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Gregory J. Tsongalis, BS, MS, PhD

Professor of Pathology and Laboratory Medicine

Additional Titles/Positions/Affiliations
Vice Chair for Research and
Director, Clinical Genomics and Advanced Technology (CGAT)

Pathology and Laboratory Medicine

Univ. of Massachusetts, Amherst, BS, 1984
Quinnipiac College, MHS, 1986
Univ. of Medicine and Dentistry of New Jersey, PhD 1990
Uniiv. of North Carolina, Chapel Hill, post-doctoral 1990-1994

Norris Cotton Cancer Center
Program in Experimental and Molecular Medicine


Contact Information

Department of Pathology and Laboratory Medicine
Dartmouth-Hitchcock Medical Center
One Medical Center Drive
Lebanon NH 03756

Office: WTRB 4th floor
Phone: 603-650-5498
Fax: 603-650-6120
Email: Gregory.J.Tsongalis@hitchcock.org

Assistant: Amber Erskine
Asst. Phone: 603-650-6821
Asst. Email: amber.j.erskine@hitchcock.org

Professional Interests

Development of advanced diagnostic technologies and disease biomarker discovery.

Grant Information

01/2014-12/30/15; Molecular profiling of tumor and ctDNA, riends of NCCC Scholar $50,000

03/01/13-01/31/2018; 1P20GM104416, Investigator / 2% COBRE Center for Molecular Epidemiology, Federal Direct Costs: $1,793,732

Selected Publications


Potential Impact of Pharmacogenomic Single Nucleotide Variants in a Rural Caucasian Population.
Williams GR, Tsongalis GJ, Lewis LD, Barney RE, Cook LJ, Geno AK, Nerenz RD
J Appl Lab Med. 2023 Jan 5; pii: jfac091. doi: 10.1093/jalm/jfac091. Epub 2023 Jan 5.
PMID: 36611001

Current Topics in Molecular Diagnostics and Precision Medicine.
Tsongalis GJ
Clin Lab Med. 2022 Dec;42(4):xi-xii. doi: 10.1016/j.cll.2022.09.019. Epub 2022 Oct 20.
PMID: 36368791

A novel method to assess copy number variation in melanoma: Droplet digital PCR for precise quantitation of the RREB1 gene in formalin-fixed, paraffin-embedded melanocytic neoplasms, a proof-of-concept study.
O'Hern K, Barney R, Chambers M, Baker C, Stevanovic M, Tsongalis GJ, Hughes E, Sriharan A
J Cutan Pathol. 2023 Feb;50(2):169-177. doi: 10.1111/cup.14352. Epub 2022 Nov 22.
PMID: 36325821

Predicting oncogene mutations of lung cancer using deep learning and histopathologic features on whole-slide images.
Tomita N, Tafe LJ, Suriawinata AA, Tsongalis GJ, Nasir-Moin M, Dragnev K, Hassanpour S
Transl Oncol. 2022 Oct;24:101494. doi: 10.1016/j.tranon.2022.101494. Epub 2022 Jul 26.
PMID: 35905641

Wastewater-Based SARS-CoV-2 Surveillance in Northern New England.
Toledo DM, Robbins AA, Gallagher TL, Hershberger KC, Barney RE, Salmela SM, Pilcher D, Cervinski MA, Nerenz RD, Szczepiorkowski ZM, Tsongalis GJ, Lefferts JA, Martin IW, Hubbard JA
Microbiol Spectr. 2022 Apr 27;10(2):e0220721. doi: 10.1128/spectrum.02207-21. Epub 2022 Apr 12.
PMID: 35412387

Actionable Tumor Alterations and Treatment Protocol Enrollment of Pediatric and Young Adult Patients With Refractory Cancers in the National Cancer Institute-Children's Oncology Group Pediatric MATCH Trial.
Parsons DW, Janeway KA, Patton DR, Winter CL, Coffey B, Williams PM, Roy-Chowdhuri S, Tsongalis GJ, Routbort M, Ramirez NC, Saguilig L, Piao J, Alonzo TA, Berg SL, Fox E, Hawkins DS, Abrams JS, Mooney M, Takebe N, Tricoli JV, Seibel NL, NCI-COG Pediatric MATCH Team
J Clin Oncol. 2022 Jul 10;40(20):2224-2234. doi: 10.1200/JCO.21.02838. Epub 2022 Mar 30.
PMID: 35353553

Living the best of both worlds: A personal scientific journey.
Tsongalis GJ
FASEB Bioadv. 2022 Feb;4(2):95-101. doi: 10.1096/fba.2021-00103. Epub 2021 Nov 5.
PMID: 35141473

Mixed Effects Machine Learning Models for Colon Cancer Metastasis Prediction using Spatially Localized Immuno-Oncology Markers.
Levy JJ, Bobak CA, Nasir-Moin M, Veziroglu EM, Palisoul SM, Barney RE, Salas LA, Christensen BC, Tsongalis GJ, Vaickus LJ
Pac Symp Biocomput. 2022;27:175-186.
PMID: 34890147

Plasmonic Nanoparticle Conjugation for Nucleic Acid Biosensing.
Tadimety A, Zhang Y, Molinski JH, Palinski TJ, Tsongalis GJ, Zhang JXJ
Methods Mol Biol. 2022;2393:73-87. doi: 10.1007/978-1-0716-1803-5_5.
PMID: 34837175

CRISPR-cas13 enzymology rapidly detects SARS-CoV-2 fragments in a clinical setting.
Khan WA, Barney RE, Tsongalis GJ
J Clin Virol. 2021 Dec;145:105019. doi: 10.1016/j.jcv.2021.105019. Epub 2021 Oct 28.
PMID: 34753073

View more publications on PubMed