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David J. Gladstone, ScD

Professor of Medicine

Additional Titles/Positions/Affiliations:
Adjunct Professor of Engineering, Thayer School of Engineering at Dartmouth
Chief of Clinical Physics, Norris Cotton Cancer Center


Harvard Medical School, Post Doctoral Fellowship 1991
Massachusetts Institute of Technology Sc.D. 1989
University of Denver, B.S.Ch. 1983

Norris Cotton Cancer Center

Contact Information:

Dartmouth Medical School
HB 7999
Hanover NH 03755

Office: 1 Medical Center Drive
Phone: 603-650-6442
Fax: 603-650-6616

Assistant: Pamela Easton
Asst. Phone: 603-650-6614
Asst. Email:

Professional Interests:

Ultra conformal radiation therapy to spare normal tissues from damage secondary to treatment. Image guided radiation therapy, biological gating of therapeutic X-ray beams, image guided brachytherapy. Cherenkov emission during radiotherapy.

Grant Information:

Drug-eluding Brachytherapy Implants Co-I 5% NIH/NCI R42CA224646-02

Norris Cotton Cancer Center Core Co-Director 2% NIH/NCI $3,290,263 Grant Radiation Shared Resource
5P30 CA 23108-40

Optical Cherenkov calibration for human radiation therapy Co-I 8% NIH $423,145 R01EB023909

Lymph node metastases optical diagnostic and radiation therapy Co-I 5% US Army $498,530

Courses Taught:

ENG-56, ENG-157, ENG-167, ENG-168, ENG-192

Selected Publications:


Producing a Beam Model of the Varian ProBeam Proton Therapy System using TOPAS Monte Carlo Toolkit.
Rahman M, Bruza P, Lin Y, Gladstone DJ, Pogue BW, Zhang R
Med Phys. 2020 Oct 8; doi: 10.1002/mp.14532. Epub 2020 Oct 8.
PMID: 33030241

High Resolution pO2 Imaging Improves Quantification of the Hypoxic Fraction in Tumors during Radiotherapy.
Cao X, Allu SR, Jiang S, Gunn JR, Yao C, Xin J, Bruza P, Gladstone DJ, Jarvis LA, Tian J, Swartz HM, Vinogradov SA, Pogue BW
Int J Radiat Oncol Biol Phys. 2020 Sep 28; pii: S0360-3016(20)34348-0. doi: 10.1016/j.ijrobp.2020.09.046. Epub 2020 Sep 28.
PMID: 33002542

Scintillation imaging as a high-resolution, remote, versatile 2D detection system for MR-linac quality assurance.
Alexander DA, Zhang R, Brůža P, Pogue BW, Gladstone DJ
Med Phys. 2020 Jun 24; doi: 10.1002/mp.14353. Epub 2020 Jun 24.
PMID: 32583484

Computer animation body surface analysis of total skin electron radiation therapy dose homogeneity via Cherenkov imaging.
Miao T, Petroccia H, Xie Y, Jermyn M, Perroni-Scharf M, Kapoor N, Mahoney JM, Zhu TC, Bruza P, Williams BB, Gladstone DJ, Pogue BW
J Med Imaging (Bellingham). 2020 May;7(3):034002. doi: 10.1117/1.JMI.7.3.034002. Epub 2020 Jun 3.
PMID: 32509916

Characterization of a new scintillation imaging system for proton pencil beam dose rate measurements.
Rahman M, Brůža P, Langen KM, Gladstone DJ, Cao X, Pogue BW, Zhang R
Phys Med Biol. 2020 Aug 21;65(16):165014. doi: 10.1088/1361-6560/ab9452. Epub 2020 Aug 21.
PMID: 32428888

Technical Note: A novel dosimeter improves total skin electron therapy surface dosimetry workflow.
Tendler II, Bruza P, Jermyn M, Soter J, Sharp G, Williams B, Jarvis LA, Pogue B, Gladstone DJ
J Appl Clin Med Phys. 2020 Jun;21(6):158-162. doi: 10.1002/acm2.12880. Epub 2020 Apr 19.
PMID: 32306551

Tracking tumor radiotherapy response in vivo with Cherenkov-excited luminescence ink imaging.
Soter JA, LaRochelle EPM, Byrd BK, Tendler II, Gunn JR, Meng B, Strawbridge RR, Wirth DJ, Davis SC, Gladstone DJ, Jarvis LA, Pogue BW
Phys Med Biol. 2020 Apr 28;65(9):095004. doi: 10.1088/1361-6560/ab7d16. Epub 2020 Apr 28.
PMID: 32135522

Tissue pO2 distributions in xenograft tumors dynamically imaged by Cherenkov-excited phosphorescence during fractionated radiation therapy.
Cao X, Rao Allu S, Jiang S, Jia M, Gunn JR, Yao C, LaRochelle EP, Shell JR, Bruza P, Gladstone DJ, Jarvis LA, Tian J, Vinogradov SA, Pogue BW
Nat Commun. 2020 Jan 29;11(1):573. doi: 10.1038/s41467-020-14415-9. Epub 2020 Jan 29.
PMID: 31996677

Optical imaging method to quantify spatial dose variation due to the electron return effect in an MR-linac.
Andreozzi JM, Brůža P, Cammin J, Pogue BW, Gladstone DJ, Green O
Med Phys. 2020 Mar;47(3):1258-1267. doi: 10.1002/mp.13954. Epub 2019 Dec 25.
PMID: 31821573

Experimentally Observed Cherenkov Light Generation in the Eye During Radiation Therapy.
Tendler II, Hartford A, Jermyn M, LaRochelle E, Cao X, Borza V, Alexander D, Bruza P, Hoopes J, Moodie K, Marr BP, Williams BB, Pogue BW, Gladstone DJ, Jarvis LA
Int J Radiat Oncol Biol Phys. 2020 Feb 1;106(2):422-429. doi: 10.1016/j.ijrobp.2019.10.031. Epub 2019 Oct 25.
PMID: 31669563

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