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David J. Gladstone, ScD

Professor of Medicine

Additional Titles/Positions/Affiliations:
Adjunct Professor of Engineering, Thayer School of Engineering at Dartmouth
Chief of Clinical Physics, Norris Cotton Cancer Center


Harvard Medical School, Post Doctoral Fellowship 1991
Massachusetts Institute of Technology Sc.D. 1989
University of Denver, B.S.Ch. 1983

EPR Center at Dartmouth Medical School
Norris Cotton Cancer Center

Contact Information:

Dartmouth Medical School
HB 7999
Hanover NH 03755

Office: 1 Medical Center Drive
Phone: 603-650-6442
Fax: 603-650-6616
Email: david.gladstone@dartmouth.edu

Assistant: Pamela Easton
Asst. Phone: 603-650-6614
Asst. Email: Pamela.L.Easton@hitchcock.org

Professional Interests:

Ultra conformal radiation therapy to spare normal tissues from damage secondary to treatment. Image guided radiation therapy, biological gating of therapeutic X-ray beams, image guided brachytherapy. Cherenkov emission during radiotherapy. EPR dosimetry.

Grant Information:

NIH/PO1 GM51630-05 Physics Consultant
NIH / NCI 1R43CA78005-01 - Phase II Co-Investigator
ACS grant #IRG82-003016IRG IRG-157M PI
NIH/NCI P01 CA23108-35 Co-director Radiation Shared Resource
NIH/NCI R43 CA103567-01 Co-Investigator

Courses Taught:

ENG-56, ENG-157, ENG-167, ENG-168, ENG-192

Selected Publications:


Cherenkov-excited luminescence scanned imaging using scanned beam differencing and iterative deconvolution in dynamic plan radiation delivery in a human breast phantom geometry.
Jia MJ, Bruza P, Andreozzi JM, Jarvis LA, Gladstone DJ, Pogue BW
Med Phys. 2019 Apr 13; doi: 10.1002/mp.13545. Epub 2019 Apr 13.
PMID: 30980725

Maps of in vivo oxygen pressure with submillimetre resolution and nanomolar sensitivity enabled by Cherenkov-excited luminescence scanned imaging.
Pogue BW, Feng J, LaRochelle EP, Bruža P, Lin H, Zhang R, Shell JR, Dehghani H, Davis SC, Vinogradov SA, Gladstone DJ, Jarvis LA
Nat Biomed Eng. 2018 Apr;2(4):254-264. doi: 10.1038/s41551-018-0220-3. Epub 2018 Apr 13.
PMID: 30899599

Multi-beam scan analysis with a clinical LINAC for high resolution Cherenkov-excited molecular luminescence imaging in tissue.
Jia MJ, Bruza P, Jarvis LA, Gladstone DJ, Pogue BW
Biomed Opt Express. 2018 Sep 1;9(9):4217-4234. doi: 10.1364/BOE.9.004217. Epub 2018 Aug 14.
PMID: 30615721

Technical Note: Time-gating to medical linear accelerator pulses: Stray radiation detector.
Ashraf MR, Bruza P, Krishnaswamy V, Gladstone DJ, Pogue BW
Med Phys. 2019 Feb;46(2):1044-1048. doi: 10.1002/mp.13311. Epub 2018 Dec 14.
PMID: 30488442

Cherenkov imaging for linac beam shape analysis as a remote electronic quality assessment verification tool.
Miao T, Bruza P, Pogue BW, Jermyn M, Krishnaswamy V, Ware W, Rafie F, Gladstone DJ, Williams BB
Med Phys. 2019 Feb;46(2):811-821. doi: 10.1002/mp.13303. Epub 2018 Dec 14.
PMID: 30471126

Remote Cherenkov imaging-based quality assurance of a magnetic resonance image-guided radiotherapy system.
Andreozzi JM, Mooney KE, Brůža P, Curcuru A, Gladstone DJ, Pogue BW, Green O
Med Phys. 2018 Jun;45(6):2647-2659. doi: 10.1002/mp.12919. Epub 2018 May 3.
PMID: 29663429

Improving treatment geometries in total skin electron therapy: Experimental investigation of linac angles and floor scatter dose contributions using Cherenkov imaging.
Andreozzi JM, Brůža P, Tendler II, Mooney KE, Jarvis LA, Cammin J, Li H, Pogue BW, Gladstone DJ
Med Phys. 2018 Jun;45(6):2639-2646. doi: 10.1002/mp.12917. Epub 2018 May 6.
PMID: 29663425

Treatment of Canine Oral Melanoma with Nanotechnology-Based Immunotherapy and Radiation.
Hoopes PJ, Wagner RJ, Duval K, Kang K, Gladstone DJ, Moodie KL, Crary-Burney M, Ariaspulido H, Veliz FA, Steinmetz NF, Fiering SN
Mol Pharm. 2018 Sep 4;15(9):3717-3722. doi: 10.1021/acs.molpharmaceut.8b00126. Epub 2018 Apr 12.
PMID: 29613803

Time-gated scintillator imaging for real-time optical surface dosimetry in total skin electron therapy.
Bruza P, Gollub SL, Andreozzi JM, Tendler II, Williams BB, Jarvis LA, Gladstone DJ, Pogue BW
Phys Med Biol. 2018 May 2;63(9):095009. doi: 10.1088/1361-6560/aaba19. Epub 2018 May 2.
PMID: 29588437

Radiotherapy-induced Cherenkov luminescence imaging in a human body phantom.
Ahmed SR, Jia JM, Bruza P, Vinogradov S, Jiang S, Gladstone DJ, Jarvis LA, Pogue BW
J Biomed Opt. 2018 Mar;23(3):1-4. doi: 10.1117/1.JBO.23.3.030504.
PMID: 29560623

View more publications on PubMed