Dunlap and Loros Laboratories

Our laboratories and research are directed towards understanding the mechanism by which eukaryotic organisms keep time on a daily basis, and how this capacity to keep time is used to regulate metabolism and development. Circadian clocks with fundamentally identical characteristics are found in all groups of eukaryotic organisms, but the uses to which these clock are put reflects the diversity of evolution. Phylogenetically this ranges from the control of cell division and enzyme activities in unicells, to a firmly established involvement in plant and animal photoperiodism and in avian and insect celestial navigation, to multiplicity of human systems including endocrine function, work-rest cycles and sleep, and drug tolerances and effectiveness.

The Case for Kinases: a Phosphorylation Driven Model for Circadian Temperature Compensation in Neurospora crassa.
Stevenson EL, Kelliher CM, Wang B, Tariq D, Crane B, Kettenbach AN, Loros JJ, Dunlap JC
Genetics. 2026 Oct 8; pii: iyag279. doi: 10.1093/genetics/iyag279. Epub 2026 Oct 8.
PMID: 42844788

Cell-Autonomous and Systemic Circadian Regulation of Gene Expression in Adipocytes.
Worthen JM, Frederick AM, Dumesic PA, Loros JJ, Dunlap JC
J Biol Rhythms. 2026 Sep 15;:7487304261480978. doi: 10.1177/07487304261480978. Epub 2026 Sep 15.
PMID: 42745238