Dunlap and Loros Laboratories

Our laboratories and research are directed towards understanding the mechanism by which eukaryotic organisms keep time on a daily basis, and how this capacity to keep time is used to regulate metabolism and development. Circadian clocks with fundamentally identical characteristics are found in all groups of eukaryotic organisms, but the uses to which these clock are put reflects the diversity of evolution. Phylogenetically this ranges from the control of cell division and enzyme activities in unicells, to a firmly established involvement in plant and animal photoperiodism and in avian and insect celestial navigation, to multiplicity of human systems including endocrine function, work-rest cycles and sleep, and drug tolerances and effectiveness.

Core Clock Protein Subcellular Dynamics Coordinate Local and Global Circadian Control in Syncytia.
Wang Z, Bartholomai BM, Wang B, Ritz D, Schultz D, Loros JJ, Dunlap JC
bioRxiv. 2025 Oct 1; pii: 2025.09.30.679467. doi: 10.1101/2025.09.30.679467. Epub 2025 Oct 1.
PMID: 41256420

Individual peroxiredoxin or Tor pathway components are not required for circadian clock function in Neurospora crassa.
Kelliher CM, Dunlap JC
Fungal Biol. 2025 Oct;129(6):101619. doi: 10.1016/j.funbio.2025.101619. Epub 2025 Jun 27.
PMID: 40915678