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Todd A MacKenzie, PhD

Title(s)
Professor of Biomedical Data Science
Professor of Medicine
Professor of The Dartmouth Institute

Department(s)
Biomedical Data Science
Medicine
The Dartmouth Institute

Education
PhD (Statistics), McGill University, 1997
MSc (Statistics), McGill University, 1993
BSc, Dalhousie University, 1990

Programs
Dartmouth Cancer Center
Quantitative Biomedical Sciences
The Dartmouth Institute for Health Policy and Clinical Practice

Websites
http://scholar.google.com/citations?user=jwW_WhMAAAAJ&hl=en


Academic Analytics
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Contact Information

Section of Clinical Research, HB 7505
One Medical Center Drive
Dartmouth Hitchcock Medical Center
Lebanon NH 03756

Phone: 603-653-3542
Fax: 603-653-3554
Email: Todd.A.MacKenzie@Dartmouth.edu


Professional Interests

I use statistics to facilitate clinical and health services research across a spectrum of disciplines and specialties. This work has been reported in over 300 publications. The majority of these projects involve comparative effectiveness, clinical trials, association studies, and prediction modeling. I am especially interested in survival (aka, time-to-event) analysis, and causal inference. Recent work includes studying the quality and effectiveness of colonoscopy for colorectal screening and surveillance.



Courses Taught

QBS 121: Biostatistics II; a course in statistical modelling (Winter) with Tor Tosteson

QBS 123: Biostatistics Consulting

Past Teaching:
PH 271 (TDI) "Practice of Statistics in Medicine" with James O'Malley: This course was aimed at junior faculty, post-doctoral fellows and PhD students.


PH 147 (TDI) "Advanced Methods in Health Services Research" with Tracy Onega

PEMM 107 "Biostatistics" : A course in biostatistics I developed for bench and translational scientists in molecular medicine.


Selected Publications

 

Association between Colonoscopy Sedation Type and Polyp Detection: A Registry-based Cohort Study.
Quaye AN, Hisey WM, Mackenzie TA, Robinson CM, Richard JM, Anderson JC, Warters RD, Butterly LF
Anesthesiology. 2024 Jun 1;140(6):1088-1097. doi: 10.1097/ALN.0000000000004955.
PMID: 38629957

Clinical Trial Protocol for "Replace Cysto": Replacing Invasive Cystoscopy with Urine Testing for Non-muscle-invasive Bladder Cancer Surveillance-A Multicenter, Randomized, Phase 2 Healthcare Delivery Trial Comparing Quality of Life During Cancer Surveillance with Xpert Bladder Cancer Monitor or Bladder EpiCheck Urine Testing Versus Frequent Cystoscopy.
Schroeck FR, Grubb R, MacKenzie TA, Ould Ismail AA, Jensen L, Tsongalis GJ, Lotan Y
Eur Urol Open Sci. 2024 May;63:19-30. doi: 10.1016/j.euros.2024.02.018. Epub 2024 Mar 21.
PMID: 38558761

Response to commentary on "Automated classification of fat-infiltrated axillary lymph nodes on screening mammograms".
Song Q, diFlorio-Alexander RM, Sieberg RT, Dwan D, Boyce W, Stumetz K, Patel SD, Karagas MR, Mackenzie TA, Hassanpour S
Br J Radiol. 2024 Feb 2;97(1154):481-482. doi: 10.1093/bjr/tqad062.
PMID: 38306449

Why Are We Weighting? Understanding the Estimates From Propensity Score Weighting and Matching Methods.
Ramkumar N, Iribarne A, Olmstead EM, Malenka DJ, Mackenzie TA
Circ Cardiovasc Qual Outcomes. 2024 Jan;17(1):e007803. doi: 10.1161/CIRCOUTCOMES.120.007803. Epub 2024 Jan 8.
PMID: 38189126

APPLICATION OF QUANTILE DISCRETIZATION AND BAYESIAN NETWORK ANALYSIS TO PUBLICLY AVAILABLE CYSTIC FIBROSIS DATA SETS.
Fukutani KF, Hampton TH, Bobak CA, MacKenzie TA, Stanton BA
Pac Symp Biocomput. 2024;29:534-548.
PMID: 38160305

Relationship Between Tobacco Product Use and Health-Related Quality of Life Among Individuals With COPD in Waves 1-5 (2013-2019) of the Population Assessment of Tobacco and Health Study.
Paulin LM, Halenar MJ, Edwards KC, Lauten K, Taylor K, Brunette M, Tanski S, MacKenzie T, Stanton CA, Hatsukami D, Hyland A, Mahoney MC, Niaura R, Trinidad D, Blanco C, Compton W, Gardner LD, Kimmel HL, Cummings KM, Lauterstein D, Roh EJ, Marshall D, Sargent JD
Chronic Obstr Pulm Dis. 2024 Jan 25;11(1):68-82. doi: 10.15326/jcopdf.2023.0422.
PMID: 38113525

Endoscopist adenomas-per-colonoscopy detection rates and risk for postcolonoscopy colorectal cancer: data from the New Hampshire Colonoscopy Registry.
Anderson JC, Rex DK, Mackenzie TA, Hisey W, Robinson CM, Butterly LF
Gastrointest Endosc. 2024 May;99(5):787-795. doi: 10.1016/j.gie.2023.11.014. Epub 2023 Nov 21.
PMID: 37993057

Automated classification of fat-infiltrated axillary lymph nodes on screening mammograms.
Song Q, diFlorio-Alexander RM, Sieberg RT, Dwan D, Boyce W, Stumetz K, Patel SD, Karagas MR, MacKenzie TA, Hassanpour S
Br J Radiol. 2023 Nov;96(1151):20220835. doi: 10.1259/bjr.20220835. Epub 2023 Sep 26.
PMID: 37751215

Novel integration of governmental data sources using machine learning to identify super-utilization among U.S. counties.
Ricket IM, Matheny ME, MacKenzie TA, Emond JA, Ailawadi KL, Brown JR
Intell Based Med. 2023;7 pii: 100093. doi: 10.1016/j.ibmed.2023.100093. Epub 2023 Jan 21.
PMID: 37476591

Candidate pathway analysis of surfactant proteins identifies CTSH and SFTA2 that influences lung cancer risk.
Luyapan J, Bosse Y, Li Z, Xiao X, Rosenberger A, Hung RJ, Lam S, Zienolddiny S, Liu G, Kiemeney LA, Chen C, McKay J, Johansson M, Johansson M, Tardon A, Fernandez-Tardon G, Brennan P, Field JK, Davies MP, Woll PJ, Cox A, Taylor F, Arnold SM, Lazarus P, Grankvist K, Landi MT, Christiani DC, MacKenzie TA, Amos CI
Hum Mol Genet. 2023 Sep 5;32(18):2842-2855. doi: 10.1093/hmg/ddad095.
PMID: 37471639

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