Lab Members / Projects

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Our lab utilizes biochemical, biophysical, cell biological, and computational techniques to understand the mechanisms of chromosome segregation during cell division in human cells. We are determining the mechanisms that drive chromosome movement and ensure error-free mitosis and the mechanisms that contribute to the orderly assembly of microtubules into the bipolar spindle apparatus.

Chromosomes must segregate accurately at each cell division. Chromosome mis-segregation leads to aneuploidy, a condition that is common in solid tumors. Many aneuploid tumor cells mis-segregate chromosomes at very high rates in a phenomenon called chromosomal instability. We are currently using biochemical and cell biological techniques to determine the underlying cause of chromosomal instability in human tumor cells (chromosome segregation). We plan to use this information to build models where we can directly test how chromosomal instability contributes to the tumorigenic phenotype.

Principal Investigator

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Duane Compton, PhD
Professor of Biochemistry
Duane.Compton@Dartmouth.edu

Research Group Members

Kristina Godek, PhD
Postdoctoral Fellow
Cancer stem cells and kinetochore biochemistry

Ana-Maria Dumitru
Graduate Student
Kinetochore-microtubule stability

Kelly Salmon
Graduate Student
Imprinted Genes

Jessica DeSimone
Graduate Student
Kinetochore-microtubule stability and cell cycle control

Sarah Valles
Graduate Student
Regulation of Aurora B kinase

Former Lab Members