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David J. Gladstone, ScD

Title(s)
Adjunct Professor of Medicine

Additional Titles/Positions/Affiliations
Professor of Engineering, Thayer School of Engineering at Dartmouth

Department(s)
Medicine

Education
Harvard Medical School, Post Doctoral Fellowship 1991
Massachusetts Institute of Technology Sc.D. 1989
University of Denver, B.S.Ch. 1983

Programs
Norris Cotton Cancer Center

Contact Information

Dartmouth Medical School
HB 7999
Hanover NH 03755

Office: 1 Medical Center Drive
Phone: 603-640-6442
Fax: 603-650-6616
Email: david.j.gladstone@dartmouth.edu

Assistant: Pamela Easton
Asst. Phone: 603-650-6614
Asst. Email: Pamela.L.Easton@hitchcock.org


Professional Interests

Highly conformal radiation therapy to spare normal tissues from damage secondary to treatment. Image guided radiation therapy, biological gating of therapeutic X-ray beams, image guided brachytherapy. Cherenkov emission during radiotherapy. Ultra-high dose rate radiation therapy to elicit the FLASH normal tissue sparing effect.

Grant Information

Drug-eluding Brachytherapy Implants Co-I 5% NIH/NCI R42CA224646-02

Norris Cotton Cancer Center Core Co-Director 2% NIH/NCI $3,290,263 Grant Radiation Shared Resource
5P30 CA 23108-40

Optical Cherenkov calibration for human radiation therapy Co-I 8% NIH $423,145 R01EB023909

Lymph node metastases optical diagnostic and radiation therapy Co-I 5% US Army $498,530
BC150584P1

Courses Taught

ENG-56, ENG-157, ENG-167, ENG-168, ENG-192


Selected Publications

 

A Radiation Biological Analysis of the Oxygen Effect as a Possible Mechanism in FLASH.
Swartz HM, Hoopes PJ, Gladstone DJ, Demidov V, Vaupel P, Flood AB, Williams BB, Zhang R, Pogue BW
Adv Exp Med Biol. 2022;1395:315-321. doi: 10.1007/978-3-031-14190-4_51.
PMID: 36527655

Sensitizing brain metastases to stereotactic radiosurgery using hyperbaric oxygen: A proof-of-principle study.
Hartford AC, Gill GS, Ravi D, Tosteson TD, Li Z, Russo G, Eskey CJ, Jarvis LA, Simmons NE, Evans LT, Williams BB, Gladstone DJ, Roberts DW, Buckey JC Jr
Radiother Oncol. 2022 Dec;177:179-184. doi: 10.1016/j.radonc.2022.10.024. Epub 2022 Oct 28.
PMID: 36404528

Failure Mode and Effects Analysis (FMEA) for Experimental Use of FLASH on a Clinical Accelerator.
Rahman M, Zhang R, Gladstone DJ, Williams BB, Chen E, Dexter CA, Thompson L, Bruza P, Pogue BW
Pract Radiat Oncol. 2022 Nov 11; pii: S1879-8500(22)00333-2. doi: 10.1016/j.prro.2022.10.011. Epub 2022 Nov 11.
PMID: 36375771

Fast Deformable Image Registration for Real-Time Target Tracking During Radiation Therapy Using Cine MRI and Deep Learning.
Hunt B, Gill GS, Alexander DA, Streeter SS, Gladstone DJ, Russo GA, Zaki BI, Pogue BW, Zhang R
Int J Radiat Oncol Biol Phys. 2022 Oct 26; pii: S0360-3016(22)03444-7. doi: 10.1016/j.ijrobp.2022.09.086. Epub 2022 Oct 26.
PMID: 36309075

Clinical implementation of the first Cherenkov imaging system in a community-based hospital.
Chen E, Pogue BW, Bruza P, Alexander DA, Andino NL, Decker SM, Gaudet DM, Gladstone DJ, Lake MJ, Levene SR, Michelson JL, Robinson HL, Stallings DN, Starkey JE, Jarvis LA
Tech Innov Patient Support Radiat Oncol. 2022 Dec;24:1-5. doi: 10.1016/j.tipsro.2022.08.011. Epub 2022 Sep 9.
PMID: 36118989

Computational dose visualization & comparison in total skin electron treatment suggests superior coverage by the rotational versus the Stanford technique.
Miao T, Zhang R, Jermyn M, Bruza P, Zhu T, Pogue BW, Gladstone DJ, Williams BB
J Med Imaging Radiat Sci. 2022 Dec;53(4):612-622. doi: 10.1016/j.jmir.2022.08.006. Epub 2022 Aug 28.
PMID: 36045017

Performance comparison of quantitative metrics for analysis of in vivo Cherenkov imaging incident detection during radiotherapy.
Decker SM, Alexander DA, Bruza P, Zhang R, Chen E, Jarvis LA, Gladstone DJ, Pogue BW
Br J Radiol. 2022 Sep 1;95(1137):20211346. doi: 10.1259/bjr.20211346. Epub 2022 Jul 27.
PMID: 35834415

One Year of Clinic-Wide Cherenkov Imaging for Discovery of Quality Improvement Opportunities in Radiation Therapy.
Alexander DA, Decker SM, Jermyn M, Bruza P, Zhang R, Chen E, McGlynn TL, Rosselot RA, Lee J, Rose ML, Williams BB, Pogue BW, Gladstone DJ, Jarvis LA
Pract Radiat Oncol. 2023 Jan-Feb;13(1):71-81. doi: 10.1016/j.prro.2022.06.009. Epub 2022 Jun 29.
PMID: 35777728

Individual pulse monitoring and dose control system for pre-clinical implementation of FLASH-RT.
Ashraf MR, Rahman M, Cao X, Duval K, Williams BB, Jack Hoopes P, Gladstone DJ, Pogue BW, Zhang R, Bruza P
Phys Med Biol. 2022 Apr 15;67(9) doi: 10.1088/1361-6560/ac5f6f. Epub 2022 Apr 15.
PMID: 35313290

Remote dose imaging from Cherenkov light using spatially resolved CT calibration in breast radiotherapy.
Hachadorian RL, Bruza P, Jermyn M, Gladstone DJ, Zhang R, Jarvis LA, Pogue BW
Med Phys. 2022 Jun;49(6):4018-4025. doi: 10.1002/mp.15614. Epub 2022 Mar 28.
PMID: 35304768

View more publications on PubMed