Dunlap and Loros Laboratories

Our laboratories and research are directed towards understanding the mechanism by which eukaryotic organisms keep time on a daily basis, and how this capacity to keep time is used to regulate metabolism and development. Circadian clocks with fundamentally identical characteristics are found in all groups of eukaryotic organisms, but the uses to which these clock are put reflects the diversity of evolution. Phylogenetically this ranges from the control of cell division and enzyme activities in unicells, to a firmly established involvement in plant and animal photoperiodism and in avian and insect celestial navigation, to multiplicity of human systems including endocrine function, work-rest cycles and sleep, and drug tolerances and effectiveness.

Principles of the animal molecular clock learned from Neurospora.
Loros JJ
Eur J Neurosci. 2019 Jan 27; doi: 10.1111/ejn.14354. Epub 2019 Jan 27.
PMID: 30687965

Circadian Proteomic Analysis Uncovers Mechanisms of Post-Transcriptional Regulation in Metabolic Pathways.
Hurley JM, Jankowski MS, De Los Santos H, Crowell AM, Fordyce SB, Zucker JD, Kumar N, Purvine SO, Robinson EW, Shukla A, Zink E, Cannon WR, Baker SE, Loros JJ, Dunlap JC
Cell Syst. 2018 Dec 26;7(6):613-626.e5. doi: 10.1016/j.cels.2018.10.014. Epub 2018 Dec 12.
PMID: 30553726