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Robert A. Maue, PhD

Title(s)
Professor of Medical Education
Professor of Biochemistry and Cell Biology

Additional Titles/Positions/Affiliations
Adjunct Professor of Biological Sciences
Adjunct Professor of Psychological Brain Sciences

Department(s)
Medical Education
Biochemistry and Cell Biology

Education
U. California - San Diego, PHD 1985

Programs
Academy of Master Faculty Educators
Molecular and Cellular Biology Graduate Programs
Program in Experimental and Molecular Medicine

Contact Information

Geisel School of Medicine
HB 7701
Hanover NH 03755

Office: Remsen 210
Phone: 603-650-1726/650-1119
Fax: 603-650-1128
Email: robert.maue@dartmouth.edu


Professional Interests

Dr. Maue is interested in understanding the mechanisms important for the development and differentiation of neurons in the brain. In particular, he is interested in the means by which a family of growth factors known as neurotrophins (NGF, BDNF, NT-3) exert their influence the growth and electrical activity of neurons, including their regulation of process outgrowth and ion channel expression. His experiments have taken advantage of transgenic mice expressing mutant ion channel genes, knockout mice lacking neurotrophin receptors, and novel mouse models of NPC disease that he discovered to analyze neurons in primary culture, in brain slices, and in vivo. This has included immunocytochemical and morphometric analyses, Western blotting and biochemical assays, single-cell, real time PCR analyses of gene expression, patch clamp recording of ion channels and electrical activity, virus-mediated expression of fluorescent proteins in vivo and in cultured neurons, and behavioral analyses of cerebellar function. Among the focus of his efforts are a class of neurons in the brain known as cerebellar Purkinje cells, and his interest in events associated with their development has included the pathology and abnormal development of these neurons in neurological disorders such as Niemann Pick Type C (NPC) disease. NPC disease is a fatal genetic disorder associated with abnormal cellular cholesterol accumulation, and a hallmark of this disorder is the preferential loss of Purkinje cells. Given the recent appreciation of the importance of cholesterol in the brain, particularly during neurodegenerative diseases such as NPC disease, Alzheimer's disease, and Huntington’s disease, understanding the effects of NPC disease and cholesterol abnormalities on Purkinje cells has widespread implications.

Grant Information

National Institutes of Health, National Niemann Pick Disease Foundation, Ara Parseghian Medical Research Foundation, Hereditary Disease Foundation, Epilepsy Foundation, Wellcome Trust

Biography

Bob received a B.S. in Biology from St John’s University in Minnesota, a Ph.D. in Physiology and Pharmacology from the University of California - San Diego (including two research expeditions to Antarctica), and did postdoctoral research at Brandeis University in Waltham and at New England Medical Center in Boston before becoming an Assistant Professor at Dartmouth Medical School in 1989. He rose to the rank of Professor in the Department of Physiology and Neurobiology and the Department of Biochemistry and Cell Biology, and in 2016 became a Professor in the Department of Medical Education in the Geisel School of Medicine. He also serves as an Adjunct Professor in the Department of Psychological Brain Sciences and the Department of Biological Sciences at Dartmouth College.

Bob is a cellular and molecular neurobiologist with research interests in neuronal development, neurotrophic factors, electrical excitability, and developmental aspects of neurodegenerative diseases, and was the first Dartmouth faculty member to receive a coveted Sloan Research Fellowship. He has garnered external support for his research for more than 30 years from sources such as the National Institutes of Health (NIH), the Epilepsy Foundation, Hereditary Disease Foundation, National Neimann Pick Disease Foundation, and Ara Parseghian Medical Research Foundation. He has spent more than 3 decades serving on and chairing numerous scientific advisory boards and grant review panels for the Veterans Administration (VA), NIH, and the National Science Foundation (NSF), including the NSF review panel for course, curriculum, and lab implementation (CCLI) proposals.

Bob is passionate about teaching, and in the past 30 years has taught a broad spectrum of medical students, graduate students, undergraduate students, and high school students in both the classroom and a variety of laboratory settings. This includes extensive teaching experience at Dartmouth College, where by invitation he has served as the course director for a systems neuroscience course and lab (2010-2021), for a physiology course and lab (2009-2020), a molecular and cellular neuroscience course (2007-2019), and an advanced neurobiology course (2006). He has mentored more than two dozen students in their Honors Thesis Research, including recipients of the “Christopher Reed Biologist Award for distinguished biological research”. He has served as the founder and co-director of a summer undergraduate nursing research program at Dartmouth Hitchcock Medical Center (2010-2020), as a member of the steering committee for the undergraduate neuroscience major (2010-present), and as a member of the committee on undergraduate research (CUGR) at Dartmouth (2013-2016). In 2013 he was one of two nominees from Dartmouth College for New Hampshire Professor of the Year. Beyond the confines of Dartmouth, Bob has taught at Hanover High School (2005-present) and Stevens High School (2010), as well as teaching and helping design teaching activities at River Valley Community College (2011-2015). For many years (2010-2020) a major focus was serving as a leader of the New Hampshire IdeA Network for Biomedical Research Excellence (NH-INBRE), a large NIH-supported initiative for developing research and science education opportunities for students at primarily undergraduate institutions (PUIs) across the state of New Hampshire.

