Paul E Holtzheimer, MD, MS
Title(s)
Professor of Psychiatry
Professor of Surgery
Additional Titles/Positions/Affiliations
Deputy Director for Research, National Center for PTSD
Staff Physician, White River Junction VAMC
Department(s)
Psychiatry
Surgery
Education
1990-1995 Pacific Lutheran University, Tacoma, WA.
B.S., Biology, summa cum laude.
B.A., Psychology and Philosophy, summa cum laude.
- Honors in Philosophy.
- Honors in the Integrated Studies Program.
1995-1999 Dartmouth Medical School, Hanover, NH.
M.D., with honors.
2005-2008 Emory University, Atlanta, GA.
M.S., Clinical Research.
Programs
National Center for Post Traumatic Stress Disorder
Program in Experimental and Molecular Medicine
Curriculum Vitae
Holtzheimer_P_CV_2026-01-06.doc
Contact Information
White River Junction VA Medical Center
215 N. Main St.
White River Junction VT 05009
Phone: 802-296-5132
Email: paul.e.holtzheimer@dartmouth.edu
Professional Interests
Dr. Holtzheimer’s clinical and preclinical research program is focused on the neurobiology and treatment of posttraumatic stress disorder, mood disorders, and related conditions such as traumatic brain injury. Current methodologies include functional and structural neuroimaging (including EEG) and focal neuromodulation techniques such as transcranial magnetic stimulation and deep brain stimulation.
Rotations and Thesis Projects
Rotations are available in the lab.
Grant Information
I01 BX006246-01 (MPI: Paul Holtzheimer, MD, Crystal Noller, PhD)
5/2025-4/2030 VA BLR&D
Targeted brain stimulation to enhance recovery after shockwave-induced blast TBI: Identifying neural biomarkers to guide treatment
IK2 CX002101-01A2 (PI: Crystal Lantrip, PhD; Primary Mentors: Paul Holtzheimer, MD, Suzannah Creech, PhD)
10/2021-9/2026 VA CSR&D
Repetitive Transcranial Magnetic Stimulation Augmented Written Exposure Therapy for Veterans with PTSD
IK2 RX003551-01 (PI: Crystal Noller, PhD; Primary Mentor: Paul Holtzheimer, MD)
10/2022-09/2027 VA RR&D
Harnessing the Cholinergic Inflammatory Reflex to Alter Neuroinflammation and Neuropsychiatric Consequences Following Traumatic Brain Injury.
1IK2BX006530-01 (PI: Krista Disano, PhD; Primary Mentor: Holtzheimer)
2024-2027 VA BLR&D
Breaching CNS barriers: Deciphering the spatiotemporal regulation of immune cell surveillance following blast TBI
I01 CX-002088 (MPI: Paul Holtzheimer, MD, Noah Philip, MD)
10/2020-9/2025 VA CSR&D
Assessing an electroencephalography (EEG) biomarker of response to transcranial magnetic stimulation for major depression
I01 CX002333-01 (MPI: Michael Hollifield, MD, Charles Brock, MD; Co-I/LSI: Paul Holtzheimer, MD)
2021-2025 VA CSR&D
Efficacy and Safety of Stellate Ganglion Block for Post-Traumatic Stress Disorder in Veterans
Biography
Paul Holtzheimer, MD, is the Deputy Director for Research at the VA's National Center for Posttraumatic Stress Disorder, Executive Division. He is Professor of Psychiatry and Surgery at the Geisel School of Medicine at Dartmouth, and a staff psychiatrist at the White River Junction VA Medical Center.
Dr. Holtzheimer’s clinical and research interests include developing better interventions for PTSD and related disorders, especially for patients with treatment-resistant and comorbid illness. He has expertise in brain imaging and brain stimulation therapies (including transcranial magnetic stimulation, electroconvulsive therapy, vagus nerve stimulation, and deep brain stimulation). A primary aim of his research program is to better understand the neural circuitry of treatment-resistant mood and anxiety disorders (especially PTSD), and to use this information to develop and advance novel treatment approaches, with a particular emphasis on focal brain stimulation therapies.
Dr. Holtzheimer is an author on over 150 publications in psychiatry, neurology, neurosurgery and neuroimaging.
Personalized fMRI-Guided TMS Targeting the Threat Neurocircuitry in PTSD: A Randomized Clinical Trial. Motivational Interviewing Targeting Pain and Substance Use in Veterans Seeking Service-Connection Payments: A Multisite Randomized Clinical Trial. Target variability and stability of neuroimaging-guided transcranial magnetic stimulation of the amygdala circuitry for posttraumatic stress disorder. The Single-Prolonged Stress Model Fails to Produce Behavioral or Corticosterone Alterations in Rats. Central amygdala single-nucleus atlas reveals chromatin and gene transcription dynamics in human alcohol use disorder. Efficacy and safety of the stellate ganglion block for posttraumatic stress disorder in veterans: Rationale for and methods of a multisite trial. Mapping DNA Methylation Signatures to Identify Epigenetic Variation Across Subcortical Regions of the Human Posttraumatic Stress Disorder Brain. Developing Clinically Interpretable Neuroimaging Biotypes in Psychiatry. Revisiting subcallosal cingulate deep brain stimulation for depression: Long-term safety and effectiveness outcomes from a pooled analysis of 172 implanted patients. Psychosocial Interventions Impact on Cardiometabolic, Neurobiological, Behavioral, and Immune Outcomes in People With a Serious Mental Illness: A Systematic Review. |
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