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David J. Gladstone, ScD

Professor of Medicine

Additional Titles/Positions/Affiliations:
Adjunct Professor of Engineering, Thayer School of Engineering at Dartmouth
Chief of Clinical Physics, Norris Cotton Cancer Center


Harvard Medical School, Post Doctoral Fellowship 1991
Massachusetts Institute of Technology Sc.D. 1989
University of Denver, B.S.Ch. 1983

Norris Cotton Cancer Center

Contact Information:

Dartmouth Medical School
HB 7999
Hanover NH 03755

Office: 1 Medical Center Drive
Phone: 603-650-6442
Fax: 603-650-6616

Assistant: Pamela Easton
Asst. Phone: 603-650-6614
Asst. Email:

Professional Interests:

Ultra conformal radiation therapy to spare normal tissues from damage secondary to treatment. Image guided radiation therapy, biological gating of therapeutic X-ray beams, image guided brachytherapy. Cherenkov emission during radiotherapy.

Grant Information:

Drug-eluding Brachytherapy Implants Co-I 5% NIH/NCI R42CA224646-02

Norris Cotton Cancer Center Core Co-Director 2% NIH/NCI $3,290,263 Grant Radiation Shared Resource
5P30 CA 23108-40

Optical Cherenkov calibration for human radiation therapy Co-I 8% NIH $423,145 R01EB023909

Lymph node metastases optical diagnostic and radiation therapy Co-I 5% US Army $498,530

Courses Taught:

ENG-56, ENG-157, ENG-167, ENG-168, ENG-192

Selected Publications:


Optimization of in vivo Cherenkov imaging dosimetry via spectral choices for ambient background lights and filtering.
Rahman M, Bruza P, Hachadorian R, Alexander D, Cao X, Zhang R, Gladstone DJ, Pogue BW
J Biomed Opt. 2021 Oct;26(10) doi: 10.1117/1.JBO.26.10.106003.
PMID: 34643072

Optical emission-based phantom to verify coincidence of radiotherapy and imaging isocenters on an MR-linac.
Andreozzi JM, Brůža P, Cammin J, Alexander DA, Pogue BW, Green O, Gladstone DJ
J Appl Clin Med Phys. 2021 Sep;22(9):252-261. doi: 10.1002/acm2.13377. Epub 2021 Aug 19.
PMID: 34409766

Spatial and temporal dosimetry of individual electron FLASH beam pulses using radioluminescence imaging.
Rahman M, Ashraf MR, Zhang R, Gladstone DJ, Cao X, Williams BB, Jack Hoopes P, Pogue BW, Bruza P
Phys Med Biol. 2021 Jun 30;66(13) doi: 10.1088/1361-6560/ac0390. Epub 2021 Jun 30.
PMID: 34015774

Verification of field match lines in whole breast radiation therapy using Cherenkov imaging.
Hachadorian R, Farwell JC, Bruza P, Jermyn M, Gladstone DJ, Pogue BW, Jarvis LA
Radiother Oncol. 2021 Jul;160:90-96. doi: 10.1016/j.radonc.2021.04.013. Epub 2021 May 1.
PMID: 33892022

Visual Isocenter Position Enhanced Review (VIPER): a Cherenkov imaging-based solution for MR-linac daily QA.
Alexander DA, Bruza P, Rassias AG, Andreozzi JM, Pogue BW, Zhang R, Gladstone DJ
Med Phys. 2021 Jun;48(6):2750-2759. doi: 10.1002/mp.14892. Epub 2021 May 9.
PMID: 33887796

Quantification of Oxygen Depletion During FLASH Irradiation In Vitro and In Vivo.
Cao X, Zhang R, Esipova TV, Allu SR, Ashraf R, Rahman M, Gunn JR, Bruza P, Gladstone DJ, Williams BB, Swartz HM, Hoopes PJ, Vinogradov SA, Pogue BW
Int J Radiat Oncol Biol Phys. 2021 Sep 1;111(1):240-248. doi: 10.1016/j.ijrobp.2021.03.056. Epub 2021 May 18.
PMID: 33845146

In Reply to Newell et al.
Rahman M, Ramish Ashraf M, Zhang R, Bruza P, Dexter CA, Thompson L, Cao X, Williams BB, Jack Hoopes P, Pogue BW, Gladstone DJ
Int J Radiat Oncol Biol Phys. 2021 Jul 1;110(3):909-910. doi: 10.1016/j.ijrobp.2021.03.045. Epub 2021 Mar 31.
PMID: 33811977

A roadmap for research in medical physics via academic medical centers: The DIVERT Model.
Pogue BW, Zhang R, Gladstone DJ
Med Phys. 2021 Jun;48(6):3151-3159. doi: 10.1002/mp.14849. Epub 2021 Apr 7.
PMID: 33735472

Technical Note: Single-pulse beam characterization for FLASH-RT using optical imaging in a water tank.
Ashraf MR, Rahman M, Zhang R, Cao X, Williams BB, Hoopes PJ, Gladstone DJ, Pogue BW, Bruza P
Med Phys. 2021 May;48(5):2673-2681. doi: 10.1002/mp.14843. Epub 2021 Mar 31.
PMID: 33730367

Electron FLASH Delivery at Treatment Room Isocenter for Efficient Reversible Conversion of a Clinical LINAC.
Rahman M, Ashraf MR, Zhang R, Bruza P, Dexter CA, Thompson L, Cao X, Williams BB, Hoopes PJ, Pogue BW, Gladstone DJ
Int J Radiat Oncol Biol Phys. 2021 Jul 1;110(3):872-882. doi: 10.1016/j.ijrobp.2021.01.011. Epub 2021 Jan 11.
PMID: 33444695

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