P30 CA 23108-40
Optical Cherenkov calibration for human radiation therapy Co-I 8% NIH $423,145 R01EB023909
Lymph node metastases optical diagnostic and radiation therapy Co-I 5% US Army $498,530
BC150584P1
Courses Taught
ENG-56, ENG-157, ENG-167, ENG-168, ENG-192
Selected Publications |
|
A Radiation Biological Analysis of the Oxygen Effect as a Possible Mechanism in FLASH. Sensitizing brain metastases to stereotactic radiosurgery using hyperbaric oxygen: A proof-of-principle study. Failure Mode and Effects Analysis (FMEA) for Experimental Use of FLASH on a Clinical Accelerator. Fast Deformable Image Registration for Real-Time Target Tracking During Radiation Therapy Using Cine MRI and Deep Learning. Clinical implementation of the first Cherenkov imaging system in a community-based hospital. Computational dose visualization & comparison in total skin electron treatment suggests superior coverage by the rotational versus the Stanford technique. Performance comparison of quantitative metrics for analysis of in vivo Cherenkov imaging incident detection during radiotherapy. One Year of Clinic-Wide Cherenkov Imaging for Discovery of Quality Improvement Opportunities in Radiation Therapy. Individual pulse monitoring and dose control system for pre-clinical implementation of FLASH-RT. Remote dose imaging from Cherenkov light using spatially resolved CT calibration in breast radiotherapy. |
|