Huang Laboratory
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Research
T lymphocytes are a critical component of the adaptive immune system and provide specific protection against pathogens and cancer cells. Defects in T cell activation or migration lead to primary immunodeficiency diseases, characterized by increased susceptibility to viral and bacterial infections. However, T cell hyperactivity can result in autoimmune attack of one’s own tissue. The quality and magnitude of a T cell response are controlled by positive and negative cues from the T cell microenvironment. We investigate how T cells appropriately and inappropriately translate activation and migration cues.
Recent Publications
The endogenous antigen-specific CD8(+) T cell repertoire is composed of unbiased and biased clonotypes with differential fate commitments.
Abdullah L, Emiliani FE, Vaidya CM, Stuart H, Musial SC, Kolling FW, Obar JJ, Rosato PC, Ackerman ME, Song L, McKenna A, Huang YH
Immunity. 2025 Mar 11;58(3):601-615.e9. doi: 10.1016/j.immuni.2025.02.001. Epub 2025 Feb 27.
PMID: 40020673
CD4 T cell depletion increases memory differentiation of endogenous and CAR T cells and enhances the efficacy of Super2 and IL-33-armored CAR T cells against solid tumors.
Mohamed AO, Boone DT, Ferry SL, Peck MC, Santos AM, Soderholm HE, Wittling MC, Paulos C, Turk MJ, Huang YH
J Immunother Cancer. 2025 Feb 11;13(2) doi: 10.1136/jitc-2024-009994. Epub 2025 Feb 11.
PMID: 39933839
Contact Us
Contact: Yina H. Huang, Ph.D
Phone: 1-603-646-5373
Email: yina@dartmouth.edu
Mailing Address:
Geisel School of Medicine at Dartmouth
Department of Microbiology & Immunology
1 Medical Center Drive
HB7556, Borwell 650E
Lebanon, NH 03756