Anne G Hoen, PhD
Title(s)
Associate Professor of Epidemiology
Associate Professor of Biomedical Data Science
Associate Professor of Microbiology and Immunology
Department(s)
Epidemiology
Biomedical Data Science
Microbiology and Immunology
Programs
Molecular and Cellular Biology Graduate Programs
Quantitative Biomedical Sciences
Websites
https:
Contact Information
Dartmouth-Hitchcock Medical Center
One Medical Center Drive
HB 7927
Lebanon NH 03756
Phone: 603-653-6087
Email: Anne.G.Hoen@Dartmouth.edu
Professional Interests
Dr. Hoen's research focus is on the development of the microbiome in infants and children, and the associations between environmental and dietary exposures, the microbiome, and risk for infectious and other diseases. She has a broad interest in the predictors of disease risk and microbial colonization dynamics in human populations and the environment as reflected in microbial genetic sequence variation and health informatics streams over space and time. Interdisciplinary approaches used in her research include spatial and time-series statistics, population genetics and novel disease surveillance methodologies along with tools from the fields of microbial ecology, molecular epidemiology and landscape epidemiology.
Rotations and Thesis Projects
Development of novel computational methods for studying the human microbiota
Investigating the environmental drivers of infant intestinal microbiome development
Associations between patterns of infant intestinal microbiome establishment and health outcomes in children
Functional characterization of the developing infant gut microbiota using metabolomics
Grant Information
K01LM011985: Bioinformatics strategies for early life microbiomics
R01LM012723: Multi-omic functional integration using networks
Courses Taught
QBS 136 Applied Epidemiologic Methods I
QBS 137 Applied Epidemiologic Methods II
Biography
Dr. Hoen completed her PhD in epidemiology and public health at Yale University and received post-doctoral training at Children's Hospital Boston, Harvard Medical School and McGill University. She has broad training in biostatistics, epidemiology and public health with research experience in the evaluation of interventions, understanding infectious disease emergence and spread, and evaluating associations between the microbiome and human health. Her research uses advanced statistical methods as well as informatics and complex systems approaches. Past studies include modeling the timing and spread of influenza to estimate the effects of interventions targeting children, modeling the evolutionary ecology of the Lyme disease agent, Borrelia burgdorferi and characterizing the initial development of the human microbiome in early life and its associations with common exposures and infectious outcomes.
Selected Publications |
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CBEA: Competitive balances for taxonomic enrichment analysis. Impact of antibiotics on off-target infant gut microbiota and resistance genes in cohort studies. INFORMATION CONTENT OF HIGH-ORDER ASSOCIATIONS OF THE HUMAN GUT MICROBIOTA NETWORK. Using Satellite Images and Deep Learning to Identify Associations Between County-Level Mortality and Residential Neighborhood Features Proximal to Schools: A Cross-Sectional Study. Chemical exposures assessed via silicone wristbands and endogenous plasma metabolomics during pregnancy. Association of Cesarean Delivery and Formula Supplementation with the Stool Metabolome of 6-Week-Old Infants. Associations between the gut microbiome and metabolome in early life. The infant gut resistome is associated with E. coli and early-life exposures. Infant Feeding Alters the Longitudinal Impact of Birth Mode on the Development of the Gut Microbiota in the First Year of Life. Information enhanced model selection for Gaussian graphical model with application to metabolomic data. |
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