Translational and Molecular Dermatology

Description: Basic science and translational studies investigating molecular mechanisms of skin disease and novel therapeutic targets

microscope image of skin
What role does the skin microbiome play in cancer progression?

Key Publications

  • Armstrong DA, Hudson TR, Hodge CA, Hampton TH, Howell AL, Hayden MS. PlmCas12e (CasX2) cleavage of CCR5: impact of guide RNA spacer length and PAM sequence on cleavage activity. RNA Biol. 2023;20(1):296-305. doi:10.1080/15476286.2023.2221510
  • McFadden JR, Salem I, Stevanovic M, Barney RE, Chaudhari AS, Chambers MA, O'Hern K, Cloutier JM, Yan S, Ramos-Rodriguez AJ, Kerr DA, Momtahen S, LeBlanc RE, Tsongalis GJ, Hughes EG, Sriharan A. A Droplet Digital Polymerase Chain Reaction-Based Tool to Aid in Melanoma Diagnosis. Arch Pathol Lab Med. 2024 Aug 1. doi: 10.5858/arpa.2024-0027-OA. Epub ahead of print. PMID: 39084636.
  • Srinivasan G, Davis MJ, LeBoeuf MR, Fatemi M, Azher ZL, Lu Y, Diallo AB, Saldias Montivero MK, Kolling FW, Perrard L, Salas LA, Christensen BC, Palys TJ, Karagas MR, Palisoul SM, Tsongalis GJ, Vaickus LJ, Preum SM, Levy JJ. Potential to Enhance Large Scale Molecular Assessments of Skin Photoaging through Virtual Inference of Spatial Transcriptomics from Routine Staining. Pac Symp Biocomput. 2024;29:477-491. PMID: 38160301; PMCID: PMC10813837.
  • Levy JJ, Davis MJ, Chacko RS, Davis MJ, Fu LJ, Goel T, Pamal A, Nafi I, Angirekula A, Suvarna A, Vempati R, Christensen BC, Hayden MS, Vaickus LJ, LeBoeuf MR. Intraoperative margin assessment for basal cell carcinoma with deep learning and histologic tumor mapping to surgical site. NPJ Precis Oncol. 2024 Jan 3;8(1):2. doi: 10.1038/s41698-023-00477-7. PMID: 38172524; PMCID: PMC10764333.
  • Baker C, Hayden MS. Gene editing in dermatology: Harnessing CRISPR for the treatment of cutaneous disease. F1000Res. 2020 Apr 23;9:281. doi: 10.12688/f1000research.23185.2. PMID: 32528662; PMCID: PMC7265575.

Faculty

Matt Hayden headshot

Matthew Hayden, MD, PhD

  • Assistant Professor of Dermatology
  • Director of Basic Research and Senior Scientist, Department of Dermatology
  • Vice Chair of Research

Full Profile

Matthew Leboeuf headshot

Matthew LeBoeuf, MD, PhD

  • Associate Professor of Dermatology
  • Section Chief of Mohs Surgery

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Grants and Funding

  • Dorothea Barton MD, Li Song PhD & Parth Shah MD.  Skin microbiome’s function in skin cancers. Prouty Pilot.
  • Brian Simmons MD. CRISPR diagnoses of onychomycosis. Dermatology Foundation Grant

Research Projects/Topics

  • CRISPR for Virus Editing
  • Cutaneous Microbiome