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Todd A MacKenzie, PhD

Title(s)
Professor of Biomedical Data Science
Professor of Medicine
Professor of The Dartmouth Institute

Department(s)
Biomedical Data Science
Medicine
The Dartmouth Institute

Education
PhD (Statistics), McGill University, 1997
MSc (Statistics), McGill University, 1993
BSc, Dalhousie University, 1990

Programs
Dartmouth Cancer Center
Quantitative Biomedical Sciences
The Dartmouth Institute for Health Policy and Clinical Practice

Websites
http://scholar.google.com/citations?user=jwW_WhMAAAAJ&hl=en


Contact Information

Section of Clinical Research, HB 7505
One Medical Center Drive
Dartmouth Hitchcock Medical Center
Lebanon NH 03756

Phone: 603-653-3542
Fax: 603-653-3554
Email: Todd.A.MacKenzie@Dartmouth.edu


Professional Interests

I use statistics to facilitate clinical and health services research across a spectrum of disciplines and specialties. This work has been reported in over 300 publications. The majority of these projects involve comparative effectiveness, clinical trials, association studies, and prediction modeling. I am especially interested in survival (aka, time-to-event) analysis, and causal inference. Recent work includes studying the quality and effectiveness of colonoscopy for colorectal screening and surveillance.



Courses Taught

QBS 121: Biostatistics II; a course in statistical modelling (Winter) with Tor Tosteson

QBS 123: Biostatistics Consulting

Past Teaching:
PH 271 (TDI) "Practice of Statistics in Medicine" with James O'Malley: This course was aimed at junior faculty, post-doctoral fellows and PhD students.


PH 147 (TDI) "Advanced Methods in Health Services Research" with Tracy Onega

PEMM 107 "Biostatistics" : A course in biostatistics I developed for bench and translational scientists in molecular medicine.


Selected Publications

 

Augmenting the Hospital Score with social risk factors to improve prediction for 30-day readmission following acute myocardial infarction.
Ricket I, Matheny ME, Reeves RM, Shah RU, Goodrich CA, Gobbel G, Stabler ME, Perkins AM, Minter F, Dorn C, Bray BE, Christensen L, Gouripeddi R, Higgins J, Chapman WW, MacKenzie T, Brown JR
Med Res Arch. 2024 Nov;12(11) pii: 6089. doi: 10.18103/mra.v12i11.6089.
PMID: 39906889

Lymph Node Adiposity and Metabolic Dysfunction-Associated Steatotic Liver Disease.
Rubino JM, Ring NY, Patel K, Xia X, MacKenzie TA, diFlorio-Alexander RM
Biomedicines. 2025 Jan 1;13(1) doi: 10.3390/biomedicines13010080. Epub 2025 Jan 1.
PMID: 39857664

Patterns of initial treatment and subsequent care escalation among medicare beneficiaries with neck pain: a retrospective cohort study.
Anderson BR, MacKenzie TA, Lurie JD, Grout L, Whedon JM
Eur Spine J. 2024 Dec 26; doi: 10.1007/s00586-024-08581-3. Epub 2024 Dec 26.
PMID: 39722095

Which is the better polyp detection metric: adenomas per colonoscopy or adenoma detection rate? A simulation modeling study.
MacKenzie T, Xiao S, Hisey WH, Robinson CM, Butterly L, Anderson JC
Endosc Int Open. 2024 Nov;12(11):E1366-E1373. doi: 10.1055/a-2417-6248. Epub 2024 Nov 28.
PMID: 39610942

Gene expression responses of CF airway epithelial cells exposed to elexacaftor/tezacaftor/ivacaftor suggest benefits beyond improved CFTR channel function.
Hampton TH, Barnaby R, Roche C, Nymon A, Fukutani KF, MacKenzie TA, Charpentier LA, Stanton BA
Am J Physiol Lung Cell Mol Physiol. 2024 Dec 1;327(6):L905-L916. doi: 10.1152/ajplung.00272.2024. Epub 2024 Oct 22.
PMID: 39437760

Population-Based Estimates of the Prevalence of Children With Congenital Heart Disease and Associated Comorbidities in the United States.
Parker DM, Stabler ME, MacKenzie TA, Zimmerman MS, Shi X, Everett AD, Bucholz EM, Brown JR
Circ Cardiovasc Qual Outcomes. 2024 Sep;17(9):e010657. doi: 10.1161/CIRCOUTCOMES.123.010657. Epub 2024 Aug 26.
PMID: 39185543

Integrated primary and community mental health care for young adults with serious mental illness: A program evaluation.
Sowden GL, Ferron JC, Pratt SI, Swenson KR, Carbin J, Gowarty MA, Tvorun Dunn AG, MacKenzie TA, Brunette MF
Early Interv Psychiatry. 2024 Nov;18(11):968-974. doi: 10.1111/eip.13601. Epub 2024 Jul 30.
PMID: 39080989

Relationship of Handgrip Strength and Asymmetry with Walking Ability in Older Adults with Excess Adiposity.
Cook SB, Chaudhry BA, Petersen CL, Mackenzie TA, Batsis JA
Adv Biol (Weinh). 2024 Oct;8(10):e2400068. doi: 10.1002/adbi.202400068. Epub 2024 Jul 15.
PMID: 39007213

Association between Colonoscopy Sedation Type and Polyp Detection: A Registry-based Cohort Study.
Quaye AN, Hisey WM, Mackenzie TA, Robinson CM, Richard JM, Anderson JC, Warters RD, Butterly LF
Anesthesiology. 2024 Jun 1;140(6):1088-1097. doi: 10.1097/ALN.0000000000004955.
PMID: 38629957

Clinical Trial Protocol for "Replace Cysto": Replacing Invasive Cystoscopy with Urine Testing for Non-muscle-invasive Bladder Cancer Surveillance-A Multicenter, Randomized, Phase 2 Healthcare Delivery Trial Comparing Quality of Life During Cancer Surveillance with Xpert Bladder Cancer Monitor or Bladder EpiCheck Urine Testing Versus Frequent Cystoscopy.
Schroeck FR, Grubb R, MacKenzie TA, Ould Ismail AA, Jensen L, Tsongalis GJ, Lotan Y
Eur Urol Open Sci. 2024 May;63:19-30. doi: 10.1016/j.euros.2024.02.018. Epub 2024 Mar 21.
PMID: 38558761

View more publications on PubMed