Samuel F Bakhoum, MD, PhD

Samuel Bakhoum is a physician-scientist and a leader in the field of chromosomal instability and its role in cancer. Prior to joining Dartmouth, Dr. Bakhoum was an Associate Member (Professor) in the Human Oncology and Pathogenesis Program at Memorial Sloan Kettering Cancer Center (MSKCC), where he also served as a practicing radiation oncologist. His research uncovered key insights into how chromosomal instability fuels cancer progression and has authored over 80 scientific publications on the subject. Dr. Bakhoum completed his postdoctoral training with Dr. Lewis Cantley at Weill Cornell Medicine and his radiation oncology training at MSKCC. He earned his M.D. and Ph.D. from Geisel School of Medicine at Dartmouth.

 

Recent Publications

Ubiquitin control of cytosolic DNA sets immune responses to DNA damage.
Bakhoum SF, Laughney AM
Cancer Cell. 2026 Feb 9;44(2):257-259. doi: 10.1016/j.ccell.2026.01.009.
PMID: 41666875

Epigenetic Regulation of Chromosomal Instability by EZH2 Methyltransferase.
Bai Y, Agustinus AS, Yomtoubian S, Meydan C, McNally DR, Yoffe L, Hubisz MJ, Tranquille M, Pramod S, Hong C, Plasilova ML, Kapoor AR, Singh A, Withers H, Dow LE, Laughney AM, Bhinder B, Elemento O, Melnick AM, Bakhoum SF, Mittal V
Cancer Discov. 2026 Jan 12;16(1):135-154. doi: 10.1158/2159-8290.CD-25-0947.
PMID: 41036949

Aneuploidy-driven vulnerabilities in breast cancer metastasis.
Bakhoum SF
Nat Genet. 2026 Jan;58(1):14-15. doi: 10.1038/s41588-025-02444-3.
PMID: 41461909

Energetics of whole genome doubling and genomic instability.
Beck RJ, Tagal V, Amin S, Bakhoum SF, Maley CC, Verhaak RGW, Gomes AP, Andor N
Cancer Lett. 2025 Oct 10;630:217878. doi: 10.1016/j.canlet.2025.217878. Epub 2025 Jun 13.
PMID: 40517938

Ongoing genome doubling shapes evolvability and immunity in ovarian cancer.
McPherson A, Vazquez-Garcia I, Myers MA, Al-Rawi DH, Zatzman M, Weiner AC, Freeman S, Mohibullah N, Satas G, Williams MJ, Ceglia N, Norkūnaitė D, Zhang AW, Li J, Lim JLP, Wu M, Choi S, Havasov E, Grewal D, Shi H, Kim M, Schwarz RF, Kaufmann T, Dinh KN, Uhlitz F, Tran J, Wu Y, Patel R, Ramakrishnan S, Kim D, Clarke J, Green H, Ali E, DiBona M, Varice N, Kundra R, Broach V, Gardner GJ, Roche KL, Sonoda Y, Zivanovic O, Kim SH, Grisham RN, Liu YL, Viale A, Rusk N, Lakhman Y, Ellenson LH, Tavare S, Aparicio S, Chi DS, Aghajanian C, Abu-Rustum NR, Friedman CF, Zamarin D, Weigelt B, Bakhoum SF, Shah SP
Nature. 2025 Aug;644(8078):1078-1087. doi: 10.1038/s41586-025-09240-3. Epub 2025 Jul 16.
PMID: 40670783