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Gregory J. Tsongalis, BS, MS, PhD

Title(s)
Emeritus Professor of Pathology and Laboratory Medicine

Additional Titles/Positions/Affiliations
Vice Chair for Research and
Director, Clinical Genomics and Advanced Technology (CGAT)

Department(s)
Pathology and Laboratory Medicine

Education
Univ. of Massachusetts, Amherst, BS, 1984
Quinnipiac College, MHS, 1986
Univ. of Medicine and Dentistry of New Jersey, PhD 1990
Uniiv. of North Carolina, Chapel Hill, post-doctoral 1990-1994

Programs
Dartmouth Cancer Center
Program in Experimental and Molecular Medicine

Websites DHMC-CGAT.com

Contact Information

Department of Pathology and Laboratory Medicine
Dartmouth-Hitchcock Medical Center
One Medical Center Drive
Lebanon NH 03756

Office: WTRB 4th floor
Phone: 603-650-5498
Fax: 603-650-6120
Email: Gregory.J.Tsongalis@hitchcock.org

Assistant: Amber Erskine
Asst. Phone: 603-650-6821
Asst. Email: amber.j.erskine@hitchcock.org


Professional Interests

Development of advanced diagnostic technologies and disease biomarker discovery.

Grant Information

01/2014-12/30/15; Molecular profiling of tumor and ctDNA, riends of NCCC Scholar $50,000

03/01/13-01/31/2018; 1P20GM104416, Investigator / 2% COBRE Center for Molecular Epidemiology, Federal Direct Costs: $1,793,732


Selected Publications

 

Germline Cancer Predisposition Results From the National Cancer Institute-Children's Oncology Group Pediatric MATCH Trial.
Scollon S, Plon SE, Joffe S, Biegel JA, Kulkarni S, Miles G, Patton DR, Coffey B, Winter CL, Tsongalis GJ, Routbort MJ, Ramirez NC, Saguilig L, Piao J, Alonzo TA, Berg SL, Fox E, Weigel B, Hawkins DS, Abrams JS, Mooney M, Takebe N, Tricoli JV, Janeway KA, Seibel NL, Parsons DW, NCI-COG Pediatric MATCH Germline Reporting Committee
JCO Precis Oncol. 2025 Oct;9:e2500742. doi: 10.1200/PO-25-00742. Epub 2025 Oct 30.
PMID: 41166674

Standardized Workflow and Analytical Validation of Cell-Free DNA Extraction for Liquid Biopsy Using a Magnetic Bead-Based Cartridge System.
Sathyanarayana SH, Spracklin SB, Deharvengt SJ, Green DC, Instasi MD, Gallagher TL, Shah PS, Tsongalis GJ
Cells. 2025 Jul 11;14(14) doi: 10.3390/cells14141062. Epub 2025 Jul 11.
PMID: 40710315

Novel Homozygous Full Gene Deletion of SLC12A5 in a Newborn With Refractory Seizures.
Wainman LM, Wright DL, Shah ND, Khan WA, Tsongalis GJ, Lefferts JA
Am J Med Genet A. 2025 Nov;197(11):e64180. doi: 10.1002/ajmg.a.64180. Epub 2025 Jul 9.
PMID: 40630017

A Concordance Study among 26 NGS Laboratories Participating in the NCI Molecular Analysis for Therapy Choice Clinical Trial.
Zane LK, Yee LM, Chang TC, Sklar J, Yang G, Wen JD, Li P, Harrington R, Sims DJ, Harper K, Trent JM, LoBello JR, Szelinger S, Benson K, Zeng J, Poorman K, Xu D, Frampton GM, Pavlick DC, Miller VA, Tandon B, Swat W, Weiss L, Funari VA, Conroy JM, Prescott JL, Chandra PK, Ma C, Champion KJ, Baschkopf GX, Fesko YA, Freitas TAK, Tomlins SA, Hovelson DH, White K, Sorrells S, Tell R, Beaubier N, King D, Li L, Kelly K, Uvalic J, Meyers B, Kolhe R, Lindeman NI, Baltay M, Sholl LM, Lopategui J, Vail E, Zhang W, Telatar M, Afkhami M, Hsiao SJ, Mansukhani MM, Adams E, Jiang L, NCI-MATCH Designated Laboratories, Aldape KD, Raffeld M, Xi L, for NCI-COMPASS Team, Stehr H, Segal JP, Aisner DL, Davies KD, Brown NA, Livingston RJ, Konnick EQ, Song W, Solomon JP, Walther Z, for NCI-MATCH Designated Laboratories, McShane LM, Harris LN, Chen AP, Tsongalis GJ, Hamilton SR, Flaherty KT, O'Dwyer PJ, Conley BA, Patton DR, Iafrate AJ, Williams PM, Tricoli JV, Karlovich C
Clin Cancer Res. 2025 Aug 14;31(16):3512-3525. doi: 10.1158/1078-0432.CCR-24-2188.
PMID: 40465838

Clinical Implementation of Expanded Solid Tumor Fusion Detection With Whole-Transcriptome Sequencing at an Academic Cancer Center.
Hughes EG, Bergman DT, Green DC, Sukhadia SS, Lefferts JA, Karrs JX, Vyas RS, Cieslak Z, Barbuto JN, Ognjenovic NB, Palisoul BE, Tsongalis GJ, Tafe LJ, Shah PS
JCO Precis Oncol. 2025 May;9:e2400830. doi: 10.1200/PO-24-00830. Epub 2025 May 29.
PMID: 40440583

Detection of Microsatellite Instability in Endometrial Carcinoma Using a Novel Homopolymer Assay.
Nicka CM, Green DC, Tsongalis GJ, Tafe LJ
Int J Surg Pathol. 2025 Sep;33(6):1341-1348. doi: 10.1177/10668969241311500. Epub 2025 Mar 3.
PMID: 40033864

Simplifying SARS-CoV-2 wastewater-based surveillance using an automated FDA EUA assay.
Sathyanarayana SH, Robins AA, Toledo DM, Gallagher TL, Tsongalis GJ, Hubbard JA, Lefferts JA, Martin IW
Microbiol Spectr. 2025 Apr;13(4):e0249024. doi: 10.1128/spectrum.02490-24. Epub 2025 Feb 25.
PMID: 39998239

Diagnostic next-generation sequencing to detect MYD88 L265P in Lymphoplasmacytic lymphoma compared to ddPCR.
Wainman LM, Huang G, Green DC, Tsongalis GJ, Tafe LJ, Khan WA, Kaur P, Shah PS, Karrs JX
Exp Mol Pathol. 2025 Mar;141:104956. doi: 10.1016/j.yexmp.2025.104956. Epub 2025 Feb 15.
PMID: 39954570

Nanopore-based random genomic sampling for intraoperative molecular diagnosis.
Emiliani FE, Ismail AAO, Hughes EG, Tsongalis GJ, Zanazzi GJ, Lin CC
Genome Med. 2025 Jan 20;17(1):6. doi: 10.1186/s13073-025-01427-7. Epub 2025 Jan 20.
PMID: 39833913

Prevalence of Human Papillomavirus-Associated Head and Neck Cancer in Rwanda: A 10-Year Review.
Rubagumya F, Businge L, Hopman WH, Murenzi G, Uwimbabazi A, Kwizera V, Imuragire J, Muvunyi TZ, Izimukwiye I, Adedimeji A, Barney RE, Tsongalis GJ, Chamberlin MD, Anastos K, Kabarriti R
Cancer Med. 2024 Nov;13(21):e70423. doi: 10.1002/cam4.70423.
PMID: 39530527

View more publications on PubMed