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Paul E Holtzheimer, MD, MS

Associate Professor of Psychiatry
Associate Professor of Surgery

Additional Titles/Positions/Affiliations:
Director, Mood Disorders Service
Staff Physician, White River Junction VAMC


1990-1995 Pacific Lutheran University, Tacoma, WA.
B.S., Biology, summa cum laude.
B.A., Psychology and Philosophy, summa cum laude.
- Honors in Philosophy.
- Honors in the Integrated Studies Program.
1995-1999 Dartmouth Medical School, Hanover, NH.
M.D., with honors.
2005-2008 Emory University, Atlanta, GA.
M.S., Clinical Research.

Program in Experimental and Molecular Medicine


Contact Information:

Dartmouth-Hitchcock Medical Center
One Medical Center Drive
Lebanon NH 03756

Office: 603-650-4914
Phone: 603-650-0438
Email: Paul.E.Holtzheimer@hitchcock.org

Asst. Email: mood@dartmouth.edu

Professional Interests:

Dr. Holtzheimer’s research program at Dartmouth is focused on the neurobiology and treatment of mood disorders, primarily treatment-resistant depression. Current methodologies include functional and structural neuroimaging and focal neuromodulation techniques such as transcranial magnetic stimulation and deep brain stimulation.

Rotations and Thesis Projects:

Rotations are available in the lab. Most projects will be focused on brain imaging research (structural MRI, resting state functional MRI, diffusion imaging, EEG).

Grant Information:

2011-2016 R01 MH091100-A1 (PI: Paul Holtzheimer, MD)


Paul Holtzheimer, MD, is Associate Professor of Psychiatry and Surgery and Director of the Mood Disorders Service at Dartmouth Medical School and Dartmouth-Hitchcock Medical Center in Lebanon, New Hampshire. He is a Diplomate of the American Board of Psychiatry and Neurology. Dr. Holtzheimer attended Pacific Lutheran University where he graduated summa cum laude with a B.S. in Biology and B.A. in Philosophy and Psychology. He then attended Dartmouth Medical School from 1995 to 1999, graduating with honors. He completed his psychiatry residency at the University of Washington School of Medicine in 2003 followed by a clinical research fellowship in transcranial magnetic stimulation from 2003 to 2004. He joined the faculty of the Department

of Psychiatry and Behavioral Sciences at the Emory University School of Medicine in 2004 where he developed further expertise in treatment-resistant mood disorders, brain imaging techniques and brain stimulation therapies (such as transcranial magnetic stimulation [TMS], electroconvulsive therapy [ECT], and deep brain stimulation [DBS]). Dr. Holtzheimer directed the Resident Psychopharmacology Clinic from 2008 to 2011. Dr. Holtzheimer’s research program at Dartmouth is focused on the neurobiology and treatment of mood disorders, primarily treatment-resistant depression. Current methodologies include functional and structural neuroimaging and focal neuromodulation techniques such as transcranial magnetic stimulation and deep brain stimulation. Dr. Holtzheimer is faculty in the Neurosciences Division of the Program in Experimental and Molecular Medicine (PEMM). Clinically, Dr. Holtzheimer provides evaluation and consultation for patients with treatment-resistant mood disorders. Dr. Holtzheimer is an author on over 70 publications in psychiatry, neurosurgery and neuroimaging. He has been an investigator on several clinical trials of novel treatments for mood disorders, including transcranial magnetic stimulation and deep brain stimulation, as well as numerous studies investigating the structural and functional neuroanatomy of mood disorders. He is an Associate Member of the American College of Neuropsychopharmacology where he serves on the Liaison Committee and the Membership Task Force; he also serves as a mentor for the Travel Awardee program. He is a member of the Society of Biological Psychiatry where he currently serves on the Program Committee and the Education Task Force, and is mentor for the Mentor/Mentee Program. He is also a member of the American College of Psychiatrists, the International Society for Electroconvulsive Therapy and Neurostimulation and the Society for Neuroscience.

