David J. Gladstone, ScD
Title(s)
Adjunct Professor of Medicine
Additional Titles/Positions/Affiliations
Professor of Engineering, Thayer School of Engineering at Dartmouth
Department(s)
Medicine
Education
Harvard Medical School, Post Doctoral Fellowship 1991
Massachusetts Institute of Technology Sc.D. 1989
University of Denver, B.S.Ch. 1983
Programs
Dartmouth Cancer Center
Contact Information
Dartmouth Medical School
HB 7999
Hanover NH 03755
Office: 1 Medical Center Drive
Phone: 603-640-6442
Fax: 603-650-6616
Email: david.j.gladstone@dartmouth.edu
Professional Interests
Highly conformal radiation therapy to spare normal tissues from damage secondary to treatment. Image guided radiation therapy, biological gating of therapeutic X-ray beams, image guided brachytherapy. Cherenkov emission during radiotherapy. Ultra-high dose rate radiation therapy to elicit the FLASH normal tissue sparing effect.
Grant Information
Drug-eluding Brachytherapy Implants Co-I 5% NIH/NCI R42CA224646-02
Norris Cotton Cancer Center Core Co-Director 2% NIH/NCI $3,290,263 Grant Radiation Shared Resource
5P30 CA 23108-40
Optical Cherenkov calibration for human radiation therapy Co-PI 8% NIH $423,145 R01EB023909
Electron FLASH Radiotherapy NIH U01 CA260446-01A1 Co-PI 10% $550,000/yr
Courses Taught
ENG-56, ENG-157, ENG-167, ENG-168, ENG-192
Timescale of FLASH Sparing Effect Determined by Varying Temporal Split of Dose Delivery in Mice. Emulating Clinical Workflow of Scintillator Array Dosimetry for FLASH PBS Proton Therapy. Anesthesia is a potent determinant of ultra-high dose rate sparing in the murine total abdominal irradiation model. Cherenkov Imaged Bio-Morphological Features Verify Patient Positioning With Deformable Tissue Translocation in Breast Radiation Therapy. Dynamic oxygen assessment techniques enable determination of anesthesia's impact on tissue. Robust real-time segmentation of bio-morphological features in human cherenkov imaging during radiotherapy via deep learning. Emerging Technologies in Radiation Therapy: Replacing Traditional Isotope-based Modalities. Design and characterization of a novel scintillator array for UHDR PBS proton therapy surface dosimetry. Cherenkov Imaged Bio-Morphological Features Verify Patient Positioning With Deformable Tissue Translocation in Breast Radiation Therapy. Oxygen Consumption In Vivo by Ultra-High Dose Rate Electron Irradiation Depends Upon Baseline Tissue Oxygenation. |
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