COVID-19 Information

Leib Laboratory

News

Congratulations to Fiona McEnany for passing her qualifying exam on August 3rd, 2022! We are thrilled for her success and thrilled for the excuse to celebrate with viral puns, swimming, washers, and cheer.

Congratulations graduates! Richard and Iara were robed and regaled on June 11th, 2022. Just look at those good looking PhDs:

Congratulations to Matt Slein for passing his qualifying exam on June 8th, 2022! To no one’s surprise, he passed with flying colors and lots and lots of virology fun facts 🙂

Congratulations to Iara Backes for successfully defending her thesis on February 28th!

 

 

 

 

 

 

 

Congratulations to Roberto Alers-Velazquez for being accepted to Cornell’s Rising Star Program! A STAR pumpkin carver and know a nationally recognized star postdoc! Read more HERE

 

 

 

 

 

 

 

 

Congratulations to Fiona McEnany for being selected as New Hampshire’s Young Person of the Year! First New Hampshire, next The World… [Read more HERE].

Congratulations to Abigail Dutton for passing her qualifying exam on July 23rd, 2021. Congratulations also to her lab for immediately reminding Abigail of her humility in a daring game of volleyball (nice moves, Audra!).

 

 

 

 

 

 

 

Congratulations to Stacey Ceron for winning the Guarini Diversity Award, 2021. You are so deserving and we are so proud! Read more here.

 

 

 

 

 

Congratulations to Stacey Ceron for successfully defending her thesis on May 4th, 2021!

 

 

 

 

 

 

 

 

 

Congratulations to Chaya Patel for successfully defending her thesis on November 10th.

Read all about the the Leib Lab’s efforts on rapid COVID-19 diagnostics.

Research scientist Audra Charron and David Leib, professor of microbiology and immunology at the Geisel School of Medicine, are working with other Dartmouth researchers to validate a new and improved test for the novel coronavirus.

 

Read more Leib lab news…

Leib Lab Statement

Research

Herpes simplex virus (HSV) is a highly evolved and successful pathogen with a very wide distribution in the human population, close to 100% in some populations. HSV often manages to forge the near-perfect lifelong relationship with us, its human host. Despite the availability of excellent antiviral drugs such as acyclovir and valtrex, HSV is refractory to cure. This is due to the ability of HSV to invade neurons, to translocate to neuronal cell bodies, and establish latent infections therein. Our over-arching interest is to understand how HSV modulates the immune system of the host. This immune-modulation allows HSV to successfully establish latency, and more remarkably, to allow the virus to escape from the immune host to infect other susceptible individuals in the population. Our experimental approach is to use forward and reverse genetics to introduce mutations into the viral genome to generate recombinant viruses. We then use these recombinant viruses in vitro and in vivo to allow the study of viral pathogenesis at the molecular level, and to examine the outcome of the host-pathogen battle.

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Recent Publications

Maternally transferred mAbs protect neonatal mice from HSV-induced mortality and morbidity.
Backes IM, Byrd BK, Slein MD, Patel CD, Taylor SA, Garland CR, MacDonald SW, Balazs AB, Davis SC, Ackerman ME, Leib DA
J Exp Med. 2022 Dec 5;219(12) doi: 10.1084/jem.20220110. Epub 2022 Sep 26.
PMID: 36156707

Monoclonal antibody therapy of herpes simplex virus: An opportunity to decrease congenital and perinatal infections.
Backes IM, Leib DA, Ackerman ME
Front Immunol. 2022;13:959603. doi: 10.3389/fimmu.2022.959603. Epub 2022 Aug 9.
PMID: 36016956

Herpes Simplex Virus-2 Variation Contributes to Neurovirulence During Neonatal Infection.
Hayes CK, Villota CK, McEnany FB, Ceron S, Awasthi S, Szpara ML, Friedman HM, Leib DA, Longnecker R, Weitzman MD, Akhtar LN
J Infect Dis. 2022 Nov 1;226(9):1499-1509. doi: 10.1093/infdis/jiac151.
PMID: 35451492

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