FEATURED ORIGINAL RESEARCH
Human cytomegalovirus regulates host DNA repair machinery for viral genome integrity. Longmire, P., S. Zeltzer, K. Zarrella, O. Daigle, M. Svoboda, J.M. Reitsma, S.S. Terhune, C. Bobak, G. Bosco, and F. Goodrum. 2025. Nucleic Acids Research, in revision.
Viral and host network analysis of the human cytomegalovirus transcriptome in latency. Collins-McMillen, D., D. De Oliviera-Pessoa, K. Zarrella, N.J. Moorman, J. P. Kamil, P. Caposio, M. Padi, and F.D. Goodrum. 2025. Proc. Natl. Acad. Sci. USA,122(22): e2416114122. PMID:40434638
Human Cytomegalovirus UL138 Interaction with USP1 Activates STAT1 in Infection. Zarrella, K., P. Longmire, S. Zeltzer, D. Collins-McMillen, M. Hancock, J. Buehler, J. Reitsma, J. Nelson, S. S. Terhune, and F. Goodrum. 2023. PLoS Pathogens, June 8; 19(6):e1011185. PMID:37289831
Host translesion polymerases are required for viral genome integrity. Zeltzer, S., P. Longmire, M. Svoboda, G. Bosco, and F. Goodrum. 2022. Proc Natl Acad Sci USA, 119(33):e2203203119. PMID: 35947614
Host signaling and EGR1 transcriptional control of human cytomegalovirus replication and latency. Buehler, J., E. Carpenter, S. Zeltzer, S. Igarashi, M. Rak, I. Mikell, J.A. Nelson, and F. Goodrum. 2019. PLoS Pathogens, 15(11):e1008037. PMID: 31725811
Alternative Promoters Drive Human Cytomegalovirus Reactivation from Latency. Collins-McMillen, D., M. Rak, J.C. Buehler, S. Igarashi-Hayes, J.P. Kamil, N.J. Moorman, and F. Goodrum. 2019. Proc Natl Acad Sci USA, 116(35):17492-17497. PMID: 31409717.
Human Cytomegalovirus UL135 Interacts with Host Adaptor Proteins to Regulate Epidermal Growth Factor Receptor and Reactivation from Latency. Rak, M., J. Buehler, S. Zeltzer, J. Reitsma, S. Terhune, F. Goodrum. 2018. J Virology, 92(20): e00919-18. PMID: 30089695
Virus control of trafficking from sorting endosomes. Zeltzer, S., C. A. Zeltzer, J. Wilson, J. G. Donaldson, and F. Goodrum. 2018. MBio, 9(4): e00683-18. PMID: 30042195
FEATURED REVIEWS
Human cytomegalovirus latency – the sum of subtleties. Hancock, M.H., P. Caposio, D. Collins-McMillen, N.L Diggins, B-.J. Lee, S. Medica, D. N. Streblow, T. White, A.D. Yurochko, F. Goodrum. 2025. J Virology, Jul30:e0066425. PMID:40736257
Virology – the next fifty years. Holmes, E., F. Krammer, and F. Goodrum. 2024. Cell, Sep 19; 187 (19): 5128-5145. PMID:39303682 PMC11467463
The complex biology of human cytomegalovirus latency and reactivation. Goodrum, F. 2022. In Adv.Virus Res. v112. Aug 1. PMID:35840181
FEATURED SCIENCE ADVOCACY
A call for the United States to continue investing in science. Blader, I. †, F. Goodrum†, M.J. Imperiale†, A. Casadevall, C. Arias, A. Baumler, C.A. Burnham, C. Cuomo, C. Detweiler, G. Forrest, J. Gilbert, S. Lovett, S. Maloy, A. McAdam, I. Newton, G. Reguera, G. O’Toole, P. D. Scloss, A. Shade, M. Whiteley. 2025. mBio, Apr 9; 16(4)e0064825. Co-published in J Virology, J Bacteriology, mSphere, mSystems, Appl. Env. Micro., ASM Case Reports, Antimicrobial Agents and Chemotherapy, J Clin.Microbiol., Microbiol Spectrum, Clin. Microbiol. Rev., Infection and Immunity, Microbiol. Resouce Announcements, Microbiol. and Mol. Bio. Rev., J Microbiol. and Bio. Educ. PMID: 40013856
The harms of promoting the lab leak hypothesis without evidence. Alwine, J.†, Goodrum†, B. Banfield, D. Bloom, W. J. Britt, A. J. Broadbent, S. K. Campos, A. Casadevall, T. Dermody, W. P. Duprex, L. W. Enquist, K. Frueh, M. Gaglia, A.P. Geballe, et al (41 authors total). 2024. J Virology, 98(9) Sep 17:e0124024. PMID: 39087765. Notable press: LA Times, TWiV, STAT
Virology – the path forward. Rasmussen, A. †, G. Gronvall†, A. Lowen†, Goodrum†, et al. (79 total authors). 2024. J Virology, 98(1)Jan 3: e0179123. PMID: 38168672
Field research is essential to counter virological threats. Runstadler, J. A., A. C. Lowen, G. Kayeli, S. M. Tompkins, R. A. Albrecht, R. A. M. Fouchier, D. E. Stallknecht, S. S. Lakdawala, F. D. Goodrum, A. Casadevall, L. W. Enquist, J. C. Alwine, M. J. Imperiale, S. Schultz-Cherry, R. J. Webby 2023. J. Virology. doi:10.1128/jvi.00544-23:e0054423. PMID:37166327
A critical analysis of the evidence for the SARS-CoV-2 origin hypotheses. Alwine, J.C., A. Casadevall, L.W. Enquist, D. Goodrum†, M.J. Imperiale. 2023. Co-published in: mBio, J Virology, mSphere. March 28. PMID: 36897089
Oversight of pathogen research must be carefully calibrated and clearly defined. Lowen, A., A. Casadevall, J.C. Alwine, L.W. Enquist, F.D. Goodrum, M.J. Imperiale, S.S. Lakdawala. 2023. Co-published in: mBio, J Virology, and mSphere. Feb 22. PMID:36811609.
