COVID-19 Information

Leib Laboratory

News

Read all about the the Leib Lab’s efforts on rapid COVID-19 diagnostics.

Research scientist Audra Charron and David Leib, professor of microbiology and immunology at the Geisel School of Medicine, are working with other Dartmouth researchers to validate a new and improved test for the novel coronavirus.

 

Congratulations to Richard, Sean, Jesse, Audra and Stacey on publishing on how HSV-1 ICP34.5 alters mitochondrial dynamics. A truly collaborative publication! Check out the article here.

 

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Research

Herpes simplex virus (HSV) is a highly evolved and successful pathogen with a very wide distribution in the human population, close to 100% in some populations. HSV often manages to forge the near-perfect lifelong relationship with us, its human host. Despite the availability of excellent antiviral drugs such as acyclovir and valtrex, HSV is refractory to cure. This is due to the ability of HSV to invade neurons, to translocate to neuronal cell bodies, and establish latent infections therein. Our over-arching interest is to understand how HSV modulates the immune system of the host. This immune-modulation allows HSV to successfully establish latency, and more remarkably, to allow the virus to escape from the immune host to infect other susceptible individuals in the population. Our experimental approach is to use forward and reverse genetics to introduce mutations into the viral genome to generate recombinant viruses. We then use these recombinant viruses in vitro and in vivo to allow the study of viral pathogenesis at the molecular level, and to examine the outcome of the host-pathogen battle.

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Recent Publications

Herpes Simplex Virus 1 ICP34.5 Alters Mitochondrial Dynamics in Neurons.
Manivanh R, Mehrbach J, Charron AJ, Grassetti A, Ceron S, Taylor SA, Cabrera JR, Gerber S, Leib DA
J Virol. 2020 Jul 1;94(14) pii: e01784-19. doi: 10.1128/JVI.01784-19. Epub 2020 Jul 1.
PMID: 32376626

Trivalent Glycoprotein Subunit Vaccine Prevents Neonatal Herpes Simplex Virus Mortality and Morbidity.
Patel CD, Taylor SA, Mehrbach J, Awasthi S, Friedman HM, Leib DA
J Virol. 2020 May 18;94(11) pii: e02163-19. doi: 10.1128/JVI.02163-19. Epub 2020 May 18.
PMID: 32188735

Maternal immunization confers protection against neonatal herpes simplex mortality and behavioral morbidity.
Patel CD, Backes IM, Taylor SA, Jiang Y, Marchant A, Pesola JM, Coen DM, Knipe DM, Ackerman ME, Leib DA
Sci Transl Med. 2019 Apr 10;11(487) pii: eaau6039. doi: 10.1126/scitranslmed.aau6039.
PMID: 30971454

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