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Anne G Hoen, PhD

Title(s)
Associate Professor of Epidemiology
Associate Professor of Biomedical Data Science
Associate Professor of Microbiology and Immunology

Department(s)
Epidemiology
Biomedical Data Science
Microbiology and Immunology

Programs
Molecular and Cellular Biology Graduate Programs
Quantitative Biomedical Sciences

Websites
https://www.hoenlab.org

Academic Analytics
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Contact Information

Dartmouth-Hitchcock Medical Center
One Medical Center Drive
HB 7927
Lebanon NH 03756

Email: Anne.G.Hoen@Dartmouth.edu


Professional Interests

Dr. Hoen's research focus is on the development of the microbiome in infants and children, and the associations between environmental and dietary exposures, the microbiome, and risk for infectious and other diseases. She has a broad interest in the predictors of disease risk and microbial colonization dynamics in human populations and the environment as reflected in microbial genetic sequence variation and health informatics streams over space and time. Interdisciplinary approaches used in her research include spatial and time-series statistics, population genetics and novel disease surveillance methodologies along with tools from the fields of microbial ecology, molecular epidemiology and landscape epidemiology.

Rotations and Thesis Projects

Development of novel computational methods for studying the human microbiota
Investigating the environmental drivers of infant intestinal microbiome development
Associations between patterns of infant intestinal microbiome establishment and health outcomes in children
Functional characterization of the developing infant gut microbiota using metabolomics

Grant Information

K01LM011985: Bioinformatics strategies for early life microbiomics
R01LM012723: Multi-omic functional integration using networks

Courses Taught

QBS 136 Applied Epidemiologic Methods

Biography

Dr. Hoen completed her PhD in epidemiology and public health at Yale University and received post-doctoral training at Harvard Medical School. She has broad training in biostatistics, epidemiology and public health with research experience in the evaluation of interventions, understanding infectious disease emergence and spread, and evaluating associations between the microbiome and human health. Her research uses advanced statistical methods as well as informatics and complex systems approaches. Past studies include modeling the timing and spread of influenza to estimate the effects of interventions targeting children, modeling the evolutionary ecology of the Lyme disease agent, Borrelia burgdorferi and characterizing the initial development of the human microbiome in early life and its associations with common exposures and infectious outcomes.


Selected Publications

 

Prospective association of the infant gut microbiome with social behaviors in the ECHO consortium.
Laue HE, Bonham KS, Coker MO, Moroishi Y, Pathmasiri W, McRitchie S, Sumner S, Hoen AG, Karagas MR, Klepac-Ceraj V, Madan JC, program collaborators for Environmental influences on Child Health Outcomes
Mol Autism. 2024 May 17;15(1):21. doi: 10.1186/s13229-024-00597-2. Epub 2024 May 17.
PMID: 38760865

Patterns of infant fecal metabolite concentrations and social behavioral development in toddlers.
Laue HE, Bauer JA, Pathmasiri W, Sumner SCJ, McRitchie S, Palys TJ, Hoen AG, Madan JC, Karagas MR
Pediatr Res. 2024 Mar 20; doi: 10.1038/s41390-024-03129-z. Epub 2024 Mar 20.
PMID: 38509226

Maternal-Infant Factors in Relation to Extracellular Vesicle and Particle miRNA in Prenatal Plasma and in Postpartum Human Milk.
Muse ME, Armstrong DA, Hoen AG, Gilbert-Diamond D, Gui J, Palys TJ, Kolling FW, Christensen BC, Karagas MR, Howe CG
Int J Mol Sci. 2024 Jan 26;25(3) doi: 10.3390/ijms25031538. Epub 2024 Jan 26.
PMID: 38338815

Metabolomic data presents challenges for epidemiological meta-analysis: a case study of childhood body mass index from the ECHO consortium.
Prince N, Liang D, Tan Y, Alshawabkeh A, Angel EE, Busgang SA, Chu SH, Cordero JF, Curtin P, Dunlop AL, Gilbert-Diamond D, Giulivi C, Hoen AG, Karagas MR, Kirchner D, Litonjua AA, Manjourides J, McRitchie S, Meeker JD, Pathmasiri W, Perng W, Schmidt RJ, Watkins DJ, Weiss ST, Zens MS, Zhu Y, Lasky-Su JA, Kelly RS
Metabolomics. 2024 Jan 24;20(1):16. doi: 10.1007/s11306-023-02082-y. Epub 2024 Jan 24.
PMID: 38267770

Periconceptional and Prenatal Exposure to Metals and Extracellular Vesicle and Particle miRNAs in Human Milk: A Pilot Study.
Howe CG, Armstrong DA, Muse ME, Gilbert-Diamond D, Gui J, Hoen AG, Palys TJ, Barnaby RL, Stanton BA, Jackson BP, Christensen BC, Karagas MR
Expo Health. 2023 Dec;15(4):731-743. doi: 10.1007/s12403-022-00520-1. Epub 2022 Nov 3.
PMID: 38074282

Machine-learning analysis of cross-study samples according to the gut microbiome in 12 infant cohorts.
Vanni P, Tejesvi MV, Paalanne N, Aagaard K, Ackermann G, Camargo CA Jr, Eggesbo M, Hasegawa K, Hoen AG, Karagas MR, Kolho K-L, Laursen MF, Ludvigsson J, Madan J, Ownby D, Stanton C, Stokholm J, Tapiainen T
mSystems. 2023 Dec 21;8(6):e0036423. doi: 10.1128/msystems.00364-23. Epub 2023 Oct 24.
PMID: 37874156

Human milk-associated bacterial communities associate with the infant gut microbiome over the first year of life.
Lundgren SN, Madan JC, Karagas MR, Morrison HG, Christensen BC, Hoen AG
Front Microbiol. 2023;14:1164553. doi: 10.3389/fmicb.2023.1164553. Epub 2023 Apr 17.
PMID: 37138613

Alterations in Microbial-Associated Fecal Metabolites in Relation to Arsenic Exposure Among Infants.
Karagas MR, McRitchie S, Hoen AG, Takigawa C, Jackson B, Baker ER, Madan J, Sumner SJ, Pathmasiri W
Expo Health. 2022 Dec;14(4):941-949. doi: 10.1007/s12403-022-00468-2. Epub 2022 Feb 3.
PMID: 36776720

Umbilical cord blood immune cell profiles in relation to the infant gut microbiome.
Moroishi Y, Salas LA, Zhou J, Baker ER, Hoen AG, Everson TM, Marsit CJ, Madan J, Gui J, Karagas MR
iScience. 2023 Jan 20;26(1):105833. doi: 10.1016/j.isci.2022.105833. Epub 2022 Dec 17.
PMID: 36632065

Associations of maternal plasma and umbilical cord plasma metabolomics profiles with birth anthropometric measures.
Yeum D, Gilbert-Diamond D, Doherty B, Coker M, Stewart D, Kirchner D, McRitchie S, Sumner S, Karagas MR, Hoen AG
Pediatr Res. 2023 Jul;94(1):135-142. doi: 10.1038/s41390-022-02449-2. Epub 2023 Jan 10.
PMID: 36627359

View more publications on PubMed