Moseley Laboratory

We study how cells coordinate cell growth and division. At the heart of this coordination are signaling pathways that link cell growth proteins with the core cell cycle machinery. We use a multi-disciplinary approach to identify these pathways, and then to understand how their activities are controlled by changes in cell size and shape. As many of these proteins are found at distinct sites in the plasma membrane, we have also become interested in the organizational principles that generate discrete compartments at the cell cortex. We use fission yeast cells as a model system because they allow us to combine a wide range of genetic, genomic, biochemical, and microscopy techniques. In addition, the basic cell growth and cell cycle systems are well conserved between fission yeast and human cells, where they have important links to the generation of cancer.

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The role of cell growth rate on accumulation of the mitotic cyclin Cdc13 in fission yeast.
Vandal SE, Rezaee S, Nieto C, Flynn MJ, Singh A, Moseley JB
bioRxiv. 2026 May 15; pii: 2026.05.14.724355. doi: 10.64898/2026.05.14.724355. Epub 2026 May 15.
PMID: 42182381

Fission yeast Pdk1 kinase regulates cytokinesis and eisosomes.
Chrupcala ML, Flynn MJ, Moseley JB
Mol Biol Cell. 2025 Dec 1;36(12):br34. doi: 10.1091/mbc.E25-07-0330. Epub 2025 Oct 22.
PMID: 41123941

Fission yeast Pdk1 kinase regulates cytokinesis and eisosomes.
Chrupcala ML, Flynn MJ, Moseley JB
bioRxiv. 2025 Oct 13; pii: 2025.07.16.665175. doi: 10.1101/2025.07.16.665175. Epub 2025 Oct 13.
PMID: 40791452