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An optimized library for reference-based deconvolution of whole-blood biospecimens assayed using the Illumina HumanMethylationEPIC BeadArray

Epidemiology Postdoc, Dr. Lucas Salas (Brock Christensen's lab) and fellow researchers have come up with a new and more precise reference library for adult blood cell deconvolution using Illumina EPIC DNA methylation microarrays. The improved library minimizes experimental artifacts and variability associated with small changes in different cell subpopulations in adult blood samples. A legacy library is also available for datasets using the now unavailable 450K platform. The improved library can be applied in Epigenome Wide Association Studies (EWAS) to explore immune profiles in cancer and other diseases (immunomethylomics). Description of this work has been published in Genome Biology.  The associated bioconductor software package can be found here.