Bacteria poison and eat their neighbors.
Nadell CD, Marx CJ
Science. 2025 Jun 12;388(6752):1134-1135. doi: 10.1126/science.ady7008. Epub 2025 Jun 12.
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A call for the United States to continue investing in science.
Blader I, Goodrum F, Imperiale MJ, Casadevall A, Arias CA, Baumler A, Burnham C-AD, Cuomo CA, Detweiler CS, Forrest GN, Gilbert JA, Lovett S, Maloy S, McAdam A, Newton I, Reguera G, O'Toole GA, Schloss PD, Shade A, Whiteley M
Clin Microbiol Rev. 2025 Jun 12;38(2):e0004425. doi: 10.1128/cmr.00044-25. Epub 2025 Feb 27.
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Giant transposons promote strain heterogeneity in a major fungal pathogen.
Gluck-Thaler E, Forsythe A, Puerner C, Gutierrez-Perez C, Stajich JE, Croll D, Cramer RA, Vogan AA
mBio. 2025 Jun 11;16(6):e0109225. doi: 10.1128/mbio.01092-25. Epub 2025 May 12.
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Intratumoral Immunotherapy with Cowpea Mosaic Virus and Interleukin-12 Eliminates Established Treated Tumors and Generates Robust Systemic Immunity to Suppress the Growth of Untreated Metastatic Tumors.
Misiaszek A, Santos AM, Ho GW, Fields J, Kamga KS, Stan R, Affonso De Oliveira JF, Steinmetz NF, Fiering S
Mol Pharm. 2025 Jun 6; doi: 10.1021/acs.molpharmaceut.4c01539. Epub 2025 Jun 6.
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Genetic analysis of flagellar-mediated surface sensing by Pseudomonas aeruginosa PA14.
Kuchma SL, Geiger CJ, Webster SS, Fu Y, Montoya R, O'Toole GA
J Bacteriol. 2025 Jun 5;:e0052024. doi: 10.1128/jb.00520-24. Epub 2025 Jun 5.
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Propranolol is efficacious against Aspergillus and Fusarium corneal isolates in vitro and in a murine model of Aspergillus keratitis.
Zegans ME, Kamath MM, Jones JT, Bao R, Ross BS, Gutierrez-Perez C, Adams EM, Lightfoot JD, Poimenidou G, Pavuluri C, Prajna V, Cramer RA, Fuller KK
Antimicrob Agents Chemother. 2025 Jun 4;69(6):e0166424. doi: 10.1128/aac.01664-24. Epub 2025 May 15.
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Environmental DNA adsorption to chitin can promote horizontal gene transfer by natural transformation.
Holt JD, Peng Y, Dalia TN, Dalia AB, Nadell CD
Proc Natl Acad Sci U S A. 2025 Jun 3;122(22):e2420708122. doi: 10.1073/pnas.2420708122. Epub 2025 May 30.
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In vitro biofilm formation by a beneficial bacterium partially predicts in planta protection against rhizosphere pathogens.
Liu Y, Gates AD, Liu Z, Duque Q, Schmidt SS, Chen MY, Hamilton CD, O'Toole GA, Haney CH
ISME J. 2025 Jun 2; pii: wraf114. doi: 10.1093/ismejo/wraf114. Epub 2025 Jun 2.
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Cancer therapy via neoepitope-specific monoclonal antibody cocktails.
Hartman CJ, Mohamed AO, Shukla GS, Pero SC, Sun YJ, Rodriguez-Jimenez RS, Genovese NF, Kohler NM, Hemphill TR, Huang YH, Krag DN, Ackerman ME
Cancer Immunol Immunother. 2025 May 31;74(7):231. doi: 10.1007/s00262-025-04075-3. Epub 2025 May 31.
PMID: 40448719
Herpes simplex virus (HSV) neurovirulence across the human lifespan.
Dutton A, Hayes CK, Leib DA, Akhtar LN
J Infect Dis. 2025 May 26; pii: jiaf275. doi: 10.1093/infdis/jiaf275. Epub 2025 May 26.
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Feasibility and Acceptability of Noninvasive Stool Testing for Surveillance of Colorectal Polyps in Older Adults.
Luft SJ, Stevanovic M, Navas CM, Robertson DJ, Kaur P, Calderwood AH
Clin Gastroenterol Hepatol. 2025 May 14; pii: S1542-3565(25)00415-X. doi: 10.1016/j.cgh.2025.03.023. Epub 2025 May 14.
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Loss of LasR function leads to decreased repression of Pseudomonas aeruginosa PhoB activity at physiological phosphate concentrations.
Conaway A, Mould DL, Todorovic I, Hogan DA
J Bacteriol. 2025 May 14;:e0018924. doi: 10.1128/jb.00189-24. Epub 2025 May 14.
