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David J. Gladstone, ScD

Professor of Medicine

Additional Titles/Positions/Affiliations
Professor of Engineering, Thayer School of Engineering at Dartmouth


Harvard Medical School, Post Doctoral Fellowship 1991
Massachusetts Institute of Technology Sc.D. 1989
University of Denver, B.S.Ch. 1983

Norris Cotton Cancer Center

Contact Information

Dartmouth Medical School
HB 7999
Hanover NH 03755

Office: 1 Medical Center Drive
Phone: 802-277-0777
Fax: 603-650-6616

Assistant: Pamela Easton
Asst. Phone: 603-650-6614
Asst. Email:

Professional Interests

Ultra conformal radiation therapy to spare normal tissues from damage secondary to treatment. Image guided radiation therapy, biological gating of therapeutic X-ray beams, image guided brachytherapy. Cherenkov emission during radiotherapy.

Grant Information

Drug-eluding Brachytherapy Implants Co-I 5% NIH/NCI R42CA224646-02

Norris Cotton Cancer Center Core Co-Director 2% NIH/NCI $3,290,263 Grant Radiation Shared Resource
5P30 CA 23108-40

Optical Cherenkov calibration for human radiation therapy Co-I 8% NIH $423,145 R01EB023909

Lymph node metastases optical diagnostic and radiation therapy Co-I 5% US Army $498,530

Courses Taught

ENG-56, ENG-157, ENG-167, ENG-168, ENG-192

Selected Publications


Individual pulse monitoring and dose control system for pre-clinical implementation of FLASH-RT.
Ashraf MR, Rahman M, Cao X, Duval K, Williams BB, Jack Hoopes P, Gladstone DJ, Pogue BW, Zhang R, Bruza P
Phys Med Biol. 2022 Apr 15;67(9) doi: 10.1088/1361-6560/ac5f6f. Epub 2022 Apr 15.
PMID: 35313290

Remote dose imaging from Cherenkov light using spatially resolved CT calibration in breast radiotherapy.
Hachadorian RL, Bruza P, Jermyn M, Gladstone DJ, Zhang R, Jarvis LA, Pogue BW
Med Phys. 2022 Mar 19; doi: 10.1002/mp.15614. Epub 2022 Mar 19.
PMID: 35304768

Treatment Planning System for Electron FLASH Radiation Therapy: Open-Source for Clinical Implementation.
Rahman M, Ashraf MR, Gladstone DJ, Bruza P, Jarvis LA, Schaner PE, Cao X, Pogue BW, Hoopes PJ, Zhang R
Int J Radiat Oncol Biol Phys. 2022 Mar 15;112(4):1023-1032. doi: 10.1016/j.ijrobp.2021.10.148. Epub 2021 Nov 8.
PMID: 34762969

Color Cherenkov imaging of clinical radiation therapy.
Alexander DA, Nomezine A, Jarvis LA, Gladstone DJ, Pogue BW, Bruza P
Light Sci Appl. 2021 Nov 4;10(1):226. doi: 10.1038/s41377-021-00660-0. Epub 2021 Nov 4.
PMID: 34737264

Optimization of in vivo Cherenkov imaging dosimetry via spectral choices for ambient background lights and filtering.
Rahman M, Bruza P, Hachadorian R, Alexander D, Cao X, Zhang R, Gladstone DJ, Pogue BW
J Biomed Opt. 2021 Oct;26(10) doi: 10.1117/1.JBO.26.10.106003.
PMID: 34643072

Optical emission-based phantom to verify coincidence of radiotherapy and imaging isocenters on an MR-linac.
Andreozzi JM, Brůža P, Cammin J, Alexander DA, Pogue BW, Green O, Gladstone DJ
J Appl Clin Med Phys. 2021 Sep;22(9):252-261. doi: 10.1002/acm2.13377. Epub 2021 Aug 19.
PMID: 34409766

Spatial and temporal dosimetry of individual electron FLASH beam pulses using radioluminescence imaging.
Rahman M, Ashraf MR, Zhang R, Gladstone DJ, Cao X, Williams BB, Jack Hoopes P, Pogue BW, Bruza P
Phys Med Biol. 2021 Jun 30;66(13) doi: 10.1088/1361-6560/ac0390. Epub 2021 Jun 30.
PMID: 34015774

Verification of field match lines in whole breast radiation therapy using Cherenkov imaging.
Hachadorian R, Farwell JC, Bruza P, Jermyn M, Gladstone DJ, Pogue BW, Jarvis LA
Radiother Oncol. 2021 Jul;160:90-96. doi: 10.1016/j.radonc.2021.04.013. Epub 2021 May 1.
PMID: 33892022

Visual Isocenter Position Enhanced Review (VIPER): a Cherenkov imaging-based solution for MR-linac daily QA.
Alexander DA, Bruza P, Rassias AG, Andreozzi JM, Pogue BW, Zhang R, Gladstone DJ
Med Phys. 2021 Jun;48(6):2750-2759. doi: 10.1002/mp.14892. Epub 2021 May 9.
PMID: 33887796

Quantification of Oxygen Depletion During FLASH Irradiation In Vitro and In Vivo.
Cao X, Zhang R, Esipova TV, Allu SR, Ashraf R, Rahman M, Gunn JR, Bruza P, Gladstone DJ, Williams BB, Swartz HM, Hoopes PJ, Vinogradov SA, Pogue BW
Int J Radiat Oncol Biol Phys. 2021 Sep 1;111(1):240-248. doi: 10.1016/j.ijrobp.2021.03.056. Epub 2021 May 18.
PMID: 33845146

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