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David J. Gladstone, ScD

Adjunct Professor of Medicine

Additional Titles/Positions/Affiliations
Professor of Engineering, Thayer School of Engineering at Dartmouth


Harvard Medical School, Post Doctoral Fellowship 1991
Massachusetts Institute of Technology Sc.D. 1989
University of Denver, B.S.Ch. 1983

Dartmouth Cancer Center

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Contact Information

Dartmouth Medical School
HB 7999
Hanover NH 03755

Office: 1 Medical Center Drive
Phone: 603-640-6442
Fax: 603-650-6616
Email: david.j.gladstone@dartmouth.edu

Assistant: Pamela Easton
Asst. Phone: 603-650-6614
Asst. Email: Pamela.L.Easton@hitchcock.org

Professional Interests

Highly conformal radiation therapy to spare normal tissues from damage secondary to treatment. Image guided radiation therapy, biological gating of therapeutic X-ray beams, image guided brachytherapy. Cherenkov emission during radiotherapy. Ultra-high dose rate radiation therapy to elicit the FLASH normal tissue sparing effect.

Grant Information

Drug-eluding Brachytherapy Implants Co-I 5% NIH/NCI R42CA224646-02

Norris Cotton Cancer Center Core Co-Director 2% NIH/NCI $3,290,263 Grant Radiation Shared Resource
5P30 CA 23108-40

Optical Cherenkov calibration for human radiation therapy Co-PI 8% NIH $423,145 R01EB023909

Electron FLASH Radiotherapy NIH U01 CA260446-01A1 Co-PI 10% $550,000/yr

Courses Taught

ENG-56, ENG-157, ENG-167, ENG-168, ENG-192

Selected Publications


Electron beam response corrections for an ultra-high-dose-rate capable diode dosimeter.
Dai T, Sloop AM, Schonfeld A, Flatten V, Kozelka J, Hildreth J, Bill S, Sunnerberg JP, Clark MA, Jarvis L, Pogue BW, Bruza P, Gladstone DJ, Zhang R
Med Phys. 2024 May 19; doi: 10.1002/mp.17121. Epub 2024 May 19.
PMID: 38762909

Anesthetic Oxygen Use and Sex Are Critical Factors in the FLASH Sparing Effect.
Tavakkoli AD, Clark MA, Kheirollah A, Sloop AM, Soderholm HE, Daniel NJ, Petusseau AF, Huang YH, Thomas CR Jr, Jarvis LA, Zhang R, Pogue BW, Gladstone DJ, Hoopes PJ
Adv Radiat Oncol. 2024 Jun;9(6):101492. doi: 10.1016/j.adro.2024.101492. Epub 2024 Mar 13.
PMID: 38711960

Technical note: Visual, rapid, scintillation point dosimetry for in vivo MV photon beam radiotherapy treatments.
Decker SM, Bruza P, Zhang R, Williams BB, Jarvis LA, Pogue BW, Gladstone DJ
Med Phys. 2024 Apr 10; doi: 10.1002/mp.17071. Epub 2024 Apr 10.
PMID: 38598093

Rapid Switching of a C-Series Linear Accelerator Between Conventional and Ultrahigh-Dose-Rate Research Mode With Beamline Modifications and Output Stabilization.
Sloop A, Ashraf MR, Rahman M, Sunnerberg J, Dexter CA, Thompson L, Gladstone DJ, Pogue BW, Bruza P, Zhang R
Int J Radiat Oncol Biol Phys. 2024 Mar 28; pii: S0360-3016(24)00299-2. doi: 10.1016/j.ijrobp.2024.01.215. Epub 2024 Mar 28.
PMID: 38552990

First Monte Carlo beam model for ultra-high dose rate radiotherapy with a compact electron LINAC.
Dai T, Sloop AM, Rahman MR, Sunnerberg JP, Clark MA, Young R, Adamczyk S, Von Voigts-Rhetz P, Patane C, Turk M, Jarvis L, Pogue BW, Gladstone DJ, Bruza P, Zhang R
Med Phys. 2024 Mar 17; doi: 10.1002/mp.17031. Epub 2024 Mar 17.
PMID: 38493501

Imaging and characterization of optical emission fromex vivotissue during conventional and UHDR PBS proton therapy.
Vasyltsiv R, Rahman M, Harms J, Clark M, Gladstone DJ, Pogue BW, Zhang R, Bruza P
Phys Med Biol. 2024 Mar 18;69(7) doi: 10.1088/1361-6560/ad2ee6. Epub 2024 Mar 18.
PMID: 38422545

Anesthetic oxygen use and sex are critical factors in the FLASH sparing effect.
Tavakkoli AD, Clark MA, Kheirollah A, Sloop AM, Soderholm HE, Daniel NJ, Petusseau AF, Huang YH, Thomas CR, Jarvis LA, Zhang R, Pogue BW, Gladstone DJ, Hoopes PJ
bioRxiv. 2023 Nov 5; pii: 2023.11.04.565626. doi: 10.1101/2023.11.04.565626. Epub 2023 Nov 5.
PMID: 37961549

Comparison of Tumor Control and Skin Damage in a Mouse Model after Ultra-High Dose Rate Irradiation and Conventional Irradiation.
Duval KEA, Aulwes E, Zhang R, Rahman M, Ashraf MR, Sloop A, Sunnerberg J, Williams BB, Cao X, Bruza P, Kheirollah A, Tavakkoli A, Jarvis LA, Schaner PE, Swartz HM, Gladstone DJ, Pogue BW, Hoopes PJ
Radiat Res. 2023 Sep 1;200(3):223-231. doi: 10.1667/RADE-23-00057.
PMID: 37590482

Proton and Electron Ultrahigh-Dose-Rate Isodose Irradiations Produce Differences in Reactive Oxygen Species Yields.
Thomas W, Sunnerberg J, Reed M, Gladstone DJ, Zhang R, Harms J, Swartz HM, Pogue BW
Int J Radiat Oncol Biol Phys. 2024 Jan 1;118(1):262-267. doi: 10.1016/j.ijrobp.2023.07.042. Epub 2023 Aug 7.
PMID: 37558097

Mean dose rate in ultra-high dose rate electron irradiation is a significant predictor for O(2)consumption and H(2)O(2)yield.
Sunnerberg JP, Zhang R, Gladstone DJ, Swartz HM, Gui J, Pogue BW
Phys Med Biol. 2023 Aug 7;68(16) doi: 10.1088/1361-6560/ace877. Epub 2023 Aug 7.
PMID: 37463588

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