Open Call for Pilot Projects
We offer the opportunity for scientists at Dartmouth and other IDeA institutions to apply for funds to conduct a 1-year pilot research study in molecular epidemiology. The study will be in collaboration with faculty in our Center for Molecular Epidemiology at the Geisel School of Medicine at Dartmouth.
Three types of awards are available (see table below).
| Type of Award | Goal | Max Funds* | |
| 1 | Early Career/New Investigator Award mentored by one or more experienced Center investigators | To expedite progress of new recruits and new or early-career investigators at Dartmouth to extramural grant support & independence | $50K |
| 2 | Multi-PI Award led by two or more faculty members | To facilitate novel collaborations among mid or senior-career stage investigators leading to mult-PI interdisciplinary program or center grants | $65K |
| 3 | Multi-Institution Collaboration Award led by two or more faculty at Dartmouth & another IDeA state institution | To catalyze the establishment of innovative multi-institution research programs | $85K |
*Note: Total costs for the entire project must not exceed the max funds for each award. This includes both direct costs and institutional indirect costs (F&A) if applicable.
Application Process
Contact us by email epi.pilots@dartmouth.edu at any time to discuss your ideas and we will set up a preliminary meeting to discuss:
- Fit of your topic to Center for Molecular Epidemiology strategic themes
- Type of award being considered, including any co-investigators and mentors
- Budgetary considerations
- Timelines/steps for the application process (see flowchart below)
Timelines
Indicative timelines are set out in this flowchart but we will discuss these with you and keep you informed of progress once you have submitted to us.
General areas of interest include, but are not limited to:
- Discovery of biomarkers of disease susceptibility, severity and/or progression
- Identification of molecular markers that inform the prevention, management, or treatment of disease
- Identification of environmental, genetic, or epigenetic risk factors of disease
- Studies of associations between the human microbiome and exposures and/or health outcomes
- Molecular typing for tracking pathogens in populations
- Biostatistical methods for addressing complex (e.g., high-dimensional, multi-comic) data types
- Biostatistical approaches to reducing biases in observational molecular epidemiological studies
- Identification of markers of heterogeneous cell subsets
- Studies that advance precision health
Project Eligibility Criteria
- Research projects will address one or more themes in our Center:
- Applying state-of-the-art scientific discoveries and technologies to address major health concerns
- Identifying early indicators of disease pathogenesis
- Exploring common pathways of disease etiology and progression
- Human Subjects approval will be in progress or in place
- The proposed project will lead to an external grant submission
- The project uses the Biorepository Core, if appropriate
- The project includes a plan for stakeholder engagement.
Projects that address health disparities within these themes will be welcomed.
Pilot project funds are intended for supporting research projects only. Projects focused on infrastructure are not eligible.
Projects are generally for one-year but a further year may be funded upon successful application with the expectation that year one milestones have been met.
Investigator Eligibility Criteria
- At the time that NIH approval of the pilot project is sought, the principal investigator (PI) or at least one PI for multiple-PI projects should be a faculty member at Dartmouth College or Dartmouth Hitchcock Medical Center. For collaborations with external institutions, all PIs should hold faculty appointments in their home institution.
- Research scientists, postdoctoral fellows, graduate students, and proposals to fund a PhD are not eligible.
- Individuals who have been funded as either a pilot or project leader in the Center for Molecular Epidemiology are not eligible
- Individuals who currently hold pilot or project funds from another institution’s COBRE are not eligible.
- Investigators may only make one application as PI in any one cycle.
Letter of Intent (LOI)
The LOI should include:
- Full name, affiliation, and email address of the project lead
- Names and affiliations of co-investigators if applicable
- Names and affiliations of mentor(s) (Early Career/New Investigator Award only)
- Type of award
- Project title
- A statement of alignment with Center themes
- Specific aims (1-page maximum)
- IRB approval place/date if approved; submission place/date if pending; if not approved or pending, IRB submission timeline
- Plan for the use of Biorepository and/or other Cores
- Brief plan for stakeholder engagement (optional for LOI)
- Project lead’s biosketch (Early Career/New Investigator Award only)
Full Application Submission
Applicants will submit the required NIH form pages (found here):
- Face page (unsigned)
- Specific aims (1-page maximum)
- Project summary
- Project narrative
- Research strategy (5 pages maximum)
- Budget and justification (for internal use only)
- Biosketch of all investigators
- Human subjects protection section
- IRB approval
- Human subjects education certification (unless the project is human subjects exempt)
- Targeted/planned enrollment table (unless the project is human subjects exempt)
- GCP training certification (if the project is a clinical trial)
Submitting LOIs and Full Proposals
These should be emailed to: epi.pilots@dartmouth.edu
Questions and inquiries
These can be emailed to: epi.pilots@dartmouth.edu
Post-award matters
Pilot project leaders are members of the Center of Molecular Epidemiology and will be supported scientifically and administratively. Pilot project leaders will identify two or more mentors who will support their career development. Pilot leaders will be informed about Center seminars and events and invited to present their research at Research in Progress seminars during the period of their award. It is expected that pilot projects will lead to the submission of an R01 (or equivalent) proposal, and grant-writing support will be provided. Any changes in funding are to be approved by the Center Director (Dr. Margaret Karagas) in writing. Unused funds will be transferred back to the COBRE.
Full details of support available and expectations will be provided and discussed when the award begins.
Center Leadership and Contact Information
Director and Principal Investigator: Dr. Margaret Karagas
Directors of Pilot Projects Program: Dr. Annie Hoen and Dr. Janet Peacock
Director of Biorepository: Dr. Brock Christensen
Contact: epi.pilots@dartmouth.edu