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Todd A MacKenzie, PhD

Professor of Biomedical Data Science
Professor of Medicine
Professor of The Dartmouth Institute

Biomedical Data Science
The Dartmouth Institute

PhD (Statistics), McGill University, 1997
MSc (Statistics), McGill University, 1993
BSc, Dalhousie University, 1990

Norris Cotton Cancer Center
Quantitative Biomedical Sciences
The Dartmouth Institute for Health Policy and Clinical Practice


Contact Information:

Section of Clinical Research, HB 7505
One Medical Center Drive
Dartmouth Hitchcock Medical Center
Lebanon NH 03756

Phone: 603-653-3542
Fax: 603-653-3554

Professional Interests:

I use statistics to facilitate clinical and health services research across a spectrum of disciplines and specialties. This work has been reported in over 250 publications. The majority of these projects involve comparative effectiveness, clinical trials, association studies, and prediction modeling. I am especially interested in survival (aka, time-to-event) analysis, and causal inference. Recently I have been studying the association of government spending with reduced mortality in order to help explain the stagnation of American longevity.

Courses Taught:

QBS 121: Biostatistics II; a course in statistical modelling (Winter) with Tor Tosteson

QBS Biostatistics Consulting

Past Teaching:
PH 271 (TDI) "Practice of Statistics in Medicine" with James O'Malley: This course was aimed at junior faculty, post-doctoral fellows and PhD students.

PH 147 (TDI) "Advanced Methods in Health Services Research" with Tracy Onega

PEMM 107 "Biostatistics" : A course in biostatistics I developed for bench and translational scientists in molecular medicine.

Selected Publications:


Incident Impaired Cognitive Function in Sarcopenic Obesity: Data From the National Health and Aging Trends Survey.
Batsis JA, Haudenschild C, Roth RM, Gooding TL, Roderka MN, Masterson T, Brand J, Lohman MC, Mackenzie TA
J Am Med Dir Assoc. 2021 Apr;22(4):865-872.e5. doi: 10.1016/j.jamda.2020.09.008. Epub 2020 Oct 21.
PMID: 34248422

Fat-enlarged axillary lymph nodes are associated with node-positive breast cancer in obese patients.
diFlorio-Alexander RM, Song Q, Dwan D, Austin-Strohbehn JA, Muller KE, Kinlaw WB, MacKenzie TA, Karagas MR, Hassanpour S
Breast Cancer Res Treat. 2021 Aug;189(1):257-267. doi: 10.1007/s10549-021-06262-z. Epub 2021 Jun 3.
PMID: 34081259

A novel Mendelian randomization method with binary risk factor and outcome.
Allman PH, Aban I, Long DM, Bridges SL Jr, Srinivasasainagendra V, MacKenzie T, Cutter G, Tiwari HK
Genet Epidemiol. 2021 Jul;45(5):549-560. doi: 10.1002/gepi.22387. Epub 2021 May 16.
PMID: 33998053

Initial Choice of Spinal Manipulative Therapy for Treatment of Chronic Low Back Pain Leads to Reduced Long-term Risk of Adverse Drug Events Among Older Medicare Beneficiaries.
Whedon JM, Kizhakkeveettil A, Toler AW, MacKenzie TA, Lurie JD, Hurwitz EL, Bezdjian S, Bangash M, Uptmor S, Rossi D, Haldeman S
Spine (Phila Pa 1976). 2021 Apr 19; doi: 10.1097/BRS.0000000000004078. Epub 2021 Apr 19.
PMID: 33882542

Temporal Trends and Geographic Variations in the Supply of Clinicians Who Provide Spinal Manipulation to Medicare Beneficiaries: A Serial Cross-Sectional Study.
Whedon JM, Haldeman S, Petersen CL, Schoellkopf W, MacKenzie TA, Lurie JD
J Manipulative Physiol Ther. 2021 Mar;44(3):177-185. doi: 10.1016/j.jmpt.2021.02.002. Epub 2021 Apr 10.
PMID: 33849727

Mortality versus Municipal and State Government Spending in American Cities.
MacKenzie T, Lebeaux R
J Urban Health. 2021 Mar 24; doi: 10.1007/s11524-021-00516-3. Epub 2021 Mar 24.
PMID: 33761065

Time dependent hazard ratio estimation using instrumental variables without conditioning on an omitted covariate.
MacKenzie TA, Martinez-Camblor P, O'Malley AJ
BMC Med Res Methodol. 2021 Mar 20;21(1):56. doi: 10.1186/s12874-021-01245-6. Epub 2021 Mar 20.
PMID: 33743583

Modified STEADI Fall Risk Categories Predict Incident Cognitive Impairment.
Crow RS, Haudenschild C, Lohman MC, Roth RM, Roderka M, Masterson T, Brand J, Gooding T, Mackenzie TA, Batsis JA
J Am Geriatr Soc. 2021 May;69(5):1257-1264. doi: 10.1111/jgs.17034. Epub 2021 Feb 10.
PMID: 33565618

Development of Electronic Health Record-Based Prediction Models for 30-Day Readmission Risk Among Patients Hospitalized for Acute Myocardial Infarction.
Matheny ME, Ricket I, Goodrich CA, Shah RU, Stabler ME, Perkins AM, Dorn C, Denton J, Bray BE, Gouripeddi R, Higgins J, Chapman WW, MacKenzie TA, Brown JR
JAMA Netw Open. 2021 Jan 4;4(1):e2035782. doi: 10.1001/jamanetworkopen.2020.35782. Epub 2021 Jan 4.
PMID: 33512518

Feasibility and acceptability of a technology-based, rural weight management intervention in older adults with obesity.
Batsis JA, Petersen CL, Clark MM, Cook SB, Kotz D, Gooding TL, Roderka MN, Al-Nimr RI, Pidgeon D, Haedrich A, Wright KC, Aquila C, Mackenzie TA
BMC Geriatr. 2021 Jan 12;21(1):44. doi: 10.1186/s12877-020-01978-x. Epub 2021 Jan 12.
PMID: 33435877

View more publications on PubMed