At the graduate student level, Bob is a member of both the Molecular and Cellular Biology (MCB) graduate program and the graduate Program in Experimental and Molecular Medicine (PEMM). As such he has served as a lecturer in MCB graduate student core course (1996-2005), course director and lecturer in the PEMM graduate student core course (2006-2013), and as a lecturer in the PEMM 211 and PEMM 271 graduate courses (2008-2010). He has trained nearly a dozen MD, PhD, and MD/PhD students in his lab, including recipients of the “Strohbehn Medal for Excellence in Biomedical Research”. He has served as Co-Director of the prestigious “Ion Channels” summer course at Cold Spring Harbor Laboratory (1996-1998), and twice has served as a course faculty member in the Woods Hole summer Neurobiology course (1988; 2004). At the Geisel School of Medicine, Bob was a fixture in the Medical Neuroscience course (1990-2018) and for his efforts was nominated for the Excellence in Education Award on numerous occasions (2010, 2011, 2012). He has been involved in medical curriculum redesign, and served on several Redesign Task Force committees (2011-2014).


Selected Publications

 

Acat1/Soat1 knockout extends the mutant Npc1 mouse lifespan and ameliorates functional deficiencies in multiple organelles of mutant cells.
Rogers MA, Chang CCY, Maue RA, Melton EM, Peden AA, Garver WS, Lee J, Schroen P, Huang M, Chang TY
Proc Natl Acad Sci U S A. 2022 May 3;119(18):e2201646119. doi: 10.1073/pnas.2201646119. Epub 2022 May 4.
PMID: 35507892

Normalization of Hepatic Homeostasis in the Npc1(nmf164) Mouse Model of Niemann-Pick Type C Disease Treated with the Histone Deacetylase Inhibitor Vorinostat.
Munkacsi AB, Hammond N, Schneider RT, Senanayake DS, Higaki K, Lagutin K, Bloor SJ, Ory DS, Maue RA, Chen FW, Hernandez-Ono A, Dahlson N, Repa JJ, Ginsberg HN, Ioannou YA, Sturley SL
J Biol Chem. 2017 Mar 17;292(11):4395-4410. doi: 10.1074/jbc.M116.770578. Epub 2016 Dec 28.
PMID: 28031458

An Undergraduate Research Fellowship Program to Prepare Nursing Students for Future Workforce Roles.
Slattery MJ, Logan BL, Mudge B, Secore K, von Reyn LJ, Maue RA
J Prof Nurs. 2016 Nov-Dec;32(6):412-420. doi: 10.1016/j.profnurs.2016.03.008. Epub 2016 Mar 21.
PMID: 27964811

Reversible symptoms and clearance of mutant prion protein in an inducible model of a genetic prion disease in Drosophila melanogaster.
Murali A, Maue RA, Dolph PJ
Neurobiol Dis. 2014 Jul;67:71-8. doi: 10.1016/j.nbd.2014.03.013. Epub 2014 Mar 28.
PMID: 24686303

A novel mouse model of Niemann-Pick type C disease carrying a D1005G-Npc1 mutation comparable to commonly observed human mutations.
Maue RA, Burgess RW, Wang B, Wooley CM, Seburn KL, Vanier MT, Rogers MA, Chang CC, Chang TY, Harris BT, Graber DJ, Penatti CA, Porter DM, Szwergold BS, Henderson LP, Totenhagen JW, Trouard TP, Borbon IA, Erickson RP
Hum Mol Genet. 2012 Feb 15;21(4):730-50. doi: 10.1093/hmg/ddr505. Epub 2011 Nov 2.
PMID: 22048958

Lack of Niemann-Pick type C1 induces age-related degeneration in the mouse retina.
Claudepierre T, Paques M, Simonutti M, Buard I, Sahel J, Maue RA, Picaud S, Pfrieger FW
Mol Cell Neurosci. 2010 Jan;43(1):164-76. doi: 10.1016/j.mcn.2009.10.007. Epub 2009 Oct 31.
PMID: 19883762

The subcellular localization of the Niemann-Pick Type C proteins depends on the adaptor complex AP-3.
Berger AC, Salazar G, Styers ML, Newell-Litwa KA, Werner E, Maue RA, Corbett AH, Faundez V
J Cell Sci. 2007 Oct 15;120(Pt 20):3640-52. Epub 2007 Sep 25.
PMID: 17895371

Understanding ion channel biology using epitope tags: progress, pitfalls, and promise.
Maue RA
J Cell Physiol. 2007 Dec;213(3):618-25.
PMID: 17849449

Differentiated pattern of sodium channel expression in dissociated Purkinje neurons maintained in long-term culture.
Fry M, Boegle AK, Maue RA
J Neurochem. 2007 May;101(3):737-48.
PMID: 17448145

Multiple endocrine neoplasia 2A due to a unique C609S RET mutation presents with pheochromocytoma and reduced penetrance of medullary thyroid carcinoma.
Kinlaw WB, Scott SM, Maue RA, Memoli VA, Harris RD, Daniels GH, Porter DM, Belloni DR, Spooner ET, Ernesti MM, Noll WW
Clin Endocrinol (Oxf). 2005 Dec;63(6):676-82.
PMID: 16343103

View more publications on PubMed