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Todd A MacKenzie, PhD

Professor of Biomedical Data Science
Professor of Medicine
Professor of The Dartmouth Institute

Biomedical Data Science
The Dartmouth Institute

PhD (Statistics), McGill University, 1997
MSc (Statistics), McGill University, 1993
BSc, Dalhousie University, 1990

Norris Cotton Cancer Center
Quantitative Biomedical Sciences
The Dartmouth Institute for Health Policy and Clinical Practice


Contact Information

Section of Clinical Research, HB 7505
One Medical Center Drive
Dartmouth Hitchcock Medical Center
Lebanon NH 03756

Phone: 603-653-3542
Fax: 603-653-3554

Professional Interests

I use statistics to facilitate clinical and health services research across a spectrum of disciplines and specialties. This work has been reported in over 290 publications. The majority of these projects involve comparative effectiveness, clinical trials, association studies, and prediction modeling. I am especially interested in survival (aka, time-to-event) analysis, and causal inference. Recent work includes studying the association of government spending with reduced mortality in order to help explain the stagnation of American longevity, and the quality and effectiveness of colonoscopy for colorectal screening and surveillance.

Courses Taught

QBS 121: Biostatistics II; a course in statistical modelling (Winter) with Tor Tosteson

QBS Biostatistics Consulting

Past Teaching:
PH 271 (TDI) "Practice of Statistics in Medicine" with James O'Malley: This course was aimed at junior faculty, post-doctoral fellows and PhD students.

PH 147 (TDI) "Advanced Methods in Health Services Research" with Tracy Onega

PEMM 107 "Biostatistics" : A course in biostatistics I developed for bench and translational scientists in molecular medicine.

Selected Publications


Spinal Manipulation vs Prescription Drug Therapy for Chronic Low Back Pain: Beliefs, Satisfaction With Care, and Qualify of Life Among Older Medicare Beneficiaries.
Kizhakkeveettil A, Bezdjian S, Hurwitz EL, Toler AWJ, Rossi D, Uptmor S, Sagester K, Bangash M, MacKenzie TA, Lurie JD, Coulter I, Haldeman S, Whedon JM
J Manipulative Physiol Ther. 2022 Mar 26; pii: S0161-4754(21)00117-2. doi: 10.1016/j.jmpt.2021.12.007. Epub 2022 Mar 26.
PMID: 35351337

Information Extraction From Electronic Health Records to Predict Readmission Following Acute Myocardial Infarction: Does Natural Language Processing Using Clinical Notes Improve Prediction of Readmission?
Brown JR, Ricket IM, Reeves RM, Shah RU, Goodrich CA, Gobbel G, Stabler ME, Perkins AM, Minter F, Cox KC, Dorn C, Denton J, Bray BE, Gouripeddi R, Higgins J, Chapman WW, MacKenzie T, Matheny ME
J Am Heart Assoc. 2022 Apr 5;11(7):e024198. doi: 10.1161/JAHA.121.024198. Epub 2022 Mar 24.
PMID: 35322668

Estimating population-averaged hazard ratios in the presence of unmeasured confounding.
Martinez-Camblor P, MacKenzie TA, O'Malley AJ
Int J Biostat. 2022 Mar 23; doi: 10.1515/ijb-2021-0096. Epub 2022 Mar 23.
PMID: 35320637

Clinically significant serrated polyp detection rates and risk for postcolonoscopy colorectal cancer: data from the New Hampshire Colonoscopy Registry.
Anderson JC, Hisey W, Mackenzie TA, Robinson CM, Srivastava A, Meester RGS, Butterly LF
Gastrointest Endosc. 2022 Mar 8; pii: S0016-5107(22)00191-2. doi: 10.1016/j.gie.2022.03.001. Epub 2022 Mar 8.
PMID: 35276209

Association between chiropractic care and use of prescription opioids among older medicare beneficiaries with spinal pain: a retrospective observational study.
Whedon JM, Uptmor S, Toler AWJ, Bezdjian S, MacKenzie TA, Kazal LA Jr
Chiropr Man Therap. 2022 Jan 31;30(1):5. doi: 10.1186/s12998-022-00415-7. Epub 2022 Jan 31.
PMID: 35101064

Clip Closure Does Not Reduce Risk of Bleeding After Resection of Large Serrated Polyps: Results From a Randomized Trial.
Crockett SD, Khashab M, Rex DK, Grimm IS, Moyer MT, Rastogi A, Mackenzie TA, Pohl H, Large Polyp Study Group Consortium.
Clin Gastroenterol Hepatol. 2021 Dec 28; pii: S1542-3565(21)01360-4. doi: 10.1016/j.cgh.2021.12.036. Epub 2021 Dec 28.
PMID: 34971811

Long-Term Medicare Costs Associated With Opioid Analgesic Therapy vs Spinal Manipulative Therapy for Chronic Low Back Pain in a Cohort of Older Adults.
Whedon JM, Kizhakkeveettil A, Toler A, MacKenzie TA, Lurie JD, Bezdjian S, Haldeman S, Hurwitz E, Coulter I
J Manipulative Physiol Ther. 2021 Sep;44(7):519-526. doi: 10.1016/j.jmpt.2021.09.001. Epub 2021 Dec 5.
PMID: 34876298

Using Satellite Images and Deep Learning to Identify Associations Between County-Level Mortality and Residential Neighborhood Features Proximal to Schools: A Cross-Sectional Study.
Levy JJ, Lebeaux RM, Hoen AG, Christensen BC, Vaickus LJ, MacKenzie TA
Front Public Health. 2021;9:766707. doi: 10.3389/fpubh.2021.766707. Epub 2021 Nov 5.
PMID: 34805078

Evaluation of an Artificial Intelligence-Augmented Digital System for Histologic Classification of Colorectal Polyps.
Nasir-Moin M, Suriawinata AA, Ren B, Liu X, Robertson DJ, Bagchi S, Tomita N, Wei JW, MacKenzie TA, Rees JR, Hassanpour S
JAMA Netw Open. 2021 Nov 1;4(11):e2135271. doi: 10.1001/jamanetworkopen.2021.35271. Epub 2021 Nov 1.
PMID: 34792588

Improvement of sepsis identification through multi-year comparison of sepsis and early warning scores.
McGrath SP, Perreard I, MacKenzie T, Calderwood M
Am J Emerg Med. 2022 Jan;51:239-247. doi: 10.1016/j.ajem.2021.10.046. Epub 2021 Nov 5.
PMID: 34775198

View more publications on PubMed