Huang Laboratory
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Research
T lymphocytes are a critical component of the adaptive immune system and provide specific protection against pathogens and cancer cells. Defects in T cell activation or migration lead to primary immunodeficiency diseases, characterized by increased susceptibility to viral and bacterial infections. However, T cell hyperactivity can result in autoimmune attack of one’s own tissue. The quality and magnitude of a T cell response are controlled by positive and negative cues from the T cell microenvironment. We investigate how T cells appropriately and inappropriately translate activation and migration cues.
Recent Publications
Depletion of conventional CD4(+) T cells is required for robust priming and dissemination of tumor antigen-specific CD8(+) T cells in the setting of anti-CD4 therapy.
Ramirez DE, Dragnev CPC, Searles TG, Spicer N, Chen T, Lines JL, Hawkes AR, Davis WL, Mohamed A, Shirai K, Phillips JD, Rosato PC, Huang YH, Turk MJ
J Immunother Cancer. 2024 Nov 9;12(11) doi: 10.1136/jitc-2024-010170. Epub 2024 Nov 9.
PMID: 39521617
Anesthetic Oxygen Use and Sex Are Critical Factors in the FLASH Sparing Effect.
Tavakkoli AD, Clark MA, Kheirollah A, Sloop AM, Soderholm HE, Daniel NJ, Petusseau AF, Huang YH, Thomas CR Jr, Jarvis LA, Zhang R, Pogue BW, Gladstone DJ, Hoopes PJ
Adv Radiat Oncol. 2024 Jun;9(6):101492. doi: 10.1016/j.adro.2024.101492. Epub 2024 Mar 13.
PMID: 38711960
Contact Us
Contact: Yina H. Huang, Ph.D
Phone: 1-603-646-5373
Email: yina@dartmouth.edu
Mailing Address:
Geisel School of Medicine at Dartmouth
Department of Microbiology & Immunology
1 Medical Center Drive
HB7556, Borwell 650E
Lebanon, NH 03756