David J. Gladstone, ScD
Title(s):
Professor of Medicine
Additional Titles/Positions/Affiliations:
Adjunct Professor of Engineering, Thayer School of Engineering at Dartmouth
Chief of Clinical Physics, Norris Cotton Cancer Center
Department(s):
Medicine
Education:
Harvard Medical School, Post Doctoral Fellowship 1991
Massachusetts Institute of Technology Sc.D. 1989
University of Denver, B.S.Ch. 1983
Programs:
Norris Cotton Cancer Center
Contact Information:
Dartmouth Medical School
HB 7999
Hanover NH 03755
Office: 1 Medical Center Drive
Phone: 603-650-6442
Fax: 603-650-6616
Email: david.gladstone@dartmouth.edu
Assistant: Pamela Easton
Asst. Phone: 603-650-6614
Asst. Email: Pamela.L.Easton@hitchcock.org
Professional Interests:
Ultra conformal radiation therapy to spare normal tissues from damage secondary to treatment. Image guided radiation therapy, biological gating of therapeutic X-ray beams, image guided brachytherapy. Cherenkov emission during radiotherapy.
Grant Information:
Drug-eluding Brachytherapy Implants Co-I 5% NIH/NCI R42CA224646-02
Norris Cotton Cancer Center Core Co-Director 2% NIH/NCI $3,290,263 Grant Radiation Shared Resource
5P30 CA 23108-40
Optical Cherenkov calibration for human radiation therapy Co-I 8% NIH $423,145 R01EB023909
Lymph node metastases optical diagnostic and radiation therapy Co-I 5% US Army $498,530
BC150584P1
Courses Taught:
ENG-56, ENG-157, ENG-167, ENG-168, ENG-192
Selected Publications: |
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Tissue pO2 distributions in xenograft tumors dynamically imaged by Cherenkov-excited phosphorescence during fractionated radiation therapy. Optical imaging method to quantify spatial dose variation due to the electron return effect in an MR-linac. Experimentally Observed Cherenkov Light Generation in the Eye During Radiation Therapy. Optical imaging provides rapid verification of static small beams, radiosurgery, and VMAT plans with millimeter resolution. Improvements to an optical scintillator imaging-based tissue dosimetry system. Technical Note: Quality assurance and relative dosimetry testing of a 60 Co total body irradiator using optical imaging. Assessment of imaging Cherenkov and scintillation signals in head and neck radiotherapy. Characterization of a non-contact imaging scintillator-based dosimetry system for total skin electron therapy. Cherenkov-excited luminescence scanned imaging using scanned beam differencing and iterative deconvolution in dynamic plan radiation delivery in a human breast phantom geometry. Maps of in vivo oxygen pressure with submillimetre resolution and nanomolar sensitivity enabled by Cherenkov-excited luminescence scanned imaging. |
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