Publications

Safety and efficacy of lenabasum in a phase 2 randomized, placebo-controlled trial in adults with systemic sclerosis.
Spiera R, Hummers L, Chung L, Frech TM, Domsic R, Hsu V, Furst DE, Gordon J, Mayes M, Simms R, Lafyatis R, Martyanov V, Wood T, Whitfield ML, Constantine S, Lee E, Dgetluck N, White B
Arthritis Rheumatol. 2020 Apr 26; doi: 10.1002/art.41294. Epub 2020 Apr 26.
PMID: 32336038

CDDO-Me Alters the Tumor Microenvironment in Estrogen Receptor Negative Breast Cancer.
Ball MS, Bhandari R, Torres GM, Martyanov V, ElTanbouly MA, Archambault K, Whitfield ML, Liby KT, Pioli PA
Sci Rep. 2020 Apr 16;10(1):6560. doi: 10.1038/s41598-020-63482-x. Epub 2020 Apr 16.
PMID: 32300202

Profibrotic Activation of Human Macrophages in Systemic Sclerosis.
Bhandari R, Ball MS, Martyanov V, Popovich D, Schaafsma E, Han S, ElTanbouly M, Orzechowski NM, Carns M, Arroyo E, Aren K, Hinchcliff M, Whitfield ML, Pioli PA
Arthritis Rheumatol. 2020 Jul;72(7):1160-1169. doi: 10.1002/art.41243. Epub 2020 May 31.
PMID: 32134204

Current and Future Outlook on Disease Modification and Defining Low Disease Activity in Systemic Sclerosis.
Nagaraja V, Matucci-Cerinic M, Furst DE, Kuwana M, Allanore Y, Denton CP, Raghu G, Mclaughlin V, Rao PS, Seibold JR, Pauling JD, Whitfield ML, Khanna D
Arthritis Rheumatol. 2020 Jul;72(7):1049-1058. doi: 10.1002/art.41246. Epub 2020 May 18.
PMID: 32134199

Global skin gene expression analysis of early diffuse cutaneous systemic sclerosis shows a prominent innate and adaptive inflammatory profile.
Skaug B, Khanna D, Swindell WR, Hinchcliff ME, Frech TM, Steen VD, Hant FN, Gordon JK, Shah AA, Zhu L, Zheng WJ, Browning JL, Barron AMS, Wu M, Visvanathan S, Baum P, Franks JM, Whitfield ML, Shanmugam VK, Domsic RT, Castelino FV, Bernstein EJ, Wareing N, Lyons MA, Ying J, Charles J, Mayes MD, Assassi S
Ann Rheum Dis. 2020 Mar;79(3):379-386. doi: 10.1136/annrheumdis-2019-215894. Epub 2019 Nov 25.
PMID: 31767698

Shared and distinct mechanisms of fibrosis.
Distler JHW, Gyorfi AH, Ramanujam M, Whitfield ML, Konigshoff M, Lafyatis R
Nat Rev Rheumatol. 2019 Dec;15(12):705-730. doi: 10.1038/s41584-019-0322-7. Epub 2019 Nov 11.
PMID: 31712723

Systemic Sclerosis Dermal Fibroblasts Induce Cutaneous Fibrosis Through Lysyl Oxidase-like 4: New Evidence From Three-Dimensional Skin-like Tissues.
Huang M, Cai G, Baugh LM, Liu Z, Smith A, Watson M, Popovich D, Zhang T, Stawski LS, Trojanowska M, Georgakoudi I, Black LD III, Pioli PA, Whitfield ML, Garlick J
Arthritis Rheumatol. 2020 May;72(5):791-801. doi: 10.1002/art.41163. Epub 2020 Apr 4.
PMID: 31705627

