COVID-19 Information

Publications

Clinical and Molecular Findings after Autologous Stem Cell Transplantation or Cyclophosphamide for Scleroderma: Handling Missing Longitudinal Data.
Keyes-Elstein L, Pinckney A, Goldmuntz E, Welch B, Franks JM, Martyanov V, Wood TA, Crofford L, Mayes M, McSweeney P, Nash R, Georges G, Csuka ME, Simms R, Furst D, Khanna D, St Clair EW, Whitfield ML, Sullivan KM
Arthritis Care Res (Hoboken). 2021 Sep 17; doi: 10.1002/acr.24785. Epub 2021 Sep 17.
PMID: 34533286

SARS-CoV-2 Impairs Dendritic Cells and Regulates DC-SIGN Gene Expression in Tissues.
Cai G, Du M, Bosse Y, Albrecht H, Qin F, Luo X, Androulakis XM, Cheng C, Nagarkatti M, Nagarkatti P, Christiani DC, Whitfield ML, Amos CI, Xiao F
Int J Mol Sci. 2021 Aug 26;22(17) pii: 9228. doi: 10.3390/ijms22179228. Epub 2021 Aug 26.
PMID: 34502134

A Case of Recalcitrant Linear Morphea Responding to Subcutaneous Abatacept.
Talia J, Bitar C, Wang Y, Whitfield ML, Khanna D
J Scleroderma Relat Disord. 2021 Jun 1;6(2):194-198. doi: 10.1177/2397198320983240. Epub 2021 Jan 10.
PMID: 34337154

Mast Cell Activation in the Systemic Sclerosis Esophagus.
Tom K, Mehta BK, Hoffmann A, Aren K, Carns M, Lee J, Martyanov V, Popovich D, Kosarek N, Wood T, Brenner D, Carlson DA, Ostilla L, Willcocks E, Bryce P, Wechsler JB, Whitfield ML, Hinchcliff M
J Scleroderma Relat Disord. 2021 Feb;6(1):77-86. doi: 10.1177/2397198320941322. Epub 2020 Jul 27.
PMID: 34179507

Correction to: Lymphocyte subset abnormalities in early diffuse cutaneous systemic sclerosis.
Fox DA, Lundy SK, Whitfield ML, Berrocal V, Campbell P, Rasmussen S, Ohara R, Stinson A, Gurrea-Rubio M, Wiewiora E, Spino C, Bush E, Furst D, Pillai S, Khanna D
Arthritis Res Ther. 2021 Mar 4;23(1):73. doi: 10.1186/s13075-021-02459-1. Epub 2021 Mar 4.
PMID: 33663570

Moving towards a molecular categorization of autoimmune disease.
Whitfield ML
Nat Rev Rheumatol. 2021 Apr;17(4):193-194. doi: 10.1038/s41584-021-00589-z.
PMID: 33654308

Lymphocyte subset abnormalities in early diffuse cutaneous systemic sclerosis.
Fox DA, Lundy SK, Whitfield ML, Berrocal V, Campbell P, Rasmussen S, Ohara R, Stinson A, Gurrea-Rubio M, Wiewiora E, Spino C, Bush E, Furst D, Pillai S, Khanna D
Arthritis Res Ther. 2021 Jan 6;23(1):10. doi: 10.1186/s13075-020-02383-w. Epub 2021 Jan 6.
PMID: 33407866

Molecular "omic" signatures in systemic sclerosis.
Mehta BK, Espinoza ME, Hinchcliff M, Whitfield ML
Eur J Rheumatol. 2020 Oct;7(Suppl 3):S173-S180. doi: 10.5152/eurjrheum.2020.19192. Epub 2020 Oct 1.
PMID: 33164732

Reply.
Spiera R, Chung L, Frech T, Domsic R, Hsu V, Furst DE, Simms R, Mayes M, Martyanov V, Whitfield ML, Dgetluck N, Dinh Q, White B
Arthritis Rheumatol. 2021 Apr;73(4):716-717. doi: 10.1002/art.41579. Epub 2021 Feb 18.
PMID: 33164325

