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Anne G Hoen, PhD

Title(s)
Associate Professor of Epidemiology
Associate Professor of Biomedical Data Science
Associate Professor of Microbiology and Immunology

Department(s)
Epidemiology
Biomedical Data Science
Microbiology and Immunology

Programs
Molecular and Cellular Biology Graduate Programs
Quantitative Biomedical Sciences

Websites
https://www.hoenlab.org

Contact Information

Dartmouth-Hitchcock Medical Center
One Medical Center Drive
HB 7927
Lebanon NH 03756

Phone: 603-653-6087
Email: Anne.G.Hoen@Dartmouth.edu


Professional Interests

Dr. Hoen's research focus is on the development of the microbiome in infants and children, and the associations between environmental and dietary exposures, the microbiome, and risk for infectious and other diseases. She has a broad interest in the predictors of disease risk and microbial colonization dynamics in human populations and the environment as reflected in microbial genetic sequence variation and health informatics streams over space and time. Interdisciplinary approaches used in her research include spatial and time-series statistics, population genetics and novel disease surveillance methodologies along with tools from the fields of microbial ecology, molecular epidemiology and landscape epidemiology.

Rotations and Thesis Projects

Development of novel computational methods for studying the human microbiota
Investigating the environmental drivers of infant intestinal microbiome development
Associations between patterns of infant intestinal microbiome establishment and health outcomes in children
Functional characterization of the developing infant gut microbiota using metabolomics

Grant Information

K01LM011985: Bioinformatics strategies for early life microbiomics
R01LM012723: Multi-omic functional integration using networks

Courses Taught

QBS 136 Applied Epidemiologic Methods

Biography

Dr. Hoen completed her PhD in epidemiology and public health at Yale University and received post-doctoral training at Harvard Medical School. She has broad training in biostatistics, epidemiology and public health with research experience in the evaluation of interventions, understanding infectious disease emergence and spread, and evaluating associations between the microbiome and human health. Her research uses advanced statistical methods as well as informatics and complex systems approaches. Past studies include modeling the timing and spread of influenza to estimate the effects of interventions targeting children, modeling the evolutionary ecology of the Lyme disease agent, Borrelia burgdorferi and characterizing the initial development of the human microbiome in early life and its associations with common exposures and infectious outcomes.


Selected Publications

 

Metagenomic analysis reveals associations between salivary microbiota and body composition in early childhood.
Coker MO, Lebeaux RM, Hoen AG, Moroishi Y, Gilbert-Diamond D, Dade EF, Palys TJ, Madan JC, Karagas MR
Sci Rep. 2022 Jul 29;12(1):13075. doi: 10.1038/s41598-022-14668-y. Epub 2022 Jul 29.
PMID: 35906254

The relationship between the gut microbiome and the risk of respiratory infections among newborns.
Moroishi Y, Gui J, Hoen AG, Morrison HG, Baker ER, Nadeau KC, Li H, Li Z, Madan JC, Karagas MR
Commun Med (Lond). 2022;2:87. doi: 10.1038/s43856-022-00152-1. Epub 2022 Jul 14.
PMID: 35847562

MarZIC: A Marginal Mediation Model for Zero-Inflated Compositional Mediators with Applications to Microbiome Data.
Wu Q, O'Malley J, Datta S, Gharaibeh RZ, Jobin C, Karagas MR, Coker MO, Hoen AG, Christensen BC, Madan JC, Li Z
Genes (Basel). 2022 Jun 11;13(6) pii: 1049. doi: 10.3390/genes13061049. Epub 2022 Jun 11.
PMID: 35741811

Bronchiolitis hospitalizations in rural New England: clues to disease prevention.
Wright PF, Hoen AG, Jarvis JD, Zens MS, Dade EF, Karagas MR, Taube J, Brickley EB
Ther Adv Infect Dis. 2022 Jan-Dec;9:20499361221099447. doi: 10.1177/20499361221099447. Epub 2022 May 27.
PMID: 35651526

CBEA: Competitive balances for taxonomic enrichment analysis.
Nguyen QP, Hoen AG, Frost HR
PLoS Comput Biol. 2022 May;18(5):e1010091. doi: 10.1371/journal.pcbi.1010091. Epub 2022 May 18.
PMID: 35584140

Impact of antibiotics on off-target infant gut microbiota and resistance genes in cohort studies.
Lebeaux RM, Madan JC, Nguyen QP, Coker MO, Dade EF, Moroishi Y, Palys TJ, Ross BD, Pettigrew MM, Morrison HG, Karagas MR, Hoen AG
Pediatr Res. 2022 May 14; doi: 10.1038/s41390-022-02104-w. Epub 2022 May 14.
PMID: 35568730

INFORMATION CONTENT OF HIGH-ORDER ASSOCIATIONS OF THE HUMAN GUT MICROBIOTA NETWORK.
Viles WD, Madan JC, Li H, Karagas MR, Hoen AG
Ann Appl Stat. 2021 Dec;15(4):1788-1807. doi: 10.1214/21-aoas1449. Epub 2021 Dec 21.
PMID: 35342498

Using Satellite Images and Deep Learning to Identify Associations Between County-Level Mortality and Residential Neighborhood Features Proximal to Schools: A Cross-Sectional Study.
Levy JJ, Lebeaux RM, Hoen AG, Christensen BC, Vaickus LJ, MacKenzie TA
Front Public Health. 2021;9:766707. doi: 10.3389/fpubh.2021.766707. Epub 2021 Nov 5.
PMID: 34805078

Chemical exposures assessed via silicone wristbands and endogenous plasma metabolomics during pregnancy.
Doherty BT, McRitchie SL, Pathmasiri WW, Stewart DA, Kirchner D, Anderson KA, Gui J, Madan JC, Hoen AG, Sumner SJ, Karagas MR, Romano ME
J Expo Sci Environ Epidemiol. 2022 Mar;32(2):259-267. doi: 10.1038/s41370-021-00394-6. Epub 2021 Oct 26.
PMID: 34702988

Association of Cesarean Delivery and Formula Supplementation with the Stool Metabolome of 6-Week-Old Infants.
Hoen AG, Coker MO, Madan JC, Pathmasiri W, McRitchie S, Dade EF, Doherty BT, Sumner S, Karagas MR
Metabolites. 2021 Oct 13;11(10) pii: 702. doi: 10.3390/metabo11100702. Epub 2021 Oct 13.
PMID: 34677417

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