January 14, 2019
A huge congrats to Stacey for publishing her work on DMXAA and HSE. Read all about it here: Cerón et al 2019
Oct 17, 2018
Congrats to Chaya on winning the Celebration of Biomedical Research at Dartmouth (CBraD) poster competition. The Leib lab had even more reason to celebrate as Iara and Paige both took home raffle prizes!
Herpes simplex virus (HSV) is a highly evolved and successful pathogen with a very wide distribution in the human population, close to 100% in some populations. HSV often manages to forge the near-perfect lifelong relationship with us, its human host. Despite the availability of excellent antiviral drugs such as acyclovir and valtrex, HSV is refractory to cure. This is due to the ability of HSV to invade neurons, to translocate to neuronal cell bodies, and establish latent infections therein. Our over-arching interest is to understand how HSV modulates the immune system of the host. This immune-modulation allows HSV to successfully establish latency, and more remarkably, to allow the virus to escape from the immune host to infect other susceptible individuals in the population. Our experimental approach is to use forward and reverse genetics to introduce mutations into the viral genome to generate recombinant viruses. We then use these recombinant viruses in vitro and in vivo to allow the study of viral pathogenesis at the molecular level, and to examine the outcome of the host-pathogen battle.
The ESCRT-Related ATPase Vps4 Is Modulated by Interferon during Herpes Simplex Virus 1 Infection.
Cabrera JR, Manivanh R, North BJ, Leib DA
MBio. 2019 Mar 5;10(2) pii: e02567-18. doi: 10.1128/mBio.02567-18. Epub 2019 Mar 5.
The US11 gene of Herpes Simplex Virus 1 promotes neuroinvasion and periocular replication following corneal infection.
Charron AJ, Ward SL, North BJ, Ceron S, Leib DA
J Virol. 2019 Feb 13; pii: JVI.02246-18. doi: 10.1128/JVI.02246-18. Epub 2019 Feb 13.
The STING agonist 5,6-dimethylxanthenone-4-acetic acid (DMXAA) stimulates an antiviral state and protects mice against herpes simplex virus-induced neurological disease.
Ceron S, North BJ, Taylor SA, Leib DA
Virology. 2019 Mar;529:23-28. doi: 10.1016/j.virol.2019.01.006. Epub 2019 Jan 6.