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David J. Gladstone, ScD

Title(s)
Adjunct Professor of Medicine

Additional Titles/Positions/Affiliations
Professor of Engineering, Thayer School of Engineering at Dartmouth

Department(s)
Medicine

Education
Harvard Medical School, Post Doctoral Fellowship 1991
Massachusetts Institute of Technology Sc.D. 1989
University of Denver, B.S.Ch. 1983

Programs
Dartmouth Cancer Center

Academic Analytics
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Contact Information

Dartmouth Medical School
HB 7999
Hanover NH 03755

Office: 1 Medical Center Drive
Phone: 603-640-6442
Fax: 603-650-6616
Email: david.j.gladstone@dartmouth.edu


Professional Interests

Highly conformal radiation therapy to spare normal tissues from damage secondary to treatment. Image guided radiation therapy, biological gating of therapeutic X-ray beams, image guided brachytherapy. Cherenkov emission during radiotherapy. Ultra-high dose rate radiation therapy to elicit the FLASH normal tissue sparing effect.

Grant Information

Drug-eluding Brachytherapy Implants Co-I 5% NIH/NCI R42CA224646-02

Norris Cotton Cancer Center Core Co-Director 2% NIH/NCI $3,290,263 Grant Radiation Shared Resource
5P30 CA 23108-40

Optical Cherenkov calibration for human radiation therapy Co-PI 8% NIH $423,145 R01EB023909

Electron FLASH Radiotherapy NIH U01 CA260446-01A1 Co-PI 10% $550,000/yr

Courses Taught

ENG-56, ENG-157, ENG-167, ENG-168, ENG-192


Selected Publications

 

Oxygen Consumption In Vivo by Ultra-High Dose Rate Electron Irradiation Depends upon Baseline Tissue Oxygenation.
Sunnerberg JP, Tavakkoli AD, Petusseau AF, Daniel NJ, Sloop AM, Schreiber WA, Gui J, Zhang R, Swartz HM, Hoopes PJ, Gladstone DJ, Vinogradov SA, Pogue BW
Int J Radiat Oncol Biol Phys. 2024 Oct 24; pii: S0360-3016(24)03510-7. doi: 10.1016/j.ijrobp.2024.10.018. Epub 2024 Oct 24.
PMID: 39461597

Cherenkov imaging combined with scintillation dosimetry provides real-time positional and dose monitoring for radiotherapy patients with cardiac implanted electronic devices.
Decker SM, Matous AL, Zhang R, Gladstone DJ, Grove EK, Williams BB, Jermyn M, McVorran S, Jarvis LA
Phys Imaging Radiat Oncol. 2024 Oct;32:100642. doi: 10.1016/j.phro.2024.100642. Epub 2024 Sep 12.
PMID: 39315342

Robust Real-time Segmentation of Bio-Morphological Features in Human Cherenkov Imaging during Radiotherapy via Deep Learning.
Wang S, Chen Y, Jarvis LA, Tang Y, Gladstone DJ, Samkoe KS, Pogue BW, Bruza P, Zhang R
ArXiv. 2024 Sep 9; Epub 2024 Sep 9.
PMID: 39314506

Dynamic oxygen assessment techniques enable determination of anesthesia's impact on tissue.
Clark MA, Tavakkoli AD, Petusseau AF, Scorzo AV, Kheirollah A, Davis SC, Strawbridge RR, Bruza P, Pogue BW, Gladstone DJ, Hoopes PJ
Res Sq. 2024 Aug 27; pii: rs.3.rs-4751349. doi: 10.21203/rs.3.rs-4751349/v1. Epub 2024 Aug 27.
PMID: 39257989

Visual Dose Monitoring for Whole Breast Radiation Therapy Treatments via Combined Cherenkov Imaging and Scintillation Dosimetry.
Decker SM, Bruza P, Zhang R, Pogue BW, Gladstone DJ, Jarvis LA
Int J Radiat Oncol Biol Phys. 2024 Sep 7; pii: S0360-3016(24)03291-7. doi: 10.1016/j.ijrobp.2024.08.033. Epub 2024 Sep 7.
PMID: 39182736

Commissioning an ultra-high-dose-rate electron linac with end-to-end tests.
Dai T, Sloop AM, Ashraf MR, Sunnerberg JP, Clark MA, Bruza P, Pogue BW, Jarvis L, Gladstone DJ, Zhang R
Phys Med Biol. 2024 Aug 9;69(16) doi: 10.1088/1361-6560/ad69fc. Epub 2024 Aug 9.
PMID: 39084661

Electron beam response corrections for an ultra-high-dose-rate capable diode dosimeter.
Dai T, Sloop AM, Schonfeld A, Flatten V, Kozelka J, Hildreth J, Bill S, Sunnerberg JP, Clark MA, Jarvis L, Pogue BW, Bruza P, Gladstone DJ, Zhang R
Med Phys. 2024 Aug;51(8):5738-5745. doi: 10.1002/mp.17121. Epub 2024 May 19.
PMID: 38762909

Anesthetic Oxygen Use and Sex Are Critical Factors in the FLASH Sparing Effect.
Tavakkoli AD, Clark MA, Kheirollah A, Sloop AM, Soderholm HE, Daniel NJ, Petusseau AF, Huang YH, Thomas CR Jr, Jarvis LA, Zhang R, Pogue BW, Gladstone DJ, Hoopes PJ
Adv Radiat Oncol. 2024 Jun;9(6):101492. doi: 10.1016/j.adro.2024.101492. Epub 2024 Mar 13.
PMID: 38711960

Technical note: Visual, rapid, scintillation point dosimetry for in vivo MV photon beam radiotherapy treatments.
Decker SM, Bruza P, Zhang R, Williams BB, Jarvis LA, Pogue BW, Gladstone DJ
Med Phys. 2024 Aug;51(8):5754-5763. doi: 10.1002/mp.17071. Epub 2024 Apr 10.
PMID: 38598093

Rapid Switching of a C-Series Linear Accelerator Between Conventional and Ultrahigh-Dose-Rate Research Mode With Beamline Modifications and Output Stabilization.
Sloop A, Ashraf MR, Rahman M, Sunnerberg J, Dexter CA, Thompson L, Gladstone DJ, Pogue BW, Bruza P, Zhang R
Int J Radiat Oncol Biol Phys. 2024 Jul 15;119(4):1317-1325. doi: 10.1016/j.ijrobp.2024.01.215. Epub 2024 Mar 28.
PMID: 38552990

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