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David J. Gladstone, ScD

Adjunct Professor of Medicine

Additional Titles/Positions/Affiliations
Professor of Engineering, Thayer School of Engineering at Dartmouth


Harvard Medical School, Post Doctoral Fellowship 1991
Massachusetts Institute of Technology Sc.D. 1989
University of Denver, B.S.Ch. 1983

Norris Cotton Cancer Center

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Contact Information

Dartmouth Medical School
HB 7999
Hanover NH 03755

Office: 1 Medical Center Drive
Phone: 603-640-6442
Fax: 603-650-6616
Email: david.j.gladstone@dartmouth.edu

Assistant: Pamela Easton
Asst. Phone: 603-650-6614
Asst. Email: Pamela.L.Easton@hitchcock.org

Professional Interests

Highly conformal radiation therapy to spare normal tissues from damage secondary to treatment. Image guided radiation therapy, biological gating of therapeutic X-ray beams, image guided brachytherapy. Cherenkov emission during radiotherapy. Ultra-high dose rate radiation therapy to elicit the FLASH normal tissue sparing effect.

Grant Information

Drug-eluding Brachytherapy Implants Co-I 5% NIH/NCI R42CA224646-02

Norris Cotton Cancer Center Core Co-Director 2% NIH/NCI $3,290,263 Grant Radiation Shared Resource
5P30 CA 23108-40

Optical Cherenkov calibration for human radiation therapy Co-PI 8% NIH $423,145 R01EB023909

Electron FLASH Radiotherapy NIH U01 CA260446-01A1 Co-PI 10% $550,000/yr

Courses Taught

ENG-56, ENG-157, ENG-167, ENG-168, ENG-192

Selected Publications


Comparison of Tumor Control and Skin Damage in a Mouse Model after Ultra-High Dose Rate Irradiation and Conventional Irradiation.
Duval KEA, Aulwes E, Zhang R, Rahman M, Ashraf MR, Sloop A, Sunnerberg J, Williams BB, Cao X, Bruza P, Kheirollah A, Tavakkoli A, Jarvis LA, Schaner PE, Swartz HM, Gladstone DJ, Pogue BW, Hoopes PJ
Radiat Res. 2023 Sep 1;200(3):223-231. doi: 10.1667/RADE-23-00057.
PMID: 37590482

Proton and Electron Ultrahigh-Dose-Rate Isodose Irradiations Produce Differences in Reactive Oxygen Species Yields.
Thomas W, Sunnerberg J, Reed M, Gladstone DJ, Zhang R, Harms J, Swartz HM, Pogue BW
Int J Radiat Oncol Biol Phys. 2023 Aug 7; pii: S0360-3016(23)07729-5. doi: 10.1016/j.ijrobp.2023.07.042. Epub 2023 Aug 7.
PMID: 37558097

Mean dose rate in ultra-high dose rate electron irradiation is a significant predictor for O(2)consumption and H(2)O(2)yield.
Sunnerberg JP, Zhang R, Gladstone DJ, Swartz HM, Gui J, Pogue BW
Phys Med Biol. 2023 Aug 7;68(16) doi: 10.1088/1361-6560/ace877. Epub 2023 Aug 7.
PMID: 37463588

Characterization of a diode dosimeter for UHDR FLASH radiotherapy.
Rahman M, Kozelka J, Hildreth J, Schonfeld A, Sloop AM, Ashraf MR, Bruza P, Gladstone DJ, Pogue BW, Simon WE, Zhang R
Med Phys. 2023 Sep;50(9):5875-5883. doi: 10.1002/mp.16474. Epub 2023 May 30.
PMID: 37249058

Education case report: CAMPEP Medical Physics PhD education program within Engineering.
Pogue BW, Gladstone DJ, Zhang R
J Appl Clin Med Phys. 2023 Jun;24(6):e14037. doi: 10.1002/acm2.14037. Epub 2023 May 21.
PMID: 37211701

Framework for Quality Assurance of Ultrahigh Dose Rate Clinical Trials Investigating FLASH Effects and Current Technology Gaps.
Zou W, Zhang R, Schuler E, Taylor PA, Mascia AE, Diffenderfer ES, Zhao T, Ayan AS, Sharma M, Yu SJ, Lu W, Bosch WR, Tsien C, Surucu M, Pollard-Larkin JM, Schuemann J, Moros EG, Bazalova-Carter M, Gladstone DJ, Li H, Simone CB 2nd, Petersson K, Kry SF, Maity A, Loo BW Jr, Dong L, Maxim PG, Xiao Y, Buchsbaum JC
Int J Radiat Oncol Biol Phys. 2023 Aug 1;116(5):1202-1217. doi: 10.1016/j.ijrobp.2023.04.018. Epub 2023 Apr 28.
PMID: 37121362

Color-resolved Cherenkov imaging allows for differential signal detection in blood and melanin content.
Wickramasinghe VA, Decker SM, Streeter SS, Sloop AM, Petusseau AF, Alexander DA, Bruza P, Gladstone DJ, Zhang R, Pogue BW
J Biomed Opt. 2023 Mar;28(3):036005. doi: 10.1117/1.JBO.28.3.036005. Epub 2023 Mar 13.
PMID: 36923987

A Radiation Biological Analysis of the Oxygen Effect as a Possible Mechanism in FLASH.
Swartz HM, Hoopes PJ, Gladstone DJ, Demidov V, Vaupel P, Flood AB, Williams BB, Zhang R, Pogue BW
Adv Exp Med Biol. 2022;1395:315-321. doi: 10.1007/978-3-031-14190-4_51.
PMID: 36527655

Sensitizing brain metastases to stereotactic radiosurgery using hyperbaric oxygen: A proof-of-principle study.
Hartford AC, Gill GS, Ravi D, Tosteson TD, Li Z, Russo G, Eskey CJ, Jarvis LA, Simmons NE, Evans LT, Williams BB, Gladstone DJ, Roberts DW, Buckey JC Jr
Radiother Oncol. 2022 Dec;177:179-184. doi: 10.1016/j.radonc.2022.10.024. Epub 2022 Oct 28.
PMID: 36404528

Failure Mode and Effects Analysis for Experimental Use of FLASH on a Clinical Accelerator.
Rahman M, Zhang R, Gladstone DJ, Williams BB, Chen E, Dexter CA, Thompson L, Bruza P, Pogue BW
Pract Radiat Oncol. 2023 Mar-Apr;13(2):153-165. doi: 10.1016/j.prro.2022.10.011. Epub 2022 Nov 12.
PMID: 36375771

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