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David J. Gladstone, ScD

Professor of Medicine

Additional Titles/Positions/Affiliations:
Adjunct Professor of Engineering, Thayer School of Engineering at Dartmouth
Chief of Clinical Physics, Norris Cotton Cancer Center


Harvard Medical School, Post Doctoral Fellowship 1991
Massachusetts Institute of Technology Sc.D. 1989
University of Denver, B.S.Ch. 1983

Norris Cotton Cancer Center

Contact Information:

Dartmouth Medical School
HB 7999
Hanover NH 03755

Office: 1 Medical Center Drive
Phone: 603-650-6442
Fax: 603-650-6616
Email: david.gladstone@dartmouth.edu

Assistant: Pamela Easton
Asst. Phone: 603-650-6614
Asst. Email: Pamela.L.Easton@hitchcock.org

Professional Interests:

Ultra conformal radiation therapy to spare normal tissues from damage secondary to treatment. Image guided radiation therapy, biological gating of therapeutic X-ray beams, image guided brachytherapy. Cherenkov emission during radiotherapy.

Grant Information:

Drug-eluding Brachytherapy Implants Co-I 5% NIH/NCI R42CA224646-02

Norris Cotton Cancer Center Core Co-Director 2% NIH/NCI $3,290,263 Grant Radiation Shared Resource
5P30 CA 23108-40

Optical Cherenkov calibration for human radiation therapy Co-I 8% NIH $423,145 R01EB023909

Lymph node metastases optical diagnostic and radiation therapy Co-I 5% US Army $498,530

Courses Taught:

ENG-56, ENG-157, ENG-167, ENG-168, ENG-192

Selected Publications:


Tracking tumor radiotherapy response <i>in vivo</i> with Cherenkov-excited luminescence ink imaging.
Soter J, LaRochelle EPM, Byrd BK, Tendler II, Gunn JR, Meng B, Strawbridge RR, Wirth DJ, Davis SC, Gladstone DJ, Jarvis LA, Pogue BW
Phys Med Biol. 2020 Mar 5; doi: 10.1088/1361-6560/ab7d16. Epub 2020 Mar 5.
PMID: 32135522

Tissue pO2 distributions in xenograft tumors dynamically imaged by Cherenkov-excited phosphorescence during fractionated radiation therapy.
Cao X, Rao Allu S, Jiang S, Jia M, Gunn JR, Yao C, LaRochelle EP, Shell JR, Bruza P, Gladstone DJ, Jarvis LA, Tian J, Vinogradov SA, Pogue BW
Nat Commun. 2020 Jan 29;11(1):573. doi: 10.1038/s41467-020-14415-9. Epub 2020 Jan 29.
PMID: 31996677

Optical imaging method to quantify spatial dose variation due to the electron return effect in an MR-linac.
Andreozzi JM, Brůža P, Cammin J, Pogue BW, Gladstone DJ, Green O
Med Phys. 2020 Mar;47(3):1258-1267. doi: 10.1002/mp.13954. Epub 2019 Dec 25.
PMID: 31821573

Experimentally Observed Cherenkov Light Generation in the Eye During Radiation Therapy.
Tendler II, Hartford A, Jermyn M, LaRochelle E, Cao X, Borza V, Alexander D, Bruza P, Hoopes J, Moodie K, Marr BP, Williams BB, Pogue BW, Gladstone DJ, Jarvis LA
Int J Radiat Oncol Biol Phys. 2020 Feb 1;106(2):422-429. doi: 10.1016/j.ijrobp.2019.10.031. Epub 2019 Oct 25.
PMID: 31669563

Optical imaging provides rapid verification of static small beams, radiosurgery, and VMAT plans with millimeter resolution.
Ashraf MR, Bruza P, Pogue BW, Nelson N, Williams BB, Jarvis LA, Gladstone DJ
Med Phys. 2019 Nov;46(11):5227-5237. doi: 10.1002/mp.13797. Epub 2019 Oct 4.
PMID: 31472093

Improvements to an optical scintillator imaging-based tissue dosimetry system.
Tendler II, Bruza P, Jermyn M, Fleury A, Williams BB, Jarvis LA, Pogue BW, Gladstone DJ
J Biomed Opt. 2019 Jul;24(7):1-6. doi: 10.1117/1.JBO.24.7.075001.
PMID: 31313537

Technical Note: Quality assurance and relative dosimetry testing of a 60 Co total body irradiator using optical imaging.
Tendler II, Bredfeldt JS, Zhang R, Bruza P, Jermyn M, Pogue BW, Gladstone DJ
Med Phys. 2019 Aug;46(8):3674-3678. doi: 10.1002/mp.13637. Epub 2019 Jun 25.
PMID: 31152565

Assessment of imaging Cherenkov and scintillation signals in head and neck radiotherapy.
Alexander DA, Tendler II, Bruza P, Cao X, Schaner PE, Marshall BS, Jarvis LA, Gladstone DJ, Pogue BW
Phys Med Biol. 2019 Jul 18;64(14):145021. doi: 10.1088/1361-6560/ab25a3. Epub 2019 Jul 18.
PMID: 31146269

Characterization of a non-contact imaging scintillator-based dosimetry system for total skin electron therapy.
Tendler II, Bruza P, Jermyn M, Cao X, Williams BB, Jarvis LA, Pogue BW, Gladstone DJ
Phys Med Biol. 2019 Jun 21;64(12):125025. doi: 10.1088/1361-6560/ab1d8a. Epub 2019 Jun 21.
PMID: 31035267

Cherenkov-excited luminescence scanned imaging using scanned beam differencing and iterative deconvolution in dynamic plan radiation delivery in a human breast phantom geometry.
Jia MJ, Bruza P, Andreozzi JM, Jarvis LA, Gladstone DJ, Pogue BW
Med Phys. 2019 Jul;46(7):3067-3077. doi: 10.1002/mp.13545. Epub 2019 May 18.
PMID: 30980725

View more publications on PubMed