Abatacept in Early Diffuse Cutaneous Systemic Sclerosis: Results of a Phase II Investigator-Initiated, Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial.
Khanna D, Spino C, Johnson S, Chung L, Whitfield ML, Denton CP, Berrocal V, Franks J, Mehta B, Molitor J, Steen VD, Lafyatis R, Simms RW, Gill A, Kafaja S, Frech TM, Hsu V, Domsic RT, Pope JE, Gordon JK, Mayes MD, Schiopu E, Young A, Sandorfi N, Park J, Hant FN, Bernstein EJ, Chatterjee S, Castelino FV, Ajam A, Wang Y, Wood T, Allanore Y, Matucci-Cerinic M, Distler O, Singer O, Bush E, Fox DA, Furst DE
Arthritis Rheumatol. 2020 Jan;72(1):125-136. doi: 10.1002/art.41055. Epub 2019 Dec 10.
PMID: 31342624

OTUD6B-AS1 Might Be a Novel Regulator of Apoptosis in Systemic Sclerosis.
Takata M, Pachera E, Frank-Bertoncelj M, Kozlova A, Jungel A, Whitfield ML, Assassi S, Calcagni M, de Vries-Bouwstra J, Huizinga TW, Kurreeman F, Kania G, Distler O
Front Immunol. 2019;10:1100. doi: 10.3389/fimmu.2019.01100. Epub 2019 May 17.
PMID: 31156645

Senescence Signature in Skin Biopsies From Systemic Sclerosis Patients Treated With Senolytic Therapy: Potential Predictor of Clinical Response?
Martyanov V, Whitfield ML, Varga J
Arthritis Rheumatol. 2019 Oct;71(10):1766-1767. doi: 10.1002/art.40934. Epub 2019 Sep 2.
PMID: 31112009

A Machine Learning Classifier for Assigning Individual Patients With Systemic Sclerosis to Intrinsic Molecular Subsets.
Franks JM, Martyanov V, Cai G, Wang Y, Li Z, Wood TA, Whitfield ML
Arthritis Rheumatol. 2019 Oct;71(10):1701-1710. doi: 10.1002/art.40898. Epub 2019 Sep 2.
PMID: 30920766

BioMethyl: an R package for biological interpretation of DNA methylation data.
Wang Y, Franks JM, Whitfield ML, Cheng C
Bioinformatics. 2019 Oct 1;35(19):3635-3641. doi: 10.1093/bioinformatics/btz137.
PMID: 30799505

Microbiome dysbiosis is associated with disease duration and increased inflammatory gene expression in systemic sclerosis skin.
Johnson ME, Franks JM, Cai G, Mehta BK, Wood TA, Archambault K, Pioli PA, Simms RW, Orzechowski N, Arron S, Whitfield ML
Arthritis Res Ther. 2019 Feb 6;21(1):49. doi: 10.1186/s13075-019-1816-z. Epub 2019 Feb 6.
PMID: 30728065

Lysyl oxidase enzymes mediate TGF-╬▓1-induced fibrotic phenotypes in human skin-like tissues.
Huang M, Liu Z, Baugh L, DeFuria J, Maione A, Smith A, Kashpur O, Black Iii LD, Georgakoudi I, Whitfield ML, Garlick J
Lab Invest. 2019 Apr;99(4):514-527. doi: 10.1038/s41374-018-0159-8. Epub 2018 Dec 19.
PMID: 30568176

Patients with systemic sclerosis-associated pulmonary arterial hypertension express a genomic signature distinct from patients with interstitial lung disease.
Moll M, Christmann RB, Zhang Y, Whitfield ML, Wang YM, Rice L, Stratton E, Lafyatis R, Farber HW
J Scleroderma Relat Disord. 2018 Oct;3(3):242-248. doi: 10.1177/2397198318764780. Epub 2018 Mar 22.
PMID: 30498788

The mechanistic implications of gene expression studies in SSc: Insights from Systems Biology.
Taroni JN, Mahoney JM, Whitfield ML
Curr Treatm Opt Rheumatol. 2017 Sep;3(3):181-192. doi: 10.1007/s40674-017-0072-0. Epub 2017 Jul 29.
PMID: 29520335

Mycophenolate Mofetil Treatment of Systemic Sclerosis Reduces Myeloid Cell Numbers and Attenuates the Inflammatory Gene Signature in Skin.
Hinchcliff M, Toledo DM, Taroni JN, Wood TA, Franks JM, Ball MS, Hoffmann A, Amin SM, Tan AU, Tom K, Nesbeth Y, Lee J, Ma M, Aren K, Carns MA, Pioli PA, Whitfield ML
J Invest Dermatol. 2018 Jun;138(6):1301-1310. doi: 10.1016/j.jid.2018.01.006. Epub 2018 Jan 31.
PMID: 29391252

