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Todd A MacKenzie, PhD

Professor of Biomedical Data Science
Professor of Medicine
Professor of The Dartmouth Institute

Biomedical Data Science
The Dartmouth Institute

PhD (Statistics), McGill University, 1997
MSc (Statistics), McGill University, 1993
BSc, Dalhousie University, 1990

Norris Cotton Cancer Center
Quantitative Biomedical Sciences
The Dartmouth Institute for Health Policy and Clinical Practice


Academic Analytics
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Contact Information

Section of Clinical Research, HB 7505
One Medical Center Drive
Dartmouth Hitchcock Medical Center
Lebanon NH 03756

Phone: 603-653-3542
Fax: 603-653-3554
Email: Todd.A.MacKenzie@Dartmouth.edu

Professional Interests

I use statistics to facilitate clinical and health services research across a spectrum of disciplines and specialties. This work has been reported in over 300 publications. The majority of these projects involve comparative effectiveness, clinical trials, association studies, and prediction modeling. I am especially interested in survival (aka, time-to-event) analysis, and causal inference. Recent work includes studying the association of government spending with reduced mortality in order to help explain the stagnation of American longevity, and the quality and effectiveness of colonoscopy for colorectal screening and surveillance.

Courses Taught

QBS 121: Biostatistics II; a course in statistical modelling (Winter) with Tor Tosteson

QBS 123: Biostatistics Consulting

Past Teaching:
PH 271 (TDI) "Practice of Statistics in Medicine" with James O'Malley: This course was aimed at junior faculty, post-doctoral fellows and PhD students.

PH 147 (TDI) "Advanced Methods in Health Services Research" with Tracy Onega

PEMM 107 "Biostatistics" : A course in biostatistics I developed for bench and translational scientists in molecular medicine.

Selected Publications


Association between sex and long-term outcomes of endovascular treatment for peripheral artery disease.
Ramkumar N, Suckow BD, Behrendt CA, Mackenzie TA, Sedrakyan A, Brown JR, Goodney PP
Catheter Cardiovasc Interv. 2023 Apr;101(5):877-887. doi: 10.1002/ccd.30617. Epub 2023 Mar 15.
PMID: 36924009

Sarcopenia Definition Outcome Consortium - defined Weakness and Risk of Falls: The National Health and Aging Trends Survey.
Batsis JA, Haudenschild C, Crow RS, Gilliam M, Mackenzie TA
Geriatr Gerontol Int. 2023 Mar;23(3):213-220. doi: 10.1111/ggi.14548. Epub 2023 Feb 8.
PMID: 36752357

Association between fat-infiltrated axillary lymph nodes on screening mammography and cardiometabolic disease.
Song Q, diFlorio-Alexander RM, Patel SD, Sieberg RT, Margron MJ, Ansari SM, Karagas MR, Mackenzie TA, Hassanpour S
Obes Sci Pract. 2022 Dec;8(6):757-766. doi: 10.1002/osp4.608. Epub 2022 May 3.
PMID: 36483128

Association between cervical artery dissection and spinal manipulative therapy -a medicare claims analysis.
Whedon JM, Petersen CL, Li Z, Schoelkopf WJ, Haldeman S, MacKenzie TA, Lurie JD
BMC Geriatr. 2022 Nov 29;22(1):917. doi: 10.1186/s12877-022-03495-5. Epub 2022 Nov 29.
PMID: 36447166

Discussion on "Instrumental variable estimation of the causal hazard ratio" by Linbo Wang, Eric Tchetgen Tchetgen, Torben Martinussen, and Stijn Vansteelandt.
O'Malley AJ, Martinez-Camblor P, MacKenzie TA
Biometrics. 2022 Nov 25; doi: 10.1111/biom.13794. Epub 2022 Nov 25.
PMID: 36427240

Quantifying differences in packaged food and drink purchases among households with diet-related cardiometabolic multi-morbidity: a cross-sectional analysis.
Ricket IM, Brown JR, MacKenzie TA, Ma Y, Grewal D, Ailawadi KL, Emond JA
BMC Public Health. 2022 Nov 17;22(1):2101. doi: 10.1186/s12889-022-14626-3. Epub 2022 Nov 17.
PMID: 36397061

Crohn's disease shared decision making intervention leads to more patients choosing combination therapy: a cluster randomised controlled trial.
Zisman-Ilani Y, Thompson KD, Siegel LS, Mackenzie T, Crate DJ, Korzenik JR, Melmed GY, Kozuch P, Sands BE, Rubin DT, Regueiro MD, Cross R, Wolf DC, Hanson JS, Schwartz RM, Vrabie R, Kreines MD, Scherer T, Dubinsky MC, Siegel CA
Aliment Pharmacol Ther. 2023 Jan;57(2):205-214. doi: 10.1111/apt.17286. Epub 2022 Nov 14.
PMID: 36377259

Using New Hampshire Colonoscopy Registry data to assess United States and European post-polypectomy surveillance guidelines.
Liu MC, Anderson JC, Hisey W, MacKenzie TA, Robinson CM, Butterly LF
Endoscopy. 2023 May;55(5):423-431. doi: 10.1055/a-1970-5377. Epub 2022 Oct 31.
PMID: 36316016

The impact of in utero transfusions on perinatal outcomes in patients with alpha thalassemia major: the UCSF registry.
Schwab ME, Lianoglou BR, Gano D, Gonzalez Velez J, Allen IE, Arvon R, Baschat A, Bianchi DW, Bitanga M, Bourguignon A, Brown RN, Chen B, Chien M, Davis-Nelson S, de Laat MWM, Ekwattanakit S, Gollin Y, Hirata G, Jelin A, Jolley J, Meyer P, Miller J, Norton ME, Ogasawara KK, Panchalee T, Schindewolf E, Shaw SW, Stumbaugh T, Thompson AA, Towner D, Tsai PS, Viprakasit V, Volanakis E, Zhang L, Vichinsky E, MacKenzie TC
Blood Adv. 2023 Jan 24;7(2):269-279. doi: 10.1182/bloodadvances.2022007823.
PMID: 36306387

Association of tobacco product use with chronic obstructive pulmonary disease (COPD) prevalence and incidence in Waves 1 through 5 (2013-2019) of the Population Assessment of Tobacco and Health (PATH) Study.
Paulin LM, Halenar MJ, Edwards KC, Lauten K, Stanton CA, Taylor K, Hatsukami D, Hyland A, MacKenzie T, Mahoney MC, Niaura R, Trinidad D, Blanco C, Compton WM, Gardner LD, Kimmel HL, Lauterstein D, Marshall D, Sargent JD
Respir Res. 2022 Oct 1;23(1):273. doi: 10.1186/s12931-022-02197-1. Epub 2022 Oct 1.
PMID: 36183112

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