PMID: 40366151
Pilot Study of Intratumoral Immunotherapy with Cowpea Mosaic Virus Nanoparticles: Safety in Refractory Canine Oral Tumors.
Delgado-Bonet P, Arias-Pulido H, Del Castillo Magan N, Emilia Zimmermann AB, Schaafsma E, Vom Berg J, Vazquez F, Beiss V, Steinmetz NF, Fiering S, Perise-Barrios AJ
Mol Pharm. 2025 May 5;22(5):2671-2683. doi: 10.1021/acs.molpharmaceut.5c00100. Epub 2025 Apr 14.
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Immunomodulatory effects of intratumoral cowpea mosaic virus and calreticulin nanoparticles in canine tumors: early results.
Singh A, Affonso de Oliveira JF, Schrader J, Kishore D, Chandrasekar SV, Fiering S, Steinmetz NF, Ranjan A
Front Immunol. 2025;16:1566394. doi: 10.3389/fimmu.2025.1566394. Epub 2025 May 2.
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Heterotrimeric G-gamma 1 (Gpg1) participates with G-beta 1 (Gpb1) in the induction of hyphal growth and virulence via the PKA pathway in Mucor lusitanicus.
Patiño-Medina JA, Vargas-Tejeda D, Reyes-Mares NY, Alejandre-Castañeda V, Torres-Cortes CJ, Perez-Arques C, Ruiz-Herrera LF, Ramirez-Emiliano J, Vellanki S, Valle-Maldonado MI, Castro-Cerritos KV, Ramirez-Diaz MI, Lee SC, Garre V, Meza-Carmen V
Fungal Genet Biol. 2025 May;178:103974. doi: 10.1016/j.fgb.2025.103974. Epub 2025 Mar 4.
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Acute respiratory distress vs healthy lung environments differently affect mesenchymal stromal cell extracellular vesicle miRNAs.
Rolandsson Enes S, Dzneladze I, Hampton TH, Neff SL, Asarian L, Barua J, Tertel T, Giebel B, Pereyra N, McKenna DH, Hu P, Acton E, Ashare A, Liu KD, Krasnodembskaya AD, English K, Stanton BA, Rocco PRM, Matthay MA, Dos Santos CC, Weiss DJ
Cytotherapy. 2025 May;27(5):581-596. doi: 10.1016/j.jcyt.2025.01.006. Epub 2025 Jan 20.
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Polymeric Anti-Antibiotic Microparticles to Prevent Antibiotic Resistance Evolution.
Koshani R, Yeh SL, He Z, Narasimhalu N, Vom Steeg LG, Sim DG, Woods RJ, Read AF, Sheikhi A
Small. 2025 May;21(21):e2407549. doi: 10.1002/smll.202407549. Epub 2025 Jan 19.
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Lung-kidney axis in cystic fibrosis: Early urinary markers of kidney injury correlate with neutrophil activation and worse lung function.
Rosner GM, Goswami HB, Sessions K, Mendyka LK, Kerin B, Vlasac I, Mellinger D, Gwilt L, Hampton TH, Graber M, Ashare A, Harris WT, Christensen B, Stanton BA, Swiatecka-Urban A, Skopelja-Gardner S
J Cyst Fibros. 2025 May;24(3):613-620. doi: 10.1016/j.jcf.2024.12.007. Epub 2025 Jan 3.
PMID: 39753455
Mycophenolate mofetil directly modulates myeloid viability and pro-fibrotic activation of human macrophages.
Morris EA, Parvizi R, Orzechowski NM, Whitfield ML, Pioli PA
Rheumatology (Oxford). 2025 May 1;64(5):3125-3133. doi: 10.1093/rheumatology/keae517.
PMID: 39312626
Binding and neutralising antibodies to respiratory syncytial virus and influenza A virus in serum and bronchoalveolar lavage fluid of healthy adults in the United States: A cross-sectional study.
Raja AI, Connor RI, Ashare A, Weiner JA, Wieland-Alter WF, Godin A, Modlin JF, Ackerman ME, Brickley EB, Wright PF
Vaccine. 2025 Apr 19;53:126936. doi: 10.1016/j.vaccine.2025.126936. Epub 2025 Mar 3.
PMID: 40037127
Interplay of virulence factors and signaling molecules: albumin and calcium-mediated biofilm regulation in Bordetella bronchiseptica.
Mugni SL, Ambrosis N, O Toole GA, Sisti F, Fernandez J
J Bacteriol. 2025 Apr 17;207(4):e0044524. doi: 10.1128/jb.00445-24. Epub 2025 Mar 26.
PMID: 40135913
Targeting fungal lipid synthesis for antifungal drug development and potentiation of contemporary antifungals.
Gutierrez-Perez C, Cramer RA
NPJ Antimicrob Resist. 2025 Apr 12;3(1):27. doi: 10.1038/s44259-025-00093-4. Epub 2025 Apr 12.
PMID: 40221522