Feature specific quantile normalization enables cross-platform classification of molecular subtypes using gene expression data.
Franks JM, Cai G, Whitfield ML
Bioinformatics. 2018 Jun 1;34(11):1868-1874. doi: 10.1093/bioinformatics/bty026.
PMID: 29360996

Antisense Long Non-Coding RNAs Are Deregulated in Skin Tissue of Patients with Systemic Sclerosis.
Messemaker TC, Chadli L, Cai G, Goelela VS, Boonstra M, Dorjee AL, Andersen SN, Mikkers HMM, van 't Hof P, Mei H, Distler O, Draisma HHM, Johnson ME, Orzechowski NM, Simms RW, Toes REM, Aarbiou J, Huizinga TW, Whitfield ML, DeGroot J, de Vries-Bouwstra J, Kurreeman F
J Invest Dermatol. 2018 Apr;138(4):826-835. doi: 10.1016/j.jid.2017.09.053. Epub 2017 Nov 24.
PMID: 29179949

Novel lung imaging biomarkers and skin gene expression subsetting in dasatinib treatment of systemic sclerosis-associated interstitial lung disease.
Martyanov V, Kim GJ, Hayes W, Du S, Ganguly BJ, Sy O, Lee SK, Bogatkevich GS, Schieven GL, Schiopu E, Marangoni RG, Goldin J, Whitfield ML, Varga J
PLoS One. 2017;12(11):e0187580. doi: 10.1371/journal.pone.0187580. Epub 2017 Nov 9.
PMID: 29121645

Belimumab for the Treatment of Early Diffuse Systemic Sclerosis: Results of a Randomized, Double-Blind, Placebo-Controlled, Pilot Trial.
Gordon JK, Martyanov V, Franks JM, Bernstein EJ, Szymonifka J, Magro C, Wildman HF, Wood TA, Whitfield ML, Spiera RF
Arthritis Rheumatol. 2018 Feb;70(2):308-316. doi: 10.1002/art.40358. Epub 2017 Dec 29.
PMID: 29073351

Limited cutaneous systemic sclerosis skin demonstrates distinct molecular subsets separated by a cardiovascular development gene expression signature.
Derrett-Smith EC, Martyanov V, Chighizola CB, Moinzadeh P, Campochiaro C, Khan K, Wood TA, Meroni PL, Abraham DJ, Ong VH, Lafyatis R, Whitfield ML, Denton CP
Arthritis Res Ther. 2017 Jul 4;19(1):156. doi: 10.1186/s13075-017-1360-7. Epub 2017 Jul 4.
PMID: 28676069

Population effect model identifies gene expression predictors of survival outcomes in lung adenocarcinoma for both Caucasian and Asian patients.
Cai G, Xiao F, Cheng C, Li Y, Amos CI, Whitfield ML
PLoS One. 2017;12(4):e0175850. doi: 10.1371/journal.pone.0175850. Epub 2017 Apr 20.
PMID: 28426704

A novel multi-network approach reveals tissue-specific cellular modulators of fibrosis in systemic sclerosis.
Taroni JN, Greene CS, Martyanov V, Wood TA, Christmann RB, Farber HW, Lafyatis RA, Denton CP, Hinchcliff ME, Pioli PA, Mahoney JM, Whitfield ML
Genome Med. 2017 Mar 23;9(1):27. doi: 10.1186/s13073-017-0417-1. Epub 2017 Mar 23.
PMID: 28330499

Myeloid Cells That Impair Immunotherapy Are Restored in Melanomas with Acquired Resistance to BRAF Inhibitors.
Steinberg SM, Shabaneh TB, Zhang P, Martyanov V, Li Z, Malik BT, Wood TA, Boni A, Molodtsov A, Angeles CV, Curiel TJ, Whitfield ML, Turk MJ
Cancer Res. 2017 Apr 1;77(7):1599-1610. doi: 10.1158/0008-5472.CAN-16-1755. Epub 2017 Feb 15.
PMID: 28202513