Fission yeast Pdk1 kinase regulates cytokinesis and eisosomes.
Chrupcala ML, Flynn MJ, Moseley JB
Mol Biol Cell. 2025 Dec 1;36(12):br34. doi: 10.1091/mbc.E25-07-0330. Epub 2025 Oct 22.
PMID: 41123941
The secretory pathway gets a molecular framework.
Barlowe C
Nat Rev Mol Cell Biol. 2025 Dec;26(12):907. doi: 10.1038/s41580-025-00912-6.
PMID: 41102338
Functional Assembly of the Qc-SNARE with Sec18 and Sec17 on Membranes.
Orr A, Lopes K, O'Dwyer J, Wickner W
Mol Biol Cell. 2025 Nov 19;:mbcE25100474. doi: 10.1091/mbc.E25-10-0474. Epub 2025 Nov 19.
PMID: 41259199
The tumor suppressor LACTB remodels mitochondria to promote cytochrome c release and apoptosis.
Kamerkar SC, Kang T, Stan RV, Usherwood EJ, Higgs HN
Sci Adv. 2025 Nov 14;11(46):eadx7809. doi: 10.1126/sciadv.adx7809. Epub 2025 Nov 12.
PMID: 41223265
Regulation of the formin INF2 by actin monomers and calcium-calmodulin.
Lee M, Jalmukhambetova A, Burgin TE, Higgs HN
bioRxiv. 2025 Oct 7; pii: 2025.10.06.680766. doi: 10.1101/2025.10.06.680766. Epub 2025 Oct 7.
PMID: 41279891
Core Clock Protein Subcellular Dynamics Coordinate Local and Global Circadian Control in Syncytia.
Wang Z, Bartholomai BM, Wang B, Ritz D, Schultz D, Loros JJ, Dunlap JC
bioRxiv. 2025 Oct 1; pii: 2025.09.30.679467. doi: 10.1101/2025.09.30.679467. Epub 2025 Oct 1.
PMID: 41256420
Peri-mitochondrial actin filaments inhibit Parkin assembly by disrupting ER-mitochondria contacts.
Fung TS, Ghosh A, Zavala MR, Nichtova Z, Shukal D, Tigano M, Csordas G, Higgs HN, Chakrabarti R
EMBO Rep. 2025 Oct;26(20):4977-5008. doi: 10.1038/s44319-025-00561-y. Epub 2025 Aug 29.
PMID: 40883511
Local Growth Hormone Facilitates Aging of the Colon Epithelial Microenvironment.
Chesnokova V, Zonis S, Ainsworth R, Apaydin T, Valencia CW, Greiner EC, Barrett R, Kettenbach AN, Melmed S
Aging Cell. 2025 Oct;24(10):e70187. doi: 10.1111/acel.70187. Epub 2025 Aug 5.
PMID: 40761135
Sequence engineering at non-motif modulator residues yields a peptide that effectively targets a single PDZ protein in a disease-relevant cellular context.
Amacher JF, Cushing PR, Vouilleme L, Cullati SN, Deng B, Gerber SA, Boisguerin P, Madden DR
bioRxiv. 2025 Sep 26; pii: 2025.09.25.678608. doi: 10.1101/2025.09.25.678608. Epub 2025 Sep 26.
PMID: 41040304
SNARE disassembly requires Sec18/NSF side loading.
Khan YA, White KI, Pfuetzner RA, Singal B, Esquivies L, Mckenzie G, Liu F, DeLong K, Choi UB, Montabana E, Mclaughlin T, Wickner WT, Brunger AT
Nat Struct Mol Biol. 2025 Sep;32(9):1708-1720. doi: 10.1038/s41594-025-01590-w. Epub 2025 Jul 2.
PMID: 40604310
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