In mice, neonatal HSV-1 infection triggers behavior changes as measured by the elevated plus maze. However, maternal immunization with an experimental HSV-2 trivalent glycoprotein vaccine prevents disseminated disease and anxiety-like behavior in infected offspring, as exemplified by the confident mouse in this image. Image captured by Sean Taylor and designed by Chaya Patel.
HSV-1 US11 Promotes Neuroinvasion and Periocular Replication
This image shows human corneal epithelial cells infected with a mixture of HSV-1 (purple) and a mutant lacking these genes (Δ34.5Δ11, green). Cells infected with Δ34.5Δ11 show elevated levels of phosphorylated eIF2α (orange) relative to cells infected with wild-type HSV-1. Captured by Audra Charron.
Photostitched fluorescent microscopy image of a human fetal trigeminal ganglion stained for IgG (green) and DNA (blue). Captured by Yike Jiang.
Sensory trigeminal ganglia (TG) neurons ((labeled by βIII-tubulin, red) are capable of responding to IFN-β, but the intrinsic IFN-driven response to infection is not sufficient to control herpes simplex virus 1 (HSV-1) replication (green). Captured by Pamela Rosato.