Huang Laboratory
Featured
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Endothelial-barrier
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Wt-CCL19-T-cells
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CaM-ltk
Research
T lymphocytes are a critical component of the adaptive immune system and provide specific protection against pathogens and cancer cells. Defects in T cell activation or migration lead to primary immunodeficiency diseases, characterized by increased susceptibility to viral and bacterial infections. However, T cell hyperactivity can result in autoimmune attack of one’s own tissue. The quality and magnitude of a T cell response are controlled by positive and negative cues from the T cell microenvironment. We investigate how T cells appropriately and inappropriately translate activation and migration cues.
Recent Publications
Superkine IL2 and IL33 armored CAR T cells reshape the tumor microenvironment and reduce growth of multiple solid tumors.
Brog RA, Ferry SL, Schiebout CT, Messier CM, Cook WJ, Abdullah L, Zou J, Kumar P, Sentman CL, Frost HR, Huang YH
Cancer Immunol Res. 2022 Jun 13; pii: canimm.0536.2021-7-6 11:54:04.690. doi: 10.1158/2326-6066.CIR-21-0536. Epub 2022 Jun 13.
PMID: 35696724
Life support for transitory exhausted CTLs.
Mohamed A, Huang YH
Trends Immunol. 2021 Dec;42(12):1057-1059. doi: 10.1016/j.it.2021.10.012. Epub 2021 Nov 9.
PMID: 34772619
Contact Us
Contact: Yina H. Huang, Ph.D
Phone: 1-603-646-5373
Email: yina@dartmouth.edu
Mailing Address:
Geisel School of Medicine at Dartmouth
Department of Microbiology & Immunology
1 Medical Center Drive
HB7556, Borwell 650E
Lebanon, NH 03756