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David J. Gladstone, ScD

Title(s):
Professor of Medicine

Additional Titles/Positions/Affiliations:
Adjunct Professor of Engineering, Thayer School of Engineering at Dartmouth
Chief of Clinical Physics, Norris Cotton Cancer Center

Department(s):
Medicine

Education:
Harvard Medical School, Post Doctoral Fellowship 1991
Massachusetts Institute of Technology Sc.D. 1989
University of Denver, B.S.Ch. 1983

Programs:
Norris Cotton Cancer Center

Contact Information:

Dartmouth Medical School
HB 7999
Hanover NH 03755

Office: 1 Medical Center Drive
Phone: 603-650-6442
Fax: 603-650-6616
Email: david.gladstone@dartmouth.edu

Assistant: Pamela Easton
Asst. Phone: 603-650-6614
Asst. Email: Pamela.L.Easton@hitchcock.org


Professional Interests:

Ultra conformal radiation therapy to spare normal tissues from damage secondary to treatment. Image guided radiation therapy, biological gating of therapeutic X-ray beams, image guided brachytherapy. Cherenkov emission during radiotherapy.

Grant Information:

Drug-eluding Brachytherapy Implants Co-I 5% NIH/NCI R42CA224646-02

Norris Cotton Cancer Center Core Co-Director 2% NIH/NCI $3,290,263 Grant Radiation Shared Resource
5P30 CA 23108-40

Optical Cherenkov calibration for human radiation therapy Co-I 8% NIH $423,145 R01EB023909

Lymph node metastases optical diagnostic and radiation therapy Co-I 5% US Army $498,530
BC150584P1

Courses Taught:

ENG-56, ENG-157, ENG-167, ENG-168, ENG-192


Selected Publications:

 

Quantification of oxygen depletion during FLASH irradiation in vitro and in vivo.
Cao X, Zhang R, Esipova TV, Allu SR, Ashraf R, Rahman M, Gunn JR, Bruza P, Gladstone DJ, Williams BB, Swartz HM, Hoopes PJ, Vinogradov SA, Pogue BW
Int J Radiat Oncol Biol Phys. 2021 Apr 9; pii: S0360-3016(21)00358-8. doi: 10.1016/j.ijrobp.2021.03.056. Epub 2021 Apr 9.
PMID: 33845146

Response to Comments Regarding: Electron FLASH Delivery at Treatment Room Isocenter for Efficient Reversible Conversion of a Clinical LINAC.
Rahman M, Ramish Ashraf M, Zhang R, Bruza P, Dexter CA, Thompson L, Cao X, Williams BB, Jack Hoopes P, Pogue BW, Gladstone DJ
Int J Radiat Oncol Biol Phys. 2021 Mar 27; pii: S0360-3016(21)00307-2. doi: 10.1016/j.ijrobp.2021.03.045. Epub 2021 Mar 27.
PMID: 33811977

A roadmap for research in medical physics via academic medical centers: The DIVERT Model.
Pogue BW, Zhang R, Gladstone DJ
Med Phys. 2021 Mar 18; doi: 10.1002/mp.14849. Epub 2021 Mar 18.
PMID: 33735472

Technical Note: Single-pulse beam characterization for FLASH-RT using optical imaging in a water tank.
Ashraf MR, Rahman M, Zhang R, Cao X, Williams BB, Hoopes PJ, Gladstone DJ, Pogue BW, Bruza P
Med Phys. 2021 Mar 17; doi: 10.1002/mp.14843. Epub 2021 Mar 17.
PMID: 33730367

Electron FLASH Delivery at Treatment Room Isocenter for Efficient Reversible Conversion of a Clinical LINAC.
Rahman M, Ashraf MR, Zhang R, Bruza P, Dexter CA, Thompson L, Cao X, Williams BB, Hoopes PJ, Pogue BW, Gladstone DJ
Int J Radiat Oncol Biol Phys. 2021 Jan 11; pii: S0360-3016(21)00024-9. doi: 10.1016/j.ijrobp.2021.01.011. Epub 2021 Jan 11.
PMID: 33444695

NRG Oncology Survey on Practice and Technology Use in SRT and SBRT Delivery.
Chetvertkov M, Monroe JI, Boparai J, Solberg TD, Pafundi DH, Ruo RL, Gladstone DJ, Yin FF, Chetty IJ, Benedict S, Followill DS, Xiao Y, Sohn JW
Front Oncol. 2020;10:602607. doi: 10.3389/fonc.2020.602607. Epub 2020 Nov 27.
PMID: 33330102

Initial Clinical Experience of Cherenkov Imaging in External Beam Radiation Therapy Identifies Opportunities to Improve Treatment Delivery.
Jarvis LA, Hachadorian RL, Jermyn M, Bruza P, Alexander DA, Tendler II, Williams BB, Gladstone DJ, Schaner PE, Zaki BI, Pogue BW
Int J Radiat Oncol Biol Phys. 2021 Apr 1;109(5):1627-1637. doi: 10.1016/j.ijrobp.2020.11.013. Epub 2020 Nov 20.
PMID: 33227443

Detective quantum efficiency of intensified CMOS cameras for Cherenkov imaging in radiotherapy.
Alexander DA, Bruza P, Farwell JCM, Krishnaswamy V, Zhang R, Gladstone DJ, Pogue BW
Phys Med Biol. 2020 Nov 12;65(22):225013. doi: 10.1088/1361-6560/abb0c5. Epub 2020 Nov 12.
PMID: 33179612

Producing a Beam Model of the Varian ProBeam Proton Therapy System using TOPAS Monte Carlo Toolkit.
Rahman M, Bruza P, Lin Y, Gladstone DJ, Pogue BW, Zhang R
Med Phys. 2020 Dec;47(12):6500-6508. doi: 10.1002/mp.14532. Epub 2020 Nov 8.
PMID: 33030241

Scintillation imaging as a high-resolution, remote, versatile 2D detection system for MR-linac quality assurance.
Alexander DA, Zhang R, Brůža P, Pogue BW, Gladstone DJ
Med Phys. 2020 Sep;47(9):3861-3869. doi: 10.1002/mp.14353. Epub 2020 Jul 18.
PMID: 32583484

View more publications on PubMed