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Anne G Hoen, PhD

Associate Professor of Epidemiology
Associate Professor of Biomedical Data Science
Associate Professor of Microbiology and Immunology

Biomedical Data Science
Microbiology and Immunology

Molecular and Cellular Biology Graduate Programs
Quantitative Biomedical Sciences


Academic Analytics
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Contact Information

Dartmouth-Hitchcock Medical Center
One Medical Center Drive
HB 7927
Lebanon NH 03756

Phone: 603-653-6087
Email: Anne.G.Hoen@Dartmouth.edu

Professional Interests

Dr. Hoen's research focus is on the development of the microbiome in infants and children, and the associations between environmental and dietary exposures, the microbiome, and risk for infectious and other diseases. She has a broad interest in the predictors of disease risk and microbial colonization dynamics in human populations and the environment as reflected in microbial genetic sequence variation and health informatics streams over space and time. Interdisciplinary approaches used in her research include spatial and time-series statistics, population genetics and novel disease surveillance methodologies along with tools from the fields of microbial ecology, molecular epidemiology and landscape epidemiology.

Rotations and Thesis Projects

Development of novel computational methods for studying the human microbiota
Investigating the environmental drivers of infant intestinal microbiome development
Associations between patterns of infant intestinal microbiome establishment and health outcomes in children
Functional characterization of the developing infant gut microbiota using metabolomics

Grant Information

K01LM011985: Bioinformatics strategies for early life microbiomics
R01LM012723: Multi-omic functional integration using networks

Courses Taught

QBS 136 Applied Epidemiologic Methods


Dr. Hoen completed her PhD in epidemiology and public health at Yale University and received post-doctoral training at Harvard Medical School. She has broad training in biostatistics, epidemiology and public health with research experience in the evaluation of interventions, understanding infectious disease emergence and spread, and evaluating associations between the microbiome and human health. Her research uses advanced statistical methods as well as informatics and complex systems approaches. Past studies include modeling the timing and spread of influenza to estimate the effects of interventions targeting children, modeling the evolutionary ecology of the Lyme disease agent, Borrelia burgdorferi and characterizing the initial development of the human microbiome in early life and its associations with common exposures and infectious outcomes.

Selected Publications


Machine-learning analysis of cross-study samples according to the gut microbiome in 12 infant cohorts.
Vanni P, Tejesvi MV, Paalanne N, Aagaard K, Ackermann G, Camargo CA Jr, Eggesbo M, Hasegawa K, Hoen AG, Karagas MR, Kolho K-L, Laursen MF, Ludvigsson J, Madan J, Ownby D, Stanton C, Stokholm J, Tapiainen T
mSystems. 2023 Oct 24;:e0036423. doi: 10.1128/msystems.00364-23. Epub 2023 Oct 24.
PMID: 37874156

Human milk-associated bacterial communities associate with the infant gut microbiome over the first year of life.
Lundgren SN, Madan JC, Karagas MR, Morrison HG, Christensen BC, Hoen AG
Front Microbiol. 2023;14:1164553. doi: 10.3389/fmicb.2023.1164553. Epub 2023 Apr 17.
PMID: 37138613

Alterations in Microbial-Associated Fecal Metabolites in Relation to Arsenic Exposure Among Infants.
Karagas MR, McRitchie S, Hoen AG, Takigawa C, Jackson B, Baker ER, Madan J, Sumner SJ, Pathmasiri W
Expo Health. 2022 Dec;14(4):941-949. doi: 10.1007/s12403-022-00468-2. Epub 2022 Feb 3.
PMID: 36776720

Umbilical cord blood immune cell profiles in relation to the infant gut microbiome.
Moroishi Y, Salas LA, Zhou J, Baker ER, Hoen AG, Everson TM, Marsit CJ, Madan J, Gui J, Karagas MR
iScience. 2023 Jan 20;26(1):105833. doi: 10.1016/j.isci.2022.105833. Epub 2022 Dec 17.
PMID: 36632065

Associations of maternal plasma and umbilical cord plasma metabolomics profiles with birth anthropometric measures.
Yeum D, Gilbert-Diamond D, Doherty B, Coker M, Stewart D, Kirchner D, McRitchie S, Sumner S, Karagas MR, Hoen AG
Pediatr Res. 2023 Jul;94(1):135-142. doi: 10.1038/s41390-022-02449-2. Epub 2023 Jan 10.
PMID: 36627359

The association between early life antibiotic exposure and the gut resistome of young children: a systematic review.
Lebeaux RM, Karalis DB, Lee J, Whitehouse HC, Madan JC, Karagas MR, Hoen AG
Gut Microbes. 2022 Jan-Dec;14(1):2120743. doi: 10.1080/19490976.2022.2120743.
PMID: 36289062

Metagenomic analysis reveals associations between salivary microbiota and body composition in early childhood.
Coker MO, Lebeaux RM, Hoen AG, Moroishi Y, Gilbert-Diamond D, Dade EF, Palys TJ, Madan JC, Karagas MR
Sci Rep. 2022 Jul 29;12(1):13075. doi: 10.1038/s41598-022-14668-y. Epub 2022 Jul 29.
PMID: 35906254

The relationship between the gut microbiome and the risk of respiratory infections among newborns.
Moroishi Y, Gui J, Hoen AG, Morrison HG, Baker ER, Nadeau KC, Li H, Li Z, Madan JC, Karagas MR
Commun Med (Lond). 2022;2:87. doi: 10.1038/s43856-022-00152-1. Epub 2022 Jul 14.
PMID: 35847562

MarZIC: A Marginal Mediation Model for Zero-Inflated Compositional Mediators with Applications to Microbiome Data.
Wu Q, O'Malley J, Datta S, Gharaibeh RZ, Jobin C, Karagas MR, Coker MO, Hoen AG, Christensen BC, Madan JC, Li Z
Genes (Basel). 2022 Jun 11;13(6) doi: 10.3390/genes13061049. Epub 2022 Jun 11.
PMID: 35741811

Bronchiolitis hospitalizations in rural New England: clues to disease prevention.
Wright PF, Hoen AG, Jarvis JD, Zens MS, Dade EF, Karagas MR, Taube J, Brickley EB
Ther Adv Infect Dis. 2022 Jan-Dec;9:20499361221099447. doi: 10.1177/20499361221099447. Epub 2022 May 27.
PMID: 35651526

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