Extensive epigenomic dysregulation is a hallmark of homologous recombination deficiency in triple-negative breast cancer.
Chen Y, Salas LA, Marotti JD, Jenkins NP, Cheng C, Miller TW, Kettenbach AN, Christensen BC
Int J Cancer. 2024 Dec 5; doi: 10.1002/ijc.35274. Epub 2024 Dec 5.
PMID: 39635770
Membrane fusion reactions limited by defective SNARE zippering or stiff lipid fatty acyl composition have distinct requirements for Sec17, Sec18, and adenine nucleotide.
Lopes K, Orr A, Wickner W
bioRxiv. 2024 Nov 15; pii: 2024.11.15.623832. doi: 10.1101/2024.11.15.623832. Epub 2024 Nov 15.
PMID: 39605500
The PNUTS phosphatase complex controls transcription pause release.
Kelley JR, Dimitrova E, Maciuszek M, Nguyen HT, Szczurek AT, Hughes AL, Blackledge NP, Kettenbach AN, Klose RJ
Mol Cell. 2024 Nov 21; pii: S1097-2765(24)00886-4. doi: 10.1016/j.molcel.2024.10.045. Epub 2024 Nov 21.
PMID: 39603239
The auxotrophic formate (for) mutant of Neurospora crassa has significantly delayed growth but a normal circadian clock.
Wang Z, Lindgren KM, Loros JJ, Dunlap JC
Fungal Genet Rep. 2024;68 pii: 1. doi: 10.4148/1941-4765.2185.
PMID: 39555235
PPP1R2 stimulates protein phosphatase-1 through stabilisation of dynamic subunit interactions.
Lemaire S, Ferreira M, Claes Z, Derua R, Lake M, Van der Hoeven G, Withof F, Cao X, Greiner EC, Kettenbach AN, Van Eynde A, Bollen M
Nat Commun. 2024 Nov 13;15(1):9822. doi: 10.1038/s41467-024-54256-4. Epub 2024 Nov 13.
PMID: 39537675
INF2 mutations cause kidney disease through a gain-of-function mechanism.
Subramanian B, Williams S, Karp S, Hennino MF, Jacas S, Lee M, Riella CV, Alper SL, Higgs HN, Pollak MR
Sci Adv. 2024 Nov 15;10(46):eadr1017. doi: 10.1126/sciadv.adr1017. Epub 2024 Nov 13.
PMID: 39536114
Self-priming of Plk1 binding to BubR1 ensures accurate mitotic progression.
Song C, Zhang M, Kruse T, Moller MH, Lopez-Mendez B, Zhang Y, Zhai Y, Wang Y, Lei T, Kettenbach AN, Nilsson J, Zhang G
Commun Biol. 2024 Nov 9;7(1):1473. doi: 10.1038/s42003-024-07205-2. Epub 2024 Nov 9.
PMID: 39516273
After their membrane assembly, Sec18 (NSF) and Sec17 (SNAP) promote membrane fusion.
Song H, Lopes K, Orr A, Wickner W
Mol Biol Cell. 2024 Dec 1;35(12):ar150. doi: 10.1091/mbc.E24-10-0439. Epub 2024 Oct 30.
PMID: 39475713
Inhibiting the Cholesterol Storage Enzyme ACAT1/SOAT1 in Myelin Debris-Treated Microglial Cell Lines Activates the Gene Expression of Cholesterol Efflux Transporter ABCA1.
Huynh TN, Havrda MC, Zanazzi GJ, Chang CCY, Chang TY
Biomolecules. 2024 Oct 14;14(10) doi: 10.3390/biom14101301. Epub 2024 Oct 14.
PMID: 39456234
A protein phosphatase 1 specific phosphatase targeting peptide (PhosTAP) to identify the PP1 phosphatome.
Choy MS, Nguyen HT, Kumar GS, Peti W, Kettenbach AN, Page R
Proc Natl Acad Sci U S A. 2024 Oct 29;121(44):e2415383121. doi: 10.1073/pnas.2415383121. Epub 2024 Oct 24.
PMID: 39446389
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