Huang Laboratory
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Research
T lymphocytes are a critical component of the adaptive immune system and provide specific protection against pathogens and cancer cells. Defects in T cell activation or migration lead to primary immunodeficiency diseases, characterized by increased susceptibility to viral and bacterial infections. However, T cell hyperactivity can result in autoimmune attack of one’s own tissue. The quality and magnitude of a T cell response are controlled by positive and negative cues from the T cell microenvironment. We investigate how T cells appropriately and inappropriately translate activation and migration cues.
Recent Publications
Anesthetic Oxygen Use and Sex Are Critical Factors in the FLASH Sparing Effect.
Tavakkoli AD, Clark MA, Kheirollah A, Sloop AM, Soderholm HE, Daniel NJ, Petusseau AF, Huang YH, Thomas CR Jr, Jarvis LA, Zhang R, Pogue BW, Gladstone DJ, Hoopes PJ
Adv Radiat Oncol. 2024 Jun;9(6):101492. doi: 10.1016/j.adro.2024.101492. Epub 2024 Mar 13.
PMID: 38711960
Hierarchal single-cell lineage tracing reveals differential fate commitment of CD8 T-cell clones in response to acute infection.
Abdullah L, Emiliani FE, Vaidya CM, Stuart H, Kolling FW, Ackerman ME, Song L, McKenna A, Huang YH
bioRxiv. 2024 Mar 27; pii: 2024.03.21.586160. doi: 10.1101/2024.03.21.586160. Epub 2024 Mar 27.
PMID: 38585810
Contact Us
Contact: Yina H. Huang, Ph.D
Phone: 1-603-646-5373
Email: yina@dartmouth.edu
Mailing Address:
Geisel School of Medicine at Dartmouth
Department of Microbiology & Immunology
1 Medical Center Drive
HB7556, Borwell 650E
Lebanon, NH 03756