Dunlap and Loros Laboratories

Our laboratories and research are directed towards understanding the mechanism by which eukaryotic organisms keep time on a daily basis, and how this capacity to keep time is used to regulate metabolism and development. Circadian clocks with fundamentally identical characteristics are found in all groups of eukaryotic organisms, but the uses to which these clock are put reflects the diversity of evolution. Phylogenetically this ranges from the control of cell division and enzyme activities in unicells, to a firmly established involvement in plant and animal photoperiodism and in avian and insect celestial navigation, to multiplicity of human systems including endocrine function, work-rest cycles and sleep, and drug tolerances and effectiveness.

Nutritional compensation of the circadian clock is a conserved process influenced by gene expression regulation and mRNA stability.
Kelliher CM, Stevenson EL, Loros JJ, Dunlap JC
PLoS Biol. 2023 Jan;21(1):e3001961. doi: 10.1371/journal.pbio.3001961. Epub 2023 Jan 5.
PMID: 36603054

Functional analysis of 110 phosphorylation sites on the circadian clock protein FRQ identifies clusters determining period length and temperature compensation.
Wang B, Stevenson EL, Dunlap JC
G3 (Bethesda). 2022 Dec 20; pii: jkac334. doi: 10.1093/g3journal/jkac334. Epub 2022 Dec 20.
PMID: 36537198