Program Overview

The Multiple Sclerosis Continuous Quality Improvement Collaborative (MS-CQI) was the first prospective multi-center randomized improvement research collaborative for multiple sclerosis (MS). MS-CQI was conducted from 2017-2020 and employed a Learning Health System design and studied site-level variation in quality and outcomes for MS care and tested the effects of exposure to quality improvement interventions vs. usual care.  MS-CQI was organized using a “hub and spoke” model in which a research “hub site” collaborating with an independent data analytics center at the Jefferson College of Population Health supported four participating MS clinical care centers. MS-CQI followed patient-reported outcomes (PROs) and clinical outcomes for approximately 5,000 persons with MS over 3 years (over 15,000 encounters).  Dr. Brant Oliver, CHIRP director served as the study PI and CHIRP served as the research coordination hub site for the multicenter research collaborative.  Participating MS care centers included the Massachusetts General Hospital in Boston, Massachusetts; the University of Vermont in Burlington, Vermont; the Concord Hospital MS Specialty Care Program in Concord, New Hampshire; and Neurology Associates, PC, in Orlando, Florida.  The MS-CQI study was supported by Biogen.