Mentoring Information:

Carey Allmendinger 2014-present

Selected Publications:


Effects of Left Versus Right Dorsolateral Prefrontal Cortex Repetitive Transcranial Magnetic Stimulation on Affective Flexibility in Healthy Women: A Pilot Study.
Lantrip C, Delaloye S, Baird L, Dreyer-Oren S, Brady RE, Roth RM, Gunning F, Holtzheimer P
Cogn Behav Neurol. 2019 Jun;32(2):69-75. doi: 10.1097/WNN.0000000000000190.
PMID: 31205120

Synchronized transcranial magnetic stimulation for posttraumatic stress disorder and comorbid major depression.
Philip NS, Aiken EE, Kelley ME, Burch W, Waterman L, Holtzheimer PE
Brain Stimul. 2019 Jun 7; pii: S1935-861X(19)30261-X. doi: 10.1016/j.brs.2019.06.010. Epub 2019 Jun 7.
PMID: 31204205

A Measure to Assess Perceptions and Knowledge About Electroconvulsive Therapy: Development and Psychometric Properties.
Tsai J, Huang M, Wilkinson ST, Edelen C, Rosenheck RA, Holtzheimer PE
J ECT. 2019 Jun 11; doi: 10.1097/YCT.0000000000000609. Epub 2019 Jun 11.
PMID: 31192871

Electroconvulsive Therapy in Recurrent Oligodendroglioma After Resection.
Almiron Bonnin DA, Holtzheimer PE, Knight J
J ECT. 2019 Apr 8; doi: 10.1097/YCT.0000000000000593. Epub 2019 Apr 8.
PMID: 30973455

Fusing Mobile Phone Sensing and Brain Imaging to Assess Depression in College Students.
Huckins JF, daSilva AW, Wang R, Wang W, Hedlund EL, Murphy EI, Lopez RB, Rogers C, Holtzheimer PE, Kelley WM, Heatherton TF, Wagner DD, Haxby JV, Campbell AT
Front Neurosci. 2019;13:248. doi: 10.3389/fnins.2019.00248. Epub 2019 Mar 21.
PMID: 30949024

Leveraging Neuroplasticity to Enhance Adaptive Learning: The Potential for Synergistic Somatic-Behavioral Treatment Combinations to Improve Clinical Outcomes in Depression.
Wilkinson ST, Holtzheimer PE, Gao S, Kirwin DS, Price RB
Biol Psychiatry. 2019 Mar 15;85(6):454-465. doi: 10.1016/j.biopsych.2018.09.004. Epub 2018 Sep 20.
PMID: 30528745

Defining Treatment-Resistant Posttraumatic Stress Disorder: A Framework for Future Research.
Sippel LM, Holtzheimer PE, Friedman MJ, Schnurr PP
Biol Psychiatry. 2018 Sep 1;84(5):e37-e41. doi: 10.1016/j.biopsych.2018.03.011. Epub 2018 Apr 10.
PMID: 29752073

Neurocognitive Effects of Repetitive Transcranial Magnetic Stimulation With a 2-Coil Device in Treatment-Resistant Major Depressive Disorder.
Kavanaugh BC, Aaronson ST, Clarke GN, Holtzheimer PE, Johnson CW, McDonald WM, Schneider MB, Carpenter LL
J ECT. 2018 Dec;34(4):258-265. doi: 10.1097/YCT.0000000000000494.
PMID: 29613944

Defining Mechanisms of Transcranial Magnetic Stimulation as a Treatment for Depression Through Neuroimaging: Progress and Challenges.
Holtzheimer PE
Biol Psychiatry Cogn Neurosci Neuroimaging. 2018 Mar;3(3):201-202. doi: 10.1016/j.bpsc.2018.01.011.
PMID: 29486857

Subcallosal cingulate deep brain stimulation for treatment-resistant depression: a multisite, randomised, sham-controlled trial.
Holtzheimer PE, Husain MM, Lisanby SH, Taylor SF, Whitworth LA, McClintock S, Slavin KV, Berman J, McKhann GM, Patil PG, Rittberg BR, Abosch A, Pandurangi AK, Holloway KL, Lam RW, Honey CR, Neimat JS, Henderson JM, DeBattista C, Rothschild AJ, Pilitsis JG, Espinoza RT, Petrides G, Mogilner AY, Matthews K, Peichel D, Gross RE, Hamani C, Lozano AM, Mayberg HS
Lancet Psychiatry. 2017 Nov;4(11):839-849. doi: 10.1016/S2215-0366(17)30371-1. Epub 2017 Oct 4.
PMID: 28988904

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