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Gregory J. Tsongalis, BS, MS, PhD

Professor of Pathology and Laboratory Medicine

Additional Titles/Positions/Affiliations
Vice Chair for Research and
Director, Clinical Genomics and Advanced Technology (CGAT)

Pathology and Laboratory Medicine

Univ. of Massachusetts, Amherst, BS, 1984
Quinnipiac College, MHS, 1986
Univ. of Medicine and Dentistry of New Jersey, PhD 1990
Uniiv. of North Carolina, Chapel Hill, post-doctoral 1990-1994

Dartmouth Cancer Center
Program in Experimental and Molecular Medicine

Websites DHMC-CGAT.com

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Contact Information

Department of Pathology and Laboratory Medicine
Dartmouth-Hitchcock Medical Center
One Medical Center Drive
Lebanon NH 03756

Office: WTRB 4th floor
Phone: 603-650-5498
Fax: 603-650-6120
Email: Gregory.J.Tsongalis@hitchcock.org

Assistant: Amber Erskine
Asst. Phone: 603-650-6821
Asst. Email: amber.j.erskine@hitchcock.org

Professional Interests

Development of advanced diagnostic technologies and disease biomarker discovery.

Grant Information

01/2014-12/30/15; Molecular profiling of tumor and ctDNA, riends of NCCC Scholar $50,000

03/01/13-01/31/2018; 1P20GM104416, Investigator / 2% COBRE Center for Molecular Epidemiology, Federal Direct Costs: $1,793,732

Selected Publications


Clinical Trial Protocol for "Replace Cysto": Replacing Invasive Cystoscopy with Urine Testing for Non-muscle-invasive Bladder Cancer Surveillance-A Multicenter, Randomized, Phase 2 Healthcare Delivery Trial Comparing Quality of Life During Cancer Surveillance with Xpert Bladder Cancer Monitor or Bladder EpiCheck Urine Testing Versus Frequent Cystoscopy.
Schroeck FR, Grubb R, MacKenzie TA, Ould Ismail AA, Jensen L, Tsongalis GJ, Lotan Y
Eur Urol Open Sci. 2024 May;63:19-30. doi: 10.1016/j.euros.2024.02.018. Epub 2024 Mar 21.
PMID: 38558761

Internal Standards for Limit Controls and Absolute Abundance Measurement of Oncogenic Fusions and Mutations.
Morrison T, Lo B, Deharvengt SJ, Lazaridis N, Tsongalis GJ
J Appl Lab Med. 2024 Jan 3;9(1):175-179. doi: 10.1093/jalm/jfad108.
PMID: 38167771

Potential to Enhance Large Scale Molecular Assessments of Skin Photoaging through Virtual Inference of Spatial Transcriptomics from Routine Staining.
Srinivasan G, Davis MJ, LeBoeuf MR, Fatemi M, Azher ZL, Lu Y, Diallo AB, Saldias Montivero MK, Kolling FW, Perrard L, Salas LA, Christensen BC, Palys TJ, Karagas MR, Palisoul SM, Tsongalis GJ, Vaickus LJ, Preum SM, Levy JJ
Pac Symp Biocomput. 2024;29:477-491.
PMID: 38160301

The Overlooked Role of Specimen Preparation in Bolstering Deep Learning-Enhanced Spatial Transcriptomics Workflows.
Fatemi MY, Lu Y, Diallo AB, Srinivasan G, Azher ZL, Christensen BC, Salas LA, Tsongalis GJ, Palisoul SM, Perreard L, Kolling FW, Vaickus LJ, Levy JJ
medRxiv. 2023 Oct 9; pii: 2023.10.09.23296700. doi: 10.1101/2023.10.09.23296700. Epub 2023 Oct 9.
PMID: 37873287

Feasibility of Inferring Spatial Transcriptomics from Single-Cell Histological Patterns for Studying Colon Cancer Tumor Heterogeneity.
Fatemi MY, Lu Y, Sharma C, Feng E, Azher ZL, Diallo AB, Srinivasan G, Rosner GM, Pointer KB, Christensen BC, Salas LA, Tsongalis GJ, Palisoul SM, Perreard L, Kolling FW, Vaickus LJ, Levy JJ
medRxiv. 2023 Oct 9; pii: 2023.10.09.23296701. doi: 10.1101/2023.10.09.23296701. Epub 2023 Oct 9.
PMID: 37873186

A rapid, multiplex digital PCR assay to detect gene variants and fusions in non-small cell lung cancer.
Leatham B, McNall K, Subramanian HKK, Jacky L, Alvarado J, Yurk D, Wang M, Green DC, Tsongalis GJ, Rajagopal A, Schwartz JJ
Mol Oncol. 2023 Nov;17(11):2221-2234. doi: 10.1002/1878-0261.13523. Epub 2023 Oct 4.
PMID: 37714814

Validation of a Droplet Digital PCR (ddPCR) Assay to Detect Cyanobacterial 16S rDNA in Human Lung Tissue.
Barney RE, Huang G, Gallagher TL, Tischbein M, DeWitt J, Martindale R, LaRochelle EMP, Tsongalis GJ, Stommel EW
Toxics. 2023 Jun 14;11(6) doi: 10.3390/toxics11060531. Epub 2023 Jun 14.
PMID: 37368631

Providing Diagnostic Pathology Services in Low and Middle-Income Countries.
Ruhangaza D, Kennedy LS, Tsongalis GJ
Hematol Oncol Clin North Am. 2024 Feb;38(1):209-216. doi: 10.1016/j.hoc.2023.05.015. Epub 2023 Jun 14.
PMID: 37328312

A Novel Method to Detect Copy Number Variation in Melanoma: Droplet Digital PCR for Quantitation of the CDKN2A Gene, a Proof-of-Concept Study.
McFadden JR, Syku M, Barney RE, Stevanovic M, Chaudhari AS, O'Hern KJ, Chambers M, Baker CM, LeBlanc RE, Doan L, Tsongalis GJ, Hughes EG, Sriharan A
Am J Dermatopathol. 2023 Jul 1;45(7):454-462. doi: 10.1097/DAD.0000000000002436. Epub 2023 May 2.
PMID: 37130203

Inferring spatial transcriptomics markers from whole slide images to characterize metastasis-related spatial heterogeneity of colorectal tumors: A pilot study.
Fatemi M, Feng E, Sharma C, Azher Z, Goel T, Ramwala O, Palisoul SM, Barney RE, Perreard L, Kolling FW, Salas LA, Christensen BC, Tsongalis GJ, Vaickus LJ, Levy JJ
J Pathol Inform. 2023;14:100308. doi: 10.1016/j.jpi.2023.100308. Epub 2023 Mar 29.
PMID: 37114077

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