Dunlap and Loros Laboratories
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Research
Our laboratories and research are directed towards understanding the mechanism by which eukaryotic organisms keep time on a daily basis, and how this capacity to keep time is used to regulate metabolism and development. Circadian clocks with fundamentally identical characteristics are found in all groups of eukaryotic organisms, but the uses to which these clock are put reflects the diversity of evolution. Phylogenetically this ranges from the control of cell division and enzyme activities in unicells, to a firmly established involvement in plant and animal photoperiodism and in avian and insect celestial navigation, to multiplicity of human systems including endocrine function, work-rest cycles and sleep, and drug tolerances and effectiveness.
Publications
Domains Required for the Interaction of the Central Negative Element FRQ with its Transcriptional Activator WCC within the Core Circadian Clock of Neurospora.
Wang B, Dunlap JC
J Biol Chem. 2023 May 21;:104850. doi: 10.1016/j.jbc.2023.104850. Epub 2023 May 21.
PMID: 37220856
A crucial role for dynamic expression of components encoding the negative arm of the circadian clock.
Wang B, Zhou X, Kettenbach AN, Mitchell HD, Markillie LM, Loros JJ, Dunlap JC
bioRxiv. 2023 Apr 24; pii: 2023.04.24.538162. doi: 10.1101/2023.04.24.538162. Epub 2023 Apr 24.
PMID: 37162945
Contact Us
Electronic Mail
Please send all general email to:
Jay.C.Dunlap@Dartmouth.edu
Jennifer.Loros@Dartmouth.edu
Telephone
Jay Dunlap: (603) 650-1108
Jennifer Loros: (603) 650-1154
Lab: (603) 650-1120
Fax
(603) 650-1233