Effector functions are required for broad and potent protection of neonatal mice with antibodies targeting HSV glycoprotein D.
Slein MD, Backes IM, Garland CR, Kelkar NS, Leib DA, Ackerman ME
Cell Rep Med. 2024 Feb 20;5(2):101417. doi: 10.1016/j.xcrm.2024.101417. Epub 2024 Feb 12.
PMID: 38350452

Antibody effector functions are required for broad and potent protection of neonates from herpes simplex virus infection.
Slein MD, Backes IM, Garland CR, Kelkar NS, Leib DA, Ackerman ME
bioRxiv. 2023 Aug 31; pii: 2023.08.29.555423. doi: 10.1101/2023.08.29.555423. Epub 2023 Aug 31.
PMID: 37693377

Maternally transferred mAbs protect neonatal mice from HSV-induced mortality and morbidity.
Backes IM, Byrd BK, Slein MD, Patel CD, Taylor SA, Garland CR, MacDonald SW, Balazs AB, Davis SC, Ackerman ME, Leib DA
J Exp Med. 2022 Dec 5;219(12) doi: 10.1084/jem.20220110. Epub 2022 Sep 26.
PMID: 36156707

Monoclonal antibody therapy of herpes simplex virus: An opportunity to decrease congenital and perinatal infections.
Backes IM, Leib DA, Ackerman ME
Front Immunol. 2022;13:959603. doi: 10.3389/fimmu.2022.959603. Epub 2022 Aug 9.
PMID: 36016956

Herpes Simplex Virus-2 Variation Contributes to Neurovirulence During Neonatal Infection.
Hayes CK, Villota CK, McEnany FB, Ceron S, Awasthi S, Szpara ML, Friedman HM, Leib DA, Longnecker R, Weitzman MD, Akhtar LN
J Infect Dis. 2022 Nov 1;226(9):1499-1509. doi: 10.1093/infdis/jiac151.
PMID: 35451492

Herpes Simplex Virus 1 ICP34.5 Alters Mitochondrial Dynamics in Neurons.
Manivanh R, Mehrbach J, Charron AJ, Grassetti A, Ceron S, Taylor SA, Cabrera JR, Gerber S, Leib DA
J Virol. 2020 Jul 1;94(14) doi: 10.1128/JVI.01784-19. Epub 2020 Jul 1.
PMID: 32376626

Trivalent Glycoprotein Subunit Vaccine Prevents Neonatal Herpes Simplex Virus Mortality and Morbidity.
Patel CD, Taylor SA, Mehrbach J, Awasthi S, Friedman HM, Leib DA
J Virol. 2020 May 18;94(11) doi: 10.1128/JVI.02163-19. Epub 2020 May 18.
PMID: 32188735

Maternal immunization confers protection against neonatal herpes simplex mortality and behavioral morbidity.
Patel CD, Backes IM, Taylor SA, Jiang Y, Marchant A, Pesola JM, Coen DM, Knipe DM, Ackerman ME, Leib DA
Sci Transl Med. 2019 Apr 10;11(487) doi: 10.1126/scitranslmed.aau6039.
PMID: 30971454

The ESCRT-Related ATPase Vps4 Is Modulated by Interferon during Herpes Simplex Virus 1 Infection.
Cabrera JR, Manivanh R, North BJ, Leib DA
mBio. 2019 Mar 5;10(2) doi: 10.1128/mBio.02567-18. Epub 2019 Mar 5.
PMID: 30837340

The US11 Gene of Herpes Simplex Virus 1 Promotes Neuroinvasion and Periocular Replication following Corneal Infection.
Charron AJ, Ward SL, North BJ, Ceron S, Leib DA
J Virol. 2019 May 1;93(9) doi: 10.1128/JVI.02246-18. Epub 2019 Apr 17.
PMID: 30760571

The STING agonist 5,6-dimethylxanthenone-4-acetic acid (DMXAA) stimulates an antiviral state and protects mice against herpes simplex virus-induced neurological disease.
Ceron S, North BJ, Taylor SA, Leib DA
Virology. 2019 Mar;529:23-28. doi: 10.1016/j.virol.2019.01.006. Epub 2019 Jan 6.
PMID: 30648635

Neuronal Subtype Determines Herpes Simplex Virus 1 Latency-Associated-Transcript Promoter Activity during Latency.
Cabrera JR, Charron AJ, Leib DA
J Virol. 2018 Jul 1;92(13) doi: 10.1128/JVI.00430-18. Epub 2018 Jun 13.
PMID: 29643250

Preventing neonatal herpes infections through maternal immunization.
Jiang Y, Leib D
Future Virol. 2017 Dec;12(12):709-711. doi: 10.2217/fvl-2017-0105.
PMID: 29339967

Role of Herpes Simplex Virus 1 γ34.5 in the Regulation of IRF3 Signaling.
Manivanh R, Mehrbach J, Knipe DM, Leib DA
J Virol. 2017 Dec 1;91(23) doi: 10.1128/JVI.01156-17. Epub 2017 Nov 14.
PMID: 28904192

Isolation, Purification, and Culture of Primary Murine Sensory Neurons.
Katzenell S, Cabrera JR, North BJ, Leib DA
Methods Mol Biol. 2017;1656:229-251. doi: 10.1007/978-1-4939-7237-1_15.
PMID: 28808974