COVID-19 Information


Superkine IL2 and IL33 armored CAR T cells reshape the tumor microenvironment and reduce growth of multiple solid tumors.
Brog RA, Ferry SL, Schiebout CT, Messier CM, Cook WJ, Abdullah L, Zou J, Kumar P, Sentman CL, Frost HR, Huang YH
Cancer Immunol Res. 2022 Jun 13; pii: canimm.0536.2021-7-6 11:54:04.690. doi: 10.1158/2326-6066.CIR-21-0536. Epub 2022 Jun 13.
PMID: 35696724

Life support for transitory exhausted CTLs.
Mohamed A, Huang YH
Trends Immunol. 2021 Dec;42(12):1057-1059. doi: 10.1016/ Epub 2021 Nov 9.
PMID: 34772619

Resident memory CD8+ T cells in regional lymph nodes mediate immunity to metastatic melanoma.
Molodtsov AK, Khatwani N, Vella JL, Lewis KA, Zhao Y, Han J, Sullivan DE, Searles TG, Preiss NK, Shabaneh TB, Zhang P, Hawkes AR, Malik BT, Kolling FW 4th, Usherwood EJ, Wong SL, Phillips JD, Shirai K, Angeles CV, Yan S, Curiel TJ, Huang YH, Cheng C, Turk MJ
Immunity. 2021 Sep 14;54(9):2117-2132.e7. doi: 10.1016/j.immuni.2021.08.019.
PMID: 34525340

IL-6 enhances CD4 cell motility by sustaining mitochondrial Ca2+ through the noncanonical STAT3 pathway.
Valenca-Pereira F, Fang Q, Marie IJ, Giddings EL, Fortner KA, Yang R, Villarino AV, Huang YH, Frank DA, Wen H, Levy DE, Rincon M
Proc Natl Acad Sci U S A. 2021 Sep 14;118(37) pii: e2103444118. doi: 10.1073/pnas.2103444118.
PMID: 34507993

Dendritic cells maintain anti-tumor immunity by positioning CD8 skin-resident memory T cells.
Vella JL, Molodtsov A, Angeles CV, Branchini BR, Turk MJ, Huang YH
Life Sci Alliance. 2021 Oct;4(10) pii: e202101056. doi: 10.26508/lsa.202101056. Epub 2021 Aug 6.
PMID: 34362825

Engineering a natural ligand-based CAR: directed evolution of the stress-receptor NKp30.
Butler SE, Brog RA, Chang CH, Sentman CL, Huang YH, Ackerman ME
Cancer Immunol Immunother. 2022 Jan;71(1):165-176. doi: 10.1007/s00262-021-02971-y. Epub 2021 May 27.
PMID: 34046711

Diverse Roles of Akt in T cells.
Abdullah L, Hills LB, Winter EB, Huang YH
Immunometabolism. 2021;3(1) pii: e210007. doi: 10.20900/immunometab20210007. Epub 2021 Jan 28.
PMID: 33604081

Foxo1 Serine 209 Is a Critical Regulatory Site of CD8 T Cell Differentiation and Survival.
Hills LB, Abdullah L, Lust HE, Degefu H, Huang YH
J Immunol. 2021 Jan 1;206(1):89-100. doi: 10.4049/jimmunol.2000216. Epub 2020 Nov 23.
PMID: 33229443

Control of B Cell Lymphoma by Gammaherpesvirus-Induced Memory CD8 T Cells.
Preiss NK, Kang T, Usherwood YK, Huang YH, Branchini BR, Usherwood EJ
J Immunol. 2020 Dec 15;205(12):3372-3382. doi: 10.4049/jimmunol.2000734. Epub 2020 Nov 13.
PMID: 33188072

AMPK Activation by Metformin Promotes Survival of Dormant ER+ Breast Cancer Cells.
Hampsch RA, Wells JD, Traphagen NA, McCleery CF, Fields JL, Shee K, Dillon LM, Pooler DB, Lewis LD, Demidenko E, Huang YH, Marotti JD, Goen AE, Kinlaw WB, Miller TW
Clin Cancer Res. 2020 Jul 15;26(14):3707-3719. doi: 10.1158/1078-0432.CCR-20-0269. Epub 2020 Apr 22.
PMID: 32321715