Allison Carl

MCB graduate student

 

About Me

I was first fascinated by immunology while pursuing my undergraduate degree in Biochemistry, Molecular and Cellular Biology at the University of New Hampshire. There, I was an undergraduate researcher in Dr. Sherine Elsawa’s lab and studied how Gli2 affects thymic T cell development. This experience led me to Dartmouth’s MCB program in the fall of 2024 where I rotated though cancer immunology labs. My thesis project combines in vivo lineage tracing and CAR T cell therapy to understand how CAR T cell subpopulations differentiate within a patient. This research can be used to understand how we can use these differentiation pathways to guide CAR T design to inform what cell states in the product that is infused into the patient lead to anti-tumor immunity in a solid tumor microenvironment. Outside of lab, I enjoy running, hiking, skiing, baking, and working at a local apple orchard in the fall.

 

Publications: 

Ferry S, Abdullah L, Balasubramanian A, Nowak E, Carl A, Turnquist A, Mohamed A, Usherwood E, Sundrud M & Huang Y. Systemic pre-conditioning favors effector over exhausted CD8 T cell subsets following Sup2-IL33 armored CAR T cell therapy. Journal for ImmunoTherapy of Cancer. 2026. jitc.bmj.com/content/14/6/e013020

Boutilier AJ, Raad M, Paar KE, Matissek SJ, Banks CE, Carl AL, Murray JM, Metzler AD, Koeppen KU, Gupta M & Elsawa SF. GLI3 Is Required for M2 Macrophage Polarization and M2-Mediated Waldenström Macroglobulinemia Growth and Survival. Int J Mol Sci. 2024 Dec 6;25(23):13120.