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Todd A MacKenzie, PhD

Title(s)
Professor of Biomedical Data Science
Professor of Medicine
Professor of The Dartmouth Institute

Department(s)
Biomedical Data Science
Medicine
The Dartmouth Institute

Education
PhD (Statistics), McGill University, 1997
MSc (Statistics), McGill University, 1993
BSc, Dalhousie University, 1990

Programs
Dartmouth Cancer Center
Quantitative Biomedical Sciences
The Dartmouth Institute for Health Policy and Clinical Practice

Websites
http://scholar.google.com/citations?user=jwW_WhMAAAAJ&hl=en


Contact Information

Section of Clinical Research, HB 7505
One Medical Center Drive
Dartmouth Hitchcock Medical Center
Lebanon NH 03756

Phone: 603-653-3542
Fax: 603-653-3554
Email: Todd.A.MacKenzie@Dartmouth.edu


Professional Interests

I use statistics to facilitate clinical and health services research across a spectrum of disciplines and specialties. This work has been reported in over 300 publications. The majority of these projects involve comparative effectiveness, clinical trials, association studies, and prediction modeling. I am especially interested in survival (aka, time-to-event) analysis, and causal inference. Recent work includes studying the quality and effectiveness of colonoscopy for colorectal cancer screening and surveillance.



Courses Taught

QBS 121: Biostatistics II; a course in statistical modelling (Winter) with Tor Tosteson

QBS 123: Biostatistics Consulting

Past Teaching:
PH 271 (TDI) "Practice of Statistics in Medicine" with James O'Malley: This course was aimed at junior faculty, post-doctoral fellows and PhD students.


PH 147 (TDI) "Advanced Methods in Health Services Research" with Tracy Onega

PEMM 107 "Biostatistics" : A course in biostatistics I developed for bench and translational scientists in molecular medicine.


Selected Publications

 

An Explanatory Deep Learning Pipeline for the Prediction and Visualization of Spatially Resolved Biomarker Expression in Triple-Negative Breast Cancer.
Rao VR, Sadanandappa MK, Black CC, Palisoul SM, Workman AA, MacKenzie TA, Liu X, Chamberlin MD, Vaickus LJ, Zanazzi GJ, Sukhadia SS
Am J Pathol. 2026 Aug 7; pii: S0002-9440(26)00229-4. doi: 10.1016/j.ajpath.2026.07.007. Epub 2026 Aug 7.
PMID: 42567444

Identifying patients at elevated risk of stroke after transcarotid artery revascularization.
Columbo JA, Martinez-Camblor P, Hicks CW, MacKenzie TA, Stone DH, O'Malley AJ
J Vasc Surg. 2026 Jun 20; pii: S0741-5214(26)01303-0. doi: 10.1016/j.jvs.2026.06.064. Epub 2026 Jun 20.
PMID: 42323112

Is Age Just a Number? Outcomes of Simultaneous Pancreas-Kidney Transplantation in Patients ≥60 Years-A Contemporary SRTR Analysis.
Zhou R, MacKenzie TA, Wright M, Shaban E, Chobanian M, Daily MF, Matar AJ
Clin Transplant. 2026 May;40(5):e70561. doi: 10.1111/ctr.70561.
PMID: 42126085

Differences in T-cell Densities and Neighborhood Patterns in Human Colorectal Adenomas and Sessile Serrated Lesions.
Seal S, Fanning LR, Bagley E, Bookhout C, Barry EL, O'Quinn EC, Snover DC, Lewin DN, Guglietta S, Kourtidis A, Shrubsole MJ, Baron JA, Mackenzie TA, Alekseyenko AV, Wallace K
Cancer Epidemiol Biomarkers Prev. 2026 Jul 1;35(7):1174-1181. doi: 10.1158/1055-9965.EPI-26-0083.
PMID: 42112839

Instrumental variable estimation of a hazard ratio for treatment with a waiting time without specifying its dependence on unmeasured confounders: application to a procedural registry.
MacKenzie TA, Martinez-Camblor P, Chen H, Columbo JA, O'Malley AJ
Lifetime Data Anal. 2026 Apr 29;32(2) doi: 10.1007/s10985-026-09706-0. Epub 2026 Apr 29.
PMID: 42053825

When normalization induces correlation: shared and unstable references can create hidden dependencies.
Fukutani KF, Hampton TH, Santiago MLA, de Oliveira EJF, MacKenzie TA
NPJ Syst Biol Appl. 2026 Apr 21;12(1) doi: 10.1038/s41540-026-00722-2. Epub 2026 Apr 21.
PMID: 42014685

Kidney Failure in Persons With Cystic Fibrosis.
Stevanovic M, MacKenzie TA, Zimmerman AM, Graber ML
Kidney Med. 2026 May;8(5):101263. doi: 10.1016/j.xkme.2026.101263. Epub 2026 Jan 13.
PMID: 41971683

Association Between Index Adenomas and Advanced Findings at Third Colonoscopy: Data From the New Hampshire Colonoscopy Registry.
Javidi DJ, Dairi O, MacKenzie TA, Amos CI, Butterly LF, Anderson JC
Clin Gastroenterol Hepatol. 2026 Mar 27; pii: S1542-3565(26)00224-7. doi: 10.1016/j.cgh.2026.03.018. Epub 2026 Mar 27.
PMID: 41905521

Bridging evidence and practice: implementation science and bundled care strategies for fluid management in critically ill neonates.
Pak AC, Neyra JA, Brown JR, Travers CP, Starr MC, Harer MW, Sullivan I, MacKenzie TA, Colicchio TK, Griffin R, Askenazi DJ
Front Med (Lausanne). 2026;13:1706165. doi: 10.3389/fmed.2026.1706165. Epub 2026 Feb 25.
PMID: 41822900

Outcomes of Kidney Transplantation in Cystic Fibrosis.
Stevanovic M, MacKenzie TA, Zimmerman AM, Graber ML
Transplant Proc. 2026 Apr;58(3):429-435. doi: 10.1016/j.transproceed.2026.02.025. Epub 2026 Mar 5.
PMID: 41791970

View more publications on PubMed