Machine learning integration of scleroderma histology and gene expression identifies fibroblast polarisation as a hallmark of clinical severity and improvement.
Showalter K, Spiera R, Magro C, Agius P, Martyanov V, Franks JM, Sharma R, Geiger H, Wood TA, Zhang Y, Hale CR, Finik J, Whitfield ML, Orange DE, Gordon JK
Ann Rheum Dis. 2021 Feb;80(2):228-237. doi: 10.1136/annrheumdis-2020-217840. Epub 2020 Oct 7.
PMID: 33028580

Machine learning predicts stem cell transplant response in severe scleroderma.
Franks JM, Martyanov V, Wang Y, Wood TA, Pinckney A, Crofford LJ, Keyes-Elstein L, Furst DE, Goldmuntz E, Mayes MD, McSweeney P, Nash RA, Sullivan KM, Whitfield ML
Ann Rheum Dis. 2020 Dec;79(12):1608-1615. doi: 10.1136/annrheumdis-2020-217033. Epub 2020 Sep 15.
PMID: 32933919

Regulator combinations identify systemic sclerosis patients with more severe disease.
Wang Y, Franks JM, Yang M, Toledo DM, Wood TA, Hinchcliff M, Whitfield ML
JCI Insight. 2020 Sep 3;5(17) pii: 137567. doi: 10.1172/jci.insight.137567. Epub 2020 Sep 3.
PMID: 32721949

Safety and Efficacy of Lenabasum in a Phase II, Randomized, Placebo-Controlled Trial in Adults With Systemic Sclerosis.
Spiera R, Hummers L, Chung L, Frech TM, Domsic R, Hsu V, Furst DE, Gordon J, Mayes M, Simms R, Lafyatis R, Martyanov V, Wood T, Whitfield ML, Constantine S, Lee E, Dgetluck N, White B
Arthritis Rheumatol. 2020 Aug;72(8):1350-1360. doi: 10.1002/art.41294. Epub 2020 Jul 17.
PMID: 32336038

CDDO-Me Alters the Tumor Microenvironment in Estrogen Receptor Negative Breast Cancer.
Ball MS, Bhandari R, Torres GM, Martyanov V, ElTanbouly MA, Archambault K, Whitfield ML, Liby KT, Pioli PA
Sci Rep. 2020 Apr 16;10(1):6560. doi: 10.1038/s41598-020-63482-x. Epub 2020 Apr 16.
PMID: 32300202

Profibrotic Activation of Human Macrophages in Systemic Sclerosis.
Bhandari R, Ball MS, Martyanov V, Popovich D, Schaafsma E, Han S, ElTanbouly M, Orzechowski NM, Carns M, Arroyo E, Aren K, Hinchcliff M, Whitfield ML, Pioli PA
Arthritis Rheumatol. 2020 Jul;72(7):1160-1169. doi: 10.1002/art.41243. Epub 2020 May 31.
PMID: 32134204

Current and Future Outlook on Disease Modification and Defining Low Disease Activity in Systemic Sclerosis.
Nagaraja V, Matucci-Cerinic M, Furst DE, Kuwana M, Allanore Y, Denton CP, Raghu G, Mclaughlin V, Rao PS, Seibold JR, Pauling JD, Whitfield ML, Khanna D
Arthritis Rheumatol. 2020 Jul;72(7):1049-1058. doi: 10.1002/art.41246. Epub 2020 May 18.
PMID: 32134199

Global skin gene expression analysis of early diffuse cutaneous systemic sclerosis shows a prominent innate and adaptive inflammatory profile.
Skaug B, Khanna D, Swindell WR, Hinchcliff ME, Frech TM, Steen VD, Hant FN, Gordon JK, Shah AA, Zhu L, Zheng WJ, Browning JL, Barron AMS, Wu M, Visvanathan S, Baum P, Franks JM, Whitfield ML, Shanmugam VK, Domsic RT, Castelino FV, Bernstein EJ, Wareing N, Lyons MA, Ying J, Charles J, Mayes MD, Assassi S
Ann Rheum Dis. 2020 Mar;79(3):379-386. doi: 10.1136/annrheumdis-2019-215894. Epub 2019 Nov 25.
PMID: 31767698

