Eliminating interactions with the viral Fc receptor improves antibody-mediated protection against neonatal HSV infection in mice.
Slein MD, Backes IM, Jimenez LM, Kelkar NS, Garland CR, Khanwalkar US, Sholukh AM, Johnston C, Leib DA, Ackerman ME
Sci Transl Med. 2025 Nov 19;17(825):eadu8579. doi: 10.1126/scitranslmed.adu8579. Epub 2025 Nov 19.
PMID: 41259538
Corrigendum to "Herpes simplex virus 1 ICP34.5 acts to maintain latency in human and mouse neurons" [Virology 611 (2025) 110652].
Canova PN, Katzenell S, Ceron S, Charron AJ, Pesola JM, Oh HS, Coen DM, Knipe DM, Leib DA
Virology. 2025 Oct;611:110669. doi: 10.1016/j.virol.2025.110669. Epub 2025 Aug 30.
PMID: 40885672
Herpes simplex virus 1 ICP34.5 acts to maintain latency in human and mouse neurons.
Canova PN, Katzenell S, Ceron S, Charron AJ, Pesola JM, Oh HS, Coen DM, Knipe DM, Leib DA
Virology. 2025 Oct;611:110652. doi: 10.1016/j.virol.2025.110652. Epub 2025 Aug 12.
PMID: 40819480
Maternal Antibodies to Neurovirulent Pathogens in Fetal Tissues.
Slein MD, Ackerman ME, Leib DA
Annu Rev Virol. 2025 Sep;12(1):471-489. doi: 10.1146/annurev-virology-092623-094004. Epub 2025 Apr 18.
PMID: 40249965
Antibodies targeting HSV glycoprotein B require effector functions to protect neonatal mice.
Slein MD, Jimenez LM, Backes IM, Turnbaugh EM, Garland CR, MacDonald SW, Balazs AB, Leib DA, Ackerman ME
bioRxiv. 2025 Jul 30; pii: 2025.07.25.666806. doi: 10.1101/2025.07.25.666806. Epub 2025 Jul 30.
PMID: 40766354
Herpes Simplex Virus Neurovirulence Across the Human Lifespan.
Dutton AJ, Hayes CK, Leib DA, Akhtar LN
J Infect Dis. 2025 Jul 30;232(1):14-24. doi: 10.1093/infdis/jiaf275.
PMID: 40418737
Regulation of the innate immune response in human neurons by ICP34.5 maintains herpes simplex virus 1 latency.
Canova PN, Katzenell S, Ceron S, Charron AJ, Pesola JM, Oh HS, Coen DM, Knipe DM, Leib DA
bioRxiv. 2025 Apr 10; pii: 2025.04.04.647253. doi: 10.1101/2025.04.04.647253. Epub 2025 Apr 10.
PMID: 40291710
Asymptomatic neonatal herpes simplex virus infection in mice leads to persistent CNS infection and long-term cognitive impairment.
Dutton AJ, Turnbaugh EM, Patel CD, Garland CR, Taylor SA, Alers-Velazquez R, Knipe DM, Nautiyal KM, Leib DA
PLoS Pathog. 2025 Feb;21(2):e1012935. doi: 10.1371/journal.ppat.1012935. Epub 2025 Feb 7.
PMID: 39919123
Improving antibody-mediated protection against HSV infection by eliminating interactions with the viral Fc receptor gE/gI.
Slein MD, Backes IM, Kelkar NS, Garland CR, Khanwalkar US, Sholukh AM, Johnston CM, Leib DA, Ackerman ME
bioRxiv. 2024 Nov 22; pii: 2024.11.20.624598. doi: 10.1101/2024.11.20.624598. Epub 2024 Nov 22.
PMID: 39605495
Models of Herpes Simplex Virus Latency.
Canova PN, Charron AJ, Leib DA
Viruses. 2024 May 8;16(5) doi: 10.3390/v16050747. Epub 2024 May 8.
PMID: 38793628
Asymptomatic neonatal herpes simplex virus infection in mice leads to long-term cognitive impairment.
Dutton A, Patel CD, Taylor SA, Garland CR, Turnbaugh EM, Alers-Velazquez R, Mehrbach J, Nautiyal KM, Leib DA
bioRxiv. 2024 Apr 22; pii: 2024.04.22.590596. doi: 10.1101/2024.04.22.590596. Epub 2024 Apr 22.
PMID: 38712140
Effector functions are required for broad and potent protection of neonatal mice with antibodies targeting HSV glycoprotein D.
Slein MD, Backes IM, Garland CR, Kelkar NS, Leib DA, Ackerman ME
Cell Rep Med. 2024 Feb 20;5(2):101417. doi: 10.1016/j.xcrm.2024.101417. Epub 2024 Feb 12.
PMID: 38350452
Antibody effector functions are required for broad and potent protection of neonates from herpes simplex virus infection.
Slein MD, Backes IM, Garland CR, Kelkar NS, Leib DA, Ackerman ME
bioRxiv. 2023 Aug 31; pii: 2023.08.29.555423. doi: 10.1101/2023.08.29.555423. Epub 2023 Aug 31.
PMID: 37693377
Maternally transferred mAbs protect neonatal mice from HSV-induced mortality and morbidity.
Backes IM, Byrd BK, Slein MD, Patel CD, Taylor SA, Garland CR, MacDonald SW, Balazs AB, Davis SC, Ackerman ME, Leib DA
J Exp Med. 2022 Dec 5;219(12) doi: 10.1084/jem.20220110. Epub 2022 Sep 26.
PMID: 36156707
Herpes Simplex Virus-2 Variation Contributes to Neurovirulence During Neonatal Infection.
Hayes CK, Villota CK, McEnany FB, Ceron S, Awasthi S, Szpara ML, Friedman HM, Leib DA, Longnecker R, Weitzman MD, Akhtar LN
J Infect Dis. 2022 Nov 1;226(9):1499-1509. doi: 10.1093/infdis/jiac151.
PMID: 35451492