Virology under the microscope – a call for rational discourse. Goodrum, F. †, A. Lowen, S. Lakdawala, J. Alwine, A. Casadevall, M. Imperiale, et al. (156 total authors). 2023. Co-published in: mBio, J Virology, and 27 Jan. . PMID: 36700640 Notable press: New York Times, NPR, Arizona Republic, and This Week in Virology (TWiV)
RECENT PUBLICATIONS - PubMed
Human cytomegalovirus regulates host DNA repair machinery for viral genome integrity.
Longmire P, Zeltzer S, Zarrella K, Daigle O, Svoboda M, Reitsma JM, et al.
Nucleic Acids Res. 2026 Jan 14;54(2) doi: 10.1093/nar/gkaf1445.
PMID: 41533576
Human cytomegalovirus promotes de novo PC synthesis during early virus replication.
Kline I, Mokry RL, Xi Y, Passols Manzano M, Layesa S, Sohrab Ali N, et al.
J Virol. 2025 Sep 23;99(9):e0057925. doi: 10.1128/jvi.00579-25. Epub 2025 Aug 19.
PMID: 40827916
Cytomegalovirus latency-the sum of subtleties.
Hancock MH, Caposio P, Collins-McMillen D, Diggins NL, Lee B-J, Medica S, et al.
J Virol. 2025 Aug 19;99(8):e0066425. doi: 10.1128/jvi.00664-25. Epub 2025 Jul 30.
PMID: 40736257
A call for the United States to continue investing in science.
Blader I, Goodrum F, Imperiale MJ, Casadevall A, Arias CA, Baumler A, et al.
Clin Microbiol Rev. 2025 Jun 12;38(2):e0004425. doi: 10.1128/cmr.00044-25. Epub 2025 Feb 27.
PMID: 40013868
Viral and host network analysis of the human cytomegalovirus transcriptome in latency.
Collins-McMillen D, De Oliveira Pessoa D, Zarrella K, Parkins CJ, Daily M, McKinzey DR, et al.
Proc Natl Acad Sci U S A. 2025 Jun 3;122(22):e2416114122. doi: 10.1073/pnas.2416114122. Epub 2025 May 28.
PMID: 40434638
Complex roles for proliferating cell nuclear antigen in restricting human cytomegalovirus replication.
Longmire P, Daigle O, Zeltzer S, Lee M, Svoboda M, Padilla-Rodriguez M, et al.
mBio. 2025 May 14;16(5):e0045025. doi: 10.1128/mbio.00450-25. Epub 2025 Mar 25.
PMID: 40130902
A call for the United States to continue investing in science.
Blader I, Goodrum F, Imperiale MJ, Casadevall A, Arias CA, Baumler A, et al.
Microbiol Spectr. 2025 May 6;13(5):e0056825. doi: 10.1128/spectrum.00568-25. Epub 2025 Feb 27.
PMID: 40013887
A call for the United States to continue investing in science.
Blader I, Goodrum F, Imperiale MJ, Casadevall A, Arias CA, Baumler A, et al.
ASM Case Rep. 2025 May;1(3) doi: 10.1128/asmcr.00043-25. Epub 2025 Feb 27.
PMID: 41246371
A call for the United States to continue investing in science.
Blader I, Goodrum F, Imperiale MJ, Casadevall A, Arias CA, Baumler A, et al.
J Microbiol Biol Educ. 2025 Apr 24;26(1):e0006725. doi: 10.1128/jmbe.00067-25. Epub 2025 Feb 27.
PMID: 40013875
A call for the United States to continue investing in science.
Blader I, Goodrum F, Imperiale MJ, Casadevall A, Arias CA, Baumler A, et al.
Appl Environ Microbiol. 2025 Apr 23;91(4):e0046725. doi: 10.1128/aem.00467-25. Epub 2025 Feb 27.
PMID: 40013896