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Gregory J. Tsongalis, BS, MS, PhD

Professor of Pathology and Laboratory Medicine

Additional Titles/Positions/Affiliations
Vice Chair for Research and
Director, Clinical Genomics and Advanced Technology (CGAT)

Pathology and Laboratory Medicine

Univ. of Massachusetts, Amherst, BS, 1984
Quinnipiac College, MHS, 1986
Univ. of Medicine and Dentistry of New Jersey, PhD 1990
Uniiv. of North Carolina, Chapel Hill, post-doctoral 1990-1994

Norris Cotton Cancer Center
Program in Experimental and Molecular Medicine

Websites DHMC-CGAT.com

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Contact Information

Department of Pathology and Laboratory Medicine
Dartmouth-Hitchcock Medical Center
One Medical Center Drive
Lebanon NH 03756

Office: WTRB 4th floor
Phone: 603-650-5498
Fax: 603-650-6120
Email: Gregory.J.Tsongalis@hitchcock.org

Assistant: Amber Erskine
Asst. Phone: 603-650-6821
Asst. Email: amber.j.erskine@hitchcock.org

Professional Interests

Development of advanced diagnostic technologies and disease biomarker discovery.

Grant Information

01/2014-12/30/15; Molecular profiling of tumor and ctDNA, riends of NCCC Scholar $50,000

03/01/13-01/31/2018; 1P20GM104416, Investigator / 2% COBRE Center for Molecular Epidemiology, Federal Direct Costs: $1,793,732

Selected Publications


A rapid, multiplex digital PCR assay to detect gene variants and fusions in non-small cell lung cancer.
Leatham B, McNall K, Subramanian HKK, Jacky L, Alvarado J, Yurk D, Wang M, Green DC, Tsongalis GJ, Rajagopal A, Schwartz JJ
Mol Oncol. 2023 Sep 15; doi: 10.1002/1878-0261.13523. Epub 2023 Sep 15.
PMID: 37714814

Validation of a Droplet Digital PCR (ddPCR) Assay to Detect Cyanobacterial 16S rDNA in Human Lung Tissue.
Barney RE, Huang G, Gallagher TL, Tischbein M, DeWitt J, Martindale R, LaRochelle EMP, Tsongalis GJ, Stommel EW
Toxics. 2023 Jun 14;11(6) doi: 10.3390/toxics11060531. Epub 2023 Jun 14.
PMID: 37368631

Providing Diagnostic Pathology Services in Low and Middle-Income Countries.
Ruhangaza D, Kennedy LS, Tsongalis GJ
Hematol Oncol Clin North Am. 2023 Jun 14; pii: S0889-8588(23)00070-9. doi: 10.1016/j.hoc.2023.05.015. Epub 2023 Jun 14.
PMID: 37328312

A Novel Method to Detect Copy Number Variation in Melanoma: Droplet Digital PCR for Quantitation of the CDKN2A Gene, a Proof-of-Concept Study.
McFadden JR, Syku M, Barney RE, Stevanovic M, Chaudhari AS, O'Hern KJ, Chambers M, Baker CM, LeBlanc RE, Doan L, Tsongalis GJ, Hughes EG, Sriharan A
Am J Dermatopathol. 2023 Jul 1;45(7):454-462. doi: 10.1097/DAD.0000000000002436. Epub 2023 May 2.
PMID: 37130203

Inferring spatial transcriptomics markers from whole slide images to characterize metastasis-related spatial heterogeneity of colorectal tumors: A pilot study.
Fatemi M, Feng E, Sharma C, Azher Z, Goel T, Ramwala O, Palisoul SM, Barney RE, Perreard L, Kolling FW, Salas LA, Christensen BC, Tsongalis GJ, Vaickus LJ, Levy JJ
J Pathol Inform. 2023;14:100308. doi: 10.1016/j.jpi.2023.100308. Epub 2023 Mar 29.
PMID: 37114077

Validation of a rapid HLA-DQA1*05 pharmacogenomics assay to identify at-risk resistance to anti-tumor necrosis factor therapy among patients with inflammatory bowel disease.
DelBaugh RM, Cook LJ, Siegel CA, Tsongalis GJ, Khan WA
Am J Clin Pathol. 2023 Aug 1;160(2):194-199. doi: 10.1093/ajcp/aqad036.
PMID: 37086490

Identification of Spatial Proteomic Signatures of Colon Tumor Metastasis: A Digital Spatial Profiling Approach.
Levy JJ, Zavras JP, Veziroglu EM, Nasir-Moin M, Kolling FW, Christensen BC, Salas LA, Barney RE, Palisoul SM, Ren B, Liu X, Kerr DA, Pointer KB, Tsongalis GJ, Vaickus LJ
Am J Pathol. 2023 Jun;193(6):778-795. doi: 10.1016/j.ajpath.2023.02.020. Epub 2023 Apr 8.
PMID: 37037284

Gain of CCND1 May Occur Too Infrequently in Cutaneous Melanoma, and Too Late in Melanomagenesis, to Be Diagnostically Useful: Genomic Analysis of 88 Cases.
McFadden JR, Chaudhari AS, Stevanovic M, Tsongalis GJ, Hughes EG, Sriharan A
Am J Dermatopathol. 2023 May 1;45(5):311-319. doi: 10.1097/DAD.0000000000002420. Epub 2023 Mar 20.
PMID: 36939129

Utility of Retrospective Molecular Analysis in Diagnostically Challenging Mesenchymal Neoplasms.
Mindiola Romero AE, Tafe LJ, Green DC, Deharvengt SJ, Winnick KN, Tsongalis GJ, Baker ML, Linos K, Levy JJ, Kerr DA
Int J Surg Pathol. 2023 Mar 13;:10668969231157783. doi: 10.1177/10668969231157783. Epub 2023 Mar 13.
PMID: 36911994

Molecular diagnostics and the laboratory developed test: A tale of success and the potential impacts of increased regulation.
Tsongalis GJ
J Mass Spectrom Adv Clin Lab. 2023 Apr;28:27-29. doi: 10.1016/j.jmsacl.2023.01.007. Epub 2023 Feb 1.
PMID: 36825239

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