Shared and distinct mechanisms of fibrosis.
Distler JHW, Gyorfi AH, Ramanujam M, Whitfield ML, Konigshoff M, Lafyatis R
Nat Rev Rheumatol. 2019 Dec;15(12):705-730. doi: 10.1038/s41584-019-0322-7. Epub 2019 Nov 11.
PMID: 31712723

Systemic Sclerosis Dermal Fibroblasts Induce Cutaneous Fibrosis Through Lysyl Oxidase-like 4: New Evidence From Three-Dimensional Skin-like Tissues.
Huang M, Cai G, Baugh LM, Liu Z, Smith A, Watson M, Popovich D, Zhang T, Stawski LS, Trojanowska M, Georgakoudi I, Black LD III, Pioli PA, Whitfield ML, Garlick J
Arthritis Rheumatol. 2020 May;72(5):791-801. doi: 10.1002/art.41163. Epub 2020 Apr 4.
PMID: 31705627

Abatacept in Early Diffuse Cutaneous Systemic Sclerosis: Results of a Phase II Investigator-Initiated, Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial.
Khanna D, Spino C, Johnson S, Chung L, Whitfield ML, Denton CP, Berrocal V, Franks J, Mehta B, Molitor J, Steen VD, Lafyatis R, Simms RW, Gill A, Kafaja S, Frech TM, Hsu V, Domsic RT, Pope JE, Gordon JK, Mayes MD, Schiopu E, Young A, Sandorfi N, Park J, Hant FN, Bernstein EJ, Chatterjee S, Castelino FV, Ajam A, Wang Y, Wood T, Allanore Y, Matucci-Cerinic M, Distler O, Singer O, Bush E, Fox DA, Furst DE
Arthritis Rheumatol. 2020 Jan;72(1):125-136. doi: 10.1002/art.41055. Epub 2019 Dec 10.
PMID: 31342624

OTUD6B-AS1 Might Be a Novel Regulator of Apoptosis in Systemic Sclerosis.
Takata M, Pachera E, Frank-Bertoncelj M, Kozlova A, Jungel A, Whitfield ML, Assassi S, Calcagni M, de Vries-Bouwstra J, Huizinga TW, Kurreeman F, Kania G, Distler O
Front Immunol. 2019;10:1100. doi: 10.3389/fimmu.2019.01100. Epub 2019 May 17.
PMID: 31156645

Senescence Signature in Skin Biopsies From Systemic Sclerosis Patients Treated With Senolytic Therapy: Potential Predictor of Clinical Response?
Martyanov V, Whitfield ML, Varga J
Arthritis Rheumatol. 2019 Oct;71(10):1766-1767. doi: 10.1002/art.40934. Epub 2019 Sep 2.
PMID: 31112009

A Machine Learning Classifier for Assigning Individual Patients With Systemic Sclerosis to Intrinsic Molecular Subsets.
Franks JM, Martyanov V, Cai G, Wang Y, Li Z, Wood TA, Whitfield ML
Arthritis Rheumatol. 2019 Oct;71(10):1701-1710. doi: 10.1002/art.40898. Epub 2019 Sep 2.
PMID: 30920766

BioMethyl: an R package for biological interpretation of DNA methylation data.
Wang Y, Franks JM, Whitfield ML, Cheng C
Bioinformatics. 2019 Oct 1;35(19):3635-3641. doi: 10.1093/bioinformatics/btz137.
PMID: 30799505

Microbiome dysbiosis is associated with disease duration and increased inflammatory gene expression in systemic sclerosis skin.
Johnson ME, Franks JM, Cai G, Mehta BK, Wood TA, Archambault K, Pioli PA, Simms RW, Orzechowski N, Arron S, Whitfield ML
Arthritis Res Ther. 2019 Feb 6;21(1):49. doi: 10.1186/s13075-019-1816-z. Epub 2019 Feb 6.
PMID: 30728065