COVID-19 Information

Edit Entry | Edit CV

Anne G Hoen, PhD

Associate Professor of Epidemiology
Associate Professor of Biomedical Data Science
Associate Professor of Microbiology and Immunology

Biomedical Data Science
Microbiology and Immunology

Molecular and Cellular Biology Graduate Programs
Quantitative Biomedical Sciences


Contact Information:

Dartmouth-Hitchcock Medical Center
One Medical Center Drive
HB 7927
Lebanon NH 03756

Phone: 603-653-6087

Professional Interests:

Dr. Hoen's research focus is on the development of the microbiome in infants and children, and the associations between environmental and dietary exposures, the microbiome, and risk for infectious and other diseases. She has a broad interest in the predictors of disease risk and microbial colonization dynamics in human populations and the environment as reflected in microbial genetic sequence variation and health informatics streams over space and time. Interdisciplinary approaches used in her research include spatial and time-series statistics, population genetics and novel disease surveillance methodologies along with tools from the fields of microbial ecology, molecular epidemiology and landscape epidemiology.

Rotations and Thesis Projects:

Development of novel computational methods for studying the human microbiota
Investigating the environmental drivers of infant intestinal microbiome development
Associations between patterns of infant intestinal microbiome establishment and health outcomes in children
Functional characterization of the developing infant gut microbiota using metabolomics

Grant Information:

K01LM011985: Bioinformatics strategies for early life microbiomics
R01LM012723: Multi-omic functional integration using networks

Courses Taught:

QBS 136 Applied Epidemiologic Methods I
QBS 137 Applied Epidemiologic Methods II


Dr. Hoen completed her PhD in epidemiology and public health at Yale University and received post-doctoral training at Children's Hospital Boston, Harvard Medical School and McGill University. She has broad training in biostatistics, epidemiology and public health with research experience in the evaluation of interventions, understanding infectious disease emergence and spread, and evaluating associations between the microbiome and human health. Her research uses advanced statistical methods as well as informatics and complex systems approaches. Past studies include modeling the timing and spread of influenza to estimate the effects of interventions targeting children, modeling the evolutionary ecology of the Lyme disease agent, Borrelia burgdorferi and characterizing the initial development of the human microbiome in early life and its associations with common exposures and infectious outcomes.

Selected Publications:


Associations between the gut microbiome and metabolome in early life.
Nguyen QP, Karagas MR, Madan JC, Dade E, Palys TJ, Morrison HG, Pathmasiri WW, McRitche S, Sumner SJ, Frost HR, Hoen AG
BMC Microbiol. 2021 Aug 28;21(1):238. doi: 10.1186/s12866-021-02282-3. Epub 2021 Aug 28.
PMID: 34454437

The infant gut resistome is associated with E. coli and early-life exposures.
Lebeaux RM, Coker MO, Dade EF, Palys TJ, Morrison HG, Ross BD, Baker ER, Karagas MR, Madan JC, Hoen AG
BMC Microbiol. 2021 Jul 2;21(1):201. doi: 10.1186/s12866-021-02129-x. Epub 2021 Jul 2.
PMID: 34215179

Infant Feeding Alters the Longitudinal Impact of Birth Mode on the Development of the Gut Microbiota in the First Year of Life.
Coker MO, Laue HE, Hoen AG, Hilliard M, Dade E, Li Z, Palys T, Morrison HG, Baker E, Karagas MR, Madan JC
Front Microbiol. 2021;12:642197. doi: 10.3389/fmicb.2021.642197. Epub 2021 Apr 7.
PMID: 33897650

Information enhanced model selection for Gaussian graphical model with application to metabolomic data.
Zhou J, Hoen AG, Mcritchie S, Pathmasiri W, Viles WD, Nguyen QP, Madan JC, Dade E, Karagas MR, Gui J
Biostatistics. 2021 Mar 15; pii: kxab006. doi: 10.1093/biostatistics/kxab006. Epub 2021 Mar 15.
PMID: 33720330

Retail store customer flow and COVID-19 transmission.
Shumsky RA, Debo L, Lebeaux RM, Nguyen QP, Hoen AG
Proc Natl Acad Sci U S A. 2021 Mar 16;118(11) pii: e2019225118. doi: 10.1073/pnas.2019225118.
PMID: 33637652

Prediction of an outcome using NETwork Clusters (NET-C).
Lee JW, Zhou J, Moen EL, Punshon T, Hoen AG, Romano ME, Karagas MR, Gui J
Comput Biol Chem. 2021 Feb;90:107425. doi: 10.1016/j.compbiolchem.2020.107425. Epub 2020 Dec 8.
PMID: 33360198

Identification of microbial interaction network: zero-inflated latent Ising model based approach.
Zhou J, Viles WD, Lu B, Li Z, Madan JC, Karagas MR, Gui J, Hoen AG
BioData Min. 2020;13:16. doi: 10.1186/s13040-020-00226-7. Epub 2020 Oct 7.
PMID: 33042226

Reliability of stool microbiome methods for DNA yields and sequencing among infants and young children.
Antosca K, Hoen AG, Palys T, Hilliard M, Morrison HG, Coker M, Madan J, Karagas MR
Microbiologyopen. 2020 May;9(5):e1018. doi: 10.1002/mbo3.1018. Epub 2020 Mar 12.
PMID: 32166902

Maternal determinants of infant immunity: Implications for effective immunization and maternal-child health.
Pasetti MF, Ackerman ME, Hoen AG, Alter G, Tsang JS, Marchant A
Vaccine. 2020 Jun 9;38(28):4491-4494. doi: 10.1016/j.vaccine.2020.01.056. Epub 2020 Feb 25.
PMID: 32111530

Microbial Communities in Human Milk Relate to Measures of Maternal Weight.
Lundgren SN, Madan JC, Karagas MR, Morrison HG, Hoen AG, Christensen BC
Front Microbiol. 2019;10:2886. doi: 10.3389/fmicb.2019.02886. Epub 2019 Dec 20.
PMID: 31921063

View more publications on PubMed