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Gregory J. Tsongalis, BS, MS, PhD

Professor of Pathology and Laboratory Medicine

Additional Titles/Positions/Affiliations
Vice Chair for Research and
Director, Clinical Genomics and Advanced Technology (CGAT)

Pathology and Laboratory Medicine

Univ. of Massachusetts, Amherst, BS, 1984
Quinnipiac College, MHS, 1986
Univ. of Medicine and Dentistry of New Jersey, PhD 1990
Uniiv. of North Carolina, Chapel Hill, post-doctoral 1990-1994

Dartmouth Cancer Center
Program in Experimental and Molecular Medicine

Websites DHMC-CGAT.com

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Contact Information

Department of Pathology and Laboratory Medicine
Dartmouth-Hitchcock Medical Center
One Medical Center Drive
Lebanon NH 03756

Office: WTRB 4th floor
Phone: 603-650-5498
Fax: 603-650-6120
Email: Gregory.J.Tsongalis@hitchcock.org

Assistant: Amber Erskine
Asst. Phone: 603-650-6821
Asst. Email: amber.j.erskine@hitchcock.org

Professional Interests

Development of advanced diagnostic technologies and disease biomarker discovery.

Grant Information

01/2014-12/30/15; Molecular profiling of tumor and ctDNA, riends of NCCC Scholar $50,000

03/01/13-01/31/2018; 1P20GM104416, Investigator / 2% COBRE Center for Molecular Epidemiology, Federal Direct Costs: $1,793,732

Selected Publications


Validation and Implementation of a Somatic-Only Tumor Exome for Routine Clinical Application.
Shah PS, Hughes EG, Sukhadia SS, Green DC, Houde BE, Tsongalis GJ, Tafe LJ
J Mol Diagn. 2024 Jul 6; pii: S1525-1578(24)00151-X. doi: 10.1016/j.jmoldx.2024.05.013. Epub 2024 Jul 6.
PMID: 38972591

Analytical validation of a semi-automated methodology for quantitative measurement of SARS-CoV-2 RNA in wastewater collected in northern New England.
Robbins AA, Gallagher TL, Toledo DM, Hershberger KC, Salmela SM, Barney RE, Szczepiorkowski ZM, Tsongalis GJ, Martin IW, Hubbard JA, Lefferts JA
Microbiol Spectr. 2024 Jun 4;12(6):e0112223. doi: 10.1128/spectrum.01122-23. Epub 2024 May 15.
PMID: 38747589

Circulating perturbation of phosphatidylcholine (PC) and phosphatidylethanolamine (PE) is associated to cardiac remodeling and NLRP3 inflammasome in cardiovascular patients with insulin resistance risk.
Vianello E, Ambrogi F, Kalousova M, Badalyan J, Dozio E, Tacchini L, Schmitz G, Zima T, Tsongalis GJ, Corsi-Romanelli MM
Exp Mol Pathol. 2024 Jun;137:104895. doi: 10.1016/j.yexmp.2024.104895. Epub 2024 May 3.
PMID: 38703553

Clinical Trial Protocol for "Replace Cysto": Replacing Invasive Cystoscopy with Urine Testing for Non-muscle-invasive Bladder Cancer Surveillance-A Multicenter, Randomized, Phase 2 Healthcare Delivery Trial Comparing Quality of Life During Cancer Surveillance with Xpert Bladder Cancer Monitor or Bladder EpiCheck Urine Testing Versus Frequent Cystoscopy.
Schroeck FR, Grubb R, MacKenzie TA, Ould Ismail AA, Jensen L, Tsongalis GJ, Lotan Y
Eur Urol Open Sci. 2024 May;63:19-30. doi: 10.1016/j.euros.2024.02.018. Epub 2024 Mar 21.
PMID: 38558761

Internal Standards for Limit Controls and Absolute Abundance Measurement of Oncogenic Fusions and Mutations.
Morrison T, Lo B, Deharvengt SJ, Lazaridis N, Tsongalis GJ
J Appl Lab Med. 2024 Jan 3;9(1):175-179. doi: 10.1093/jalm/jfad108.
PMID: 38167771

Potential to Enhance Large Scale Molecular Assessments of Skin Photoaging through Virtual Inference of Spatial Transcriptomics from Routine Staining.
Srinivasan G, Davis MJ, LeBoeuf MR, Fatemi M, Azher ZL, Lu Y, Diallo AB, Saldias Montivero MK, Kolling FW, Perrard L, Salas LA, Christensen BC, Palys TJ, Karagas MR, Palisoul SM, Tsongalis GJ, Vaickus LJ, Preum SM, Levy JJ
Pac Symp Biocomput. 2024;29:477-491.
PMID: 38160301

The Overlooked Role of Specimen Preparation in Bolstering Deep Learning-Enhanced Spatial Transcriptomics Workflows.
Fatemi MY, Lu Y, Diallo AB, Srinivasan G, Azher ZL, Christensen BC, Salas LA, Tsongalis GJ, Palisoul SM, Perreard L, Kolling FW, Vaickus LJ, Levy JJ
medRxiv. 2023 Oct 9; pii: 2023.10.09.23296700. doi: 10.1101/2023.10.09.23296700. Epub 2023 Oct 9.
PMID: 37873287

Feasibility of Inferring Spatial Transcriptomics from Single-Cell Histological Patterns for Studying Colon Cancer Tumor Heterogeneity.
Fatemi MY, Lu Y, Sharma C, Feng E, Azher ZL, Diallo AB, Srinivasan G, Rosner GM, Pointer KB, Christensen BC, Salas LA, Tsongalis GJ, Palisoul SM, Perreard L, Kolling FW, Vaickus LJ, Levy JJ
medRxiv. 2023 Oct 9; pii: 2023.10.09.23296701. doi: 10.1101/2023.10.09.23296701. Epub 2023 Oct 9.
PMID: 37873186

A rapid, multiplex digital PCR assay to detect gene variants and fusions in non-small cell lung cancer.
Leatham B, McNall K, Subramanian HKK, Jacky L, Alvarado J, Yurk D, Wang M, Green DC, Tsongalis GJ, Rajagopal A, Schwartz JJ
Mol Oncol. 2023 Nov;17(11):2221-2234. doi: 10.1002/1878-0261.13523. Epub 2023 Oct 4.
PMID: 37714814

Validation of a Droplet Digital PCR (ddPCR) Assay to Detect Cyanobacterial 16S rDNA in Human Lung Tissue.
Barney RE, Huang G, Gallagher TL, Tischbein M, DeWitt J, Martindale R, LaRochelle EMP, Tsongalis GJ, Stommel EW
Toxics. 2023 Jun 14;11(6) doi: 10.3390/toxics11060531. Epub 2023 Jun 14.
PMID: 37368631

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