Anne G Hoen, PhD
Title(s)
Associate Professor of Epidemiology
Associate Professor of Biomedical Data Science
Associate Professor of Microbiology and Immunology
Department(s)
Epidemiology
Biomedical Data Science
Microbiology and Immunology
Programs
Molecular and Cellular Biology Graduate Programs
Quantitative Biomedical Sciences
Websites
https:
Contact Information
Dartmouth-Hitchcock Medical Center
One Medical Center Drive
HB 7927
Lebanon NH 03756
Email: Anne.G.Hoen@Dartmouth.edu
Professional Interests
Dr. Hoen's research focus is on the development of the microbiome in infants and children, and the associations between environmental and dietary exposures, the microbiome, and risk for infectious and other diseases. She has a broad interest in the predictors of disease risk and microbial colonization dynamics in human populations and the environment as reflected in microbial genetic sequence variation and health informatics streams over space and time. Interdisciplinary approaches used in her research include spatial and time-series statistics, population genetics and novel disease surveillance methodologies along with tools from the fields of microbial ecology, molecular epidemiology and landscape epidemiology.
Rotations and Thesis Projects
Development of novel computational methods for studying the human microbiota
Investigating the environmental drivers of infant intestinal microbiome development
Associations between patterns of infant intestinal microbiome establishment and health outcomes in children
Functional characterization of the developing infant gut microbiota using metabolomics
Grant Information
K01LM011985: Bioinformatics strategies for early life microbiomics
R01LM012723: Multi-omic functional integration using networks
Courses Taught
QBS 136 Applied Epidemiologic Methods
Biography
Dr. Hoen completed her PhD in epidemiology and public health at Yale University and received post-doctoral training at Harvard Medical School. She has broad training in biostatistics, epidemiology and public health with research experience in the evaluation of interventions, understanding infectious disease emergence and spread, and evaluating associations between the microbiome and human health. Her research uses advanced statistical methods as well as informatics and complex systems approaches. Past studies include modeling the timing and spread of influenza to estimate the effects of interventions targeting children, modeling the evolutionary ecology of the Lyme disease agent, Borrelia burgdorferi and characterizing the initial development of the human microbiome in early life and its associations with common exposures and infectious outcomes.
Early-life arsenic exposure modulates the developing microbiome in a rural cohort. Increased dose of H1N1 pandemic influenza vaccine during pregnancy improves immunity in mothers and infants. Maternal Diet Quality in Pregnancy and Human Milk Extracellular Vesicle and Particle microRNA. Optimizing Protocols for MicroRNA Profiling of Infant and Toddler Stool. Maternal diet quality and circulating extracellular vesicle and particle miRNA during pregnancy. Prospective association of the infant gut microbiome with social behaviors in the ECHO consortium. Patterns of infant fecal metabolite concentrations and social behavioral development in toddlers. Maternal-Infant Factors in Relation to Extracellular Vesicle and Particle miRNA in Prenatal Plasma and in Postpartum Human Milk. Metabolomic data presents challenges for epidemiological meta-analysis: a case study of childhood body mass index from the ECHO consortium. Identifying stationary microbial interaction networks based on irregularly spaced longitudinal 16S rRNA gene sequencing data. |
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